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Fusion gene ID: 1183 |
FusionGeneSummary for AHCYL1_DENND2D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AHCYL1_DENND2D | Fusion gene ID: 1183 | Hgene | Tgene | Gene symbol | AHCYL1 | DENND2D | Gene ID | 10768 | 79961 |
| Gene name | adenosylhomocysteinase like 1 | DENN domain containing 2D | |
| Synonyms | DCAL|IRBIT|PPP1R78|PRO0233|XPVKONA | - | |
| Cytomap | 1p13.3 | 1p13.3-p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like moleculeIP(3)Rs binding protein released with IP(3)S-adenosyl homocysteine hydrolase homologS-adenosyl-L-homocysteine hydrolase 2adenosylhomocysteinase 2adoHcyase 2dendritic cell | DENN domain-containing protein 2DDENN/MADD domain containing 2DRP5-1180E21.2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43865 | Q9H6A0 | |
| Ensembl transtripts involved in fusion gene | ENST00000369799, ENST00000475081, ENST00000359172, ENST00000393614, | ENST00000357640, ENST00000369752, ENST00000473682, | |
| Fusion gene scores | * DoF score | 10 X 9 X 4=360 | 3 X 3 X 2=18 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/360*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AHCYL1 [Title/Abstract] AND DENND2D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AHCYL1 | GO:0006378 | mRNA polyadenylation | 19224921 |
| Hgene | AHCYL1 | GO:0031440 | regulation of mRNA 3'-end processing | 19224921 |
| Hgene | AHCYL1 | GO:0038166 | angiotensin-activated signaling pathway | 20584908 |
| Hgene | AHCYL1 | GO:0051592 | response to calcium ion | 18829453 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E9-A5FK-01A | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369799 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| In-frame | ENST00000369799 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| 5CDS-intron | ENST00000369799 | ENST00000473682 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| 3UTR-3CDS | ENST00000475081 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| 3UTR-3CDS | ENST00000475081 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| 3UTR-intron | ENST00000475081 | ENST00000473682 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| intron-3CDS | ENST00000359172 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| intron-3CDS | ENST00000359172 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| intron-intron | ENST00000359172 | ENST00000473682 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| intron-3CDS | ENST00000393614 | ENST00000357640 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| intron-3CDS | ENST00000393614 | ENST00000369752 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
| intron-intron | ENST00000393614 | ENST00000473682 | AHCYL1 | chr1 | 110527794 | + | DENND2D | chr1 | 111737348 | - |
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FusionProtFeatures for AHCYL1_DENND2D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AHCYL1 | DENND2D |
| Multifaceted cellular regulator which coordinatesseveral essential cellular functions including regulation ofepithelial HCO3(-) and fluid secretion, mRNA processing and DNAreplication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting asendogenous 'pseudoligand' whose inhibitory activity can bemodulated by its phosphorylation status. In the pancreatic andsalivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1(PubMed:16793548). When extracellular stimuli induce ITPR1phosphorylation or inositol 1,4,5-trisphosphate production,dissociates of ITPR1 to interact with CFTR and SLC26A6 mediatingtheir synergistic activation by calcium and cAMP that stimulatesthe epithelial secretion of electrolytes and fluid (Bysimilarity). Also activates basolateral SLC4A4 isoform 1 tocoordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibitsthe effect of STK39 on SLC4A4 and CFTR by recruiting PP1phosphatase which activates SLC4A4, SLC26A6 and CFTR throughdephosphorylation (By similarity). Mediates the induction ofSLC9A3 surface expression produced by Angiotensin-2(PubMed:20584908). Depending on the cell type, activates SLC9A3 inresponse to calcium or reverses SLC9A3R2-dependent calciuminhibition (PubMed:18829453). May modulate the polyadenylationstate of specific mRNAs, both by controlling the subcellularlocation of FIP1L1 and by inhibiting PAPOLA activity, in responseto a stimulus that alters its phosphorylation state(PubMed:19224921). Acts as a (dATP)-dependent inhibitor ofribonucleotide reductase large subunit RRM1, controlling theendogenous dNTP pool and ensuring normal cell cycle progression(PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).{ECO:0000250|UniProtKB:B5DFN2, ECO:0000250|UniProtKB:Q80SW1,ECO:0000269|PubMed:16769890, ECO:0000269|PubMed:16793548,ECO:0000269|PubMed:18829453, ECO:0000269|PubMed:19224921,ECO:0000269|PubMed:20584908, ECO:0000269|PubMed:25237103}. | Guanine nucleotide exchange factor (GEF) which mayactivate RAB9A and RAB9B. Promotes the exchange of GDP to GTP,converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269|PubMed:20937701}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >DENND2D | chr1:110527794 | chr1:111737348 | ENST00000357640 | - | 5 | 12 | 226_359 | 215 | 472 | Domain | cDENN |
| Tgene | >DENND2D | chr1:110527794 | chr1:111737348 | ENST00000357640 | - | 5 | 12 | 361_445 | 215 | 472 | Domain | dDENN |
| Tgene | >DENND2D | chr1:110527794 | chr1:111737348 | ENST00000369752 | - | 5 | 12 | 226_359 | 212 | 469 | Domain | cDENN |
