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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11620

FusionGeneSummary for ENO1_SNW1

check button Fusion gene summary
Fusion gene informationFusion gene name: ENO1_SNW1
Fusion gene ID: 11620
HgeneTgene
Gene symbol

ENO1

SNW1

Gene ID

2023

22938

Gene nameenolase 1SNW domain containing 1
SynonymsENO1L1|HEL-S-17|MPB1|NNE|PPHBx42|FUN20|NCOA-62|PRPF45|Prp45|SKIIP|SKIP|SKIP1
Cytomap

1p36.23

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-enolasec-myc promoter-binding protein-12-phospho-D-glycerate hydro-lyaseMYC promoter-binding protein 1alpha enolase like 1enolase 1, (alpha)enolase-alphaepididymis secretory protein Li 17non-neural enolasephosphopyruvate hydrataseplasminogSNW domain-containing protein 1SKI interacting proteinhomolog of Drosophila BX42nuclear protein SkiPnuclear receptor coactivator NCoA-62nuclear receptor coactivator, 62-kDski-interacting protein
Modification date2018052320180519
UniProtAcc

P06733

Q13573

Ensembl transtripts involved in fusion geneENST00000234590, ENST00000261531, 
ENST00000554775, ENST00000555761, 
Fusion gene scores* DoF score14 X 15 X 7=147015 X 4 X 12=720
# samples 2116
** MAII scorelog2(21/1470*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/720*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENO1 [Title/Abstract] AND SNW1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneENO1

GO:0000122

negative regulation of transcription by RNA polymerase II

2005901

HgeneENO1

GO:0030308

negative regulation of cell growth

10082554

HgeneENO1

GO:0045892

negative regulation of transcription, DNA-templated

10082554

HgeneENO1

GO:1903298

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

15459207

HgeneENO1

GO:2001171

positive regulation of ATP biosynthetic process

15459207

TgeneSNW1

GO:0000122

negative regulation of transcription by RNA polymerase II

14985122

TgeneSNW1

GO:0000398

mRNA splicing, via spliceosome

15194481|28076346

TgeneSNW1

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

11278756

TgeneSNW1

GO:0043923

positive regulation by host of viral transcription

15905409

TgeneSNW1

GO:0045892

negative regulation of transcription, DNA-templated

10713164|15878163

TgeneSNW1

GO:0045944

positive regulation of transcription by RNA polymerase II

14985122|19934264

TgeneSNW1

GO:0048384

retinoic acid receptor signaling pathway

19934264

TgeneSNW1

GO:0048385

regulation of retinoic acid receptor signaling pathway

14985122

TgeneSNW1

GO:0070562

regulation of vitamin D receptor signaling pathway

14985122

TgeneSNW1

GO:0070564

positive regulation of vitamin D receptor signaling pathway

9632709|11514567

TgeneSNW1

GO:0071300

cellular response to retinoic acid

19934264


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-BQ-7061-01AENO1chr1

8921061

-SNW1chr14

78189203

-
TCGARVLUADTCGA-78-7149-01AENO1chr1

8921061

-SNW1chr14

78189203

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000234590ENST00000261531ENO1chr1

8921061

-SNW1chr14

78189203

-
5CDS-intronENST00000234590ENST00000554775ENO1chr1

8921061

-SNW1chr14

78189203

-
5CDS-intronENST00000234590ENST00000555761ENO1chr1

8921061

-SNW1chr14

78189203

-

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FusionProtFeatures for ENO1_SNW1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENO1

P06733

SNW1

Q13573

Involved in pre-mRNA splicing as component of thespliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).Is required in the specific splicing of CDKN1A pre-mRNA; thefunction probably involves the recruitment of U2AF2 to the mRNA.Is proposed to recruit PPIL1 to the spliceosome. May be involvedin cyclin-D1/CCND1 mRNA stability through the SNARP complex whichassociates with both the 3'end of the CCND1 gene and its mRNA.Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediatedtranscriptional repression, and retinoid-X receptor (RXR)- andvitamin D receptor (VDR)-dependent gene transcription in a cellline-specific manner probably involving coactivators NCOA1 andGRIP1. Is involved in NOTCH1-mediated transcriptional activation.Binds to multimerized forms of Notch intracellular domain (NICD)and is proposed to recruit transcriptional coactivators such asMAML1 to form an intermediate preactivation complex whichassociates with DNA-bound CBF-1/RBPJ to form a transcriptionalactivation complex by releasing SNW1 and redundant NOTCH1 NICD.{ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756,ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567,ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015,ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481,ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151,ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387,ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346,ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709}. (Microbial infection) Is recruited by HIV-1 Tat toTat:P-TEFb:TAR RNA complexes and is involved in Tat transcriptionby recruitment of MYC, MEN1 and TRRAP to the HIV promoter.{ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}. (Microbial infection) Proposed to be involved intranscriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressedpromoters. {ECO:0000269|PubMed:10644367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ENO1_SNW1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ENO1_SNW1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ENO1FANCA, PLG, TRAPPC2, ISG15, MAP2K5, HDAC1, H2AFX, CD4, YWHAZ, INSIG2, PCNA, GRB2, PSMA3, FBXO25, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, CAND1, MYOC, IVNS1ABP, AGTPBP1, AKT1, FYN, SRC, PGK1, GAPDH, TPI1, FLNC, PPIA, ITPA, ENO3, BRCA1, LIG4, MDC1, VCAM1, FN1, ATF2, ITGA4, NPM1, RAD52, TERT, AMBP, SERPING1, BHLHE40, UPF2, YWHAQ, FBXO6, WWOX, STAU1, HUWE1, FUS, SZRD1, NUDC, RCC1, YARS, LRRC42, MRPL37, DPH5, GSTM3, STRIP1, HIST2H2AB, CDC42SE1, POGZ, LMNA, HDGF, DEDD, TOMM40L, STX6, SRSF7, EFEMP1, CCT7, POLR1A, BIN1, IWS1, NAB1, ABI2, EEF1B2, ARPC4, SNORA6, DHX30, QRICH1, IFRD2, THOC7, DHX15, HNRNPD, FAT4, DCLK2, ERAP1, RAPGEF6, HSPA9, STK10, FARS2, HIST1H2BG, HIST1H4I, KLHDC3, MYO6, ASCC3, HDAC2, FBXO5, SCAF8, OSBPL3, OGDH, TNS3, GATAD1, PMPCB, NUP205, XPO7, SCARA3, MTFR1, C8orf33, KANK1, MPDZ, ACO1, UBAP1, ANXA1, POLE3, HNRNPH3, BTRC, NAP1L4, COPB1, CAT, PRPF19, CPSF7, SYT12, CPT1A, NUMA1, ENDOD1, YAP1, DCPS, NCAPD3, VPS26B, M6PR, PPFIBP1, LETMD1, RBMS2, NTN4, MVK, RNF10, RHOF, STX2, MPHOSPH8, DIAPH3, MBNL2, CARKD, PNP, IPO4, RBM25, C14orf1, KNSTRN, TP53BP1, MYO1E, KIF23, PTPN9, SNRNP25, STUB1, TXNDC11, VPS35, E2F4, NFATC3, CYB5B, PDPR, AARS, WDR81, CHD3, RAB34, MYO18A, ACACA, THRA, SMARCE1, DHX8, SLC25A39, ANKRD40, LUC7L3, NPLOC4, CEP192, GIPC3, HNRNPM, CRLF1, MED29, SUPT5H, FBL, PPP5C, ISOC2, NOP56, XRN2, POFUT1, CEP250, ZNFX1, ATP5J, SUMO3, CLTCL1, PITPNB, NIPSNAP1, SF3A1, XRCC6, CYB5R3, TXLNG, SH3KBP1, PRDX4, POLA1, EBP, MORC4, BCAP31, CUL7, OBSL1, CCDC8, EED, EMC1, TXNDC16, FAF2, SUMO2, ENO2, HNRNPA1, AKR1B1, AKR1B15, CALR, DUT, EEF2, ABAT, ACAA2, ALDH4A1, ALDOA, CFL1, EZR, FH, FKBP2, GPX4, HINT1, HSD17B10, LDHA, LDHB, MSN, NME1-NME2, NME2, PARK7, PCMT1, PDCD6IP, PGK2, PGM1, PPIB, RCN1, RDX, SOD1, TAGLN, TAGLN2, TAGLN3, TKT, WDR1, FABP5, FKBP1A, FKBP1B, FKBP7, GPI, MIF, NIT2, P4HB, PEF1, PGAM1, PMP2, PUS7, SRI, TALDO1, TXN, UCHL3, NTRK1, HSPB2, CHEK2, CLK1, AHSA1, ATP6AP2, HEMGN, MCM2, MCM5, FBXW7, CDC73, ATOH1, WWP2, CDH1, SLC9A1, TRIM25, MCPH1, HDAC6SNW1SKI, RBPJ, CIR1, HDAC2, SIN3A, NCOR2, SND1, NOTCH1, NOTCH3, ASCC2, RB1, RBL1, RBL2, SMAD2, SMAD3, SMAD4, SKIL, VDR, PABPN1, MYOD1, RXRA, NCOA2, NCOA1, TCEA2, CCNT1, MYC, CDK9, KMT2A, MEN1, IKBKG, PCBD2, TRIM15, ZSCAN1, SRRM1, NCOR1, EP300, TADA2A, PRPF8, UBR5, ZMAT3, EFTUD2, HNRNPU, DDB1, SFPQ, DDX23, CDC5L, HSPA5, PFKL, ABCF2, TUBB4A, EEF1G, EEF1A1, TUBB1, MSH2, NR0B1, NR0B2, ACTN2, CKAP5, MAPK6, TNNT1, VAV2, SIRT7, PRKAA2, CUL3, CUL2, DAXX, LNX1, MAGEA1, TOP1, PABPC1, CWC27, DHX38, SKIV2L2, DHX15, SNRPD2, DDX5, RAD21, EIF4A3, MAGOH, NHP2L1, SART1, CTNNBL1, XAB2, SNIP1, MFAP1, ZNF830, CXorf56, TTC14, HDAC11, HECW2, AURKB, TP53, TUBGCP3, GOLGA2, TRAF1, IKZF1, MTUS2, TFIP11, PPIL1, CEP55, TEX11, RINT1, LZTS2, KRT40, NXF1, MSL1, ZDHHC17, CUL7, OBSL1, SIRT1, RARA, SUZ12, RNF2, BMI1, OCLN, SNRPA1, DHX8, TSSC4, USB1, FHL3, PPIE, WDR83, CCDC94, LUC7L2, HSPB1, NTRK1, GCN1L1, HARS, HNRNPR, PFKM, PRPF4, SEPT2, SEPT7, SNRNP200, BUD31, CDC40, CRNKL1, PFKP, PLRG1, PRPF19, SARS, TRMT6, SYF2, TTC37, VARS, MUS81, KRAS, SF3B4, SYNCRIP, CPSF4, HNRNPA0, EBNA1BP2, CLP1, CPSF6, SRSF3, HNRNPA3, RBMX, CPSF1, HNRNPA1, HNRNPAB, HNRNPD, NCBP1, PCF11, LUC7L3, PPP2R1B, PRPF40A, METTL3, SRSF2, SRSF5, SRSF6, SNRPB2, RBM10, SRSF11, DDX46, PPP1CA, LOC102724594, BCAS2, SF3A1, CHERP, SF3A3, SF3B2, DDX42, U2AF2, HNRNPK, TRUB1, CSTF3, ELAVL1, XRN2, SNW1, U2SURP, TARDBP, SF3B3, SF3B1, PRPF6, FUS, HNRNPA2B1, HNRNPC, HNRNPF, HNRNPH1, HSPA8, HNRNPM, NONO, GEMIN4, PCBP1, SF3B6, CPSF3, EXOSC10, CPSF2, LUC7L, RBM4, SRSF1, SMN1, SMN2, SNRNP70, SNRPD3, U2AF1, CPSF7, RBM17, HNRNPLL, SNRNP40, RBM39, BZW1, PDCD6IP, SNUPN, ACTR1A, CDK3, STAG1, TUBB3, SEC23B, ARFGEF2, MAGED2, COPS6, CHD3, CHD4, WDR5, PKP3, KTI12, ARAP1, CSK, DCTN1, DDX1, DHX9, DOCK1, DOCK2, MLKL, CTTN, PUF60, ACIN1, WAPAL, XPO6, DNAJC13, SRRM2, GTPBP4, XRCC6, NIPBL, SEC31B, LDLRAP1, KIAA1279, ZNF326, BABAM1, GSPT1, OLA1, PIK3R4, IK, ILK, KPNA1, MLH1, ATM, PAK1, METTL13, CDK12, POLE, ATR, APBB1IP, ATRX, PPP2R1A, KIF27, UBE2Q1, CHD7, PRKAG1, ASUN, EXOC1, CAND1, MAP2K2, MAP2K3, LRRC47, TAOK1, PURA, WIZ, BLM, NCAPG, RBM15, YTHDC2, SRP19, AURKA, TTK, VASP, VRK1, NUP37, SPATA5L1, SHOC2, FIP1L1, DIAPH3, RIOK1, USP48, FYTTD1, RAE1, COPS3, API5, AP3B1, FUBP1, CPNE3, OTULIN, BCL7C, TRIP12, GNA14, AQR, CDK1, TOX4, G3BP2, NUP153, PSMC3, ACTB, SMC4, DNM1L, TUBB, ACTR2, RAD50, TRAP1, TUBA4A, PSMC6, DDX39A, PAK4, TUBB4B, NDC80, DCTN2, CCT7, CCT4, CCT2, EXOC5, KHDRBS1, CCT8, NUDC, SEPT9, TUBGCP2, RUVBL2, SUGT1, EHD1, KIF2C, CHEK1, DDX19B, PSMC1, RBM45, COPA, COPB1, CSE1L, AP1B1, SPATA5, DFNA5, DIAPH1, DYNC1LI2, DNM2, DSP, FASN, LRWD1, FEN1, COPG1, RALY, CCT5, CNOT1, MDN1, EXOC7, SMCHD1, NCAPH, ORC6, ORC3, KIF4A, HSPA12A, INTS1, PHGDH, VPS33B, COPG2, ZNF638, FHOD1, RACGAP1, MSH6, PARVB, HDLBP, HELLS, EHD4, DNAJA1, HSP90AA1, HSP90AB1, HSPD1, ARCN1, KIF11, KPNB1, KPNA2, LIMS1, LMNA, MRE11A, MYH9, NBN, DRG1, NSF, ORC2, ORC4, ORC5, UCHL5, DDX41, GULP1, RTCB, PLEC, PLK1, PNN, POLD1, ANLN, RIF1, FANCI, DDX19A, ABCF3, WDR33, CDKN2AIP, KIF21A, FERMT1, LRRC40, SCYL2, NSUN5, IPO9, ENAH, PARVA, EXOC2, PKN2, UNC45A, PRKDC, MAP2K7, RAD18, SMARCAD1, PSMC2, PSMC4, PSMC5, PSMD1, PSMD2, PSMD3, PSMD11, PSMD12, PSMD13, WDR18, TWF1, SHROOM3, CHD8, RANBP2, RANGAP1, RBBP5, RBBP7, UPF1, RFC2, RFC3, RFC4, RFC5, EXOC4, RPA1, SRSF7, ANAPC1, EPS8L2, FAM129B, INTS3, HLTF, SPTAN1, SPTBN1, SRP54, SRP68, SRP72, TCP1, BUB1, BUB1B, TLN1, TMPO, HSP90B1, CCT3, TUBG1, UBE2N, VIM, AHNAK, DDX39B, CDC73, UBA5, MYO15B, SYMPK, SEH1L, CAPG, SMC1A, UBL4A, ARID1A, CAPZA1, PICALM, EPPK1, NUF2, MAD1L1, CUL1, SMARCA5, RUVBL1, CDC23, IQGAP1, CCNB1, HIP1R, UBE2M, BTAF1, CCT6A, SMC3, ARHGEF1, DEPDC7, ARHGEF2, BUB3, PDLIM7, TRIP13, ROCK2, CHD1L, NUP155, NCAPD2, OXSR1, CDC27, MVP, TUBA1B, EXOC3, SNRPE, DVL3, ELAVL2, C11orf57, SNRPG, KIAA1143, SNRPF, ZC3H18, CD2BP2, EAPP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ENO1_SNW1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneENO1P06733DB01593ZincAlpha-enolasesmall moleculeapproved|investigational
HgeneENO1P06733DB11638ArtenimolAlpha-enolasesmall moleculeapproved|investigational

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RelatedDiseases for ENO1_SNW1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneENO1C0001418Adenocarcinoma1CTD_human
HgeneENO1C0002395Alzheimer's Disease1CTD_human
HgeneENO1C0003873Rheumatoid Arthritis1CTD_human
HgeneENO1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneENO1C0007137Squamous cell carcinoma1CTD_human
HgeneENO1C0014859Esophageal Neoplasms1CTD_human
HgeneENO1C0021364Male infertility1CTD_human
HgeneENO1C0024667Animal Mammary Neoplasms1CTD_human
HgeneENO1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneENO1C0026640Mouth Neoplasms1CTD_human
HgeneENO1C0027626Neoplasm Invasiveness1CTD_human
HgeneENO1C0029408Degenerative polyarthritis1CTD_human
HgeneENO1C0029456Osteoporosis1CTD_human
HgeneENO1C0036341Schizophrenia1PSYGENET
HgeneENO1C0038356Stomach Neoplasms1CTD_human
HgeneENO1C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneENO1C0520459Necrotizing Enterocolitis1CTD_human
HgeneENO1C0948089Acute Coronary Syndrome1CTD_human
HgeneENO1C1458155Mammary Neoplasms1CTD_human
HgeneENO1C2239176Liver carcinoma1CTD_human
HgeneENO1C4277682Chemical and Drug Induced Liver Injury1CTD_human