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Fusion gene ID: 11868 |
FusionGeneSummary for EPS15_OSBPL9 |
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Fusion gene information | Fusion gene name: EPS15_OSBPL9 | Fusion gene ID: 11868 | Hgene | Tgene | Gene symbol | EPS15 | OSBPL9 | Gene ID | 2060 | 114883 |
Gene name | epidermal growth factor receptor pathway substrate 15 | oxysterol binding protein like 9 | |
Synonyms | AF-1P|AF1P|MLLT5 | ORP-9|ORP9 | |
Cytomap | 1p32.3 | 1p32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | epidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p | oxysterol-binding protein-related protein 9OSBP-related protein 9 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P42566 | Q96SU4 | |
Ensembl transtripts involved in fusion gene | ENST00000371730, ENST00000371733, ENST00000396122, ENST00000493793, | ENST00000371714, ENST00000371710, ENST00000337809, ENST00000435686, ENST00000447887, ENST00000453295, ENST00000428468, ENST00000530544, ENST00000531828, ENST00000361556, ENST00000473207, ENST00000462759, ENST00000486942, | |
Fusion gene scores | * DoF score | 10 X 7 X 8=560 | 5 X 5 X 5=125 |
# samples | 10 | 7 | |
** MAII score | log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/125*10)=-0.836501267717121 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EPS15 [Title/Abstract] AND OSBPL9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EPS15 | GO:0048268 | clathrin coat assembly | 12807910 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CV-5971-01A | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000371730 | ENST00000371714 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000371710 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000337809 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000435686 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000447887 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000453295 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000428468 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000530544 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000531828 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371730 | ENST00000361556 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
5CDS-intron | ENST00000371730 | ENST00000473207 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
5CDS-intron | ENST00000371730 | ENST00000462759 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
5CDS-intron | ENST00000371730 | ENST00000486942 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000371714 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000371710 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000337809 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000435686 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000447887 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000453295 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000428468 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000530544 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000531828 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
Frame-shift | ENST00000371733 | ENST00000361556 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
5CDS-intron | ENST00000371733 | ENST00000473207 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
5CDS-intron | ENST00000371733 | ENST00000462759 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
5CDS-intron | ENST00000371733 | ENST00000486942 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000371714 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000371710 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000337809 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000435686 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000447887 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000453295 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000428468 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000530544 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000531828 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000396122 | ENST00000361556 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-intron | ENST00000396122 | ENST00000473207 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-intron | ENST00000396122 | ENST00000462759 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-intron | ENST00000396122 | ENST00000486942 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000371714 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000371710 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000337809 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000435686 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000447887 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000453295 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000428468 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000530544 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000531828 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-3CDS | ENST00000493793 | ENST00000361556 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-intron | ENST00000493793 | ENST00000473207 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-intron | ENST00000493793 | ENST00000462759 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
intron-intron | ENST00000493793 | ENST00000486942 | EPS15 | chr1 | 51946945 | - | OSBPL9 | chr1 | 52246836 | + |
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FusionProtFeatures for EPS15_OSBPL9 |
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Hgene | Tgene |
EPS15 | OSBPL9 |
Involved in cell growth regulation. May be involved inthe regulation of mitogenic signals and control of cellproliferation. Involved in the internalization of ligand-induciblereceptors of the receptor tyrosine kinase (RTK) type, inparticular EGFR. Plays a role in the assembly of clathrin-coatedpits (CCPs). Acts as a clathrin adapter required for post-Golgitrafficking. Seems to be involved in CCPs maturation includinginvagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1as DAB2-dependent cargo but not TFR seems to require associationwith DAB2. {ECO:0000269|PubMed:16903783,ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185,ECO:0000269|PubMed:22648170}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EPS15_OSBPL9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EPS15_OSBPL9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EPS15 | RNF11, SNAP91, AGFG1, NAGPA, STON2, HGS, AP2A2, DNM2, AP2A1, EGFR, CLINT1, EPN1, SCAMP1, STAM2, GRB2, CRK, RAB11FIP2, REPS2, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2E1, SLC6A3, PARK2, USP8, CD4, EPS15, OCLN, UBQLN1, UBC, NEDD4, GJA1, TGFB1, FCHO2, ITSN1, ITSN2, ELAVL1, RAD23A, UBQLN2, EPN3, SH3BP4, AP1B1, NUMB, SPG20, TFAP2A, ABL1, AP2B1, IQGAP1, KRT85, KRT1, KRT10, KRT2, AP2M1, KRT14, KRT86, KRT5, KRT6A, KRT16, KRT9, HSPA8, KRT35, HSPA9, KRT17, KRT33B, KRT83, BMP2K, KRT34, KRT82, NONO, KRT38, KRT75, KRT79, PRDX1, KRT36, KRT32, MAP4, HSPA1L, HSPA1B, KRT37, HSPA5, KRT73, AP2S1, NECAP2, TRAF2, MCCC2, KRT4, ACTB, KRT3, VPRBP, TUBB, HIST4H4, PCCB, KRTAP9-3, NECAP1, VSIG8, CCT3, CRKL, FN1, VCAM1, LAPTM5, ITGA4, OPTN, RABL6, EPHA2, CORO7, AGFG2, SLC25A41, AURKA, SPC25, NTRK1, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, FLNA, GAK, MYH9, PPP1CB, PICALM, PDLIM7, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, MAPK14, AP1G1, MYO6, SPOPL, SGIP1, FCHO1, CDH1, RUNDC3A, LSR, STAMBPL1, CCDC172, OXCT1, MTNR1A, RNF26 | OSBPL9 | GCH1, HIST1H2BL, VAPB, VAPA, WRAP73, DTNBP1, KBTBD6, USP11, OSBPL10, OSBPL11, HAUS1, BLOC1S2, TERF2, DNAJA1, CYP1A1, HSPB1, COPE, POLD2, NTRK1, KRAS, CHMP4B, FUZ, CFAP36 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EPS15_OSBPL9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EPS15_OSBPL9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |