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Fusion gene ID: 11867 |
FusionGeneSummary for EPS15_INADL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EPS15_INADL | Fusion gene ID: 11867 | Hgene | Tgene | Gene symbol | EPS15 | INADL | Gene ID | 2060 | 10207 |
| Gene name | epidermal growth factor receptor pathway substrate 15 | PATJ, crumbs cell polarity complex component | |
| Synonyms | AF-1P|AF1P|MLLT5 | Cipp|INADL|InaD-like|hINADL | |
| Cytomap | 1p32.3 | 1p31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | epidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p | inaD-like proteinPALS1-associated tight junction proteinPDZ domain proteinchannel-interacting PDZ domain proteininactivation no after-potential D-like proteininactivation-no-afterpotential D-likeprotein associated to tight junctions | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | P42566 | ||
| Ensembl transtripts involved in fusion gene | ENST00000371730, ENST00000371733, ENST00000396122, ENST00000493793, | ENST00000316485, ENST00000371158, ENST00000543708, ENST00000545929, ENST00000472512, | |
| Fusion gene scores | * DoF score | 10 X 7 X 8=560 | 5 X 5 X 3=75 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EPS15 [Title/Abstract] AND INADL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EPS15 | GO:0048268 | clathrin coat assembly | 12807910 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-91-8499-01A | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000371730 | ENST00000316485 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| Frame-shift | ENST00000371730 | ENST00000371158 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| Frame-shift | ENST00000371730 | ENST00000543708 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| 5CDS-5UTR | ENST00000371730 | ENST00000545929 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| 5CDS-intron | ENST00000371730 | ENST00000472512 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| Frame-shift | ENST00000371733 | ENST00000316485 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| Frame-shift | ENST00000371733 | ENST00000371158 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| Frame-shift | ENST00000371733 | ENST00000543708 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| 5CDS-5UTR | ENST00000371733 | ENST00000545929 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| 5CDS-intron | ENST00000371733 | ENST00000472512 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-3CDS | ENST00000396122 | ENST00000316485 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-3CDS | ENST00000396122 | ENST00000371158 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-3CDS | ENST00000396122 | ENST00000543708 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-5UTR | ENST00000396122 | ENST00000545929 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-intron | ENST00000396122 | ENST00000472512 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-3CDS | ENST00000493793 | ENST00000316485 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-3CDS | ENST00000493793 | ENST00000371158 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-3CDS | ENST00000493793 | ENST00000543708 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-5UTR | ENST00000493793 | ENST00000545929 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
| intron-intron | ENST00000493793 | ENST00000472512 | EPS15 | chr1 | 51984871 | - | INADL | chr1 | 62503649 | + |
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FusionProtFeatures for EPS15_INADL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EPS15 | INADL |
| Involved in cell growth regulation. May be involved inthe regulation of mitogenic signals and control of cellproliferation. Involved in the internalization of ligand-induciblereceptors of the receptor tyrosine kinase (RTK) type, inparticular EGFR. Plays a role in the assembly of clathrin-coatedpits (CCPs). Acts as a clathrin adapter required for post-Golgitrafficking. Seems to be involved in CCPs maturation includinginvagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1as DAB2-dependent cargo but not TFR seems to require associationwith DAB2. {ECO:0000269|PubMed:16903783,ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185,ECO:0000269|PubMed:22648170}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EPS15_INADL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EPS15_INADL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EPS15 | RNF11, SNAP91, AGFG1, NAGPA, STON2, HGS, AP2A2, DNM2, AP2A1, EGFR, CLINT1, EPN1, SCAMP1, STAM2, GRB2, CRK, RAB11FIP2, REPS2, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2E1, SLC6A3, PARK2, USP8, CD4, EPS15, OCLN, UBQLN1, UBC, NEDD4, GJA1, TGFB1, FCHO2, ITSN1, ITSN2, ELAVL1, RAD23A, UBQLN2, EPN3, SH3BP4, AP1B1, NUMB, SPG20, TFAP2A, ABL1, AP2B1, IQGAP1, KRT85, KRT1, KRT10, KRT2, AP2M1, KRT14, KRT86, KRT5, KRT6A, KRT16, KRT9, HSPA8, KRT35, HSPA9, KRT17, KRT33B, KRT83, BMP2K, KRT34, KRT82, NONO, KRT38, KRT75, KRT79, PRDX1, KRT36, KRT32, MAP4, HSPA1L, HSPA1B, KRT37, HSPA5, KRT73, AP2S1, NECAP2, TRAF2, MCCC2, KRT4, ACTB, KRT3, VPRBP, TUBB, HIST4H4, PCCB, KRTAP9-3, NECAP1, VSIG8, CCT3, CRKL, FN1, VCAM1, LAPTM5, ITGA4, OPTN, RABL6, EPHA2, CORO7, AGFG2, SLC25A41, AURKA, SPC25, NTRK1, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, FLNA, GAK, MYH9, PPP1CB, PICALM, PDLIM7, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, MAPK14, AP1G1, MYO6, SPOPL, SGIP1, FCHO1, CDH1, RUNDC3A, LSR, STAMBPL1, CCDC172, OXCT1, MTNR1A, RNF26 | INADL | TJP3, CLDN1, MPP5, ARHGAP17, AMOT, PARD3, BAI1, AMOTL2, LATS1, LATS2, SAV1, YAP1, TP53RK, RNF166, LIN7C, LIN7A, GBA, GJB2, HSF2, SNCA, SLC33A1, RNASEH2A, RAB32, ANAPC15, CEP170P1, CDH1, HOMER3, PCDHAC2, WWC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EPS15_INADL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EPS15_INADL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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