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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11913

FusionGeneSummary for ERBB2_PPP1R1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ERBB2_PPP1R1B
Fusion gene ID: 11913
HgeneTgene
Gene symbol

ERBB2

PPP1R1B

Gene ID

2064

84152

Gene nameerb-b2 receptor tyrosine kinase 2protein phosphatase 1 regulatory inhibitor subunit 1B
SynonymsCD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1DARPP-32|DARPP32
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32
Modification date2018052720180527
UniProtAcc

P04626

Q9UD71

Ensembl transtripts involved in fusion geneENST00000584601, ENST00000406381, 
ENST00000541774, ENST00000445658, 
ENST00000540147, ENST00000584450, 
ENST00000269571, ENST00000578199, 
ENST00000540042, ENST00000584888, 
ENST00000580825, ENST00000254079, 
ENST00000579000, ENST00000394265, 
ENST00000394267, 
Fusion gene scores* DoF score27 X 20 X 14=756010 X 5 X 11=550
# samples 4619
** MAII scorelog2(46/7560*10)=-4.03868046816406
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/550*10)=-1.53343220008107
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERBB2 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB2

GO:0007165

signal transduction

10572067

HgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

HgeneERBB2

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

7514177

HgeneERBB2

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

HgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

HgeneERBB2

GO:0042060

wound healing

12646923

HgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

HgeneERBB2

GO:0045945

positive regulation of transcription by RNA polymerase III

19372587

HgeneERBB2

GO:0046777

protein autophosphorylation

7556068

HgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

HgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870

TgenePPP1R1B

GO:0032515

negative regulation of phosphoprotein phosphatase activity

10807923


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A1A3-01AERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
TCGALDBRCATCGA-C8-A12Z-01AERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
TCGALDBRCATCGA-UU-A93S-01AERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
TCGALDCESCTCGA-4J-AA1J-01AERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
TCGALDCESCTCGA-Q1-A73R-01AERBB2chr17

37883800

+PPP1R1Bchr17

37791860

+
TCGALDESCATCGA-2H-A9GF-01AERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
TCGARVLIHCTCGA-KR-A7K2-01AERBB2chr17

37883800

+PPP1R1Bchr17

37791860

+
TCGALDLUSCTCGA-22-0944-01AERBB2chr17

37876087

+PPP1R1Bchr17

37792069

+
TCGALDOVTCGA-24-2033-01AERBB2chr17

37856564

+PPP1R1Bchr17

37785423

+
TCGARVPAADTCGA-LB-A7SX-01AERBB2chr17

37883800

+PPP1R1Bchr17

37791860

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000584601ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000445658ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000445658ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000445658ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000445658ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000445658ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000580825ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000254079ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000579000ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000394265ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000394267ERBB2chr17

37866734

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584601ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000406381ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000541774ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540147ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000269571ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000578199ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
In-frameENST00000540042ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000580825ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000254079ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000579000ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000394265ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584888ENST00000394267ERBB2chr17

37872192

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584601ENST00000580825ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584601ENST00000254079ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584601ENST00000579000ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584601ENST00000394265ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000584601ENST00000394267ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000406381ENST00000580825ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000406381ENST00000254079ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000406381ENST00000579000ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000406381ENST00000394265ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000406381ENST00000394267ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000541774ENST00000580825ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000541774ENST00000254079ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000541774ENST00000579000ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000541774ENST00000394265ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
intron-3CDSENST00000541774ENST00000394267ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000580825ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000254079ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000579000ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000394265ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000445658ENST00000394267ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
5UTR-3CDSENST00000540147ENST00000580825ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
5UTR-3CDSENST00000540147ENST00000254079ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
5UTR-3CDSENST00000540147ENST00000579000ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
5UTR-3CDSENST00000540147ENST00000394265ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
5UTR-3CDSENST00000540147ENST00000394267ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000580825ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000254079ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000579000ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000394265ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
In-frameENST00000584450ENST00000394267ERBB2chr17

37856564

+PPP1R1Bchr17

37790136

+
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intron-3CDSENST00000578199ENST00000580825ERBB2chr17

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intron-3CDSENST00000578199ENST00000254079ERBB2chr17

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intron-3CDSENST00000578199ENST00000579000ERBB2chr17

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intron-3CDSENST00000578199ENST00000394265ERBB2chr17

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intron-3CDSENST00000578199ENST00000394267ERBB2chr17

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intron-3CDSENST00000540042ENST00000580825ERBB2chr17

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intron-3CDSENST00000540042ENST00000254079ERBB2chr17

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intron-3CDSENST00000540042ENST00000579000ERBB2chr17

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intron-3CDSENST00000540042ENST00000394265ERBB2chr17

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intron-3CDSENST00000540042ENST00000394267ERBB2chr17

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intron-3CDSENST00000584888ENST00000580825ERBB2chr17

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intron-3CDSENST00000584888ENST00000254079ERBB2chr17

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intron-3CDSENST00000584888ENST00000579000ERBB2chr17

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intron-3CDSENST00000584888ENST00000394265ERBB2chr17

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intron-3CDSENST00000584888ENST00000394267ERBB2chr17

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intron-3CDSENST00000584450ENST00000580825ERBB2chr17

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intron-3CDSENST00000584450ENST00000254079ERBB2chr17

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intron-3CDSENST00000584450ENST00000579000ERBB2chr17

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intron-3CDSENST00000584450ENST00000394267ERBB2chr17

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intron-3CDSENST00000578199ENST00000580825ERBB2chr17

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intron-3CDSENST00000578199ENST00000254079ERBB2chr17

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intron-3CDSENST00000578199ENST00000579000ERBB2chr17

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intron-3CDSENST00000578199ENST00000394265ERBB2chr17

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intron-3CDSENST00000578199ENST00000394267ERBB2chr17

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intron-3CDSENST00000540042ENST00000580825ERBB2chr17

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intron-3CDSENST00000540042ENST00000254079ERBB2chr17

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intron-3CDSENST00000540042ENST00000579000ERBB2chr17

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intron-3CDSENST00000540042ENST00000394265ERBB2chr17

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intron-3CDSENST00000540042ENST00000394267ERBB2chr17

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intron-3CDSENST00000584888ENST00000580825ERBB2chr17

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intron-3CDSENST00000584888ENST00000254079ERBB2chr17

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intron-3CDSENST00000584888ENST00000579000ERBB2chr17

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intron-3CDSENST00000584888ENST00000394265ERBB2chr17

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intron-3CDSENST00000584888ENST00000394267ERBB2chr17

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Frame-shitENST00000406381ENST00000580825ERBB2chr17

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Frame-shitENST00000541774ENST00000254079ERBB2chr17

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Frame-shitENST00000445658ENST00000580825ERBB2chr17

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Frame-shitENST00000445658ENST00000254079ERBB2chr17

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Frame-shitENST00000584450ENST00000580825ERBB2chr17

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Frame-shitENST00000584450ENST00000254079ERBB2chr17

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Frame-shitENST00000269571ENST00000580825ERBB2chr17

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intron-3CDSENST00000578199ENST00000580825ERBB2chr17

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intron-3CDSENST00000578199ENST00000254079ERBB2chr17

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intron-3CDSENST00000578199ENST00000579000ERBB2chr17

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intron-3CDSENST00000578199ENST00000394265ERBB2chr17

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intron-3CDSENST00000578199ENST00000394267ERBB2chr17

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intron-3CDSENST00000540042ENST00000580825ERBB2chr17

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intron-3CDSENST00000540042ENST00000254079ERBB2chr17

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intron-3CDSENST00000540042ENST00000579000ERBB2chr17

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intron-3CDSENST00000540042ENST00000394265ERBB2chr17

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intron-3CDSENST00000540042ENST00000394267ERBB2chr17

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intron-3CDSENST00000584888ENST00000580825ERBB2chr17

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intron-3CDSENST00000584888ENST00000254079ERBB2chr17

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intron-3CDSENST00000584888ENST00000579000ERBB2chr17

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intron-3CDSENST00000584601ENST00000579000ERBB2chr17

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intron-5UTRENST00000584601ENST00000394265ERBB2chr17

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intron-3CDSENST00000406381ENST00000580825ERBB2chr17

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intron-3CDSENST00000406381ENST00000254079ERBB2chr17

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intron-3CDSENST00000406381ENST00000579000ERBB2chr17

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intron-5UTRENST00000406381ENST00000394267ERBB2chr17

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intron-3CDSENST00000541774ENST00000580825ERBB2chr17

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intron-3CDSENST00000541774ENST00000254079ERBB2chr17

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intron-3CDSENST00000541774ENST00000579000ERBB2chr17

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intron-5UTRENST00000541774ENST00000394265ERBB2chr17

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intron-5UTRENST00000541774ENST00000394267ERBB2chr17

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5CDS-5UTRENST00000445658ENST00000394265ERBB2chr17

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5CDS-5UTRENST00000445658ENST00000394267ERBB2chr17

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5UTR-3CDSENST00000540147ENST00000580825ERBB2chr17

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5UTR-3CDSENST00000540147ENST00000254079ERBB2chr17

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5UTR-3CDSENST00000540147ENST00000579000ERBB2chr17

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5UTR-5UTRENST00000540147ENST00000394265ERBB2chr17

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5UTR-5UTRENST00000540147ENST00000394267ERBB2chr17

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5CDS-5UTRENST00000584450ENST00000394265ERBB2chr17

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5CDS-5UTRENST00000584450ENST00000394267ERBB2chr17

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5CDS-5UTRENST00000269571ENST00000394265ERBB2chr17

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intron-3CDSENST00000578199ENST00000580825ERBB2chr17

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intron-3CDSENST00000578199ENST00000254079ERBB2chr17

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intron-3CDSENST00000578199ENST00000579000ERBB2chr17

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intron-5UTRENST00000578199ENST00000394267ERBB2chr17

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intron-3CDSENST00000540042ENST00000580825ERBB2chr17

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intron-3CDSENST00000540042ENST00000254079ERBB2chr17

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intron-3CDSENST00000540042ENST00000579000ERBB2chr17

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intron-5UTRENST00000540042ENST00000394265ERBB2chr17

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intron-5UTRENST00000540042ENST00000394267ERBB2chr17

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intron-3CDSENST00000584888ENST00000580825ERBB2chr17

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intron-3CDSENST00000584888ENST00000254079ERBB2chr17

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intron-3CDSENST00000584888ENST00000579000ERBB2chr17

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+
intron-5UTRENST00000584888ENST00000394265ERBB2chr17

37856564

+PPP1R1Bchr17

37785423

+
intron-5UTRENST00000584888ENST00000394267ERBB2chr17

37856564

+PPP1R1Bchr17

37785423

+

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FusionProtFeatures for ERBB2_PPP1R1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB2

