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Fusion gene ID: 11797 |
FusionGeneSummary for EPHA1-AS1_RPSA |
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Fusion gene information | Fusion gene name: EPHA1-AS1_RPSA | Fusion gene ID: 11797 | Hgene | Tgene | Gene symbol | EPHA1-AS1 | RPSA | Gene ID | 285965 | 3921 |
Gene name | EPHA1 antisense RNA 1 | ribosomal protein SA | |
Synonyms | - | 37LRP|67LR|ICAS|LAMBR|LAMR1|LBP|LBP/p40|LRP|LRP/LR|NEM/1CHD4|SA|lamR|p40 | |
Cytomap | 7q35 | 3p22.1 | |
Type of gene | ncRNA | protein-coding | |
Description | EPHA1 antisense RNA 1 (non-protein coding) | 40S ribosomal protein SA37 kDa laminin receptor37/67 kDa laminin receptor67 kDa laminin receptorcolon carcinoma laminin-binding proteinlaminin receptor 1 (67kD, ribosomal protein SA)laminin-binding protein precursor p40multidrug resistance-associat | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | P08865 | ||
Ensembl transtripts involved in fusion gene | ENST00000429289, ENST00000421648, | ENST00000301821, ENST00000443003, ENST00000478027, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 1=25 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EPHA1-AS1 [Title/Abstract] AND RPSA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BC015654 | EPHA1-AS1 | chr7 | 143112168 | - | RPSA | chr19 | 24009919 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000429289 | ENST00000301821 | EPHA1-AS1 | chr7 | 143112168 | - | RPSA | chr19 | 24009919 | + |
3UTR-intron | ENST00000429289 | ENST00000443003 | EPHA1-AS1 | chr7 | 143112168 | - | RPSA | chr19 | 24009919 | + |
3UTR-intron | ENST00000429289 | ENST00000478027 | EPHA1-AS1 | chr7 | 143112168 | - | RPSA | chr19 | 24009919 | + |
3UTR-intron | ENST00000421648 | ENST00000301821 | EPHA1-AS1 | chr7 | 143112168 | - | RPSA | chr19 | 24009919 | + |
3UTR-intron | ENST00000421648 | ENST00000443003 | EPHA1-AS1 | chr7 | 143112168 | - | RPSA | chr19 | 24009919 | + |
3UTR-intron | ENST00000421648 | ENST00000478027 | EPHA1-AS1 | chr7 | 143112168 | - | RPSA | chr19 | 24009919 | + |
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FusionProtFeatures for EPHA1-AS1_RPSA |
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Hgene | Tgene |
EPHA1-AS1 | RPSA |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EPHA1-AS1_RPSA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EPHA1-AS1_RPSA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EPHA1-AS1_RPSA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EPHA1-AS1_RPSA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RPSA | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | RPSA | C0685889 | Splenic Hypoplasia | 1 | ORPHANET;UNIPROT |