![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 11860 |
FusionGeneSummary for EPS15L1_ZNF675 |
![]() |
Fusion gene information | Fusion gene name: EPS15L1_ZNF675 | Fusion gene ID: 11860 | Hgene | Tgene | Gene symbol | EPS15L1 | ZNF675 | Gene ID | 58513 | 171392 |
Gene name | epidermal growth factor receptor pathway substrate 15 like 1 | zinc finger protein 675 | |
Synonyms | EPS15R | TBZF|TIZ | |
Cytomap | 19p13.11 | 19p12 | |
Type of gene | protein-coding | protein-coding | |
Description | epidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related protein | zinc finger protein 675TRAF6 inhibitory zinc fingerTRAF6-binding zinc finger proteinTRAF6-inhibitory zinc finger protein | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q9UBC2 | Q8TD23 | |
Ensembl transtripts involved in fusion gene | ENST00000455140, ENST00000248070, ENST00000535753, ENST00000594975, ENST00000602009, ENST00000597937, | ENST00000601935, ENST00000600313, ENST00000596211, ENST00000359788, ENST00000601010, ENST00000599168, | |
Fusion gene scores | * DoF score | 15 X 11 X 10=1650 | 3 X 2 X 3=18 |
# samples | 18 | 3 | |
** MAII score | log2(18/1650*10)=-3.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EPS15L1 [Title/Abstract] AND ZNF675 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ZNF675 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11751921 |
Tgene | ZNF675 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 11751921 |
Tgene | ZNF675 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 11751921 |
Tgene | ZNF675 | GO:0019221 | cytokine-mediated signaling pathway | 11751921 |
Tgene | ZNF675 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11751921 |
Tgene | ZNF675 | GO:0043508 | negative regulation of JUN kinase activity | 11751921 |
Tgene | ZNF675 | GO:0045671 | negative regulation of osteoclast differentiation | 11751921|11851921 |
Tgene | ZNF675 | GO:0046329 | negative regulation of JNK cascade | 11751921 |
Tgene | ZNF675 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway | 11751921 |
Tgene | ZNF675 | GO:2000678 | negative regulation of transcription regulatory region DNA binding | 11751921 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A0RL-01A | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000455140 | ENST00000601935 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000455140 | ENST00000600313 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000455140 | ENST00000596211 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000455140 | ENST00000359788 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000455140 | ENST00000601010 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000455140 | ENST00000599168 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000248070 | ENST00000601935 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000248070 | ENST00000600313 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000248070 | ENST00000596211 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000248070 | ENST00000359788 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000248070 | ENST00000601010 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000248070 | ENST00000599168 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000535753 | ENST00000601935 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000535753 | ENST00000600313 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000535753 | ENST00000596211 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000535753 | ENST00000359788 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000535753 | ENST00000601010 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000535753 | ENST00000599168 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000594975 | ENST00000601935 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000594975 | ENST00000600313 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000594975 | ENST00000596211 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000594975 | ENST00000359788 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000594975 | ENST00000601010 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000594975 | ENST00000599168 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000602009 | ENST00000601935 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000602009 | ENST00000600313 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000602009 | ENST00000596211 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000602009 | ENST00000359788 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000602009 | ENST00000601010 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000602009 | ENST00000599168 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000597937 | ENST00000601935 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000597937 | ENST00000600313 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000597937 | ENST00000596211 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000597937 | ENST00000359788 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000597937 | ENST00000601010 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
5CDS-intron | ENST00000597937 | ENST00000599168 | EPS15L1 | chr19 | 16524584 | - | ZNF675 | chr19 | 23757034 | - |
Top |
FusionProtFeatures for EPS15L1_ZNF675 |
![]() |
Hgene | Tgene |
EPS15L1 | ZNF675 |
Seems to be a constitutive component of clathrin-coatedpits that is required for receptor-mediated endocytosis. Involvedin endocytosis of integrin beta-1 (ITGB1) and transferrin receptor(TFR); internalization of ITGB1 as DAB2-dependent cargo but notTFR seems to require association with DAB2.{ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:9407958}. | May be involved in transcriptional regulation. May playa role during osteoclast differentiation by modulating TRAF6signaling activity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for EPS15L1_ZNF675 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for EPS15L1_ZNF675 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EPS15L1 | AGFG1, STON2, EPN1, ITSN1, ITSN2, UBQLN1, GRB2, BIRC6, GBF1, NCAPG, PRPF4, ZZEF1, AP2M1, GNG5, TRAPPC2B, MOV10, NXF1, AGFG2, SPC25, NTRK1, MED4, XPO1, PLK1, KIAA1107, CDH1, AP2S1, RUNDC3A, LSR, FCHO1, NCKIPSD, CDR2, AURKA, UBC, DCAF7, USP15, SPAG9, MCM2, MCM4, MCM6, IVNS1ABP, GTF3C4, SMC1A, GAPVD1, ANK3, SBNO1, SMC3, CDK11A, SOX4, HSF1, TRIM25, TXNIP | ZNF675 | TRAF6, TNFSF11, IL1B, LMO4 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for EPS15L1_ZNF675 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for EPS15L1_ZNF675 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |