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Fusion gene ID: 11930 |
FusionGeneSummary for ERBB3_CSN2 |
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Fusion gene information | Fusion gene name: ERBB3_CSN2 | Fusion gene ID: 11930 | Hgene | Tgene | Gene symbol | ERBB3 | CSN2 | Gene ID | 2065 | 9318 |
Gene name | erb-b2 receptor tyrosine kinase 3 | COP9 signalosome subunit 2 | |
Synonyms | ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 | ALIEN|CSN2|SGN2|TRIP15 | |
Cytomap | 12q13.2 | 15q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | receptor tyrosine-protein kinase erbB-3human epidermal growth factor receptor 3proto-oncogene-like protein c-ErbB-3tyrosine kinase-type cell surface receptor HER3v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | COP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P21860 | P05814 | |
Ensembl transtripts involved in fusion gene | ENST00000267101, ENST00000450146, ENST00000415288, ENST00000553131, ENST00000411731, ENST00000549832, | ENST00000353151, | |
Fusion gene scores | * DoF score | 16 X 15 X 9=2160 | 14 X 11 X 2=308 |
# samples | 16 | 3 | |
** MAII score | log2(16/2160*10)=-3.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/308*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ERBB3 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ERBB3 | GO:0007162 | negative regulation of cell adhesion | 7556068 |
Hgene | ERBB3 | GO:0007165 | signal transduction | 10572067 |
Hgene | ERBB3 | GO:0009968 | negative regulation of signal transduction | 11389077 |
Hgene | ERBB3 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
Hgene | ERBB3 | GO:0042127 | regulation of cell proliferation | 11389077 |
Hgene | ERBB3 | GO:0051048 | negative regulation of secretion | 10559227 |
Tgene | CSN2 | GO:0000338 | protein deneddylation | 19141280 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A1KO-01A | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000267101 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
3UTR-3CDS | ENST00000450146 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
3UTR-3CDS | ENST00000415288 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
3UTR-3CDS | ENST00000553131 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
intron-3CDS | ENST00000411731 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
3UTR-3CDS | ENST00000549832 | ENST00000353151 | ERBB3 | chr12 | 56496111 | + | CSN2 | chr4 | 70826725 | - |
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FusionProtFeatures for ERBB3_CSN2 |
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Hgene | Tgene |
ERBB3 | CSN2 |
Tyrosine-protein kinase that plays an essential role ascell surface receptor for neuregulins. Binds to neuregulin-1(NRG1) and is activated by it; ligand-binding increasesphosphorylation on tyrosine residues and promotes its associationwith the p85 subunit of phosphatidylinositol 3-kinase(PubMed:20682778). May also be activated by CSPG5(PubMed:15358134). {ECO:0000269|PubMed:15358134,ECO:0000269|PubMed:20682778}. | Important role in determination of the surfaceproperties of the casein micelles. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ERBB3_CSN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ERBB3_CSN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ERBB3 | GRB2, PIK3R2, CSK, SHC1, CD82, RGS4, ODF2L, GRB7, PA2G4, EGF, RNF41, NRG1, PIK3R1, IL6ST, PTK6, EGFR, MUC1, NRG2, ERBB2, RPN1, EGR1, ZNF207, HDAC6, LRIG1, MDM2, AKT1, PTPN11, HSP90AA1, NCK2, JAK2, SH2D1A, DAB1, ABL1, HCK, FGFR1, SRC, NCK1, FER, PLCG1, RASA1, TXK, ABL2, ZAP70, SYK, CRK, CRKL, JAK3, VAV2, CHN2, ITK, RIN1, BCAR3, TENC1, TNS3, TNS4, SHC3, PIK3R3, VAV1, VAV3, DAPP1, SH2B3, NEDD4, HLA-DPA1, UQCR10, B3GALTL, PDF, TUBA4A, TUBB8, HLA-A, YBEY, SLC31A1, EIF1AX, SRPK2, HLA-B, SLC25A5, SLC25A6, AIFM1, ANXA2, AP1M2, ATP5A1, B2M, C1QBP, CANX, CDC37, DNAJB11, DNAJA1, TUFM, ERBB3, GFAP, HSPA5, HNRNPH1, HNRNPH2, HNRNPF, HSP90AB1, HSPA8, LGALS3BP, MASP1, PHLDA1, PIK3CA, PIK3CB, PTCD3, RAE1, RPL23, RPS27, RPS27A, RPS27L, MRPS14, MRPS17, MRPS23, MRPS27, MRPS28, S100A10, SSR1, TUBB, ACTA2, ACTB, ACTBL2, POTEKP, ACTC1, ACTG1, ACTG2, ACTA1, HBA1, HBB, HBD, HBE1, HBG1, HBG2, HNRNPH3, HSPA1A, LRPPRC, PON2, POTEE, POTEF, HNRNPA2B1, HNRNPAB, MRPS18B, MRPS22, MRPS25, MRPS26, MRPS34, TUBA1B, PCGF1, DPPA4, NANOG, POU5F1, EPN1, L1CAM, MET, NEDD4L, PTK2B, NDRG1, CDH1, PTPRH, UQCRH, PPM1A, PPM1B, PPM1F, PPM1K, PPM1M, ILKAP, PTPRR, PTPN6, PTPN7, PTPN12, PTPN20B, DUSP14, DUSP18, DUSP19, DUSP21, DUPD1, STYX, PTPDC1, PTEN, TPTE, MTMR1, MTMR2, MTMR6, MTMR8, MTMR9, MTMR10, CDC25C, EYA4, CSPG5, HGS | CSN2 | CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ERBB3_CSN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERBB3_CSN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ERBB3 | C0036341 | Schizophrenia | 3 | PSYGENET |
Hgene | ERBB3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | ERBB3 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | ERBB3 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
Hgene | ERBB3 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | ERBB3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | ERBB3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | ERBB3 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Hgene | ERBB3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | ERBB3 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
Tgene | CSN2 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Tgene | CSN2 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |