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Fusion gene ID: 11967 |
FusionGeneSummary for ERC1_ZNF492 |
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Fusion gene information | Fusion gene name: ERC1_ZNF492 | Fusion gene ID: 11967 | Hgene | Tgene | Gene symbol | ERC1 | ZNF492 | Gene ID | 23085 | 57615 |
Gene name | ELKS/RAB6-interacting/CAST family member 1 | zinc finger protein 492 | |
Synonyms | Cast2|ELKS|ERC-1|RAB6IP2 | ZNF115 | |
Cytomap | 12p13.33 | 19p12 | |
Type of gene | protein-coding | protein-coding | |
Description | ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2 | zinc finger protein 492zinc finger protein 115 (Y20) | |
Modification date | 20180522 | 20180403 | |
UniProtAcc | Q8IUD2 | Q9P255 | |
Ensembl transtripts involved in fusion gene | ENST00000543086, ENST00000546231, ENST00000397203, ENST00000360905, ENST00000589028, ENST00000355446, ENST00000536573, | ENST00000456783, | |
Fusion gene scores | * DoF score | 20 X 16 X 12=3840 | 1 X 1 X 1=1 |
# samples | 23 | 1 | |
** MAII score | log2(23/3840*10)=-4.06140054466414 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ERC1 [Title/Abstract] AND ZNF492 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ERC1 | GO:0007252 | I-kappaB phosphorylation | 15218148 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-44-5644-01A | ERC1 | chr12 | 1399178 | + | ZNF492 | chr19 | 22846602 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000543086 | ENST00000456783 | ERC1 | chr12 | 1399178 | + | ZNF492 | chr19 | 22846602 | + |
Frame-shift | ENST00000546231 | ENST00000456783 | ERC1 | chr12 | 1399178 | + | ZNF492 | chr19 | 22846602 | + |
Frame-shift | ENST00000397203 | ENST00000456783 | ERC1 | chr12 | 1399178 | + | ZNF492 | chr19 | 22846602 | + |
Frame-shift | ENST00000360905 | ENST00000456783 | ERC1 | chr12 | 1399178 | + | ZNF492 | chr19 | 22846602 | + |
Frame-shift | ENST00000589028 | ENST00000456783 | ERC1 | chr12 | 1399178 | + | ZNF492 | chr19 | 22846602 | + |
Frame-shift | ENST00000355446 | ENST00000456783 | ERC1 | chr12 | 1399178 | + | ZNF492 | chr19 | 22846602 | + |
intron-3CDS | ENST00000536573 | ENST00000456783 | ERC1 | chr12 | 1399178 | + | ZNF492 | chr19 | 22846602 | + |
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FusionProtFeatures for ERC1_ZNF492 |
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Hgene | Tgene |
ERC1 | ZNF492 |
May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ERC1_ZNF492 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ERC1_ZNF492 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ERC1 | YWHAG, TWF2, RAB6A, RAB6B, KBTBD7, IKBKB, MAP3K7, IKBKG, XIAP, ITSN2, RAD23A, SH3KBP1, CHUK, NFKBIA, CUL3, APP, ATP6V0D1, NCBP1, WDR4, ERC2, MYC, PAN2, CDK19, MAPK4, CDK20, LATS2, STK4, GFOD1, ADPRHL2, SNX2, MED4, EWSR1, SRPK2, OFD1, PCM1, CEP104, CEP162, CEP152, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, SCLT1, SASS6, DVL2, SLC16A6, KIF23, MAPRE1, RACGAP1, CHST15, PPP1R21, MACROD1, PCGF1, NANOG, POU5F1, NHLRC2, CDH1, EYA4, TSHB, SPERT, TRIM25, BRCA1 | ZNF492 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ERC1_ZNF492 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERC1_ZNF492 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |