	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 11835

FusionGeneSummary for EPN2_EPN2

Fusion gene summary

Fusion gene information	Fusion gene name: EPN2_EPN2
	Fusion gene ID: 11835
		Hgene	Tgene
	Gene symbol	EPN2	EPN2
	Gene ID	22905	22905
	Gene name	epsin 2	epsin 2
	Synonyms	EHB21	EHB21
	Cytomap	17p11.2	17p11.2
	Type of gene	protein-coding	protein-coding
	Description	epsin-2EPS-15-interacting protein 2Eps15 binding protein	epsin-2EPS-15-interacting protein 2Eps15 binding protein
	Modification date	20180522	20180522
	UniProtAcc	O95208	O95208
	Ensembl transtripts involved in fusion gene	ENST00000441293, ENST00000314728, ENST00000347697, ENST00000395618, ENST00000575595, ENST00000395620, ENST00000395626, ENST00000571254,	ENST00000441293, ENST00000314728, ENST00000347697, ENST00000395618, ENST00000575595, ENST00000395620, ENST00000395626, ENST00000571254,
Fusion gene scores	* DoF score	5 X 3 X 4=60	9 X 9 X 5=405
	# samples	6	10
	** MAII score	log2(6/60*10)=0	log2(10/405*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EPN2 [Title/Abstract] AND EPN2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BM992471	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
ChiTaRS3.1			BF351514	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000441293	ENST00000441293	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000441293	ENST00000314728	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000441293	ENST00000347697	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000441293	ENST00000395618	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000441293	ENST00000575595	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000441293	ENST00000395620	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000441293	ENST00000395626	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000441293	ENST00000571254	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000314728	ENST00000441293	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000314728	ENST00000314728	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000314728	ENST00000347697	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000314728	ENST00000395618	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000314728	ENST00000575595	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000314728	ENST00000395620	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000314728	ENST00000395626	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000314728	ENST00000571254	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000347697	ENST00000441293	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000347697	ENST00000314728	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000347697	ENST00000347697	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000347697	ENST00000395618	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000347697	ENST00000575595	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000347697	ENST00000395620	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000347697	ENST00000395626	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000347697	ENST00000571254	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000395618	ENST00000441293	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000395618	ENST00000314728	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000395618	ENST00000347697	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000395618	ENST00000395618	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000395618	ENST00000575595	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000395618	ENST00000395620	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000395618	ENST00000395626	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000395618	ENST00000571254	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000575595	ENST00000441293	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000575595	ENST00000314728	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000575595	ENST00000347697	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000575595	ENST00000395618	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000575595	ENST00000575595	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-5UTR	ENST00000575595	ENST00000395620	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000575595	ENST00000395626	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000575595	ENST00000571254	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395620	ENST00000441293	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000395620	ENST00000314728	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000395620	ENST00000347697	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395620	ENST00000395618	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395620	ENST00000575595	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000395620	ENST00000395620	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395620	ENST00000395626	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395620	ENST00000571254	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395626	ENST00000441293	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000395626	ENST00000314728	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000395626	ENST00000347697	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395626	ENST00000395618	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395626	ENST00000575595	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000395626	ENST00000395620	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395626	ENST00000395626	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000395626	ENST00000571254	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000571254	ENST00000441293	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000571254	ENST00000314728	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000571254	ENST00000347697	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000571254	ENST00000395618	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000571254	ENST00000575595	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-5UTR	ENST00000571254	ENST00000395620	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000571254	ENST00000395626	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
5UTR-intron	ENST00000571254	ENST00000571254	EPN2	chr17	19186382	-	EPN2	chr17	19186270	+
intron-intron	ENST00000441293	ENST00000441293	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000441293	ENST00000314728	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000441293	ENST00000347697	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000441293	ENST00000395618	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000441293	ENST00000575595	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000441293	ENST00000395620	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000441293	ENST00000395626	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000441293	ENST00000571254	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000314728	ENST00000441293	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000314728	ENST00000314728	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000314728	ENST00000347697	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000314728	ENST00000395618	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000314728	ENST00000575595	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000314728	ENST00000395620	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000314728	ENST00000395626	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000314728	ENST00000571254	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000347697	ENST00000441293	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000347697	ENST00000314728	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000347697	ENST00000347697	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000347697	ENST00000395618	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000347697	ENST00000575595	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000347697	ENST00000395620	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000347697	ENST00000395626	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000347697	ENST00000571254	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395618	ENST00000441293	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395618	ENST00000314728	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395618	ENST00000347697	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395618	ENST00000395618	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395618	ENST00000575595	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395618	ENST00000395620	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395618	ENST00000395626	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395618	ENST00000571254	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000575595	ENST00000441293	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000575595	ENST00000314728	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000575595	ENST00000347697	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000575595	ENST00000395618	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000575595	ENST00000575595	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000575595	ENST00000395620	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000575595	ENST00000395626	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000575595	ENST00000571254	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395620	ENST00000441293	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395620	ENST00000314728	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395620	ENST00000347697	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395620	ENST00000395618	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395620	ENST00000575595	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395620	ENST00000395620	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395620	ENST00000395626	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395620	ENST00000571254	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395626	ENST00000441293	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395626	ENST00000314728	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395626	ENST00000347697	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395626	ENST00000395618	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395626	ENST00000575595	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395626	ENST00000395620	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395626	ENST00000395626	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000395626	ENST00000571254	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000571254	ENST00000441293	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000571254	ENST00000314728	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000571254	ENST00000347697	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000571254	ENST00000395618	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000571254	ENST00000575595	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000571254	ENST00000395620	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000571254	ENST00000395626	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+
intron-intron	ENST00000571254	ENST00000571254	EPN2	chr17	19162003	-	EPN2	chr17	19162449	+

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FusionProtFeatures for EPN2_EPN2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EPN2 O95208	EPN2 O95208
Plays a role in the formation of clathrin-coatedinvaginations and endocytosis. {ECO:0000269\|PubMed:10567358}.	Plays a role in the formation of clathrin-coatedinvaginations and endocytosis. {ECO:0000269\|PubMed:10567358}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for EPN2_EPN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EPN2_EPN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for EPN2_EPN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for EPN2_EPN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Statistics

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Fusion gene ID: 11835

FusionGeneSummary for EPN2_EPN2

FusionProtFeatures for EPN2_EPN2

FusionGeneSequence for EPN2_EPN2

FusionGenePPI for EPN2_EPN2

RelatedDrugs for EPN2_EPN2

RelatedDiseases for EPN2_EPN2