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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 11802

FusionGeneSummary for EPHA2_LSM14B

check button Fusion gene summary
Fusion gene informationFusion gene name: EPHA2_LSM14B
Fusion gene ID: 11802
HgeneTgene
Gene symbol

EPHA2

LSM14B

Gene ID

1969

149986

Gene nameEPH receptor A2LSM family member 14B
SynonymsARCC2|CTPA|CTPP1|CTRCT6|ECKC20orf40|FAM61B|FT005|LSM13|RAP55B|bA11M20.3
Cytomap

1p36.13

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionephrin type-A receptor 2epithelial cell receptor protein tyrosine kinasesoluble EPHA2 variant 1tyrosine-protein kinase receptor ECKprotein LSM14 homolog BLSM14 homolog BLSM14B, SCD6 homolog BRNA-associated protein 55Bfamily with sequence similarity 61, member BhRAP55B
Modification date2018052320180519
UniProtAcc

P29317

Q9BX40

Ensembl transtripts involved in fusion geneENST00000358432, ENST00000461614, 
ENST00000370915, ENST00000253001, 
ENST00000279068, 
Fusion gene scores* DoF score3 X 1 X 3=93 X 3 X 2=18
# samples 33
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EPHA2 [Title/Abstract] AND LSM14B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPHA2

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

18339848

HgeneEPHA2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgeneEPHA2

GO:0043491

protein kinase B signaling

19573808

HgeneEPHA2

GO:0048013

ephrin receptor signaling pathway

10655584|20861311

HgeneEPHA2

GO:0051898

negative regulation of protein kinase B signaling

19573808


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N9-A4PZ-01AEPHA2chr1

16474873

-LSM14Bchr20

60699673

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000358432ENST00000370915EPHA2chr1

16474873

-LSM14Bchr20

60699673

+
In-frameENST00000358432ENST00000253001EPHA2chr1

16474873

-LSM14Bchr20

60699673

+
In-frameENST00000358432ENST00000279068EPHA2chr1

16474873

-LSM14Bchr20

60699673

+
In-frameENST00000461614ENST00000370915EPHA2chr1

16474873

-LSM14Bchr20

60699673

+
In-frameENST00000461614ENST00000253001EPHA2chr1

16474873

-LSM14Bchr20

60699673

+
In-frameENST00000461614ENST00000279068EPHA2chr1

16474873

-LSM14Bchr20

60699673

+

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FusionProtFeatures for EPHA2_LSM14B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPHA2

P29317

LSM14B

Q9BX40

Receptor tyrosine kinase which binds promiscuouslymembrane-bound ephrin-A family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling intoneighboring cells. The signaling pathway downstream of thereceptor is referred to as forward signaling while the signalingpathway downstream of the ephrin ligand is referred to as reversesignaling. Activated by the ligand ephrin-A1/EFNA1 regulatesmigration, integrin-mediated adhesion, proliferation anddifferentiation of cells. Regulates cell adhesion anddifferentiation through DSG1/desmoglein-1 and inhibition of theERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May alsoparticipate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.During development, may function in distinctive aspects of patternformation and subsequently in development of several fetaltissues. Involved for instance in angiogenesis, in early hindbraindevelopment and epithelial proliferation and branchingmorphogenesis during mammary gland development. Engaged by theligand ephrin-A5/EFNA5 may regulate lens fiber cells shape andinteractions and be important for lens transparency developmentand maintenance. With ephrin-A2/EFNA2 may play a role in boneremodeling through regulation of osteoclastogenesis andosteoblastogenesis. {ECO:0000269|PubMed:10655584,ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848,ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435,ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419,ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}. (Microbial infection) Acts as a receptor for hepatitis Cvirus (HCV) in hepatocytes and facilitates its cell entry.Mediates HCV entry by promoting the formation of the CD81-CLDN1receptor complexes that are essential for HCV entry and byenhancing membrane fusion of cells expressing HCV envelopeglycoproteins. {ECO:0000269|PubMed:21516087}. May play a role in control of mRNA translation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-31728_206274977DomainEph LBD
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000253001+09241_27742680DomainDFDF
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000279068+09241_27742695DomainDFDF
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000370915+04241_27742222DomainDFDF
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000253001+09310_32642680MotifNote=FFD box
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000253001+09330_35042680MotifNote=TFG box
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000279068+09310_32642695MotifNote=FFD box
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000279068+09330_35042695MotifNote=TFG box
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000370915+04310_32642222MotifNote=FFD box
TgeneLSM14Bchr1:16474873chr20:60699673ENST00000370915+04330_35042222MotifNote=TFG box

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317188_325274977Compositional biasNote=Cys-rich
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317328_432274977DomainFibronectin type-III 1
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317438_529274977DomainFibronectin type-III 2
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317613_875274977DomainProtein kinase
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317904_968274977DomainSAM
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317974_976274977MotifPDZ-binding
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317619_627274977Nucleotide bindingATP
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-31724_537274977Topological domainExtracellular
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317559_976274977Topological domainCytoplasmic
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317538_558274977TransmembraneHelical


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FusionGeneSequence for EPHA2_LSM14B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000370915_chr20_60699673_+_454aa
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPTGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYTAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEITEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQTAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSP

>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000253001_chr20_60699673_+_618aa
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPTGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYTAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEITEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQTAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSP
CSRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGP

>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000279068_chr20_60699673_+_618aa
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPTGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYTAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEITEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQTAASLGLGAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRR
PQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGP

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000370915_chr20_60699673_+_202aa
WYCWTLLQLEGSSAGSHTRMAKGEVLWH_RPSHR_ACAPQRGDL_VHHFPRK_HQGTHCV_TSESSAHTPAGSRHCSVFPGFCLRLALPA
ARALQPFPRDGALRPAGGQLPAQPAVCRLPGSREVGKPSSLSRCFQP_LFSISTARFRA_LVLRATAAHCQG_QQFGRTACCLANHSESE

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000253001_chr20_60699673_+_366aa
WYCWTLLQLEGSSAGSHTRMAKGEVLWH_RPSHR_ACAPQRGDL_VHHFPRK_HQGTHCV_TSESSAHTPAGSRHCSVFPGFCLRLALPA
ARALQPFPRDGALRPAGGQLPAQPAVCRLPGSREVGKPSSLSRCFQP_LFSISTARFRA_LVLRATAAHCQG_QQFGRTACCLANHSESE
G_SSRQNDSSCSRSFAKPMQQEAIRKQANKESLQRAKPSN_R_GKHNQI_G_L_FRECKCPVQPRGA_QRI_EETEF_R_QG_EGGREGP
GCGDPECRSAR_GRPSGAQLLL_QIQVVLRQHLF_TQDQLQADDVGRREEAQHRDLWGVREVSSWPQFSGRIPRRQGQWDHPSQPHFPQG

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000279068_chr20_60699673_+_366aa
WYCWTLLQLEGSSAGSHTRMAKGEVLWH_RPSHR_ACAPQRGDL_VHHFPRK_HQGTHCV_TSESSAHTPAGSRHCSVFPGFCLRLALPA
ARALQPFPRDGALRPAGGQLPAQPAVCRLPGSRSWFSIHPSRQEPHGGAGCADWFC_QPEC_KAVTWQGHHRDAAQRSSGPAEQQDGQRC
SPAGSCASSRAGE_REQKTSEEAIRKQANKESLQRAKPSN_R_GKHNQI_G_L_FRECKCPVQPRGA_QRI_EETEF_R_QG_EGGREGP
GCGDPECRSAR_GRPSGAQLLL_QIQVVLRQHLF_TQDQLQADDVGRREEAQHRDLWGVREVSSWPQFSGRIPRRQGQWDHPSQPHFPQG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000370915_chr20_60699673_+_1362nt
ATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTA
CTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAAT
GACATGCCGATCTACATGTACTCCGTGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAG
GCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAAC
CTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATC
ACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTG
GCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCAC
TTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGT
GAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAG
GATGCCTGCCAGGTGAGGTCCTTTGGCACTGAAGACCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATT
TTCCGAGGAAGTGACATCAAGGATATCACTGTGTGTGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCT
TCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCCGCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCC
AGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCTGGGTCTAGAGAAGTTGGTAAGCCCTCCAGCCTCAGCCGCTGCTTCCAGCCCTAGC
TCTTCTCCATCTCCACAGCCCGTTTCAGAGCTTGACTTGTCCTCAGAGCCACAGCAGCTCACTGCCAAGGGTAACAGCAGTTTGGGAGAA
CTGCATGCTGTCTTGCAAACCATTCTGAGAGCGAGGGGTAAAGCAGCAGACAGAATGACAGTAGCTGTAGCAGATCATTTGCCAAGCCCA

>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000253001_chr20_60699673_+_1854nt
ATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTA
CTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAAT
GACATGCCGATCTACATGTACTCCGTGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAG
GCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAAC
CTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATC
ACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTG
GCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCAC
TTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGT
GAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAG
GATGCCTGCCAGGTGAGGTCCTTTGGCACTGAAGACCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATT
TTCCGAGGAAGTGACATCAAGGATATCACTGTGTGTGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCT
TCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCCGCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCC
AGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCTGGGTCTAGAGAAGTTGGTAAGCCCTCCAGCCTCAGCCGCTGCTTCCAGCCCTAGC
TCTTCTCCATCTCCACAGCCCGTTTCAGAGCTTGACTTGTCCTCAGAGCCACAGCAGCTCACTGCCAAGGGTAACAGCAGTTTGGGAGAA
CTGCATGCTGTCTTGCAAACCATTCTGAGAGCGAGGGGTAAAGCAGCAGACAGAATGACAGTAGCTGTAGCAGATCATTTGCCAAGCCCA
TGCAGCAGGAGGCGATCAGGAAACAGGCGAACAAGGAATCGCTCCAGAGGGCAAAACCGTCCAACTAACGTTAAGGAAAACACAATCAAA
TTTGAGGGTGACTTTGATTTCGAGAGTGCAAATGCCCAGTTCAACCGAGAGGAGCTTGACAAAGAATTTAAGAAGAAACTGAATTTTAAA
GATGACAAGGCTGAGAAGGGGGAAGAGAAGGACCTGGCTGTGGTGACCCAGAGTGCCGAAGCGCCCGCTGAGGAAGACCTTCTGGGGCCC
AACTGCTACTATGACAAATCCAAGTCGTTCTTCGACAACATCTCTTCTGAACTCAAGACCAGCTCCAGGCGGACGACGTGGGCCGAAGAG
AGGAAGCTCAACACAGAGACCTTTGGGGTGTCAGGGAGGTTTCTTCGTGGCCGCAGTTCTCGGGGCGGATTCCGAGGAGGCAGGGGCAAT

>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000279068_chr20_60699673_+_1854nt
ATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTA
CTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAAT
GACATGCCGATCTACATGTACTCCGTGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAG
GCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAAC
CTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATC
ACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTG
GCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCAC
TTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGT
GAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAG
GATGCCTGCCAGGTGAGGTCCTTTGGCACTGAAGACCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATT
TTCCGAGGAAGTGACATCAAGGATATCACTGTGTGTGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCT
TCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCCGCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCC
AGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCTGGGTCTAGGAGCTGGTTTTCCATCCATCCCAGTCGGCAAGAGCCCCATGGTGGAG
CAGGCTGTGCAGACTGGTTCTGCTGACAACCTGAATGCTAAAAAGCTGTTACCTGGCAAGGGCACCACAGGGACGCAGCTCAACGGTCGT
CAGGCCCAGCCGAGCAGCAAGACGGCCAGCGATGTAGTCCAGCCGGCAGCTGTGCAAGCTCAAGGGCAGGTGAATGACGAGAACAGAAGA
CCTCAGAGGAGGCGATCAGGAAACAGGCGAACAAGGAATCGCTCCAGAGGGCAAAACCGTCCAACTAACGTTAAGGAAAACACAATCAAA
TTTGAGGGTGACTTTGATTTCGAGAGTGCAAATGCCCAGTTCAACCGAGAGGAGCTTGACAAAGAATTTAAGAAGAAACTGAATTTTAAA
GATGACAAGGCTGAGAAGGGGGAAGAGAAGGACCTGGCTGTGGTGACCCAGAGTGCCGAAGCGCCCGCTGAGGAAGACCTTCTGGGGCCC
AACTGCTACTATGACAAATCCAAGTCGTTCTTCGACAACATCTCTTCTGAACTCAAGACCAGCTCCAGGCGGACGACGTGGGCCGAAGAG
AGGAAGCTCAACACAGAGACCTTTGGGGTGTCAGGGAGGTTTCTTCGTGGCCGCAGTTCTCGGGGCGGATTCCGAGGAGGCAGGGGCAAT

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000370915_chr20_60699673_+_607nt
TGGTACTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGAGGTCCTTTGGCACTGAAGA
CCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATATCACTGTGTG
TGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCC
GCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCT
GGGTCTAGAGAAGTTGGTAAGCCCTCCAGCCTCAGCCGCTGCTTCCAGCCCTAGCTCTTCTCCATCTCCACAGCCCGTTTCAGAGCTTGA
CTTGTCCTCAGAGCCACAGCAGCTCACTGCCAAGGGTAACAGCAGTTTGGGAGAACTGCATGCTGTCTTGCAAACCATTCTGAGAGCGAG

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000253001_chr20_60699673_+_1099nt
TGGTACTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGAGGTCCTTTGGCACTGAAGA
CCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATATCACTGTGTG
TGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCC
GCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCT
GGGTCTAGAGAAGTTGGTAAGCCCTCCAGCCTCAGCCGCTGCTTCCAGCCCTAGCTCTTCTCCATCTCCACAGCCCGTTTCAGAGCTTGA
CTTGTCCTCAGAGCCACAGCAGCTCACTGCCAAGGGTAACAGCAGTTTGGGAGAACTGCATGCTGTCTTGCAAACCATTCTGAGAGCGAG
GGGTAAAGCAGCAGACAGAATGACAGTAGCTGTAGCAGATCATTTGCCAAGCCCATGCAGCAGGAGGCGATCAGGAAACAGGCGAACAAG
GAATCGCTCCAGAGGGCAAAACCGTCCAACTAACGTTAAGGAAAACACAATCAAATTTGAGGGTGACTTTGATTTCGAGAGTGCAAATGC
CCAGTTCAACCGAGAGGAGCTTGACAAAGAATTTAAGAAGAAACTGAATTTTAAAGATGACAAGGCTGAGAAGGGGGAAGAGAAGGACCT
GGCTGTGGTGACCCAGAGTGCCGAAGCGCCCGCTGAGGAAGACCTTCTGGGGCCCAACTGCTACTATGACAAATCCAAGTCGTTCTTCGA
CAACATCTCTTCTGAACTCAAGACCAGCTCCAGGCGGACGACGTGGGCCGAAGAGAGGAAGCTCAACACAGAGACCTTTGGGGTGTCAGG
GAGGTTTCTTCGTGGCCGCAGTTCTCGGGGCGGATTCCGAGGAGGCAGGGGCAATGGGACCACCCGTCGCAACCCCACTTCCCACAGGGC

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000279068_chr20_60699673_+_1099nt
TGGTACTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGAGGTCCTTTGGCACTGAAGA
CCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATATCACTGTGTG
TGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCC
GCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCT
GGGTCTAGGAGCTGGTTTTCCATCCATCCCAGTCGGCAAGAGCCCCATGGTGGAGCAGGCTGTGCAGACTGGTTCTGCTGACAACCTGAA
TGCTAAAAAGCTGTTACCTGGCAAGGGCACCACAGGGACGCAGCTCAACGGTCGTCAGGCCCAGCCGAGCAGCAAGACGGCCAGCGATGT
AGTCCAGCCGGCAGCTGTGCAAGCTCAAGGGCAGGTGAATGACGAGAACAGAAGACCTCAGAGGAGGCGATCAGGAAACAGGCGAACAAG
GAATCGCTCCAGAGGGCAAAACCGTCCAACTAACGTTAAGGAAAACACAATCAAATTTGAGGGTGACTTTGATTTCGAGAGTGCAAATGC
CCAGTTCAACCGAGAGGAGCTTGACAAAGAATTTAAGAAGAAACTGAATTTTAAAGATGACAAGGCTGAGAAGGGGGAAGAGAAGGACCT
GGCTGTGGTGACCCAGAGTGCCGAAGCGCCCGCTGAGGAAGACCTTCTGGGGCCCAACTGCTACTATGACAAATCCAAGTCGTTCTTCGA
CAACATCTCTTCTGAACTCAAGACCAGCTCCAGGCGGACGACGTGGGCCGAAGAGAGGAAGCTCAACACAGAGACCTTTGGGGTGTCAGG
GAGGTTTCTTCGTGGCCGCAGTTCTCGGGGCGGATTCCGAGGAGGCAGGGGCAATGGGACCACCCGTCGCAACCCCACTTCCCACAGGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000370915_chr20_60699673_+_1724nt
GGTTCTCACCCAACTTCCATTAAGGACTCGGGGCAGGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGC
GTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGGGGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCT
GCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTACTGCTGGACTTTGCTGCAGCTGGAG
GGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCG
TGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCA
AGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGG
ACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCAC
GCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTG
TGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTG
ATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAG
TGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGTGAGGTCCTTTG
GCACTGAAGACCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATA
TCACTGTGTGTGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGC
CCTTCCAGCCGCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATG
CCGCCTCCCTGGGTCTAGAGAAGTTGGTAAGCCCTCCAGCCTCAGCCGCTGCTTCCAGCCCTAGCTCTTCTCCATCTCCACAGCCCGTTT
CAGAGCTTGACTTGTCCTCAGAGCCACAGCAGCTCACTGCCAAGGGTAACAGCAGTTTGGGAGAACTGCATGCTGTCTTGCAAACCATTC
TGAGAGCGAGGGGTAAAGCAGCAGACAGAATGACAGTAGCTGTAGCAGATCATTTGCCAAGCCCATGCAGCCGCTGAGCTGCTTGTTTTG
CTTCAGCATGTAGTCCTGATTGATGAACTCTCAGTGTTAAAGAAGGGATTACGAAGAATCAGCGGAGTAGTTTGTTCTCTCTCCCTGGGT
CCAGGTTCTCTGTTGACCTGTACCATGACTACCACATACGGGAAACTTCACTGTTCACAGAAAGTCATTTCCCTGGGGTTTTTGCTGGGT

>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000253001_chr20_60699673_+_3239nt
GGTTCTCACCCAACTTCCATTAAGGACTCGGGGCAGGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGC
GTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGGGGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCT
GCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTACTGCTGGACTTTGCTGCAGCTGGAG
GGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCG
TGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCA
AGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGG
ACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCAC
GCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTG
TGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTG
ATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAG
TGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGTGAGGTCCTTTG
GCACTGAAGACCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATA
TCACTGTGTGTGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGC
CCTTCCAGCCGCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATG
CCGCCTCCCTGGGTCTAGAGAAGTTGGTAAGCCCTCCAGCCTCAGCCGCTGCTTCCAGCCCTAGCTCTTCTCCATCTCCACAGCCCGTTT
CAGAGCTTGACTTGTCCTCAGAGCCACAGCAGCTCACTGCCAAGGGTAACAGCAGTTTGGGAGAACTGCATGCTGTCTTGCAAACCATTC
TGAGAGCGAGGGGTAAAGCAGCAGACAGAATGACAGTAGCTGTAGCAGATCATTTGCCAAGCCCATGCAGCAGGAGGCGATCAGGAAACA
GGCGAACAAGGAATCGCTCCAGAGGGCAAAACCGTCCAACTAACGTTAAGGAAAACACAATCAAATTTGAGGGTGACTTTGATTTCGAGA
GTGCAAATGCCCAGTTCAACCGAGAGGAGCTTGACAAAGAATTTAAGAAGAAACTGAATTTTAAAGATGACAAGGCTGAGAAGGGGGAAG
AGAAGGACCTGGCTGTGGTGACCCAGAGTGCCGAAGCGCCCGCTGAGGAAGACCTTCTGGGGCCCAACTGCTACTATGACAAATCCAAGT
CGTTCTTCGACAACATCTCTTCTGAACTCAAGACCAGCTCCAGGCGGACGACGTGGGCCGAAGAGAGGAAGCTCAACACAGAGACCTTTG
GGGTGTCAGGGAGGTTTCTTCGTGGCCGCAGTTCTCGGGGCGGATTCCGAGGAGGCAGGGGCAATGGGACCACCCGTCGCAACCCCACTT
CCCACAGGGCCGGGACTGGCAGGGTGTGAGGGTGCAGCCAAAGGCTCCTACTGAAGTGGCGCATAACTGACGCTGTGTGTGTCAGGACGC
GAGGAAAACGCTGCACTTACAGGGAGAGGTGGTCACTTTGTTTACGGAGTTTGGAAGAGACCCATACTGCTACTTGTGTTTTGGACTTAA
CTGAACTTGGACATGGTCTGAGTTAGAACCACTTGTTTTGGGGAAGTATTCATGGGTAACCTCTTTGAGGTCTCTTTATCTGTGTTTCCT
TTTTAGTTGCGCATAGCCTAATTCTAAGGTTTTGGTATTTTGCAAAAAGGTTTCTATAGTGAAAGCTGAATCCTTACTTTGTGACTTTTT
TTTTTTTTTTTAATGACAAGCTTTGACTTTTAAAAGTGGAACCAAATCTGTTGGCAGAGGTGGCAGCCAAGTACATCTCTGTAACCCAGC
TGGCCCCTGGTGCTGTTGGCCTGGCACCCCACTGCCAAGGGTGGGGTCTCAGGAGTCAGGCAGGGCCAGCACAGGGTGGCGTGGGGGGCA
GGGGTGGGTGGGTGGAGGGCACGGAAGGGGTTTTCCCATGGATCATGTTGTATAAGTGAACCAGACCACCCTGATGGCATCCACAGTGAT
GTCAAGGTTGGGGCTGGCCAGGGGTGGGTGGACTAGAAGCATTTGGGAGTAGTGGCCAGGGGCCCTGGACGCTAGCCACGGAGCTGCTGC
ACAGAGCCTGGTGTCCACAAGCTTCCAGGTTGGGGTTGGAGCCTGGGATGAGCCCCGGCAGCGCCTTGGCCCTTCTGTGGTCCCTGCCAG
CCTCTGACCTGGGCCGGTCAGTCATTGCTGGACTCTGGCCACACACTGGCGTTCTCATCCACTTGGAAACAAGCCAGTCTTTTCTGCAAG
GTCAGTTGACCAAGAGCATATTTCCCCTCTGTTGTACATCGTTGTTTTGTGTTTGTGTTGTAACAGTGGGTGGAGGGAGGGTGGGGTCTA
CATTTGTTGCATGAGTCGATGGGTCAGAACTTTAGTATACGCATGCGTCCTCTGAGTGACAGGGCATTTTGTCGAAAATAAGCACCTTGG
TAACTAAACCCCTCTAATAGCTATAAAGGCTTTAGTTCTGTATTGATTAAGTTACTGTAAAAGCTTGGGTTTATTTTTGTAGGACTTAAT

>In-frame_EPHA2_ENST00000358432_chr1_16474873_-_LSM14B_ENST00000279068_chr20_60699673_+_3239nt
GGTTCTCACCCAACTTCCATTAAGGACTCGGGGCAGGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGC
GTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGGGGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCT
GCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTACTGCTGGACTTTGCTGCAGCTGGAG
GGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCG
TGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCA
AGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGG
ACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCAC
GCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTG
TGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTG
ATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAG
TGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGTGAGGTCCTTTG
GCACTGAAGACCGTCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATA
TCACTGTGTGTGAACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGC
CCTTCCAGCCGCACGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATG
CCGCCTCCCTGGGTCTAGGAGCTGGTTTTCCATCCATCCCAGTCGGCAAGAGCCCCATGGTGGAGCAGGCTGTGCAGACTGGTTCTGCTG
ACAACCTGAATGCTAAAAAGCTGTTACCTGGCAAGGGCACCACAGGGACGCAGCTCAACGGTCGTCAGGCCCAGCCGAGCAGCAAGACGG
CCAGCGATGTAGTCCAGCCGGCAGCTGTGCAAGCTCAAGGGCAGGTGAATGACGAGAACAGAAGACCTCAGAGGAGGCGATCAGGAAACA
GGCGAACAAGGAATCGCTCCAGAGGGCAAAACCGTCCAACTAACGTTAAGGAAAACACAATCAAATTTGAGGGTGACTTTGATTTCGAGA
GTGCAAATGCCCAGTTCAACCGAGAGGAGCTTGACAAAGAATTTAAGAAGAAACTGAATTTTAAAGATGACAAGGCTGAGAAGGGGGAAG
AGAAGGACCTGGCTGTGGTGACCCAGAGTGCCGAAGCGCCCGCTGAGGAAGACCTTCTGGGGCCCAACTGCTACTATGACAAATCCAAGT
CGTTCTTCGACAACATCTCTTCTGAACTCAAGACCAGCTCCAGGCGGACGACGTGGGCCGAAGAGAGGAAGCTCAACACAGAGACCTTTG
GGGTGTCAGGGAGGTTTCTTCGTGGCCGCAGTTCTCGGGGCGGATTCCGAGGAGGCAGGGGCAATGGGACCACCCGTCGCAACCCCACTT
CCCACAGGGCCGGGACTGGCAGGGTGTGAGGGTGCAGCCAAAGGCTCCTACTGAAGTGGCGCATAACTGACGCTGTGTGTGTCAGGACGC
GAGGAAAACGCTGCACTTACAGGGAGAGGTGGTCACTTTGTTTACGGAGTTTGGAAGAGACCCATACTGCTACTTGTGTTTTGGACTTAA
CTGAACTTGGACATGGTCTGAGTTAGAACCACTTGTTTTGGGGAAGTATTCATGGGTAACCTCTTTGAGGTCTCTTTATCTGTGTTTCCT
TTTTAGTTGCGCATAGCCTAATTCTAAGGTTTTGGTATTTTGCAAAAAGGTTTCTATAGTGAAAGCTGAATCCTTACTTTGTGACTTTTT
TTTTTTTTTTTAATGACAAGCTTTGACTTTTAAAAGTGGAACCAAATCTGTTGGCAGAGGTGGCAGCCAAGTACATCTCTGTAACCCAGC
TGGCCCCTGGTGCTGTTGGCCTGGCACCCCACTGCCAAGGGTGGGGTCTCAGGAGTCAGGCAGGGCCAGCACAGGGTGGCGTGGGGGGCA
GGGGTGGGTGGGTGGAGGGCACGGAAGGGGTTTTCCCATGGATCATGTTGTATAAGTGAACCAGACCACCCTGATGGCATCCACAGTGAT
GTCAAGGTTGGGGCTGGCCAGGGGTGGGTGGACTAGAAGCATTTGGGAGTAGTGGCCAGGGGCCCTGGACGCTAGCCACGGAGCTGCTGC
ACAGAGCCTGGTGTCCACAAGCTTCCAGGTTGGGGTTGGAGCCTGGGATGAGCCCCGGCAGCGCCTTGGCCCTTCTGTGGTCCCTGCCAG
CCTCTGACCTGGGCCGGTCAGTCATTGCTGGACTCTGGCCACACACTGGCGTTCTCATCCACTTGGAAACAAGCCAGTCTTTTCTGCAAG
GTCAGTTGACCAAGAGCATATTTCCCCTCTGTTGTACATCGTTGTTTTGTGTTTGTGTTGTAACAGTGGGTGGAGGGAGGGTGGGGTCTA
CATTTGTTGCATGAGTCGATGGGTCAGAACTTTAGTATACGCATGCGTCCTCTGAGTGACAGGGCATTTTGTCGAAAATAAGCACCTTGG
TAACTAAACCCCTCTAATAGCTATAAAGGCTTTAGTTCTGTATTGATTAAGTTACTGTAAAAGCTTGGGTTTATTTTTGTAGGACTTAAT

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000370915_chr20_60699673_+_1621nt
GGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGCGTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGG
GGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCG
GCCGCGGCGGCGCAGGGCAAGGAAGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCGTGTGCAACGTGAT
GTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACG
TGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAA
CTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCT
GAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTC
CGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCT
GGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTG
GCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGTGAGGTCCTTTGGCACTGAAGACCG
TCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATATCACTGTGTGTGA
ACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCCGCA
CGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCTGGG
TCTAGAGAAGTTGGTAAGCCCTCCAGCCTCAGCCGCTGCTTCCAGCCCTAGCTCTTCTCCATCTCCACAGCCCGTTTCAGAGCTTGACTT
GTCCTCAGAGCCACAGCAGCTCACTGCCAAGGGTAACAGCAGTTTGGGAGAACTGCATGCTGTCTTGCAAACCATTCTGAGAGCGAGGGG
TAAAGCAGCAGACAGAATGACAGTAGCTGTAGCAGATCATTTGCCAAGCCCATGCAGCCGCTGAGCTGCTTGTTTTGCTTCAGCATGTAG
TCCTGATTGATGAACTCTCAGTGTTAAAGAAGGGATTACGAAGAATCAGCGGAGTAGTTTGTTCTCTCTCCCTGGGTCCAGGTTCTCTGT
TGACCTGTACCATGACTACCACATACGGGAAACTTCACTGTTCACAGAAAGTCATTTCCCTGGGGTTTTTGCTGGGTCCTAAATGTGTTC

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000253001_chr20_60699673_+_3136nt
GGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGCGTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGG
GGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCG
GCCGCGGCGGCGCAGGGCAAGGAAGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCGTGTGCAACGTGAT
GTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACG
TGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAA
CTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCT
GAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTC
CGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCT
GGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTG
GCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGTGAGGTCCTTTGGCACTGAAGACCG
TCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATATCACTGTGTGTGA
ACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCCGCA
CGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCTGGG
TCTAGAGAAGTTGGTAAGCCCTCCAGCCTCAGCCGCTGCTTCCAGCCCTAGCTCTTCTCCATCTCCACAGCCCGTTTCAGAGCTTGACTT
GTCCTCAGAGCCACAGCAGCTCACTGCCAAGGGTAACAGCAGTTTGGGAGAACTGCATGCTGTCTTGCAAACCATTCTGAGAGCGAGGGG
TAAAGCAGCAGACAGAATGACAGTAGCTGTAGCAGATCATTTGCCAAGCCCATGCAGCAGGAGGCGATCAGGAAACAGGCGAACAAGGAA
TCGCTCCAGAGGGCAAAACCGTCCAACTAACGTTAAGGAAAACACAATCAAATTTGAGGGTGACTTTGATTTCGAGAGTGCAAATGCCCA
GTTCAACCGAGAGGAGCTTGACAAAGAATTTAAGAAGAAACTGAATTTTAAAGATGACAAGGCTGAGAAGGGGGAAGAGAAGGACCTGGC
TGTGGTGACCCAGAGTGCCGAAGCGCCCGCTGAGGAAGACCTTCTGGGGCCCAACTGCTACTATGACAAATCCAAGTCGTTCTTCGACAA
CATCTCTTCTGAACTCAAGACCAGCTCCAGGCGGACGACGTGGGCCGAAGAGAGGAAGCTCAACACAGAGACCTTTGGGGTGTCAGGGAG
GTTTCTTCGTGGCCGCAGTTCTCGGGGCGGATTCCGAGGAGGCAGGGGCAATGGGACCACCCGTCGCAACCCCACTTCCCACAGGGCCGG
GACTGGCAGGGTGTGAGGGTGCAGCCAAAGGCTCCTACTGAAGTGGCGCATAACTGACGCTGTGTGTGTCAGGACGCGAGGAAAACGCTG
CACTTACAGGGAGAGGTGGTCACTTTGTTTACGGAGTTTGGAAGAGACCCATACTGCTACTTGTGTTTTGGACTTAACTGAACTTGGACA
TGGTCTGAGTTAGAACCACTTGTTTTGGGGAAGTATTCATGGGTAACCTCTTTGAGGTCTCTTTATCTGTGTTTCCTTTTTAGTTGCGCA
TAGCCTAATTCTAAGGTTTTGGTATTTTGCAAAAAGGTTTCTATAGTGAAAGCTGAATCCTTACTTTGTGACTTTTTTTTTTTTTTTTAA
TGACAAGCTTTGACTTTTAAAAGTGGAACCAAATCTGTTGGCAGAGGTGGCAGCCAAGTACATCTCTGTAACCCAGCTGGCCCCTGGTGC
TGTTGGCCTGGCACCCCACTGCCAAGGGTGGGGTCTCAGGAGTCAGGCAGGGCCAGCACAGGGTGGCGTGGGGGGCAGGGGTGGGTGGGT
GGAGGGCACGGAAGGGGTTTTCCCATGGATCATGTTGTATAAGTGAACCAGACCACCCTGATGGCATCCACAGTGATGTCAAGGTTGGGG
CTGGCCAGGGGTGGGTGGACTAGAAGCATTTGGGAGTAGTGGCCAGGGGCCCTGGACGCTAGCCACGGAGCTGCTGCACAGAGCCTGGTG
TCCACAAGCTTCCAGGTTGGGGTTGGAGCCTGGGATGAGCCCCGGCAGCGCCTTGGCCCTTCTGTGGTCCCTGCCAGCCTCTGACCTGGG
CCGGTCAGTCATTGCTGGACTCTGGCCACACACTGGCGTTCTCATCCACTTGGAAACAAGCCAGTCTTTTCTGCAAGGTCAGTTGACCAA
GAGCATATTTCCCCTCTGTTGTACATCGTTGTTTTGTGTTTGTGTTGTAACAGTGGGTGGAGGGAGGGTGGGGTCTACATTTGTTGCATG
AGTCGATGGGTCAGAACTTTAGTATACGCATGCGTCCTCTGAGTGACAGGGCATTTTGTCGAAAATAAGCACCTTGGTAACTAAACCCCT
CTAATAGCTATAAAGGCTTTAGTTCTGTATTGATTAAGTTACTGTAAAAGCTTGGGTTTATTTTTGTAGGACTTAATGGCTAAGAATTAG

>In-frame_EPHA2_ENST00000461614_chr1_16474873_-_LSM14B_ENST00000279068_chr20_60699673_+_3136nt
GGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGCGTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGG
GGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCG
GCCGCGGCGGCGCAGGGCAAGGAAGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCGTGTGCAACGTGAT
GTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACG
TGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAA
CTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCT
GAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTC
CGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCT
GGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTG
GCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGTGAGGTCCTTTGGCACTGAAGACCG
TCCCACAGATAGGCCTGCGCCCCCCAGAGAGGAGATTTATGAGTACATCATTTTCCGAGGAAGTGACATCAAGGATATCACTGTGTGTGA
ACCTCCGAAAGCTCAGCACACACTCCCGCAGGATCCCGCCATTGTTCAGTCTTCCCTGGGTTCTGCCTCCGCCTCGCCCTTCCAGCCGCA
CGTGCCTTACAGCCCTTTCCGAGGGATGGCGCCCTACGGCCCGCTGGCGGCCAGCTCCCTGCTCAGCCAGCAGTATGCCGCCTCCCTGGG
TCTAGGAGCTGGTTTTCCATCCATCCCAGTCGGCAAGAGCCCCATGGTGGAGCAGGCTGTGCAGACTGGTTCTGCTGACAACCTGAATGC
TAAAAAGCTGTTACCTGGCAAGGGCACCACAGGGACGCAGCTCAACGGTCGTCAGGCCCAGCCGAGCAGCAAGACGGCCAGCGATGTAGT
CCAGCCGGCAGCTGTGCAAGCTCAAGGGCAGGTGAATGACGAGAACAGAAGACCTCAGAGGAGGCGATCAGGAAACAGGCGAACAAGGAA
TCGCTCCAGAGGGCAAAACCGTCCAACTAACGTTAAGGAAAACACAATCAAATTTGAGGGTGACTTTGATTTCGAGAGTGCAAATGCCCA
GTTCAACCGAGAGGAGCTTGACAAAGAATTTAAGAAGAAACTGAATTTTAAAGATGACAAGGCTGAGAAGGGGGAAGAGAAGGACCTGGC
TGTGGTGACCCAGAGTGCCGAAGCGCCCGCTGAGGAAGACCTTCTGGGGCCCAACTGCTACTATGACAAATCCAAGTCGTTCTTCGACAA
CATCTCTTCTGAACTCAAGACCAGCTCCAGGCGGACGACGTGGGCCGAAGAGAGGAAGCTCAACACAGAGACCTTTGGGGTGTCAGGGAG
GTTTCTTCGTGGCCGCAGTTCTCGGGGCGGATTCCGAGGAGGCAGGGGCAATGGGACCACCCGTCGCAACCCCACTTCCCACAGGGCCGG
GACTGGCAGGGTGTGAGGGTGCAGCCAAAGGCTCCTACTGAAGTGGCGCATAACTGACGCTGTGTGTGTCAGGACGCGAGGAAAACGCTG
CACTTACAGGGAGAGGTGGTCACTTTGTTTACGGAGTTTGGAAGAGACCCATACTGCTACTTGTGTTTTGGACTTAACTGAACTTGGACA
TGGTCTGAGTTAGAACCACTTGTTTTGGGGAAGTATTCATGGGTAACCTCTTTGAGGTCTCTTTATCTGTGTTTCCTTTTTAGTTGCGCA
TAGCCTAATTCTAAGGTTTTGGTATTTTGCAAAAAGGTTTCTATAGTGAAAGCTGAATCCTTACTTTGTGACTTTTTTTTTTTTTTTTAA
TGACAAGCTTTGACTTTTAAAAGTGGAACCAAATCTGTTGGCAGAGGTGGCAGCCAAGTACATCTCTGTAACCCAGCTGGCCCCTGGTGC
TGTTGGCCTGGCACCCCACTGCCAAGGGTGGGGTCTCAGGAGTCAGGCAGGGCCAGCACAGGGTGGCGTGGGGGGCAGGGGTGGGTGGGT
GGAGGGCACGGAAGGGGTTTTCCCATGGATCATGTTGTATAAGTGAACCAGACCACCCTGATGGCATCCACAGTGATGTCAAGGTTGGGG
CTGGCCAGGGGTGGGTGGACTAGAAGCATTTGGGAGTAGTGGCCAGGGGCCCTGGACGCTAGCCACGGAGCTGCTGCACAGAGCCTGGTG
TCCACAAGCTTCCAGGTTGGGGTTGGAGCCTGGGATGAGCCCCGGCAGCGCCTTGGCCCTTCTGTGGTCCCTGCCAGCCTCTGACCTGGG
CCGGTCAGTCATTGCTGGACTCTGGCCACACACTGGCGTTCTCATCCACTTGGAAACAAGCCAGTCTTTTCTGCAAGGTCAGTTGACCAA
GAGCATATTTCCCCTCTGTTGTACATCGTTGTTTTGTGTTTGTGTTGTAACAGTGGGTGGAGGGAGGGTGGGGTCTACATTTGTTGCATG
AGTCGATGGGTCAGAACTTTAGTATACGCATGCGTCCTCTGAGTGACAGGGCATTTTGTCGAAAATAAGCACCTTGGTAACTAAACCCCT
CTAATAGCTATAAAGGCTTTAGTTCTGTATTGATTAAGTTACTGTAAAAGCTTGGGTTTATTTTTGTAGGACTTAATGGCTAAGAATTAG


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FusionGenePPI for EPHA2_LSM14B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EPHA2SLA, SHC1, GRB2, PIK3R1, PTK2, PTPN11, ACP1, ELAVL1, CBL, EPHA2, APP, EEF2, HSP90AA1, GATAD1, KPNA3, RBL1, NUDT9, ADRBK1, CDK17, PSME2, LSM7, ITGA3, ITGB1, ITGB3, ITGB5, ITGAV, CLTC, AP2M1, AP2B1, AP2A1, AP2S1, EPS15, UBE4A, EGFR, SLC25A41, TAS2R7, CCR1, TMEM185A, RD3, PIFO, NTRK1, TMEM17, TMEM216, FANCD2, SSR3, TGFBR1, ZBTB14, VPS4B, SCAMP3, HEXIM1, GOLIM4, NDUFA13, SMARCAD1, MRPS35, MICALL1, TSG101, CDH1, DUSP18, DUSP19, DUPD1, DUSP26, SDC1, CYP2S1, GJB7, LRRIQ1, NCSTN, NTRK3, MAS1, CIR1, SIGLECL1, TARDBP, MRAP2, PPM1L, ILKAP, PTPRR, PTPN7, DUSP14, STYX, TPTE, TPTE2, TESLSM14BHECW2, LGR4, DDX6, SEMG2, SEMG1, SIRT3, ICK, LUC7L, NTRK1, DCTN1, XPO1, SMC1A, HUWE1, PHF8, POU5F1, CLEC3A, BHLHA15, GTF3C2, CHCHD10, CASP3, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EPHA2_LSM14B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneEPHA2P29317DB08896RegorafenibEphrin type-A receptor 2small moleculeapproved
HgeneEPHA2P29317DB01254DasatinibEphrin type-A receptor 2small moleculeapproved|investigational

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RelatedDiseases for EPHA2_LSM14B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEPHA2C1861825CATARACT, POSTERIOR POLAR, 12UNIPROT
HgeneEPHA2C0028326Noonan Syndrome1CTD_human
HgeneEPHA2C0175704LEOPARD Syndrome1CTD_human