| Tgene | >DENND2D | chr1:110527794 | chr1:111737348 | ENST00000369752 | - | 5 | 12 | 361_445 | 212 | 469 | Domain | dDENN |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 318_322 | -114 | 484 | Nucleotide binding | NAD |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 397_399 | -114 | 484 | Nucleotide binding | NAD |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 318_322 | 40 | 531 | Nucleotide binding | NAD |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 397_399 | 40 | 531 | Nucleotide binding | NAD |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 318_322 | -110 | 484 | Nucleotide binding | NAD |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 397_399 | -110 | 484 | Nucleotide binding | NAD |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 281_448 | -114 | 484 | Region | NAD binding |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 520_530 | -114 | 484 | Region | PDZ-binding |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000359172 | + | 1 | 17 | 65_92 | -114 | 484 | Region | PEST |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 281_448 | 40 | 531 | Region | NAD binding |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 520_530 | 40 | 531 | Region | PDZ-binding |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000369799 | + | 1 | 17 | 65_92 | 40 | 531 | Region | PEST |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 281_448 | -110 | 484 | Region | NAD binding |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 520_530 | -110 | 484 | Region | PDZ-binding |
| Hgene | >AHCYL1 | chr1:110527794 | chr1:111737348 | ENST00000393614 | + | 1 | 17 | 65_92 | -110 | 484 | Region | PEST |
| Tgene | DENND2D | chr1:110527794 | chr1:111737348 | ENST00000357640 | - | 5 | 12 | 55_204 | 215 | 472 | Domain | uDENN |
| Tgene | DENND2D | chr1:110527794 | chr1:111737348 | ENST00000369752 | - | 5 | 12 | 55_204 | 212 | 469 | Domain | uDENN |
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FusionGeneSequence for AHCYL1_DENND2D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AHCYL1_ENST00000369799_chr1_110527794_+_DENND2D_ENST00000357640_chr1_111737348_-_297aa MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLS TLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDIL DSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPP >In-frame_AHCYL1_ENST00000369799_chr1_110527794_+_DENND2D_ENST00000369752_chr1_111737348_-_297aa MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLS TLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDIL DSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AHCYL1_ENST00000369799_chr1_110527794_+_DENND2D_ENST00000357640_chr1_111737348_-_891nt ATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTACTCCTTC ATGGCCACCGTCACCAAGGCGCCCAAGAAGTTCATTTCACTGACACGGCCCCTGGACTCCCACCTAGAACATGTGGATTTTAGTTCTCTA TTGCACTGTCTCAGTTTTGAACAGATACTTCAGATCTTTGCCTCTGCCGTGCTGGAGAGAAAAATCATCTTCCTGGCGGAAGGTCTCAGC ACCTTGTCTCAGTGCATCCATGCTGCTGCCGCACTGCTCTACCCCTTCAGCTGGGCGCACACCTACATCCCTGTTGTCCCTGAGAGCCTT CTGGCCACCGTCTGCTGCCCCACCCCCTTCATGGTTGGAGTACAAATGCGCTTCCAGCAGGAGGTCATGGACAGCCCTATGGAAGAGGTC CTGCTGGTCAATCTTTGTGAAGGAACCTTCTTAATGTCGGTTGGTGATGAAAAAGACATCCTGCCACCGAAGCTTCAGGATGACATCTTA GACTCTCTTGGTCAGGGGATCAATGAGTTAAAGACTGCAGAACAAATCAACGAGCATGTTTCAGGCCCCTTTGTGCAGTTCTTTGTCAAG ATTGTGGGCCATTATGCTTCCTATATCAAGCGGGAGGCAAATGGGCAAGGCCACTTCCAAGAAAGATCCTTCTGTAAGGCTCTGACCTCC AAGACCAACCGCCGATTTGTGAAGAAGTTTGTGAAGACACAGCTCTTCTCACTTTTCATCCAGGAAGCCGAGAAGAGCAAGAATCCTCCT >In-frame_AHCYL1_ENST00000369799_chr1_110527794_+_DENND2D_ENST00000369752_chr1_111737348_-_891nt ATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTACTCCTTC ATGGCCACCGTCACCAAGGCGCCCAAGAAGTTCATTTCACTGACACGGCCCCTGGACTCCCACCTAGAACATGTGGATTTTAGTTCTCTA TTGCACTGTCTCAGTTTTGAACAGATACTTCAGATCTTTGCCTCTGCCGTGCTGGAGAGAAAAATCATCTTCCTGGCGGAAGGTCTCAGC ACCTTGTCTCAGTGCATCCATGCTGCTGCCGCACTGCTCTACCCCTTCAGCTGGGCGCACACCTACATCCCTGTTGTCCCTGAGAGCCTT CTGGCCACCGTCTGCTGCCCCACCCCCTTCATGGTTGGAGTACAAATGCGCTTCCAGCAGGAGGTCATGGACAGCCCTATGGAAGAGGTC CTGCTGGTCAATCTTTGTGAAGGAACCTTCTTAATGTCGGTTGGTGATGAAAAAGACATCCTGCCACCGAAGCTTCAGGATGACATCTTA GACTCTCTTGGTCAGGGGATCAATGAGTTAAAGACTGCAGAACAAATCAACGAGCATGTTTCAGGCCCCTTTGTGCAGTTCTTTGTCAAG ATTGTGGGCCATTATGCTTCCTATATCAAGCGGGAGGCAAATGGGCAAGGCCACTTCCAAGAAAGATCCTTCTGTAAGGCTCTGACCTCC AAGACCAACCGCCGATTTGTGAAGAAGTTTGTGAAGACACAGCTCTTCTCACTTTTCATCCAGGAAGCCGAGAAGAGCAAGAATCCTCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AHCYL1_ENST00000369799_chr1_110527794_+_DENND2D_ENST00000357640_chr1_111737348_-_1689nt CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGTTCATTTCACTGACACGGCCCCTGGACTCCCACCTAGAACATGTGGATTTTAG TTCTCTATTGCACTGTCTCAGTTTTGAACAGATACTTCAGATCTTTGCCTCTGCCGTGCTGGAGAGAAAAATCATCTTCCTGGCGGAAGG TCTCAGCACCTTGTCTCAGTGCATCCATGCTGCTGCCGCACTGCTCTACCCCTTCAGCTGGGCGCACACCTACATCCCTGTTGTCCCTGA GAGCCTTCTGGCCACCGTCTGCTGCCCCACCCCCTTCATGGTTGGAGTACAAATGCGCTTCCAGCAGGAGGTCATGGACAGCCCTATGGA AGAGGTCCTGCTGGTCAATCTTTGTGAAGGAACCTTCTTAATGTCGGTTGGTGATGAAAAAGACATCCTGCCACCGAAGCTTCAGGATGA CATCTTAGACTCTCTTGGTCAGGGGATCAATGAGTTAAAGACTGCAGAACAAATCAACGAGCATGTTTCAGGCCCCTTTGTGCAGTTCTT TGTCAAGATTGTGGGCCATTATGCTTCCTATATCAAGCGGGAGGCAAATGGGCAAGGCCACTTCCAAGAAAGATCCTTCTGTAAGGCTCT GACCTCCAAGACCAACCGCCGATTTGTGAAGAAGTTTGTGAAGACACAGCTCTTCTCACTTTTCATCCAGGAAGCCGAGAAGAGCAAGAA TCCTCCTGCAGGCTATTTCCAACAGAAAATACTTGAATATGAGGAACAGAAGAAACAGAAGAAACCAAGGGAAAAAACTGTGAAATAAGA GCTGTGGTGAATAAGAATGACTAGAGCTACACACCATTTCTGGACTTCAGCCCCTGCCAGTGTGGCAGGATCAGCAAAACTGTCAGCTCC CAAAATCCATATCCTCACTCTGAGTCTTGGTATCCAGGTATTGCTTCAAACTGGTGTCTGAGATTTGGATCCCTGGTATTGATTTCTCAG GACTTTGGAGGGCTCTGACACCATGCTCACAGAACTGGGCTCAGAGCTCCATTTTTTGCAGAGGTGACACAGGTAGGAAACAGTAGTACA TGTGTTGTAGACACTTGGTTAGAAGCTGCTGCAACTGCCCTCTCCCATCATTATAACATCTTCAACACAGAACACACTTTGTGGTCGAAA >In-frame_AHCYL1_ENST00000369799_chr1_110527794_+_DENND2D_ENST00000369752_chr1_111737348_-_1689nt CAGAGTGCCCTTTCTCCCCGCCTCTTCCCCCTCCCGGGAGCTGCCAGTACTTGACGTGGCGTCACCGCCCTCTACCCTCGCTTTGCGTGC GTGTTTGCGTACAGCGGAGGTGGCGGCGCGGGCAGGTCGGAGCTCGGAGCTGCTGTTCTGGTTCTCTTGTGGCCGCCGTCGCTGTCCGGC TGCCTTGGGCTGCCGAACAGACAAGGCGTGGGCCACAGCACCTCAGAAGCCGACGCAGCTCGACGCAGGGGCCGGCAGGAGGGTGGGCGA TCGCGTGTCGGAGGGCGCCGCGCGGGCAGGCGGGCGGGCGCCAGAGGGGGAAAGAGGCGGGGGCGGCGGGTCAGCCGCTGGCCGGGCCGG CCGGGGAATGTCGATGCCTGACGCGATGCCGCTGCCCGGGGTCGGGGAGGAGCTGAAGCAGGCCAAGGAGATCGAGGACGCCGAGAAGTA