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Fusion gene ID: 11801 |
FusionGeneSummary for EPHA2_FBXO42 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EPHA2_FBXO42 | Fusion gene ID: 11801 | Hgene | Tgene | Gene symbol | EPHA2 | FBXO42 | Gene ID | 1969 | 54455 |
| Gene name | EPH receptor A2 | F-box protein 42 | |
| Synonyms | ARCC2|CTPA|CTPP1|CTRCT6|ECK | Fbx42|JFK | |
| Cytomap | 1p36.13 | 1p36.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ephrin type-A receptor 2epithelial cell receptor protein tyrosine kinasesoluble EPHA2 variant 1tyrosine-protein kinase receptor ECK | F-box only protein 42just one F-box and Kelch domain-containing protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P29317 | Q6P3S6 | |
| Ensembl transtripts involved in fusion gene | ENST00000358432, ENST00000461614, | ENST00000375592, ENST00000478089, | |
| Fusion gene scores | * DoF score | 3 X 1 X 3=9 | 6 X 6 X 5=180 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/180*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EPHA2 [Title/Abstract] AND FBXO42 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EPHA2 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 18339848 |
| Hgene | EPHA2 | GO:0033628 | regulation of cell adhesion mediated by integrin | 10655584 |
| Hgene | EPHA2 | GO:0043491 | protein kinase B signaling | 19573808 |
| Hgene | EPHA2 | GO:0048013 | ephrin receptor signaling pathway | 10655584|20861311 |
| Hgene | EPHA2 | GO:0051898 | negative regulation of protein kinase B signaling | 19573808 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-VQ-AA6D-01A | EPHA2 | chr1 | 16474873 | - | FBXO42 | chr1 | 16583254 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000358432 | ENST00000375592 | EPHA2 | chr1 | 16474873 | - | FBXO42 | chr1 | 16583254 | - |
| 5CDS-intron | ENST00000358432 | ENST00000478089 | EPHA2 | chr1 | 16474873 | - | FBXO42 | chr1 | 16583254 | - |
| In-frame | ENST00000461614 | ENST00000375592 | EPHA2 | chr1 | 16474873 | - | FBXO42 | chr1 | 16583254 | - |
| 5CDS-intron | ENST00000461614 | ENST00000478089 | EPHA2 | chr1 | 16474873 | - | FBXO42 | chr1 | 16583254 | - |
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FusionProtFeatures for EPHA2_FBXO42 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EPHA2 | FBXO42 |
| Receptor tyrosine kinase which binds promiscuouslymembrane-bound ephrin-A family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling intoneighboring cells. The signaling pathway downstream of thereceptor is referred to as forward signaling while the signalingpathway downstream of the ephrin ligand is referred to as reversesignaling. Activated by the ligand ephrin-A1/EFNA1 regulatesmigration, integrin-mediated adhesion, proliferation anddifferentiation of cells. Regulates cell adhesion anddifferentiation through DSG1/desmoglein-1 and inhibition of theERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May alsoparticipate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.During development, may function in distinctive aspects of patternformation and subsequently in development of several fetaltissues. Involved for instance in angiogenesis, in early hindbraindevelopment and epithelial proliferation and branchingmorphogenesis during mammary gland development. Engaged by theligand ephrin-A5/EFNA5 may regulate lens fiber cells shape andinteractions and be important for lens transparency developmentand maintenance. With ephrin-A2/EFNA2 may play a role in boneremodeling through regulation of osteoclastogenesis andosteoblastogenesis. {ECO:0000269|PubMed:10655584,ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848,ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435,ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419,ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}. (Microbial infection) Acts as a receptor for hepatitis Cvirus (HCV) in hepatocytes and facilitates its cell entry.Mediates HCV entry by promoting the formation of the CD81-CLDN1receptor complexes that are essential for HCV entry and byenhancing membrane fusion of cells expressing HCV envelopeglycoproteins. {ECO:0000269|PubMed:21516087}. | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specificallyrecognizes p53/TP53, promoting its ubiquitination and degradation.{ECO:0000269|PubMed:19509332}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 28_206 | 274 | 977 | Domain | Eph LBD |
| Tgene | >FBXO42 | chr1:16474873 | chr1:16583254 | ENST00000375592 | - | 3 | 10 | 186_242 | 167 | 718 | Repeat | Note=Kelch 2 |
| Tgene | >FBXO42 | chr1:16474873 | chr1:16583254 | ENST00000375592 | - | 3 | 10 | 244_293 | 167 | 718 | Repeat | Note=Kelch 3 |
| Tgene | >FBXO42 | chr1:16474873 | chr1:16583254 | ENST00000375592 | - | 3 | 10 | 295_342 | 167 | 718 | Repeat | Note=Kelch 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 188_325 | 274 | 977 | Compositional bias | Note=Cys-rich |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 328_432 | 274 | 977 | Domain | Fibronectin type-III 1 |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 438_529 | 274 | 977 | Domain | Fibronectin type-III 2 |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 613_875 | 274 | 977 | Domain | Protein kinase |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 904_968 | 274 | 977 | Domain | SAM |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 974_976 | 274 | 977 | Motif | PDZ-binding |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 619_627 | 274 | 977 | Nucleotide binding | ATP |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 24_537 | 274 | 977 | Topological domain | Extracellular |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 559_976 | 274 | 977 | Topological domain | Cytoplasmic |
| Hgene | >EPHA2 | chr1:16474873 | chr1:16583254 | ENST00000358432 | - | 3 | 17 | 538_558 | 274 | 977 | Transmembrane | Helical |
| Tgene | FBXO42 | chr1:16474873 | chr1:16583254 | ENST00000375592 | - | 3 | 10 | 44_93 | 167 | 718 | Domain | F-box |
| Tgene | FBXO42 | chr1:16474873 | chr1:16583254 | ENST00000375592 | - | 3 | 10 | 132_184 | 167 | 718 | Repeat | Note=Kelch 1 |
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FusionGeneSequence for EPHA2_FBXO42 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EPHA2_ENST00000358432_chr1_16474873_-_FBXO42_ENST00000375592_chr1_16583254_-_825aa MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE DACQGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGS RQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHP ACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARG DGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTV GGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHS LPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKY >In-frame_EPHA2_ENST00000461614_chr1_16474873_-_FBXO42_ENST00000375592_chr1_16583254_-_573aa WYCWTLLQLEGSSAGSHTRMAKGVLSFPQSWSNSGRVQGLASAVWWLDAAKPLSPTPAREILXXNTHLLTLXKLVELHCDNPWATSHGWP LLLCDRXXNDCLWWLFRIPANEQXCLGPXPXAVGVVQAEHLWPQSSSSRWPISDCHRXCNYLNPRRVWRSQCSIQGCLVVAHAFWSLGLA ATQGRKXRAWGPRTVVPSSLPGGTVCGGLQPGSXWESPTQPQFELSPITYQCHSSSSRSXNPRVPLSVSSKKHGXSSLCXRPLGNTETQG SKADSFRFPGREPFPSQRRRLSYPQWWEFVSRNGSCGWLFFGQSCTGHISKYSICSXRIRPENRTFFGPPTRITTRSERSEIRIHRSELG SETRFQXXSHGWHGQXDSWGKYETPSXTDKWCAYPTSRGQCPCRGRLPRCPASESGSHQSDVLQRPLGLCSTKSSSWVFSRLSWEPEFEQ WRNSAHPSPRACPRRWTFLTSHCSPPGPPPSTVPKCWQTPIPEYELQAHADVRAGHXRHQGEGAGQMESIXXQFCGWTSXNQPAYRGTRQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EPHA2_ENST00000358432_chr1_16474873_-_FBXO42_ENST00000375592_chr1_16583254_-_2475nt ATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTA CTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAAT GACATGCCGATCTACATGTACTCCGTGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAG GCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAAC CTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATC ACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTG GCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCAC TTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGT GAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAG GATGCCTGCCAGGGGTCCTATCCTTCCCCCAAAGCTGGAGCAACTCTGGTCGTGTACAAGGACTTGCTAGTGCTGTTTGGTGGCTGGACG CGGCCAAGCCCTTATCCCCTACACCAGCCAGAGAGATTCTTTGATGAAATACACACTTACTCACCCTCTAAAAATTGGTGGAACTGCATT GTGACAACCCATGGGCCACCTCCCATGGCTGGCCACTCCTCCTGTGTGATAGATGATAAAATGATTGTCTTTGGTGGCTCTTTAGGATCC CGGCAAATGAGCAATGATGTCTGGGTCCTTGACCTTGAGCAGTGGGCGTGGTCCAAGCCGAACATCTCTGGCCCCAGTCCTCATCCTCGA GGTGGCCAATCTCAGATTGTCATAGATGATGCAACTATCTTAATCCTCGGAGGGTGTGGCGGTCCCAATGCTCTATTCAAGGATGCTTGG TTGTTGCACATGCATTCTGGTCCTTGGGCCTGGCAGCCACTCAAGGTAGAAAATGAAGAGCATGGGGCCCCAGAACTGTGGTGCCATCCA GCTTGCCGGGTGGGACAGTGTGTGGTGGTCTTCAGCCAGGCTCCTAGTGGGAGAGCCCCACTCAGCCCCAGTTTGAACTCTCGCCCATCA CCTATCAGTGCCACTCCTCCAGCTCTCGTTCCTGAAACCCGAGAGTACCGCTCTCAGTCTCCAGTAAGAAGCATGGATGAAGCTCCTTGT GTTAACGGCCGCTGGGGAACACTGAGACCCAGGGCTCAAAGGCAGACTCCTTCAGGTTCCCGGGAAGGGAGCCTTTCCCCAGCCAGAGGA GACGGCTCTCCTATCCTCAATGGTGGGAGTTTGTCTCCAGGAACGGCAGCTGTGGGTGGCTCTTCTTTGGACAGTCCTGTACAGGCCATA TCTCCAAGTACTCCATCTGCTCCTGAAGGATACGACCTGAAAATAGGACTTTCTTTGGCCCCCCGACGAGGATCACTACCAGATCAGAAA GATCTGAGATTAGGATCCATAGATCTGAATTGGGATCTGAAACCCGCTTCCAGTAGTAATCCCATGGATGGCATGGACAATAGGACAGTT GGGGGAAGTATGAGACACCCTCCTGAACAGACAAATGGTGTGCATACCCCACCTCACGTGGCCAGTGCCCTTGCAGGGGCCGTCTCCCCA GGTGCCCTGCGTCGGAGTCTGGAAGCCATCAAAGCGATGTCCTCCAAAGGCCCCTCGGCCTCTGCAGCACTAAGTCCTCCTCTTGGGTCT TCTCCAGGCTCTCCTGGGAGCCAGAGTTTGAGCAGTGGAGAAACAGTGCCCATCCCTCGCCCAGGGCCTGCCCAAGGAGATGGACATTCC TTACCTCCCATTGCTCGCCGCCTGGGCCACCACCCTCCACAGTCCCTAAATGTTGGCAAACCCCTATACCAGAGTATGAACTGCAAGCCC ATGCAGATGTACGTGCTGGACATTAAAGACACCAAGGAGAAGGGGCGGGTCAAATGGAAAGTATTTAATAGCAGTTCTGTGGTTGGACCT CCTGAAACCAGCCTGCATACCGTGGTACAAGGCAGGGGTGAACTCATCATATTTGGAGGACTCATGGACAAGAAACAGAATGTGAAGTAC >In-frame_EPHA2_ENST00000461614_chr1_16474873_-_FBXO42_ENST00000375592_chr1_16583254_-_1720nt TGGTACTGCTGGACTTTGCTGCAGCTGGAGGGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGGGTCCTATCCTTCCCCCAAAGC TGGAGCAACTCTGGTCGTGTACAAGGACTTGCTAGTGCTGTTTGGTGGCTGGACGCGGCCAAGCCCTTATCCCCTACACCAGCCAGAGAG ATTCTTTGATGAAATACACACTTACTCACCCTCTAAAAATTGGTGGAACTGCATTGTGACAACCCATGGGCCACCTCCCATGGCTGGCCA CTCCTCCTGTGTGATAGATGATAAAATGATTGTCTTTGGTGGCTCTTTAGGATCCCGGCAAATGAGCAATGATGTCTGGGTCCTTGACCT TGAGCAGTGGGCGTGGTCCAAGCCGAACATCTCTGGCCCCAGTCCTCATCCTCGAGGTGGCCAATCTCAGATTGTCATAGATGATGCAAC TATCTTAATCCTCGGAGGGTGTGGCGGTCCCAATGCTCTATTCAAGGATGCTTGGTTGTTGCACATGCATTCTGGTCCTTGGGCCTGGCA GCCACTCAAGGTAGAAAATGAAGAGCATGGGGCCCCAGAACTGTGGTGCCATCCAGCTTGCCGGGTGGGACAGTGTGTGGTGGTCTTCAG CCAGGCTCCTAGTGGGAGAGCCCCACTCAGCCCCAGTTTGAACTCTCGCCCATCACCTATCAGTGCCACTCCTCCAGCTCTCGTTCCTGA AACCCGAGAGTACCGCTCTCAGTCTCCAGTAAGAAGCATGGATGAAGCTCCTTGTGTTAACGGCCGCTGGGGAACACTGAGACCCAGGGC TCAAAGGCAGACTCCTTCAGGTTCCCGGGAAGGGAGCCTTTCCCCAGCCAGAGGAGACGGCTCTCCTATCCTCAATGGTGGGAGTTTGTC TCCAGGAACGGCAGCTGTGGGTGGCTCTTCTTTGGACAGTCCTGTACAGGCCATATCTCCAAGTACTCCATCTGCTCCTGAAGGATACGA CCTGAAAATAGGACTTTCTTTGGCCCCCCGACGAGGATCACTACCAGATCAGAAAGATCTGAGATTAGGATCCATAGATCTGAATTGGGA TCTGAAACCCGCTTCCAGTAGTAATCCCATGGATGGCATGGACAATAGGACAGTTGGGGGAAGTATGAGACACCCTCCTGAACAGACAAA TGGTGTGCATACCCCACCTCACGTGGCCAGTGCCCTTGCAGGGGCCGTCTCCCCAGGTGCCCTGCGTCGGAGTCTGGAAGCCATCAAAGC GATGTCCTCCAAAGGCCCCTCGGCCTCTGCAGCACTAAGTCCTCCTCTTGGGTCTTCTCCAGGCTCTCCTGGGAGCCAGAGTTTGAGCAG TGGAGAAACAGTGCCCATCCCTCGCCCAGGGCCTGCCCAAGGAGATGGACATTCCTTACCTCCCATTGCTCGCCGCCTGGGCCACCACCC TCCACAGTCCCTAAATGTTGGCAAACCCCTATACCAGAGTATGAACTGCAAGCCCATGCAGATGTACGTGCTGGACATTAAAGACACCAA GGAGAAGGGGCGGGTCAAATGGAAAGTATTTAATAGCAGTTCTGTGGTTGGACCTCCTGAAACCAGCCTGCATACCGTGGTACAAGGCAG GGGTGAACTCATCATATTTGGAGGACTCATGGACAAGAAACAGAATGTGAAGTACTATCCAAAAACAAACGCCTTGTACTTTGTACGAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EPHA2_ENST00000358432_chr1_16474873_-_FBXO42_ENST00000375592_chr1_16583254_-_6461nt GGTTCTCACCCAACTTCCATTAAGGACTCGGGGCAGGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGC GTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGGGGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCT GCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTACTGCTGGACTTTGCTGCAGCTGGAG GGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCG TGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCA AGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGG ACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCAC GCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTG TGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTG ATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAG TGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGGGTCCTATCCTT CCCCCAAAGCTGGAGCAACTCTGGTCGTGTACAAGGACTTGCTAGTGCTGTTTGGTGGCTGGACGCGGCCAAGCCCTTATCCCCTACACC AGCCAGAGAGATTCTTTGATGAAATACACACTTACTCACCCTCTAAAAATTGGTGGAACTGCATTGTGACAACCCATGGGCCACCTCCCA TGGCTGGCCACTCCTCCTGTGTGATAGATGATAAAATGATTGTCTTTGGTGGCTCTTTAGGATCCCGGCAAATGAGCAATGATGTCTGGG TCCTTGACCTTGAGCAGTGGGCGTGGTCCAAGCCGAACATCTCTGGCCCCAGTCCTCATCCTCGAGGTGGCCAATCTCAGATTGTCATAG ATGATGCAACTATCTTAATCCTCGGAGGGTGTGGCGGTCCCAATGCTCTATTCAAGGATGCTTGGTTGTTGCACATGCATTCTGGTCCTT GGGCCTGGCAGCCACTCAAGGTAGAAAATGAAGAGCATGGGGCCCCAGAACTGTGGTGCCATCCAGCTTGCCGGGTGGGACAGTGTGTGG TGGTCTTCAGCCAGGCTCCTAGTGGGAGAGCCCCACTCAGCCCCAGTTTGAACTCTCGCCCATCACCTATCAGTGCCACTCCTCCAGCTC TCGTTCCTGAAACCCGAGAGTACCGCTCTCAGTCTCCAGTAAGAAGCATGGATGAAGCTCCTTGTGTTAACGGCCGCTGGGGAACACTGA GACCCAGGGCTCAAAGGCAGACTCCTTCAGGTTCCCGGGAAGGGAGCCTTTCCCCAGCCAGAGGAGACGGCTCTCCTATCCTCAATGGTG GGAGTTTGTCTCCAGGAACGGCAGCTGTGGGTGGCTCTTCTTTGGACAGTCCTGTACAGGCCATATCTCCAAGTACTCCATCTGCTCCTG AAGGATACGACCTGAAAATAGGACTTTCTTTGGCCCCCCGACGAGGATCACTACCAGATCAGAAAGATCTGAGATTAGGATCCATAGATC TGAATTGGGATCTGAAACCCGCTTCCAGTAGTAATCCCATGGATGGCATGGACAATAGGACAGTTGGGGGAAGTATGAGACACCCTCCTG AACAGACAAATGGTGTGCATACCCCACCTCACGTGGCCAGTGCCCTTGCAGGGGCCGTCTCCCCAGGTGCCCTGCGTCGGAGTCTGGAAG CCATCAAAGCGATGTCCTCCAAAGGCCCCTCGGCCTCTGCAGCACTAAGTCCTCCTCTTGGGTCTTCTCCAGGCTCTCCTGGGAGCCAGA GTTTGAGCAGTGGAGAAACAGTGCCCATCCCTCGCCCAGGGCCTGCCCAAGGAGATGGACATTCCTTACCTCCCATTGCTCGCCGCCTGG GCCACCACCCTCCACAGTCCCTAAATGTTGGCAAACCCCTATACCAGAGTATGAACTGCAAGCCCATGCAGATGTACGTGCTGGACATTA AAGACACCAAGGAGAAGGGGCGGGTCAAATGGAAAGTATTTAATAGCAGTTCTGTGGTTGGACCTCCTGAAACCAGCCTGCATACCGTGG TACAAGGCAGGGGTGAACTCATCATATTTGGAGGACTCATGGACAAGAAACAGAATGTGAAGTACTATCCAAAAACAAACGCCTTGTACT TTGTACGAGCAAAGAGATAATGTGTTCTAAACCCCTTTCCTTTTCTGTGGCTTTTAATTTGGAATTTTCCAGTGTGTAAGCATTTGGACT GAGAATTGGGAAAACAAAATTACTCCCAGAAGCCAAAACTCTTTAATTCCCAACCGAAGTCACTCCAGGCTGGGATCAAATCTCCATTAA GAAAAAAAATTATATATAAATATATATATATATATTATATAGCCAACTCTGTTGACAAAAAAAGGGAGAGATTTCCATCCTGGTTCAGAT AAAGTTGTTGCTGTGTTTTAACAGGGGCTGGGCTGCCTTTTTCTACCTTGCTGGTAACTAGACCAAGAAGTTAGAGAATAGACTAACATC AGTAACTTCCCAAAAGAAACTGAAGAGCCCCCTGTAAATCTTTATGTGGCCTTCTTGGAGTTAAAAAATGAAAGGGCATATGTAAGTTGC AAAGGTGGAGGGTTTTAGACTCTCATGCTTCAGGTGCTGTCGGGGTAAAAGTAACTGTTTTTCCCCTTCTCTTAAAACCACAGAGGACCT GTGACAGCTCTGCAGAAATGCCAGTGCCTGGCCCCCTCTTGCCTTTTATGGCTGAGGAAAGTTACCCAACAAAGGATTTTATTCCACATT TGTGTGCCGGGTCATTGTGAAATAATGTTTATGCAGCCAACATCTGACCGCCTAGTAGTGTCCATTGGTCTTTGGAGTGCTTCTTGTGTG TCTCAGAAAACATTTTGTGTCTGATTGTGGAAATTTCTGACAATCAATCATATTTGGTGGCAAGTTGCCAAAAAACATATTTATTCTCCT CTTTCTTCCCTTAGAACATGGTACTTGGAAACTGCCTTTTCCATTCACTTACAGGCTGCTTTTTTCTTCTACCTTTTTTCTTTTCTTTTT TTTTTTTCATATGTGGTGAAGTCCTAAAACCTGTCTGACTTTCTGTTTCTTTTACAAAGCTCAGGTGCCTACAGAAATCAGAAGCTGCTT AGAAATACTTGTGGAACCCTTTCCCTGGTGTCACTAGGGGGCCAGTAGGGAATTCTAAGATGCCAATATTGTGAGAAATCTTTGAAGCAA GCATCAAAAGATACTGTTTTTTCCCTATGGGCTTCTTTTTACTTCCAAAGCACATTGAGCACACTCATCCCATATTTGTAGAATGTGGAA ATTGATTCTGGAAGGGAATTCCAATAACAGTTCTTTTTAGAAATGTTTTTTTCCTTGTGGTGACATATATTCCTCTTCCTGGCTATTGGC AGGTGATGGAGTTGAGAATCATGTACTTGACTTCTTGACGCATGGCTGACCTCAGAAACAGCTCCATCCTTTGCACTTGTCTTCTTCATG TGTCACCCAAATAGGGCTTGGGTTTTTACTTTCACTTCATTTCTGAGATTAAGGTGTAACCAAGTAGAGCATTTCTTTGCTTGATACAGA AAGTTACTAGTCTCAACCATGGCCTGGGCATAGGAGATGTCAAAATAAGTTTATTTCAAATGGCACCATTTAAATAGGGATTTTTGGTGA TTTCTCATCAGTGGAAAGAGGATTTTTGTTTTGCCTTTGTTTTGTTTTGAAATTTAAATCCTAATTTCAAAACATCACCTTGCCACCCTG ACACTCCTCTTTTTATTATTAGCGTTTCTCAGGCACAAAGCCTGCTGCAGCTGGCCCTGGGTCCTGGCTTTCAGCCAGCATCTGGCAGCC TAAGTGTACTGATAAGTGTGTTTTCTCCTGTTACATCATGCTGAATCCTTTCCCTTAGCCATTAGCTTTTATGATGTGGTCTTCGTAGGA AAGCCACCCTGGTGCCAAGCCTAGCTTGTGGGGAGGGGTATGTGTTCCAGAAACTGCTCTTTGTGTTCCCTTCAATGAGGAAACAACATG TGTCTACTTATGTGGCATCCAACTGCTTGGAGCTCCACACTTCCCTTTCGCGACTCAGGCTCTGGTGCTGTTGCCAATCCTTGCTTGGCA AAGACTGTTCGATCATGTGGGGTCCTTATTTACAAGGGAAAGCTGGGCCAGAAGGCTAGCAATTCAGGTGTTACCGCTATTGCTGTACCT TGTGTTAGGACATTGTGTTTGTGCATGGACTGTGCCTCCAAACTCAGTAGTTCCTATCTAAATATAAAGTATATTAGAAACCTGAAAGTA CAGAATCTCAACCTTACAGTCTTTCCCTTAGTCCTGTGGCCTTCCTAAGCCAGCTGTTAACGTGTTGATTCCTTCCACTTCCCCCAAGTA GGCAGGCAACAGATATGTTGATTGTCTTAGAAAGTAATCTGGTTCCTCTGAACTCCATTGAATTCCAGTTTGACGCATACTGCCTGGAAC CAGACTGTTTGCTTACAGCTTTTTAAGAAAAATCTGCCTTGTCTGCCCCCATTATGGTTGGTCTTGGTAGCTCCTGGGCACTGTGGGCGT GTACCATGGGAAAGTGATTCAACACAGTGAAGGTGATTGTCTCCTCAGGCCTCCTGAAGCCACCTGTGCGGTGGGACTTCACGTGTCTCG GCCAAGGCGAGCATTTCCACAATGCCGTGGATGCTGCAGTCAGGCCAGATTGAACCATGACCCCATTTTTCACATGATACCAATTTTGTC TTAAAATTCACTGAGAAAAATGAGACTAAATTTTTTTTAACCCTCAGGAGCACCTGAAGCAAATATTTATCCGTATTTATTGAAAATTCA TTTTGTTTCTACTTGAAGCTTTAACCCCTTCCATTCCTGCAAGTGTGCCTTTTGAGAGCTCCCATGGCCTAGTGACTTCACTGGTCACCT TGTCCATCTTACTTAAGAATTTTAGTCTCTCCCTACCCTCTTGGACAGAGCTTCCTGTTCTCTTATTTCACAGGTTATACAGCAGAGCGG GTTTTGTGTTTTCATTCCTATTTCCACCCTTCATTTGGTTGGTGGACTCCACAACCTCACCCTACCCTACACTTTGGGAGCACAAATTTG GTGTTGAAACAAGCTTAAATTTCATTTTAGGGCATACTGGGCTTACTCTCCTCCCAGCTGTCTGTGGATTGATTTGATTTTAATGTTCGA GTTTTACAGCAACAGCTGAAAACCATGAACTATTCTAGGAACTGTGTTGGAACTCTTTAAAATAAAGAAAAGAGGAGGAGGAGGAGGAAG AAAGAAAACCAACTTAAGAAGCCTTGACTTTGGAGGACAGAAAGCCACCAGCCAATGGAGAACAAAGAGATGTTTCCCTTTCCTTTCTTT CACCTTGTCATTCTGGGTTTCCTTCTGCTTCACTCTTTCCTTCCCCCTTAAAAGTGGTATTCCTGGTTGGTCTGTCTGTCTGTCCTTGTC CTTGTGGTGATCCTGGCATGGTGATATGCTCCACTTTGCATTATCCATGGTCTCTTACCAGCGCACAAGTCAGTGGGGAGGATCTAACCA CGCCTGGTGGTGAGGAAGCTGAATTTCCAGGCCTGCGTCCCATGTAGCCTCTCCATGAACTGCAGAAGGCATGTTCTGCATGGTTACCAG TAAGTGGCTCCCTCTCACCGTGTTCATTGTCAAATGAGAGCAAACTTTAGGTGTTGGCTCCATTGTACACTCTACTTGCTCTGCTCCCCT CCCTCCAACCAGGGTTCATGTCAGTGCACACCCCATGTGCCCTGGCGAAGCTGGTGCTGTGAGTGATGTTTCCCATACAACTCAGGGATG CCAGGTGGCTTACCCTGAGATAGTCATTTTGGGCACATAACAGTGTAGGAATGAAACATGGATTTCATTGATATTTAAATCTGTCAATTT >In-frame_EPHA2_ENST00000461614_chr1_16474873_-_FBXO42_ENST00000375592_chr1_16583254_-_6358nt GGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGCGTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGG GGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCG GCCGCGGCGGCGCAGGGCAAGGAAGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCGTGTGCAACGTGAT GTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACG TGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAA CTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCT GAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTC CGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCT GGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTG GCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGGGTCCTATCCTTCCCCCAAAGCTGG AGCAACTCTGGTCGTGTACAAGGACTTGCTAGTGCTGTTTGGTGGCTGGACGCGGCCAAGCCCTTATCCCCTACACCAGCCAGAGAGATT CTTTGATGAAATACACACTTACTCACCCTCTAAAAATTGGTGGAACTGCATTGTGACAACCCATGGGCCACCTCCCATGGCTGGCCACTC CTCCTGTGTGATAGATGATAAAATGATTGTCTTTGGTGGCTCTTTAGGATCCCGGCAAATGAGCAATGATGTCTGGGTCCTTGACCTTGA GCAGTGGGCGTGGTCCAAGCCGAACATCTCTGGCCCCAGTCCTCATCCTCGAGGTGGCCAATCTCAGATTGTCATAGATGATGCAACTAT CTTAATCCTCGGAGGGTGTGGCGGTCCCAATGCTCTATTCAAGGATGCTTGGTTGTTGCACATGCATTCTGGTCCTTGGGCCTGGCAGCC ACTCAAGGTAGAAAATGAAGAGCATGGGGCCCCAGAACTGTGGTGCCATCCAGCTTGCCGGGTGGGACAGTGTGTGGTGGTCTTCAGCCA GGCTCCTAGTGGGAGAGCCCCACTCAGCCCCAGTTTGAACTCTCGCCCATCACCTATCAGTGCCACTCCTCCAGCTCTCGTTCCTGAAAC CCGAGAGTACCGCTCTCAGTCTCCAGTAAGAAGCATGGATGAAGCTCCTTGTGTTAACGGCCGCTGGGGAACACTGAGACCCAGGGCTCA AAGGCAGACTCCTTCAGGTTCCCGGGAAGGGAGCCTTTCCCCAGCCAGAGGAGACGGCTCTCCTATCCTCAATGGTGGGAGTTTGTCTCC AGGAACGGCAGCTGTGGGTGGCTCTTCTTTGGACAGTCCTGTACAGGCCATATCTCCAAGTACTCCATCTGCTCCTGAAGGATACGACCT GAAAATAGGACTTTCTTTGGCCCCCCGACGAGGATCACTACCAGATCAGAAAGATCTGAGATTAGGATCCATAGATCTGAATTGGGATCT GAAACCCGCTTCCAGTAGTAATCCCATGGATGGCATGGACAATAGGACAGTTGGGGGAAGTATGAGACACCCTCCTGAACAGACAAATGG TGTGCATACCCCACCTCACGTGGCCAGTGCCCTTGCAGGGGCCGTCTCCCCAGGTGCCCTGCGTCGGAGTCTGGAAGCCATCAAAGCGAT GTCCTCCAAAGGCCCCTCGGCCTCTGCAGCACTAAGTCCTCCTCTTGGGTCTTCTCCAGGCTCTCCTGGGAGCCAGAGTTTGAGCAGTGG AGAAACAGTGCCCATCCCTCGCCCAGGGCCTGCCCAAGGAGATGGACATTCCTTACCTCCCATTGCTCGCCGCCTGGGCCACCACCCTCC ACAGTCCCTAAATGTTGGCAAACCCCTATACCAGAGTATGAACTGCAAGCCCATGCAGATGTACGTGCTGGACATTAAAGACACCAAGGA GAAGGGGCGGGTCAAATGGAAAGTATTTAATAGCAGTTCTGTGGTTGGACCTCCTGAAACCAGCCTGCATACCGTGGTACAAGGCAGGGG TGAACTCATCATATTTGGAGGACTCATGGACAAGAAACAGAATGTGAAGTACTATCCAAAAACAAACGCCTTGTACTTTGTACGAGCAAA GAGATAATGTGTTCTAAACCCCTTTCCTTTTCTGTGGCTTTTAATTTGGAATTTTCCAGTGTGTAAGCATTTGGACTGAGAATTGGGAAA ACAAAATTACTCCCAGAAGCCAAAACTCTTTAATTCCCAACCGAAGTCACTCCAGGCTGGGATCAAATCTCCATTAAGAAAAAAAATTAT ATATAAATATATATATATATATTATATAGCCAACTCTGTTGACAAAAAAAGGGAGAGATTTCCATCCTGGTTCAGATAAAGTTGTTGCTG TGTTTTAACAGGGGCTGGGCTGCCTTTTTCTACCTTGCTGGTAACTAGACCAAGAAGTTAGAGAATAGACTAACATCAGTAACTTCCCAA AAGAAACTGAAGAGCCCCCTGTAAATCTTTATGTGGCCTTCTTGGAGTTAAAAAATGAAAGGGCATATGTAAGTTGCAAAGGTGGAGGGT TTTAGACTCTCATGCTTCAGGTGCTGTCGGGGTAAAAGTAACTGTTTTTCCCCTTCTCTTAAAACCACAGAGGACCTGTGACAGCTCTGC AGAAATGCCAGTGCCTGGCCCCCTCTTGCCTTTTATGGCTGAGGAAAGTTACCCAACAAAGGATTTTATTCCACATTTGTGTGCCGGGTC ATTGTGAAATAATGTTTATGCAGCCAACATCTGACCGCCTAGTAGTGTCCATTGGTCTTTGGAGTGCTTCTTGTGTGTCTCAGAAAACAT TTTGTGTCTGATTGTGGAAATTTCTGACAATCAATCATATTTGGTGGCAAGTTGCCAAAAAACATATTTATTCTCCTCTTTCTTCCCTTA GAACATGGTACTTGGAAACTGCCTTTTCCATTCACTTACAGGCTGCTTTTTTCTTCTACCTTTTTTCTTTTCTTTTTTTTTTTTCATATG TGGTGAAGTCCTAAAACCTGTCTGACTTTCTGTTTCTTTTACAAAGCTCAGGTGCCTACAGAAATCAGAAGCTGCTTAGAAATACTTGTG GAACCCTTTCCCTGGTGTCACTAGGGGGCCAGTAGGGAATTCTAAGATGCCAATATTGTGAGAAATCTTTGAAGCAAGCATCAAAAGATA CTGTTTTTTCCCTATGGGCTTCTTTTTACTTCCAAAGCACATTGAGCACACTCATCCCATATTTGTAGAATGTGGAAATTGATTCTGGAA GGGAATTCCAATAACAGTTCTTTTTAGAAATGTTTTTTTCCTTGTGGTGACATATATTCCTCTTCCTGGCTATTGGCAGGTGATGGAGTT GAGAATCATGTACTTGACTTCTTGACGCATGGCTGACCTCAGAAACAGCTCCATCCTTTGCACTTGTCTTCTTCATGTGTCACCCAAATA GGGCTTGGGTTTTTACTTTCACTTCATTTCTGAGATTAAGGTGTAACCAAGTAGAGCATTTCTTTGCTTGATACAGAAAGTTACTAGTCT CAACCATGGCCTGGGCATAGGAGATGTCAAAATAAGTTTATTTCAAATGGCACCATTTAAATAGGGATTTTTGGTGATTTCTCATCAGTG GAAAGAGGATTTTTGTTTTGCCTTTGTTTTGTTTTGAAATTTAAATCCTAATTTCAAAACATCACCTTGCCACCCTGACACTCCTCTTTT TATTATTAGCGTTTCTCAGGCACAAAGCCTGCTGCAGCTGGCCCTGGGTCCTGGCTTTCAGCCAGCATCTGGCAGCCTAAGTGTACTGAT AAGTGTGTTTTCTCCTGTTACATCATGCTGAATCCTTTCCCTTAGCCATTAGCTTTTATGATGTGGTCTTCGTAGGAAAGCCACCCTGGT GCCAAGCCTAGCTTGTGGGGAGGGGTATGTGTTCCAGAAACTGCTCTTTGTGTTCCCTTCAATGAGGAAACAACATGTGTCTACTTATGT GGCATCCAACTGCTTGGAGCTCCACACTTCCCTTTCGCGACTCAGGCTCTGGTGCTGTTGCCAATCCTTGCTTGGCAAAGACTGTTCGAT CATGTGGGGTCCTTATTTACAAGGGAAAGCTGGGCCAGAAGGCTAGCAATTCAGGTGTTACCGCTATTGCTGTACCTTGTGTTAGGACAT TGTGTTTGTGCATGGACTGTGCCTCCAAACTCAGTAGTTCCTATCTAAATATAAAGTATATTAGAAACCTGAAAGTACAGAATCTCAACC TTACAGTCTTTCCCTTAGTCCTGTGGCCTTCCTAAGCCAGCTGTTAACGTGTTGATTCCTTCCACTTCCCCCAAGTAGGCAGGCAACAGA TATGTTGATTGTCTTAGAAAGTAATCTGGTTCCTCTGAACTCCATTGAATTCCAGTTTGACGCATACTGCCTGGAACCAGACTGTTTGCT TACAGCTTTTTAAGAAAAATCTGCCTTGTCTGCCCCCATTATGGTTGGTCTTGGTAGCTCCTGGGCACTGTGGGCGTGTACCATGGGAAA GTGATTCAACACAGTGAAGGTGATTGTCTCCTCAGGCCTCCTGAAGCCACCTGTGCGGTGGGACTTCACGTGTCTCGGCCAAGGCGAGCA TTTCCACAATGCCGTGGATGCTGCAGTCAGGCCAGATTGAACCATGACCCCATTTTTCACATGATACCAATTTTGTCTTAAAATTCACTG AGAAAAATGAGACTAAATTTTTTTTAACCCTCAGGAGCACCTGAAGCAAATATTTATCCGTATTTATTGAAAATTCATTTTGTTTCTACT TGAAGCTTTAACCCCTTCCATTCCTGCAAGTGTGCCTTTTGAGAGCTCCCATGGCCTAGTGACTTCACTGGTCACCTTGTCCATCTTACT TAAGAATTTTAGTCTCTCCCTACCCTCTTGGACAGAGCTTCCTGTTCTCTTATTTCACAGGTTATACAGCAGAGCGGGTTTTGTGTTTTC ATTCCTATTTCCACCCTTCATTTGGTTGGTGGACTCCACAACCTCACCCTACCCTACACTTTGGGAGCACAAATTTGGTGTTGAAACAAG CTTAAATTTCATTTTAGGGCATACTGGGCTTACTCTCCTCCCAGCTGTCTGTGGATTGATTTGATTTTAATGTTCGAGTTTTACAGCAAC AGCTGAAAACCATGAACTATTCTAGGAACTGTGTTGGAACTCTTTAAAATAAAGAAAAGAGGAGGAGGAGGAGGAAGAAAGAAAACCAAC TTAAGAAGCCTTGACTTTGGAGGACAGAAAGCCACCAGCCAATGGAGAACAAAGAGATGTTTCCCTTTCCTTTCTTTCACCTTGTCATTC TGGGTTTCCTTCTGCTTCACTCTTTCCTTCCCCCTTAAAAGTGGTATTCCTGGTTGGTCTGTCTGTCTGTCCTTGTCCTTGTGGTGATCC TGGCATGGTGATATGCTCCACTTTGCATTATCCATGGTCTCTTACCAGCGCACAAGTCAGTGGGGAGGATCTAACCACGCCTGGTGGTGA GGAAGCTGAATTTCCAGGCCTGCGTCCCATGTAGCCTCTCCATGAACTGCAGAAGGCATGTTCTGCATGGTTACCAGTAAGTGGCTCCCT CTCACCGTGTTCATTGTCAAATGAGAGCAAACTTTAGGTGTTGGCTCCATTGTACACTCTACTTGCTCTGCTCCCCTCCCTCCAACCAGG GTTCATGTCAGTGCACACCCCATGTGCCCTGGCGAAGCTGGTGCTGTGAGTGATGTTTCCCATACAACTCAGGGATGCCAGGTGGCTTAC CCTGAGATAGTCATTTTGGGCACATAACAGTGTAGGAATGAAACATGGATTTCATTGATATTTAAATCTGTCAATTTCATTTTTTGTTAA |
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FusionGenePPI for EPHA2_FBXO42 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EPHA2 | SLA, SHC1, GRB2, PIK3R1, PTK2, PTPN11, ACP1, ELAVL1, CBL, EPHA2, APP, EEF2, HSP90AA1, GATAD1, KPNA3, RBL1, NUDT9, ADRBK1, CDK17, PSME2, LSM7, ITGA3, ITGB1, ITGB3, ITGB5, ITGAV, CLTC, AP2M1, AP2B1, AP2A1, AP2S1, EPS15, UBE4A, EGFR, SLC25A41, TAS2R7, CCR1, TMEM185A, RD3, PIFO, NTRK1, TMEM17, TMEM216, FANCD2, SSR3, TGFBR1, ZBTB14, VPS4B, SCAMP3, HEXIM1, GOLIM4, NDUFA13, SMARCAD1, MRPS35, MICALL1, TSG101, CDH1, DUSP18, DUSP19, DUPD1, DUSP26, SDC1, CYP2S1, GJB7, LRRIQ1, NCSTN, NTRK3, MAS1, CIR1, SIGLECL1, TARDBP, MRAP2, PPM1L, ILKAP, PTPRR, PTPN7, DUSP14, STYX, TPTE, TPTE2, TES | FBXO42 | TP53, CUL1, SKP1, RBX1, COPS6, SMURF1, RBPJ, GSK3A, ROCK2, RAB28, CCDC6, CST1, KLK6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EPHA2_FBXO42 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | EPHA2 | P29317 | DB08896 | Regorafenib | Ephrin type-A receptor 2 | small molecule | approved |
| Hgene | EPHA2 | P29317 | DB01254 | Dasatinib | Ephrin type-A receptor 2 | small molecule | approved|investigational |
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RelatedDiseases for EPHA2_FBXO42 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EPHA2 | C1861825 | CATARACT, POSTERIOR POLAR, 1 | 2 | UNIPROT |
| Hgene | EPHA2 | C0028326 | Noonan Syndrome | 1 | CTD_human |
| Hgene | EPHA2 | C0175704 | LEOPARD Syndrome | 1 | CTD_human |
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