	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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Fusion gene ID: 11913

FusionGeneSummary for ERBB2_PPP1R1B

Fusion gene summary

Fusion gene information	Fusion gene name: ERBB2_PPP1R1B
	Fusion gene ID: 11913
		Hgene	Tgene
	Gene symbol	ERBB2	PPP1R1B
	Gene ID	2064	84152
	Gene name	erb-b2 receptor tyrosine kinase 2	protein phosphatase 1 regulatory inhibitor subunit 1B
	Synonyms	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1	DARPP-32\|DARPP32
	Cytomap	17q12	17q12
	Type of gene	protein-coding	protein-coding
	Description	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2	protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32
	Modification date	20180527	20180527
	UniProtAcc	P04626	Q9UD71
	Ensembl transtripts involved in fusion gene	ENST00000584601, ENST00000406381, ENST00000541774, ENST00000445658, ENST00000540147, ENST00000584450, ENST00000269571, ENST00000578199, ENST00000540042, ENST00000584888,	ENST00000580825, ENST00000254079, ENST00000579000, ENST00000394265, ENST00000394267,
Fusion gene scores	* DoF score	27 X 20 X 14=7560	10 X 5 X 11=550
	# samples	46	19
	** MAII score	log2(46/7560*10)=-4.03868046816406 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/550*10)=-1.53343220008107 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ERBB2 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERBB2	GO:0007165	signal transduction	10572067
Hgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Hgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Hgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Hgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Hgene	ERBB2	GO:0042060	wound healing	12646923
Hgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Hgene	ERBB2	GO:0045945	positive regulation of transcription by RNA polymerase III	19372587
Hgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Hgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Hgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870
Tgene	PPP1R1B	GO:0032515	negative regulation of phosphoprotein phosphatase activity	10807923

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-DK-A1A3-01A	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
TCGA	LD	BRCA	TCGA-C8-A12Z-01A	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
TCGA	LD	BRCA	TCGA-UU-A93S-01A	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
TCGA	LD	CESC	TCGA-4J-AA1J-01A	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
TCGA	LD	CESC	TCGA-Q1-A73R-01A	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
TCGA	LD	ESCA	TCGA-2H-A9GF-01A	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
TCGA	RV	LIHC	TCGA-KR-A7K2-01A	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
TCGA	LD	LUSC	TCGA-22-0944-01A	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
TCGA	LD	OV	TCGA-24-2033-01A	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
TCGA	RV	PAAD	TCGA-LB-A7SX-01A	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000584601	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000445658	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000445658	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000445658	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000445658	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000445658	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000580825	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000254079	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000579000	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000394265	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000394267	ERBB2	chr17	37866734	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000406381	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000541774	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540147	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000578199	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000540042	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000580825	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000254079	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000579000	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000394265	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000394267	ERBB2	chr17	37872192	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584601	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584601	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584601	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584601	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584601	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000406381	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000406381	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000406381	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000406381	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000406381	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000541774	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000541774	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000541774	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000541774	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000541774	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000445658	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
5UTR-3CDS	ENST00000540147	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
5UTR-3CDS	ENST00000540147	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
5UTR-3CDS	ENST00000540147	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
5UTR-3CDS	ENST00000540147	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
5UTR-3CDS	ENST00000540147	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584450	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000269571	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000578199	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000578199	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000578199	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000578199	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000578199	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000540042	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000540042	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000540042	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000540042	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000540042	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
intron-3CDS	ENST00000584888	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37790136	+
In-frame	ENST00000584601	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000584601	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000584601	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000584601	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000584601	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000406381	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000406381	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000406381	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000406381	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000406381	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000541774	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000541774	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000541774	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000541774	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000541774	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000445658	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000445658	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000445658	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000445658	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000445658	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000540147	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000540147	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000540147	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000540147	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000540147	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584450	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584450	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584450	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584450	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584450	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000269571	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000269571	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000269571	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000269571	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
In-frame	ENST00000269571	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000578199	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000578199	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000578199	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000578199	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000578199	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000540042	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000540042	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000540042	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000540042	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000540042	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584888	ENST00000580825	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584888	ENST00000254079	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584888	ENST00000579000	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584888	ENST00000394265	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
intron-3CDS	ENST00000584888	ENST00000394267	ERBB2	chr17	37883800	+	PPP1R1B	chr17	37791860	+
Frame-shit	ENST00000584601	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000584601	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000584601	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000584601	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000584601	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000406381	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000406381	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000406381	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000406381	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000406381	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000541774	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000541774	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000541774	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000541774	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000541774	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000445658	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000445658	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000445658	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000445658	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000445658	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000540147	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000540147	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000540147	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000540147	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000540147	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000584450	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000584450	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000584450	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000584450	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000584450	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000269571	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000269571	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000269571	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
In-frame	ENST00000269571	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
Frame-shit	ENST00000269571	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000578199	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000578199	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000578199	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000578199	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000578199	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000540042	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000540042	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000540042	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000540042	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000540042	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000584888	ENST00000580825	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000584888	ENST00000254079	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000584888	ENST00000579000	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000584888	ENST00000394265	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000584888	ENST00000394267	ERBB2	chr17	37876087	+	PPP1R1B	chr17	37792069	+
intron-3CDS	ENST00000584601	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000584601	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000584601	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000584601	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000584601	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000406381	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000406381	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000406381	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000406381	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000406381	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000541774	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000541774	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000541774	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000541774	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000541774	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000445658	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000445658	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000445658	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000445658	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000445658	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5UTR-3CDS	ENST00000540147	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5UTR-3CDS	ENST00000540147	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5UTR-3CDS	ENST00000540147	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5UTR-5UTR	ENST00000540147	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5UTR-5UTR	ENST00000540147	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000584450	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000584450	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000584450	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000584450	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000584450	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000269571	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000269571	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
Frame-shit	ENST00000269571	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000269571	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
5CDS-5UTR	ENST00000269571	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000578199	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000578199	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000578199	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000578199	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000578199	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000540042	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000540042	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000540042	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000540042	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000540042	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000584888	ENST00000580825	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000584888	ENST00000254079	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-3CDS	ENST00000584888	ENST00000579000	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000584888	ENST00000394265	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+
intron-5UTR	ENST00000584888	ENST00000394267	ERBB2	chr17	37856564	+	PPP1R1B	chr17	37785423	+

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FusionProtFeatures for ERBB2_PPP1R1B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERBB2 P04626	PPP1R1B Q9UD71
Protein tyrosine kinase that is part of several cellsurface receptor complexes, but that apparently needs a coreceptorfor ligand binding. Essential component of a neuregulin-receptorcomplex, although neuregulins do not interact with it alone. GP30is a potential ligand for this receptor. Regulates outgrowth andstabilization of peripheral microtubules (MTs). Upon ERBB2activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits thephosphorylation and thus the inhibition of GSK3B at cell membrane.This prevents the phosphorylation of APC and CLASP2, allowing itsassociation with the cell membrane. In turn, membrane-bound APCallows the localization of MACF1 to the cell membrane, which isrequired for microtubule capture and stabilization. {ECO:0000305}. In the nucleus is involved in transcriptionalregulation. Associates with the 5'-TCAAATTC-3' sequence in thePTGS2/COX-2 promoter and activates its transcription. Implicatedin transcriptional activation of CDKN1A; the function involvesSTAT3 and SRC. Involved in the transcription of rRNA genes by RNAPol I and enhances protein synthesis and cell growth.{ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516,ECO:0000269\|PubMed:21555369}.	Inhibitor of protein-phosphatase 1.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000269571

720_987

1137

1256

Domain

Protein kinase

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000541774

720_987

1122

1241

Domain

Protein kinase

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000269571

676_689

1137

1256

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000541774

676_689

1122

1241

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000269571

726_734

1137

1256

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000541774

726_734

1122

1241

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000269571

23_652

1137

1256

Topological domain

Extracellular

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000541774

23_652

1122

1241

Topological domain

Extracellular

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000269571

653_675

1137

1256

Transmembrane

Helical

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000541774

653_675

1122

1241

Transmembrane

Helical

Tgene

PPP1R1B

chr17:37866734

chr17:37790136

ENST00000254079

119_136

205

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37866734

chr17:37790136

ENST00000394265

119_136

169

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37866734

chr17:37790136

ENST00000394267

119_136

169

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37866734

chr17:37790136

ENST00000580825

119_136

205

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37872192

chr17:37790136

ENST00000254079

119_136

205

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37872192

chr17:37790136

ENST00000394265

119_136

169

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37872192

chr17:37790136

ENST00000394267

119_136

169

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37872192

chr17:37790136

ENST00000580825

119_136

205

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37883800

chr17:37791860

ENST00000394265

119_136

112

169

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37883800

chr17:37791860

ENST00000394267

119_136

112

169

Compositional bias

Note=Asp/Glu-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.

>>>>>>>>>>>>>>>>>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000269571

720_987

300

1256

Domain

Protein kinase

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000541774

720_987

285

1241

Domain

Protein kinase

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000269571

720_987

504

1256

Domain

Protein kinase

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000541774

720_987

489

1241

Domain

Protein kinase

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000269571

676_689

300

1256

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000541774

676_689

285

1241

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000269571

676_689

504

1256

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000541774

676_689

489

1241

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000269571

726_734

300

1256

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000541774

726_734

285

1241

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000269571

726_734

504

1256

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000541774

726_734

489

1241

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000269571

23_652

300

1256

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000269571

676_1255

300

1256

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000541774

23_652

285

1241

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000541774

676_1255

285

1241

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000269571

23_652

504

1256

Topological domain

Extracellular

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000269571

676_1255

504

1256

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000541774

23_652

489

1241

Topological domain

Extracellular

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000541774

676_1255

489

1241

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000269571

676_1255

1137

1256

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37883800

chr17:37791860

ENST00000541774

676_1255

1122

1241

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000269571

653_675

300

1256

Transmembrane

Helical

Hgene

ERBB2

chr17:37866734

chr17:37790136

ENST00000541774

653_675

285

1241

Transmembrane

Helical

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000269571

653_675

504

1256

Transmembrane

Helical

Hgene

ERBB2

chr17:37872192

chr17:37790136

ENST00000541774

653_675

489

1241

Transmembrane

Helical

Tgene

PPP1R1B

chr17:37883800

chr17:37791860

ENST00000254079

119_136

148

205

Compositional bias

Note=Asp/Glu-rich (acidic)

Tgene

PPP1R1B

chr17:37883800

chr17:37791860

ENST00000580825

119_136

148

205

Compositional bias

Note=Asp/Glu-rich (acidic)

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FusionGeneSequence for ERBB2_PPP1R1B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERBB2_PPP1R1B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
ERBB2	SHC1, SH3BGRL, PTPN11, GRB2, MUC1, CTNNB1, ERBB2, CD82, EGF, PAK1, ERBB2IP, PICK1, PIK3R2, DLG4, ERBB4, NRG1, JUP, STAT3, SRC, JAK2, HSP90B1, CD44, GRB7, PLCG1, IL6ST, OSMR, PTK2B, HSP90AA1, ELF3, EGFR, ERBB3, HDAC6, LRIG1, STUB1, HSPA4, IGF1R, CUL5, ESR1, PPP1R13B, H2AFY, PIK3R1, PIN1, PTK6, ACTB, POLR1B, KPNB1, XPO1, CLTC, AP2B1, EEA1, APBB1, SH2B2, IRS4, SH2D1B, SOCS1, NCK2, DAB1, GRAP2, APBB3, ABL1, FGR, CHN1, FER, PLCG2, RASA1, JAK1, IRS1, STAT1, MATK, TEC, TXK, ABL2, SYK, CRK, CRKL, BLK, BMX, VAV2, SH3BP2, SHC2, ITK, SLA, MAPK8IP2, RIN1, BCAR3, TENC1, TNS3, DOK6, SH2D5, SUPT6H, ANKS1B, CLNK, DOK4, BLNK, RIN2, SHC3, PIK3R3, ANKS1A, VAV1, DOK1, SH2D3A, SLA2, SH2D2A, CISH, VAV3, MAPK8IP1, SH2B3, TLN1, SRPK1, CBL, ERRFI1, FRS3, USP2, NXF1, DTWD2, TGFBR2, NAALADL2, LPAR6, VSIG4, PTGER3, CYP17A1, GLCE, IL13RA2, KLK5, LYPD3, NAT2, PRDM14, PSMC3IP, RHOBTB2, THRSP, ANXA6, BAI1, CLCN6, GMPR2, HDLBP, IARS, MTCH1, MUCL1, PHF23, POLD2, PSAP, STK24, TCEAL2, ATP6AP1, TTC9B, UTP18, ATP1A1, EEF1G, TNPO1, PC, SURF4, TFRC, VAPB, PTDSS1, HPSE, ZNF280C, CCDC88A, ZNF622, BTC, PTK2, TGFA, BCAR1, ESRRB, CDC37, EZR, RDX, ITGAV, L1CAM, ITGB1, CHEK2, TOP1, RRM2, CDK4, CDH2, CDH1, PTPN6, PTPRR, PTPRT, PTPRU, PTPRA, PTPRH, MPZL2, SSH1, CD79B, MAS1, HAVCR2, IL4R, PPM1A, PPM1F, ILKAP, DUSP14, DUSP18, DUSP19, STYX, GAB1	PPP1R1B	DLGAP4, CSNK2A1, PPP1CC, PPP1CA, TFCP2, KLHL6, ACTBL2

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ERBB2	chr17:37866734	chr17:37790136	ENST00000269571	+	7	27	1195_1197	300	1256	PIK3C2B
Hgene	ERBB2	chr17:37866734	chr17:37790136	ENST00000541774	+	7	27	1195_1197	285	1241	PIK3C2B
Hgene	ERBB2	chr17:37872192	chr17:37790136	ENST00000269571	+	12	27	1195_1197	504	1256	PIK3C2B
Hgene	ERBB2	chr17:37872192	chr17:37790136	ENST00000541774	+	12	27	1195_1197	489	1241	PIK3C2B
Hgene	ERBB2	chr17:37883800	chr17:37791860	ENST00000269571	+	26	27	1195_1197	1137	1256	PIK3C2B
Hgene	ERBB2	chr17:37883800	chr17:37791860	ENST00000541774	+	26	27	1195_1197	1122	1241	PIK3C2B

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ERBB2_PPP1R1B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	ERBB2	P04626	DB06366	Pertuzumab	Receptor tyrosine-protein kinase erbB-2	biotech	approved
Hgene	ERBB2	P04626	DB08916	Afatinib	Receptor tyrosine-protein kinase erbB-2	small molecule	approved
Hgene	ERBB2	P04626	DB00072	Trastuzumab	Receptor tyrosine-protein kinase erbB-2	biotech	approved\|investigational
Hgene	ERBB2	P04626	DB01259	Lapatinib	Receptor tyrosine-protein kinase erbB-2	small molecule	approved\|investigational
Hgene	ERBB2	P04626	DB05773	Trastuzumab emtansine	Receptor tyrosine-protein kinase erbB-2	biotech	approved\|investigational

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RelatedDiseases for ERBB2_PPP1R1B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ERBB2	C1458155	Mammary Neoplasms	40	CTD_human
Hgene	ERBB2	C0033578	Prostatic Neoplasms	3	CTD_human
Hgene	ERBB2	C0038356	Stomach Neoplasms	3	CTD_human
Hgene	ERBB2	C0001418	Adenocarcinoma	2	CTD_human
Hgene	ERBB2	C0024668	Mammary Neoplasms, Experimental	2	CTD_human
Hgene	ERBB2	C0919267	ovarian neoplasm	2	CTD_human
Hgene	ERBB2	C0007117	Basal cell carcinoma	1	CTD_human
Hgene	ERBB2	C0007134	Renal Cell Carcinoma	1	CTD_human
Hgene	ERBB2	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	ERBB2	C0014859	Esophageal Neoplasms	1	CTD_human
Hgene	ERBB2	C0016978	gallbladder neoplasm	1	CTD_human
Hgene	ERBB2	C0017185	Gastrointestinal Neoplasms	1	CTD_human
Hgene	ERBB2	C0024121	Lung Neoplasms	1	CTD_human
Hgene	ERBB2	C0024232	Lymphatic Metastasis	1	CTD_human
Hgene	ERBB2	C0024667	Animal Mammary Neoplasms	1	CTD_human
Hgene	ERBB2	C0025149	Medulloblastoma	1	CTD_human
Hgene	ERBB2	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	ERBB2	C0027643	Neoplasm Recurrence, Local	1	CTD_human
Hgene	ERBB2	C0027659	Neoplasms, Experimental	1	CTD_human
Hgene	ERBB2	C0030354	Papilloma	1	CTD_human
Hgene	ERBB2	C0206698	Cholangiocarcinoma	1	CTD_human
Hgene	ERBB2	C0596263	Carcinogenesis	1	CTD_human
Hgene	ERBB2	C2931822	Nasopharyngeal carcinoma	1	CTD_human
Tgene	PPP1R1B	C0036341	Schizophrenia	5	PSYGENET
Tgene	PPP1R1B	C0005586	Bipolar Disorder	4	PSYGENET
Tgene	PPP1R1B	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene	PPP1R1B	C0007370	Catalepsy	1	CTD_human
Tgene	PPP1R1B	C0011570	Mental Depression	1	PSYGENET
Tgene	PPP1R1B	C0011581	Depressive disorder	1	PSYGENET
Tgene	PPP1R1B	C0013384	Dyskinetic syndrome	1	CTD_human

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Fusion gene ID: 11913

FusionGeneSummary for ERBB2_PPP1R1B

FusionProtFeatures for ERBB2_PPP1R1B

FusionGeneSequence for ERBB2_PPP1R1B

FusionGenePPI for ERBB2_PPP1R1B

RelatedDrugs for ERBB2_PPP1R1B

RelatedDiseases for ERBB2_PPP1R1B