CTCCTTCATGGCCACCGTCACCAAGGCGCCCAAGAAGTTCATTTCACTGACACGGCCCCTGGACTCCCACCTAGAACATGTGGATTTTAG TTCTCTATTGCACTGTCTCAGTTTTGAACAGATACTTCAGATCTTTGCCTCTGCCGTGCTGGAGAGAAAAATCATCTTCCTGGCGGAAGG TCTCAGCACCTTGTCTCAGTGCATCCATGCTGCTGCCGCACTGCTCTACCCCTTCAGCTGGGCGCACACCTACATCCCTGTTGTCCCTGA GAGCCTTCTGGCCACCGTCTGCTGCCCCACCCCCTTCATGGTTGGAGTACAAATGCGCTTCCAGCAGGAGGTCATGGACAGCCCTATGGA AGAGGTCCTGCTGGTCAATCTTTGTGAAGGAACCTTCTTAATGTCGGTTGGTGATGAAAAAGACATCCTGCCACCGAAGCTTCAGGATGA CATCTTAGACTCTCTTGGTCAGGGGATCAATGAGTTAAAGACTGCAGAACAAATCAACGAGCATGTTTCAGGCCCCTTTGTGCAGTTCTT TGTCAAGATTGTGGGCCATTATGCTTCCTATATCAAGCGGGAGGCAAATGGGCAAGGCCACTTCCAAGAAAGATCCTTCTGTAAGGCTCT GACCTCCAAGACCAACCGCCGATTTGTGAAGAAGTTTGTGAAGACACAGCTCTTCTCACTTTTCATCCAGGAAGCCGAGAAGAGCAAGAA TCCTCCTGCAGGCTATTTCCAACAGAAAATACTTGAATATGAGGAACAGAAGAAACAGAAGAAACCAAGGGAAAAAACTGTGAAATAAGA GCTGTGGTGAATAAGAATGACTAGAGCTACACACCATTTCTGGACTTCAGCCCCTGCCAGTGTGGCAGGATCAGCAAAACTGTCAGCTCC CAAAATCCATATCCTCACTCTGAGTCTTGGTATCCAGGTATTGCTTCAAACTGGTGTCTGAGATTTGGATCCCTGGTATTGATTTCTCAG GACTTTGGAGGGCTCTGACACCATGCTCACAGAACTGGGCTCAGAGCTCCATTTTTTGCAGAGGTGACACAGGTAGGAAACAGTAGTACA TGTGTTGTAGACACTTGGTTAGAAGCTGCTGCAACTGCCCTCTCCCATCATTATAACATCTTCAACACAGAACACACTTTGTGGTCGAAA |
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FusionGenePPI for AHCYL1_DENND2D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AHCYL1 | ITPR1, HGS, JOSD2, USP42, WDR48, ELAVL1, TBCA, TRIP6, UBE2C, UBQLN1, UCHL3, ZPR1, STAM, C11orf58, PTGES3, SGTA, STIP1, SUGT1, TACC3, TARDBP, THADA, TKT, YAP1, ZRANB2, TOM1L2, UBA2, SEC24C, SULT1A1, TTLL12, UBE2D2, UBE2L3, USP34, CD2BP2, SEC24A, KIAA1598, SOD1, STMN1, TAGLN2, TLE3, TMOD3, TPM2, TTC1, UBE2V1, UBE2B, UBQLN4, UBA52, GINS4, SEPHS1, STUB1, SUMO2, SNCG, CCT5, TPM3P4, UBL7, LAGE3, PPIL3, SNRPA, SP100, SRXN1, TPD52L2, TTC9C, UBE2D1, UBE4B, UFC1, ZYX, SPR, TXN, USP9X, ATP6V1B2, VPS4B, PSAT1, SRSF1, SKP1, SNX12, STAT6, UBXN1, TUBB6, HSPA5, PPM1G, SERPINH1, SH3BGRL3, SNX3, STMN2, TES, TPM1, TYMS, UFM1, VPS26A, ZFYVE19, SIN3A, ECT2, SOX2, FBXL7, SRPK2, SRPK1, PDCD6IP, PPP2CA, UBA6, CSNK1E, BID, CDKN2C, DACH1, GEM, MEOX2, PPL, PSMD9, ZNF165, SLC23A1, AHCYL1, SOX30, MOV10, NXF1, MAB21L3, HOXC9, DHX8, ZC3H3, DOK4, PITX2, EDA, ZNF444, AHCY, FAM13C, ANP32A, ANP32B, ANP32E, C1QBP, CDC37, ECHS1, EIF3M, MYL6, PSMD4, PSMD6, PSME3, PTS, TPM3, PSMD12, RPL37A, CEP128, POC1A, TMEM17, XPO1, AHCYL2, PIP4K2A, HEXIM2, ZNF263, RASL10B, FAM19A3, CAMKV, ABCF2, TGIF2LY, CEP72, FOXD4, ZNF414, ARRB2, PTPN21 | DENND2D | MYPN, FAM9B, HSPA1B, HSPA8, HSPA1L, HSPA9, NOLC1, TCOF1, HSPA4, BRD2, TPP2, PNN, ELL, RNPS1, GRPEL1, COIL, MLLT3, CWC22, RTF1, EPB41L5, FBXL19, C1orf35, C1orf52, AFF4, MLLT1, SRRM2, ACIN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AHCYL1_DENND2D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AHCYL1_DENND2D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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