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Fusion gene ID: 1192 |
FusionGeneSummary for AHCYL2_PTGES3 |
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Fusion gene information | Fusion gene name: AHCYL2_PTGES3 | Fusion gene ID: 1192 | Hgene | Tgene | Gene symbol | AHCYL2 | PTGES3 | Gene ID | 23382 | 10728 |
Gene name | adenosylhomocysteinase like 2 | prostaglandin E synthase 3 | |
Synonyms | ADOHCYASE3|IRBIT2 | P23|TEBP|cPGES | |
Cytomap | 7q32.1 | 12q13.3|12 | |
Type of gene | protein-coding | protein-coding | |
Description | adenosylhomocysteinase 3IP(3)Rs binding protein released with IP(3) 2S-adenosyl-L-homocysteine hydrolase 3S-adenosylhomocysteine hydrolase-like 2long-IRBITputative adenosylhomocysteinase 3 | prostaglandin E synthase 3Hsp90 co-chaperonecytosolic prostaglandin E synthasecytosolic prostaglandin E2 synthaseprogesterone receptor complex p23prostaglandin E synthase 3 (cytosolic)telomerase-binding protein p23unactive progesterone receptor, 23 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96HN2 | Q15185 | |
Ensembl transtripts involved in fusion gene | ENST00000325006, ENST00000446544, ENST00000531335, ENST00000474594, ENST00000446212, ENST00000490911, ENST00000472554, | ENST00000262033, ENST00000537473, ENST00000414274, ENST00000436399, ENST00000448157, ENST00000456859, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 4 X 2=32 |
# samples | 6 | 6 | |
** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: AHCYL2 [Title/Abstract] AND PTGES3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTGES3 | GO:0001516 | prostaglandin biosynthetic process | 10922363 |
Tgene | PTGES3 | GO:0007004 | telomere maintenance via telomerase | 10197982|19740745 |
Tgene | PTGES3 | GO:0042327 | positive regulation of phosphorylation | 19740745 |
Tgene | PTGES3 | GO:0051085 | chaperone cofactor-dependent protein refolding | 12853476 |
Tgene | PTGES3 | GO:0051973 | positive regulation of telomerase activity | 10197982|19740745 |
Tgene | PTGES3 | GO:1905323 | telomerase holoenzyme complex assembly | 10197982 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW793520 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + | ||
ChiTaRS3.1 | BE070114 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000325006 | ENST00000262033 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000325006 | ENST00000537473 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000325006 | ENST00000414274 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000325006 | ENST00000436399 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000325006 | ENST00000448157 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-intron | ENST00000325006 | ENST00000456859 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-3CDS | ENST00000446544 | ENST00000262033 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000446544 | ENST00000537473 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000446544 | ENST00000414274 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000446544 | ENST00000436399 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000446544 | ENST00000448157 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-intron | ENST00000446544 | ENST00000456859 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-3CDS | ENST00000531335 | ENST00000262033 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000531335 | ENST00000537473 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000531335 | ENST00000414274 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000531335 | ENST00000436399 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000531335 | ENST00000448157 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-intron | ENST00000531335 | ENST00000456859 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-3CDS | ENST00000474594 | ENST00000262033 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000474594 | ENST00000537473 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000474594 | ENST00000414274 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000474594 | ENST00000436399 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000474594 | ENST00000448157 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-intron | ENST00000474594 | ENST00000456859 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-3CDS | ENST00000446212 | ENST00000262033 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000446212 | ENST00000537473 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000446212 | ENST00000414274 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000446212 | ENST00000436399 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000446212 | ENST00000448157 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-intron | ENST00000446212 | ENST00000456859 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-3CDS | ENST00000490911 | ENST00000262033 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000490911 | ENST00000537473 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000490911 | ENST00000414274 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000490911 | ENST00000436399 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000490911 | ENST00000448157 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-intron | ENST00000490911 | ENST00000456859 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-3CDS | ENST00000472554 | ENST00000262033 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000472554 | ENST00000537473 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000472554 | ENST00000414274 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000472554 | ENST00000436399 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-5UTR | ENST00000472554 | ENST00000448157 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
intron-intron | ENST00000472554 | ENST00000456859 | AHCYL2 | chr7 | 128909673 | + | PTGES3 | chr12 | 57066563 | + |
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FusionProtFeatures for AHCYL2_PTGES3 |
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Hgene | Tgene |
AHCYL2 | PTGES3 |
May regulate the electrogenic sodium/bicarbonatecotransporter SLC4A4 activity and Mg(2+)-sensitivity. On thecontrary of its homolog AHCYL1, does not regulate ITPR1sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705).{ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}. | Cytosolic prostaglandin synthase that catalyzes theoxidoreduction of prostaglandin endoperoxide H2 (PGH2) toprostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperonethat localizes to genomic response elements in a hormone-dependentmanner and disrupts receptor-mediated transcriptional activation,by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteinshydroxylation via interaction with EGLN1/PHD2, leading to recruitEGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).{ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138,ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AHCYL2_PTGES3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AHCYL2_PTGES3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AHCYL2_PTGES3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AHCYL2_PTGES3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AHCYL2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |