FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1192

FusionGeneSummary for AHCYL2_PTGES3

check button Fusion gene summary
Fusion gene informationFusion gene name: AHCYL2_PTGES3
Fusion gene ID: 1192
HgeneTgene
Gene symbol

AHCYL2

PTGES3

Gene ID

23382

10728

Gene nameadenosylhomocysteinase like 2prostaglandin E synthase 3
SynonymsADOHCYASE3|IRBIT2P23|TEBP|cPGES
Cytomap

7q32.1

12q13.3|12

Type of geneprotein-codingprotein-coding
Descriptionadenosylhomocysteinase 3IP(3)Rs binding protein released with IP(3) 2S-adenosyl-L-homocysteine hydrolase 3S-adenosylhomocysteine hydrolase-like 2long-IRBITputative adenosylhomocysteinase 3prostaglandin E synthase 3Hsp90 co-chaperonecytosolic prostaglandin E synthasecytosolic prostaglandin E2 synthaseprogesterone receptor complex p23prostaglandin E synthase 3 (cytosolic)telomerase-binding protein p23unactive progesterone receptor, 23
Modification date2018052320180523
UniProtAcc

Q96HN2

Q15185

Ensembl transtripts involved in fusion geneENST00000325006, ENST00000446544, 
ENST00000531335, ENST00000474594, 
ENST00000446212, ENST00000490911, 
ENST00000472554, 
ENST00000262033, 
ENST00000537473, ENST00000414274, 
ENST00000436399, ENST00000448157, 
ENST00000456859, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 4 X 2=32
# samples 66
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AHCYL2 [Title/Abstract] AND PTGES3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTGES3

GO:0001516

prostaglandin biosynthetic process

10922363

TgenePTGES3

GO:0007004

telomere maintenance via telomerase

10197982|19740745

TgenePTGES3

GO:0042327

positive regulation of phosphorylation

19740745

TgenePTGES3

GO:0051085

chaperone cofactor-dependent protein refolding

12853476

TgenePTGES3

GO:0051973

positive regulation of telomerase activity

10197982|19740745

TgenePTGES3

GO:1905323

telomerase holoenzyme complex assembly

10197982


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW793520AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
ChiTaRS3.1BE070114AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000325006ENST00000262033AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000325006ENST00000537473AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000325006ENST00000414274AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000325006ENST00000436399AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000325006ENST00000448157AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-intronENST00000325006ENST00000456859AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-3CDSENST00000446544ENST00000262033AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000446544ENST00000537473AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000446544ENST00000414274AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000446544ENST00000436399AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000446544ENST00000448157AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-intronENST00000446544ENST00000456859AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-3CDSENST00000531335ENST00000262033AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000531335ENST00000537473AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000531335ENST00000414274AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000531335ENST00000436399AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000531335ENST00000448157AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-intronENST00000531335ENST00000456859AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-3CDSENST00000474594ENST00000262033AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000474594ENST00000537473AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000474594ENST00000414274AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000474594ENST00000436399AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000474594ENST00000448157AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-intronENST00000474594ENST00000456859AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-3CDSENST00000446212ENST00000262033AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000446212ENST00000537473AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000446212ENST00000414274AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000446212ENST00000436399AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000446212ENST00000448157AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-intronENST00000446212ENST00000456859AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-3CDSENST00000490911ENST00000262033AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000490911ENST00000537473AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000490911ENST00000414274AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000490911ENST00000436399AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000490911ENST00000448157AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-intronENST00000490911ENST00000456859AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-3CDSENST00000472554ENST00000262033AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000472554ENST00000537473AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000472554ENST00000414274AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000472554ENST00000436399AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-5UTRENST00000472554ENST00000448157AHCYL2chr7

128909673

+PTGES3chr12

57066563

+
intron-intronENST00000472554ENST00000456859AHCYL2chr7

128909673

+PTGES3chr12

57066563

+

Top

FusionProtFeatures for AHCYL2_PTGES3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHCYL2

Q96HN2

PTGES3

Q15185

May regulate the electrogenic sodium/bicarbonatecotransporter SLC4A4 activity and Mg(2+)-sensitivity. On thecontrary of its homolog AHCYL1, does not regulate ITPR1sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705).{ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}. Cytosolic prostaglandin synthase that catalyzes theoxidoreduction of prostaglandin endoperoxide H2 (PGH2) toprostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperonethat localizes to genomic response elements in a hormone-dependentmanner and disrupts receptor-mediated transcriptional activation,by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteinshydroxylation via interaction with EGLN1/PHD2, leading to recruitEGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).{ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138,ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for AHCYL2_PTGES3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for AHCYL2_PTGES3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for AHCYL2_PTGES3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for AHCYL2_PTGES3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAHCYL2C0033578Prostatic Neoplasms1CTD_human