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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1191

FusionGeneSummary for AHCYL2_IP6K2

check button Fusion gene summary
Fusion gene informationFusion gene name: AHCYL2_IP6K2
Fusion gene ID: 1191
HgeneTgene
Gene symbol

AHCYL2

IP6K2

Gene ID

23382

51447

Gene nameadenosylhomocysteinase like 2inositol hexakisphosphate kinase 2
SynonymsADOHCYASE3|IRBIT2IHPK2|PIUS
Cytomap

7q32.1

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionadenosylhomocysteinase 3IP(3)Rs binding protein released with IP(3) 2S-adenosyl-L-homocysteine hydrolase 3S-adenosylhomocysteine hydrolase-like 2long-IRBITputative adenosylhomocysteinase 3inositol hexakisphosphate kinase 2ATP:1D-myo-inositol-hexakisphosphate phosphotransferaseinositol hexaphosphate kinase 2insp6 kinase 2pi uptake stimulator
Modification date2018052320180519
UniProtAcc

Q96HN2

Q9UHH9

Ensembl transtripts involved in fusion geneENST00000325006, ENST00000446544, 
ENST00000531335, ENST00000474594, 
ENST00000446212, ENST00000490911, 
ENST00000472554, 		ENST00000328631, 
ENST00000340879, ENST00000432678, 
ENST00000431721, ENST00000449610, 
ENST00000413298, ENST00000450045, 
ENST00000446860, ENST00000417896, 
ENST00000443964, ENST00000436134, 
ENST00000453202, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 5 X 3=75
# samples 66
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHCYL2 [Title/Abstract] AND IP6K2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIP6K2

GO:0046854

phosphatidylinositol phosphorylation

10574768


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-CM-4747-01AAHCYL2chr7

129008392

+IP6K2chr3

48732854

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000325006ENST00000328631AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000340879AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000432678AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000431721AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000449610AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000413298AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000450045AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000446860AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000417896AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000443964AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000436134AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000325006ENST00000453202AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000328631AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000340879AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000432678AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000431721AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000449610AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000413298AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000450045AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000446860AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000417896AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000443964AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000436134AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000446544ENST00000453202AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000328631AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000340879AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000432678AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000431721AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000449610AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000413298AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000450045AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000446860AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000417896AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000443964AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000436134AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000531335ENST00000453202AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000328631AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000340879AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000432678AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000431721AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000449610AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000413298AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000450045AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000446860AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000417896AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000443964AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000436134AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000474594ENST00000453202AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000328631AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000340879AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000432678AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000431721AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000449610AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000413298AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000450045AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000446860AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000417896AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000443964AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000436134AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
5CDS-5UTRENST00000446212ENST00000453202AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000328631AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000340879AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000432678AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000431721AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000449610AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000413298AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000450045AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000446860AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000417896AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000443964AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000436134AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000490911ENST00000453202AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000328631AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000340879AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000432678AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000431721AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000449610AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000413298AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000450045AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000446860AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000417896AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000443964AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000436134AHCYL2chr7

129008392

+IP6K2chr3

48732854

-
intron-5UTRENST00000472554ENST00000453202AHCYL2chr7

129008392

+IP6K2chr3

48732854

-

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FusionProtFeatures for AHCYL2_IP6K2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHCYL2

Q96HN2

IP6K2

Q9UHH9

May regulate the electrogenic sodium/bicarbonatecotransporter SLC4A4 activity and Mg(2+)-sensitivity. On thecontrary of its homolog AHCYL1, does not regulate ITPR1sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705).{ECO:0000250|UniProtKB:A6QLP2, ECO:0000269|PubMed:19220705}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AHCYL2_IP6K2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AHCYL2_IP6K2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AHCYL2BAP1, JOSD2, WDR48, CLK4, CSNK1E, HOXC9, DHX8, UNKL, ZC3H3, DOK4, PITX2, MSL1, VSX2, GRN, RBM23, SYT6, ZNF444, FAM13C, ZBTB44, ANP32B, ANP32E, RPL17, PSMD4, RPS8, XPO1, AHCYL1, PIP4K2A, CAMKV, ZIC2, FOXK2, HEXIM2, ABCF2, ZNF263, RASL10B, NFKBIL1, PIP4K2C, FOXK1, DUSP11, TGIF2LY, CEP72, HOXB6, FAM19A3, BANP, PIP4K2B, KIF18B, FBXW11, FOXD4, HOXB9, PLCD3, ARRB2, NUAK2, ZNHIT6, EEF1D, CAB39, SNX20, PIP5K1A, ZNF414, C4orf26, CLK3, WDR33, PDCD2L, ARSI, JUN, SOST, PTPN21IP6K2PLSCR1, GABRR1, TRAF2, HSP90AA1, HSP90AB1, MEOX2, RBPMS, GTPBP6, UNK, LNX2, PGK2, RHOU, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AHCYL2_IP6K2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AHCYL2_IP6K2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAHCYL2C0033578Prostatic Neoplasms1CTD_human
TgeneIP6K2C0020179Huntington Disease1CTD_human