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Fusion gene ID: 11956 |
FusionGeneSummary for ERC1_MRPS9 |
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Fusion gene information | Fusion gene name: ERC1_MRPS9 | Fusion gene ID: 11956 | Hgene | Tgene | Gene symbol | ERC1 | MRPS9 | Gene ID | 23085 | 64965 |
Gene name | ELKS/RAB6-interacting/CAST family member 1 | mitochondrial ribosomal protein S9 | |
Synonyms | Cast2|ELKS|ERC-1|RAB6IP2 | MRP-S9|RPMS9|S9mt | |
Cytomap | 12p13.33 | 2q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2 | 28S ribosomal protein S9, mitochondrialmitochondrial small ribosomal subunit protein uS9m | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q8IUD2 | P82933 | |
Ensembl transtripts involved in fusion gene | ENST00000543086, ENST00000546231, ENST00000397203, ENST00000360905, ENST00000589028, ENST00000355446, ENST00000536573, | ENST00000258455, | |
Fusion gene scores | * DoF score | 20 X 16 X 12=3840 | 3 X 3 X 3=27 |
# samples | 23 | 3 | |
** MAII score | log2(23/3840*10)=-4.06140054466414 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ERC1 [Title/Abstract] AND MRPS9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ERC1 | GO:0007252 | I-kappaB phosphorylation | 15218148 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-QQ-A5VC-01A | ERC1 | chr12 | 1481143 | + | MRPS9 | chr2 | 105716128 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000543086 | ENST00000258455 | ERC1 | chr12 | 1481143 | + | MRPS9 | chr2 | 105716128 | + |
Frame-shift | ENST00000546231 | ENST00000258455 | ERC1 | chr12 | 1481143 | + | MRPS9 | chr2 | 105716128 | + |
Frame-shift | ENST00000397203 | ENST00000258455 | ERC1 | chr12 | 1481143 | + | MRPS9 | chr2 | 105716128 | + |
Frame-shift | ENST00000360905 | ENST00000258455 | ERC1 | chr12 | 1481143 | + | MRPS9 | chr2 | 105716128 | + |
Frame-shift | ENST00000589028 | ENST00000258455 | ERC1 | chr12 | 1481143 | + | MRPS9 | chr2 | 105716128 | + |
Frame-shift | ENST00000355446 | ENST00000258455 | ERC1 | chr12 | 1481143 | + | MRPS9 | chr2 | 105716128 | + |
intron-3CDS | ENST00000536573 | ENST00000258455 | ERC1 | chr12 | 1481143 | + | MRPS9 | chr2 | 105716128 | + |
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FusionProtFeatures for ERC1_MRPS9 |
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Hgene | Tgene |
ERC1 | MRPS9 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ERC1_MRPS9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ERC1_MRPS9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ERC1 | YWHAG, TWF2, RAB6A, RAB6B, KBTBD7, IKBKB, MAP3K7, IKBKG, XIAP, ITSN2, RAD23A, SH3KBP1, CHUK, NFKBIA, CUL3, APP, ATP6V0D1, NCBP1, WDR4, ERC2, MYC, PAN2, CDK19, MAPK4, CDK20, LATS2, STK4, GFOD1, ADPRHL2, SNX2, MED4, EWSR1, SRPK2, OFD1, PCM1, CEP104, CEP162, CEP152, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, SCLT1, SASS6, DVL2, SLC16A6, KIF23, MAPRE1, RACGAP1, CHST15, PPP1R21, MACROD1, PCGF1, NANOG, POU5F1, NHLRC2, CDH1, EYA4, TSHB, SPERT, TRIM25, BRCA1 | MRPS9 | DDX56, HAP1, ICT1, CUL3, CAND1, MRPL3, MRPS2, MRPS25, MRPL13, MRPL32, MRPL39, MRPL40, MRPL38, MRPS7, MRPL42, MRPL21, MRPL55, MRPL41, MRPS16, MRPL50, MRPL23, MRPS28, MRPS18B, MRPL12, MRPS26, MRPS21, EWSR1, ILF3, HNRNPC, SDHA, HNRNPR, LAMTOR3, SLC3A2, RPS18, NPLOC4, HNRNPM, ESR1, C1QBP, SOX2, HECW2, CEP250, TP53, FBXW11, NOL12, RPL13, NSA2, TRA2A, RPL6, HNRNPDL, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, LUC7L, MRPS31, MRPS5, MRPS11, NTRK1, MRPS22, MRPS23, DAP3, MRPS35, PSMB1, PTCD3, PSMA4, PSMA5, PSMB2, PSMB8, HNRNPU, TERF1, EMC2, APOL2, ATP6V1C2, ZNF746, MRPS34, MRPS27, MRPS15, AURKAIP1, E4F1, SNRNP70, RBM42, CCDC59, RRS1, PDGFB, ZC3HAV1, GLTSCR2, FGF8, ZNF169, ZBTB48, RPL18, ZNF331, ZNF2, ZNF574, STRBP, ZNF550, CDX1, KBTBD7, U2AF2, BHLHA15, RBM3, PARK7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ERC1_MRPS9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERC1_MRPS9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |