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Fusion gene ID: 1190 |
FusionGeneSummary for AHCYL1_UGDH-AS1 |
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Fusion gene information | Fusion gene name: AHCYL1_UGDH-AS1 | Fusion gene ID: 1190 | Hgene | Tgene | Gene symbol | AHCYL1 | UGDH-AS1 | Gene ID | 10768 | 100885776 |
Gene name | adenosylhomocysteinase like 1 | UGDH antisense RNA 1 | |
Synonyms | DCAL|IRBIT|PPP1R78|PRO0233|XPVKONA | - | |
Cytomap | 1p13.3 | 4p14 | |
Type of gene | protein-coding | ncRNA | |
Description | S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like moleculeIP(3)Rs binding protein released with IP(3)S-adenosyl homocysteine hydrolase homologS-adenosyl-L-homocysteine hydrolase 2adenosylhomocysteinase 2adoHcyase 2dendritic cell | UGDH antisense RNA 1 (non-protein coding) | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | O43865 | ||
Ensembl transtripts involved in fusion gene | ENST00000369799, ENST00000475081, ENST00000359172, ENST00000393614, | ENST00000504032, | |
Fusion gene scores | * DoF score | 10 X 9 X 4=360 | 2 X 2 X 1=4 |
# samples | 12 | 2 | |
** MAII score | log2(12/360*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: AHCYL1 [Title/Abstract] AND UGDH-AS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AHCYL1 | GO:0006378 | mRNA polyadenylation | 19224921 |
Hgene | AHCYL1 | GO:0031440 | regulation of mRNA 3'-end processing | 19224921 |
Hgene | AHCYL1 | GO:0038166 | angiotensin-activated signaling pathway | 20584908 |
Hgene | AHCYL1 | GO:0051592 | response to calcium ion | 18829453 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA407754 | AHCYL1 | chr1 | 110565530 | + | UGDH-AS1 | chr4 | 39548974 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000369799 | ENST00000504032 | AHCYL1 | chr1 | 110565530 | + | UGDH-AS1 | chr4 | 39548974 | - |
intron-intron | ENST00000475081 | ENST00000504032 | AHCYL1 | chr1 | 110565530 | + | UGDH-AS1 | chr4 | 39548974 | - |
intron-intron | ENST00000359172 | ENST00000504032 | AHCYL1 | chr1 | 110565530 | + | UGDH-AS1 | chr4 | 39548974 | - |
intron-intron | ENST00000393614 | ENST00000504032 | AHCYL1 | chr1 | 110565530 | + | UGDH-AS1 | chr4 | 39548974 | - |
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FusionProtFeatures for AHCYL1_UGDH-AS1 |
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Hgene | Tgene |
AHCYL1 | UGDH-AS1 |
Multifaceted cellular regulator which coordinatesseveral essential cellular functions including regulation ofepithelial HCO3(-) and fluid secretion, mRNA processing and DNAreplication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting asendogenous 'pseudoligand' whose inhibitory activity can bemodulated by its phosphorylation status. In the pancreatic andsalivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1(PubMed:16793548). When extracellular stimuli induce ITPR1phosphorylation or inositol 1,4,5-trisphosphate production,dissociates of ITPR1 to interact with CFTR and SLC26A6 mediatingtheir synergistic activation by calcium and cAMP that stimulatesthe epithelial secretion of electrolytes and fluid (Bysimilarity). Also activates basolateral SLC4A4 isoform 1 tocoordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibitsthe effect of STK39 on SLC4A4 and CFTR by recruiting PP1phosphatase which activates SLC4A4, SLC26A6 and CFTR throughdephosphorylation (By similarity). Mediates the induction ofSLC9A3 surface expression produced by Angiotensin-2(PubMed:20584908). Depending on the cell type, activates SLC9A3 inresponse to calcium or reverses SLC9A3R2-dependent calciuminhibition (PubMed:18829453). May modulate the polyadenylationstate of specific mRNAs, both by controlling the subcellularlocation of FIP1L1 and by inhibiting PAPOLA activity, in responseto a stimulus that alters its phosphorylation state(PubMed:19224921). Acts as a (dATP)-dependent inhibitor ofribonucleotide reductase large subunit RRM1, controlling theendogenous dNTP pool and ensuring normal cell cycle progression(PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).{ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1,ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921,ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AHCYL1_UGDH-AS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AHCYL1_UGDH-AS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AHCYL1_UGDH-AS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AHCYL1_UGDH-AS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |