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Fusion gene ID: 11942 |
FusionGeneSummary for ERBB3_TRIM37 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERBB3_TRIM37 | Fusion gene ID: 11942 | Hgene | Tgene | Gene symbol | ERBB3 | TRIM37 | Gene ID | 2065 | 4591 |
| Gene name | erb-b2 receptor tyrosine kinase 3 | tripartite motif containing 37 | |
| Synonyms | ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | MUL|POB1|TEF3 | |
| Cytomap | 12q13.2 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | E3 ubiquitin-protein ligase TRIM37RING-B-box-coiled-coil proteinRING-type E3 ubiquitin transferase TRIM37mulibrey nanism protein | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | P21860 | O94972 | |
| Ensembl transtripts involved in fusion gene | ENST00000267101, ENST00000450146, ENST00000415288, ENST00000553131, ENST00000411731, ENST00000549832, | ENST00000393066, ENST00000262294, ENST00000376149, ENST00000393065, ENST00000584889, | |
| Fusion gene scores | * DoF score | 16 X 15 X 9=2160 | 7 X 6 X 7=294 |
| # samples | 16 | 7 | |
| ** MAII score | log2(16/2160*10)=-3.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ERBB3 [Title/Abstract] AND TRIM37 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
| Hgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
| Hgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
| Hgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
| Hgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
| Hgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
| Tgene | TRIM37 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 25470042 |
| Tgene | TRIM37 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11279055 |
| Tgene | TRIM37 | GO:0035518 | histone H2A monoubiquitination | 25470042 |
| Tgene | TRIM37 | GO:0036353 | histone H2A-K119 monoubiquitination | 25470042 |
| Tgene | TRIM37 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 23077300 |
| Tgene | TRIM37 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 23077300 |
| Tgene | TRIM37 | GO:0051865 | protein autoubiquitination | 15885686 |
| Tgene | TRIM37 | GO:0070842 | aggresome assembly | 15885686 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DN914711 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000267101 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000267101 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000267101 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000267101 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000267101 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000450146 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000450146 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000450146 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000450146 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000450146 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000415288 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000415288 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000415288 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000415288 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000415288 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000553131 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000553131 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000553131 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000553131 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000553131 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-intron | ENST00000411731 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-3UTR | ENST00000411731 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-3UTR | ENST00000411731 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-3UTR | ENST00000411731 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| intron-intron | ENST00000411731 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000549832 | ENST00000393066 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000549832 | ENST00000262294 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000549832 | ENST00000376149 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-3UTR | ENST00000549832 | ENST00000393065 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
| 5CDS-intron | ENST00000549832 | ENST00000584889 | ERBB3 | chr12 | 56495716 | - | TRIM37 | chr17 | 57076529 | - |
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FusionProtFeatures for ERBB3_TRIM37 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERBB3 | TRIM37 |
| Tyrosine-protein kinase that plays an essential role ascell surface receptor for neuregulins. Binds to neuregulin-1(NRG1) and is activated by it; ligand-binding increasesphosphorylation on tyrosine residues and promotes its associationwith the p85 subunit of phosphatidylinositol 3-kinase(PubMed:20682778). May also be activated by CSPG5(PubMed:15358134). {ECO:0000269|PubMed:15358134,ECO:0000269|PubMed:20682778}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ERBB3_TRIM37 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ERBB3_TRIM37 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ERBB3_TRIM37 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERBB3_TRIM37 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ERBB3 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | ERBB3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | ERBB3 | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | ERBB3 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
| Hgene | ERBB3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | ERBB3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | ERBB3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | ERBB3 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Hgene | ERBB3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | ERBB3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
| Tgene | TRIM37 | C0524582 | Mulibrey Nanism | 4 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TRIM37 | C0016063 | Osteitis Fibrosa Disseminata | 1 | CTD_human |
| Tgene | TRIM37 | C0019209 | Hepatomegaly | 1 | CTD_human;HPO |
| Tgene | TRIM37 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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