P04626

PPP1R1B

Q9UD71

Protein tyrosine kinase that is part of several cellsurface receptor complexes, but that apparently needs a coreceptorfor ligand binding. Essential component of a neuregulin-receptorcomplex, although neuregulins do not interact with it alone. GP30is a potential ligand for this receptor. Regulates outgrowth andstabilization of peripheral microtubules (MTs). Upon ERBB2activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits thephosphorylation and thus the inhibition of GSK3B at cell membrane.This prevents the phosphorylation of APC and CLASP2, allowing itsassociation with the cell membrane. In turn, membrane-bound APCallows the localization of MACF1 to the cell membrane, which isrequired for microtubule capture and stabilization. {ECO:0000305}. In the nucleus is involved in transcriptionalregulation. Associates with the 5'-TCAAATTC-3' sequence in thePTGS2/COX-2 promoter and activates its transcription. Implicatedin transcriptional activation of CDKN1A; the function involvesSTAT3 and SRC. Involved in the transcription of rRNA genes by RNAPol I and enhances protein synthesis and cell growth.{ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516,ECO:0000269|PubMed:21555369}. Inhibitor of protein-phosphatase 1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
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PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERBB2chr17:37883800chr17:37791860ENST00000269571+2627720_98711371256DomainProtein kinase
HgeneERBB2chr17:37883800chr17:37791860ENST00000541774+2627720_98711221241DomainProtein kinase
HgeneERBB2chr17:37883800chr17:37791860ENST00000269571+2627676_68911371256MotifNote=Nuclear localization signal
HgeneERBB2chr17:37883800chr17:37791860ENST00000541774+2627676_68911221241MotifNote=Nuclear localization signal
HgeneERBB2chr17:37883800chr17:37791860ENST00000269571+2627726_73411371256Nucleotide bindingATP
HgeneERBB2chr17:37883800chr17:37791860ENST00000541774+2627726_73411221241Nucleotide bindingATP
HgeneERBB2chr17:37883800chr17:37791860ENST00000269571+262723_65211371256Topological domainExtracellular
HgeneERBB2chr17:37883800chr17:37791860ENST00000541774+262723_65211221241Topological domainExtracellular
HgeneERBB2chr17:37883800chr17:37791860ENST00000269571+2627653_67511371256TransmembraneHelical
HgeneERBB2chr17:37883800chr17:37791860ENST00000541774+2627653_67511221241TransmembraneHelical
TgenePPP1R1Bchr17:37866734chr17:37790136ENST00000254079+37119_13680205Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37866734chr17:37790136ENST00000394265+37119_13644169Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37866734chr17:37790136ENST00000394267+37119_13644169Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37866734chr17:37790136ENST00000580825+48119_13680205Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37872192chr17:37790136ENST00000254079+37119_13680205Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37872192chr17:37790136ENST00000394265+37119_13644169Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37872192chr17:37790136ENST00000394267+37119_13644169Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37872192chr17:37790136ENST00000580825+48119_13680205Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37883800chr17:37791860ENST00000394265+47119_136112169Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37883800chr17:37791860ENST00000394267+47119_136112169Compositional biasNote=Asp/Glu-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERBB2chr17:37866734chr17:37790136ENST00000269571+727720_9873001256DomainProtein kinase
HgeneERBB2chr17:37866734chr17:37790136ENST00000541774+727720_9872851241DomainProtein kinase
HgeneERBB2chr17:37872192chr17:37790136ENST00000269571+1227720_9875041256DomainProtein kinase
HgeneERBB2chr17:37872192chr17:37790136ENST00000541774+1227720_9874891241DomainProtein kinase
HgeneERBB2chr17:37866734chr17:37790136ENST00000269571+727676_6893001256MotifNote=Nuclear localization signal
HgeneERBB2chr17:37866734chr17:37790136ENST00000541774+727676_6892851241MotifNote=Nuclear localization signal
HgeneERBB2chr17:37872192chr17:37790136ENST00000269571+1227676_6895041256MotifNote=Nuclear localization signal
HgeneERBB2chr17:37872192chr17:37790136ENST00000541774+1227676_6894891241MotifNote=Nuclear localization signal
HgeneERBB2chr17:37866734chr17:37790136ENST00000269571+727726_7343001256Nucleotide bindingATP
HgeneERBB2chr17:37866734chr17:37790136ENST00000541774+727726_7342851241Nucleotide bindingATP
HgeneERBB2chr17:37872192chr17:37790136ENST00000269571+1227726_7345041256Nucleotide bindingATP
HgeneERBB2chr17:37872192chr17:37790136ENST00000541774+1227726_7344891241Nucleotide bindingATP
HgeneERBB2chr17:37866734chr17:37790136ENST00000269571+72723_6523001256Topological domainExtracellular
HgeneERBB2chr17:37866734chr17:37790136ENST00000269571+727676_12553001256Topological domainCytoplasmic
HgeneERBB2chr17:37866734chr17:37790136ENST00000541774+72723_6522851241Topological domainExtracellular
HgeneERBB2chr17:37866734chr17:37790136ENST00000541774+727676_12552851241Topological domainCytoplasmic
HgeneERBB2chr17:37872192chr17:37790136ENST00000269571+122723_6525041256Topological domainExtracellular
HgeneERBB2chr17:37872192chr17:37790136ENST00000269571+1227676_12555041256Topological domainCytoplasmic
HgeneERBB2chr17:37872192chr17:37790136ENST00000541774+122723_6524891241Topological domainExtracellular
HgeneERBB2chr17:37872192chr17:37790136ENST00000541774+1227676_12554891241Topological domainCytoplasmic
HgeneERBB2chr17:37883800chr17:37791860ENST00000269571+2627676_125511371256Topological domainCytoplasmic
HgeneERBB2chr17:37883800chr17:37791860ENST00000541774+2627676_125511221241Topological domainCytoplasmic
HgeneERBB2chr17:37866734chr17:37790136ENST00000269571+727653_6753001256TransmembraneHelical
HgeneERBB2chr17:37866734chr17:37790136ENST00000541774+727653_6752851241TransmembraneHelical
HgeneERBB2chr17:37872192chr17:37790136ENST00000269571+1227653_6755041256TransmembraneHelical
HgeneERBB2chr17:37872192chr17:37790136ENST00000541774+1227653_6754891241TransmembraneHelical
TgenePPP1R1Bchr17:37883800chr17:37791860ENST00000254079+47119_136148205Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr17:37883800chr17:37791860ENST00000580825+58119_136148205Compositional biasNote=Asp/Glu-rich (acidic)


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FusionGeneSequence for ERBB2_PPP1R1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERBB2_PPP1R1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERBB2SHC1, SH3BGRL, PTPN11, GRB2, MUC1, CTNNB1, ERBB2, CD82, EGF, PAK1, ERBB2IP, PICK1, PIK3R2, DLG4, ERBB4, NRG1, JUP, STAT3, SRC, JAK2, HSP90B1, CD44, GRB7, PLCG1, IL6ST, OSMR, PTK2B, HSP90AA1, ELF3, EGFR, ERBB3, HDAC6, LRIG1, STUB1, HSPA4, IGF1R, CUL5, ESR1, PPP1R13B, H2AFY, PIK3R1, PIN1, PTK6, ACTB, POLR1B, KPNB1, XPO1, CLTC, AP2B1, EEA1, APBB1, SH2B2, IRS4, SH2D1B, SOCS1, NCK2, DAB1, GRAP2, APBB3, ABL1, FGR, CHN1, FER, PLCG2, RASA1, JAK1, IRS1, STAT1, MATK, TEC, TXK, ABL2, SYK, CRK, CRKL, BLK, BMX, VAV2, SH3BP2, SHC2, ITK, SLA, MAPK8IP2, RIN1, BCAR3, TENC1, TNS3, DOK6, SH2D5, SUPT6H, ANKS1B, CLNK, DOK4, BLNK, RIN2, SHC3, PIK3R3, ANKS1A, VAV1, DOK1, SH2D3A, SLA2, SH2D2A, CISH, VAV3, MAPK8IP1, SH2B3, TLN1, SRPK1, CBL, ERRFI1, FRS3, USP2, NXF1, DTWD2, TGFBR2, NAALADL2, LPAR6, VSIG4, PTGER3, CYP17A1, GLCE, IL13RA2, KLK5, LYPD3, NAT2, PRDM14, PSMC3IP, RHOBTB2, THRSP, ANXA6, BAI1, CLCN6, GMPR2, HDLBP, IARS, MTCH1, MUCL1, PHF23, POLD2, PSAP, STK24, TCEAL2, ATP6AP1, TTC9B, UTP18, ATP1A1, EEF1G, TNPO1, PC, SURF4, TFRC, VAPB, PTDSS1, HPSE, ZNF280C, CCDC88A, ZNF622, BTC, PTK2, TGFA, BCAR1, ESRRB, CDC37, EZR, RDX, ITGAV, L1CAM, ITGB1, CHEK2, TOP1, RRM2, CDK4, CDH2, CDH1, PTPN6, PTPRR, PTPRT, PTPRU, PTPRA, PTPRH, MPZL2, SSH1, CD79B, MAS1, HAVCR2, IL4R, PPM1A, PPM1F, ILKAP, DUSP14, DUSP18, DUSP19, STYX, GAB1PPP1R1BDLGAP4, CSNK2A1, PPP1CC, PPP1CA, TFCP2, KLHL6, ACTBL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneERBB2chr17:37866734chr17:37790136ENST00000269571+7271195_11973001256PIK3C2B
HgeneERBB2chr17:37866734chr17:37790136ENST00000541774+7271195_11972851241PIK3C2B
HgeneERBB2chr17:37872192chr17:37790136ENST00000269571+12271195_11975041256PIK3C2B
HgeneERBB2chr17:37872192chr17:37790136ENST00000541774+12271195_11974891241PIK3C2B
HgeneERBB2chr17:37883800chr17:37791860ENST00000269571+26271195_119711371256PIK3C2B
HgeneERBB2chr17:37883800chr17:37791860ENST00000541774+26271195_119711221241PIK3C2B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERBB2_PPP1R1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneERBB2P04626DB06366PertuzumabReceptor tyrosine-protein kinase erbB-2biotechapproved
HgeneERBB2P04626DB08916AfatinibReceptor tyrosine-protein kinase erbB-2small moleculeapproved
HgeneERBB2P04626DB00072TrastuzumabReceptor tyrosine-protein kinase erbB-2biotechapproved|investigational
HgeneERBB2P04626DB01259LapatinibReceptor tyrosine-protein kinase erbB-2small moleculeapproved|investigational
HgeneERBB2P04626DB05773Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2biotechapproved|investigational

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RelatedDiseases for ERBB2_PPP1R1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERBB2C1458155Mammary Neoplasms40CTD_human
HgeneERBB2C0033578Prostatic Neoplasms3CTD_human
HgeneERBB2C0038356Stomach Neoplasms3CTD_human
HgeneERBB2C0001418Adenocarcinoma2CTD_human
HgeneERBB2C0024668Mammary Neoplasms, Experimental2CTD_human
HgeneERBB2C0919267ovarian neoplasm2CTD_human
HgeneERBB2C0007117Basal cell carcinoma1CTD_human
HgeneERBB2C0007134Renal Cell Carcinoma1CTD_human
HgeneERBB2C0009375Colonic Neoplasms1CTD_human
HgeneERBB2C0014859Esophageal Neoplasms1CTD_human
HgeneERBB2C0016978gallbladder neoplasm1CTD_human
HgeneERBB2C0017185Gastrointestinal Neoplasms1CTD_human
HgeneERBB2C0024121Lung Neoplasms1CTD_human
HgeneERBB2C0024232Lymphatic Metastasis1CTD_human
HgeneERBB2C0024667Animal Mammary Neoplasms1CTD_human
HgeneERBB2C0025149Medulloblastoma1CTD_human
HgeneERBB2C0027627Neoplasm Metastasis1CTD_human
HgeneERBB2C0027643Neoplasm Recurrence, Local1CTD_human
HgeneERBB2C0027659Neoplasms, Experimental1CTD_human
HgeneERBB2C0030354Papilloma1CTD_human
HgeneERBB2C0206698Cholangiocarcinoma1CTD_human
HgeneERBB2C0596263Carcinogenesis1CTD_human
HgeneERBB2C2931822Nasopharyngeal carcinoma1CTD_human
TgenePPP1R1BC0036341Schizophrenia5PSYGENET
TgenePPP1R1BC0005586Bipolar Disorder4PSYGENET
TgenePPP1R1BC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgenePPP1R1BC0007370Catalepsy1CTD_human
TgenePPP1R1BC0011570Mental Depression1PSYGENET
TgenePPP1R1BC0011581Depressive disorder1PSYGENET
TgenePPP1R1BC0013384Dyskinetic syndrome1CTD_human