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Fusion gene ID: 11806 |
FusionGeneSummary for EPHA5_KPNA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EPHA5_KPNA4 | Fusion gene ID: 11806 | Hgene | Tgene | Gene symbol | EPHA5 | KPNA4 | Gene ID | 2044 | 3840 |
| Gene name | EPH receptor A5 | karyopherin subunit alpha 4 | |
| Synonyms | CEK7|EHK-1|EHK1|EK7|HEK7|TYRO4 | IPOA3|QIP1|SRP3 | |
| Cytomap | 4q13.1-q13.2 | 3q25.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ephrin type-A receptor 5EPH homology kinase 1EPH-like kinase 7brain-specific kinasereceptor protein-tyrosine kinase HEK7tyrosine-protein kinase receptor EHK-1 | importin subunit alpha-3importin alpha Q1importin subunit alpha-4karyopherin alpha 4 (importin alpha 3) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P54756 | O00629 | |
| Ensembl transtripts involved in fusion gene | ENST00000273854, ENST00000432638, ENST00000354839, ENST00000511294, | ENST00000334256, ENST00000469804, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 4 X 3=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EPHA5 [Title/Abstract] AND KPNA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM828717 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000273854 | ENST00000334256 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
| intron-intron | ENST00000273854 | ENST00000469804 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
| intron-3UTR | ENST00000432638 | ENST00000334256 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
| intron-intron | ENST00000432638 | ENST00000469804 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
| intron-3UTR | ENST00000354839 | ENST00000334256 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
| intron-intron | ENST00000354839 | ENST00000469804 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
| intron-3UTR | ENST00000511294 | ENST00000334256 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
| intron-intron | ENST00000511294 | ENST00000469804 | EPHA5 | chr4 | 66439405 | + | KPNA4 | chr3 | 160219426 | - |
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FusionProtFeatures for EPHA5_KPNA4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EPHA5 | KPNA4 |
| Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling intoneighboring cells. The signaling pathway downstream of thereceptor is referred to as forward signaling while the signalingpathway downstream of the ephrin ligand is referred to as reversesignaling. Among GPI-anchored ephrin-A ligands, EFNA5 mostprobably constitutes the cognate/functional ligand for EPHA5.Functions as an axon guidance molecule during development and maybe involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5plays also a role in synaptic plasticity in adult brain throughregulation of synaptogenesis. In addition to its function in thenervous system, the interaction of EPHA5 with EFNA5 mediatescommunication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). {ECO:0000250}. | Functions in nuclear protein import as an adapterprotein for nuclear receptor KPNB1. Binds specifically anddirectly to substrates containing either a simple or bipartite NLSmotif. Docking of the importin/substrate complex to the nuclearpore complex (NPC) is mediated by KPNB1 through binding tonucleoporin FxFG repeats and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to importin-beta and the three components separate andimportin-alpha and -beta are re-exported from the nucleus to thecytoplasm where GTP hydrolysis releases Ran from importin. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. In vitro, mediates the nuclearimport of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of humancytomegalovirus UL84 by recognizing a non-classical NLS. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EPHA5_KPNA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EPHA5_KPNA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EPHA5_KPNA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | EPHA5 | P54756 | DB01254 | Dasatinib | Ephrin type-A receptor 5 | small molecule | approved|investigational |
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RelatedDiseases for EPHA5_KPNA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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