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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11992

FusionGeneSummary for ERGIC1_ERGIC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERGIC1_ERGIC1
Fusion gene ID: 11992
HgeneTgene
Gene symbol

ERGIC1

ERGIC1

Gene ID

57222

57222

Gene nameendoplasmic reticulum-golgi intermediate compartment 1endoplasmic reticulum-golgi intermediate compartment 1
SynonymsAMCN|ERGIC-32|ERGIC32|NET24AMCN|ERGIC-32|ERGIC32|NET24
Cytomap

5q35.1

5q35.1

Type of geneprotein-codingprotein-coding
Descriptionendoplasmic reticulum-Golgi intermediate compartment protein 1ER-Golgi intermediate compartment 32 kDa proteinendoplasmic reticulum-golgi intermediate compartment (ERGIC) 1endoplasmic reticulum-golgi intermediate compartment 32 kDa proteinendoplasmic reticulum-Golgi intermediate compartment protein 1ER-Golgi intermediate compartment 32 kDa proteinendoplasmic reticulum-golgi intermediate compartment (ERGIC) 1endoplasmic reticulum-golgi intermediate compartment 32 kDa protein
Modification date2018052320180523
UniProtAcc

Q969X5

Q969X5

Ensembl transtripts involved in fusion geneENST00000393784, ENST00000519860, 
ENST00000523291, ENST00000326654, 
ENST00000393784, ENST00000519860, 
ENST00000523291, ENST00000326654, 
Fusion gene scores* DoF score11 X 13 X 6=8587 X 9 X 4=252
# samples 2016
** MAII scorelog2(20/858*10)=-2.10097764772482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/252*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERGIC1 [Title/Abstract] AND ERGIC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERGIC1

GO:0006888

ER to Golgi vesicle-mediated transport

15308636

TgeneERGIC1

GO:0006888

ER to Golgi vesicle-mediated transport

15308636


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW798048ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
ChiTaRS3.1AW798061ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
ChiTaRS3.1BE939392ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
ChiTaRS3.1BE939413ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
ChiTaRS3.1BF985014ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
ChiTaRS3.1BF985035ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
ChiTaRS3.1BE084567ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
ChiTaRS3.1CN411868ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000393784ENST00000393784ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
3UTR-intronENST00000393784ENST00000519860ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
3UTR-intronENST00000393784ENST00000523291ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
3UTR-intronENST00000393784ENST00000326654ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-3UTRENST00000519860ENST00000393784ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000519860ENST00000519860ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000519860ENST00000523291ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000519860ENST00000326654ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-3UTRENST00000523291ENST00000393784ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000523291ENST00000519860ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000523291ENST00000523291ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000523291ENST00000326654ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-3UTRENST00000326654ENST00000393784ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000326654ENST00000519860ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000326654ENST00000523291ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000326654ENST00000326654ERGIC1chr5

172378428

-ERGIC1chr5

172378692

+
intron-intronENST00000393784ENST00000393784ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000393784ENST00000519860ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000393784ENST00000523291ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000393784ENST00000326654ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000519860ENST00000393784ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000519860ENST00000519860ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000519860ENST00000523291ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000519860ENST00000326654ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000523291ENST00000393784ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000523291ENST00000519860ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000523291ENST00000523291ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000523291ENST00000326654ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000326654ENST00000393784ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000326654ENST00000519860ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000326654ENST00000523291ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
intron-intronENST00000326654ENST00000326654ERGIC1chr5

172305780

+ERGIC1chr5

172305677

-
3UTR-3UTRENST00000393784ENST00000393784ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
3UTR-intronENST00000393784ENST00000519860ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
3UTR-intronENST00000393784ENST00000523291ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
3UTR-intronENST00000393784ENST00000326654ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-3UTRENST00000519860ENST00000393784ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000519860ENST00000519860ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000519860ENST00000523291ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000519860ENST00000326654ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-3UTRENST00000523291ENST00000393784ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000523291ENST00000519860ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000523291ENST00000523291ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000523291ENST00000326654ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-3UTRENST00000326654ENST00000393784ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000326654ENST00000519860ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000326654ENST00000523291ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+
intron-intronENST00000326654ENST00000326654ERGIC1chr5

172378975

-ERGIC1chr5

172379088

+

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FusionProtFeatures for ERGIC1_ERGIC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERGIC1

Q969X5

ERGIC1

Q969X5

Possible role in transport between endoplasmic reticulumand Golgi. {ECO:0000303|PubMed:15308636}. Possible role in transport between endoplasmic reticulumand Golgi. {ECO:0000303|PubMed:15308636}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERGIC1_ERGIC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERGIC1_ERGIC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERGIC1_ERGIC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERGIC1_ERGIC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource