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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1171

FusionGeneSummary for AGTPBP1_DAPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: AGTPBP1_DAPK1
Fusion gene ID: 1171
HgeneTgene
Gene symbol

AGTPBP1

DAPK1

Gene ID

23287

1612

Gene nameATP/GTP binding protein 1death associated protein kinase 1
SynonymsCCP1|NNA1DAPK|ROCO3
Cytomap

9q21.33

9q21.33

Type of geneprotein-codingprotein-coding
Descriptioncytosolic carboxypeptidase 1carboxypeptidase-tubulinnervous system nuclear protein induced by axotomy protein 1 homologsoluble carboxypeptidasetubulinyl-Tyr carboxypeptidasetyrosine carboxypeptidasedeath-associated protein kinase 1DAP kinase 1
Modification date2018051920180523
UniProtAcc

Q9UPW5

P53355

Ensembl transtripts involved in fusion geneENST00000337006, ENST00000376083, 
ENST00000357081, ENST00000376109, 
ENST00000432218, ENST00000376081, 
ENST00000491784, ENST00000376080, 
ENST00000358077, ENST00000472284, 
ENST00000469640, ENST00000408954, 
ENST00000491893, ENST00000466188, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 4 X 5=100
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGTPBP1 [Title/Abstract] AND DAPK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDAPK1

GO:0006468

protein phosphorylation

10629061

TgeneDAPK1

GO:0017148

negative regulation of translation

18995835

TgeneDAPK1

GO:0035556

intracellular signal transduction

10629061

TgeneDAPK1

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

16132846

TgeneDAPK1

GO:0046777

protein autophosphorylation

10629061|12730201

TgeneDAPK1

GO:0071346

cellular response to interferon-gamma

18995835


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-K1-A6RU-01AAGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000337006ENST00000358077AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000337006ENST00000472284AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000337006ENST00000469640AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000337006ENST00000408954AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000337006ENST00000491893AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-intronENST00000337006ENST00000466188AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376083ENST00000358077AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376083ENST00000472284AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376083ENST00000469640AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376083ENST00000408954AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376083ENST00000491893AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-intronENST00000376083ENST00000466188AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000357081ENST00000358077AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000357081ENST00000472284AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000357081ENST00000469640AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000357081ENST00000408954AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000357081ENST00000491893AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-intronENST00000357081ENST00000466188AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
Frame-shitENST00000376109ENST00000358077AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
Frame-shitENST00000376109ENST00000472284AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
Frame-shitENST00000376109ENST00000469640AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
Frame-shitENST00000376109ENST00000408954AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
Frame-shitENST00000376109ENST00000491893AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5CDS-intronENST00000376109ENST00000466188AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000432218ENST00000358077AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000432218ENST00000472284AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000432218ENST00000469640AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000432218ENST00000408954AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000432218ENST00000491893AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-intronENST00000432218ENST00000466188AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376081ENST00000358077AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376081ENST00000472284AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376081ENST00000469640AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376081ENST00000408954AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-3CDSENST00000376081ENST00000491893AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
5UTR-intronENST00000376081ENST00000466188AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000491784ENST00000358077AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000491784ENST00000472284AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000491784ENST00000469640AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000491784ENST00000408954AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000491784ENST00000491893AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-intronENST00000491784ENST00000466188AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000376080ENST00000358077AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000376080ENST00000472284AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000376080ENST00000469640AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000376080ENST00000408954AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-3CDSENST00000376080ENST00000491893AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+
intron-intronENST00000376080ENST00000466188AGTPBP1chr9

88356690

-DAPK1chr9

90252858

+

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FusionProtFeatures for AGTPBP1_DAPK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGTPBP1

Q9UPW5

DAPK1

P53355

Calcium/calmodulin-dependent serine/threonine kinaseinvolved in multiple cellular signaling pathways that trigger cellsurvival, apoptosis, and autophagy. Regulates both type Iapoptotic and type II autophagic cell deaths signal, depending onthe cellular setting. The former is caspase-dependent, while thelatter is caspase-independent and is characterized by theaccumulation of autophagic vesicles. Phosphorylates PIN1 resultingin inhibition of its catalytic activity, nuclear localization, andcellular function. Phosphorylates TPM1, enhancing stress fiberformation in endothelial cells. Phosphorylates STX1A andsignificantly decreases its binding to STXBP1. PhosphorylatesPRKD1 and regulates JNK signaling by binding and activating PRKD1under oxidative stress. Phosphorylates BECN1, reducing itsinteraction with BCL2 and BCL2L1 and promoting the induction ofautophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complexand stimulating mTORC1 activity in a growth factor-dependentpathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signalingamplifier of NMDA receptors at extrasynaptic sites for mediatingbrain damage in stroke. Cerebral ischemia recruits DAPK1 into theNMDA receptor complex and it phosphorylates GRINB at Ser-1303inducing injurious Ca(2+) influx through NMDA receptor channels,resulting in an irreversible neuronal death. Required togetherwith DAPK3 for phosphorylation of RPL13A upon interferon-gammaactivation which is causing RPL13A involvement in transcript-selective translation inhibition. Isoform 2 cannot induce apoptosis but can inducemembrane blebbing.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AGTPBP1_DAPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AGTPBP1_DAPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AGTPBP1DISC1, TNIK, CYCS, NYNRIN, CBY1, PPFIA1, PPFIA4, ENO1, PNKP, TMOD1, CEP128, XPO1, FOXK1, EGFR, PHLPP1, TTLL4, UBC, FBXL13DAPK1TNFRSF1A, KRIT1, FADD, YWHAQ, TP53, HSP90AA1, ST13, CCNDBP1, IKBKG, KLHL20, CUL3, LNX1, CALM1, MIB1, DAPK1, LRRK2, LRRK1, MDM2, MAPK3, MAPK1, MYL12B, BECN1, PDCD6, PPP2R2D, PPP2R5A, PPP2CA, PPP2R1A, ACTC1, TTLL3, BAG2, CAPZA2, CAPZB, CORO1C, DDX5, EEF2, IFI30, MYO1B, MYO1D, SVIL, TMOD3, TPM3, TWF1, TSC2, TSC1, UNC5B, PPP2R1B, UNC5A, UNC5C, IVNS1ABP, ERP44


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGTPBP1_DAPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AGTPBP1_DAPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGTPBP1C0027746Nerve Degeneration1CTD_human
TgeneDAPK1C0001418Adenocarcinoma1CTD_human
TgeneDAPK1C0006118Brain Neoplasms1CTD_human
TgeneDAPK1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneDAPK1C0007134Renal Cell Carcinoma1CTD_human
TgeneDAPK1C0007138Carcinoma, Transitional Cell1CTD_human
TgeneDAPK1C0009759Conjunctival Diseases1CTD_human
TgeneDAPK1C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneDAPK1C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneDAPK1C0024121Lung Neoplasms1CTD_human
TgeneDAPK1C0027627Neoplasm Metastasis1CTD_human
TgeneDAPK1C0031117Peripheral Neuropathy1CTD_human
TgeneDAPK1C0035242Respiratory Tract Diseases1CTD_human
TgeneDAPK1C0036095Salivary Gland Neoplasms1CTD_human
TgeneDAPK1C0085183Neoplasms, Second Primary1CTD_human
TgeneDAPK1C3463824MYELODYSPLASTIC SYNDROME1CTD_human
TgeneDAPK1C3495559Juvenile arthritis1CTD_human