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Fusion gene ID: 11612 |
FusionGeneSummary for ENO1_COL4A2 |
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Fusion gene information | Fusion gene name: ENO1_COL4A2 | Fusion gene ID: 11612 | Hgene | Tgene | Gene symbol | ENO1 | COL4A2 | Gene ID | 2023 | 1284 |
Gene name | enolase 1 | collagen type IV alpha 2 chain | |
Synonyms | ENO1L1|HEL-S-17|MPB1|NNE|PPH | ICH|POREN2 | |
Cytomap | 1p36.23 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha-enolasec-myc promoter-binding protein-12-phospho-D-glycerate hydro-lyaseMYC promoter-binding protein 1alpha enolase like 1enolase 1, (alpha)enolase-alphaepididymis secretory protein Li 17non-neural enolasephosphopyruvate hydrataseplasminog | collagen alpha-2(IV) chaincanstatin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P06733 | P08572 | |
Ensembl transtripts involved in fusion gene | ENST00000234590, | ENST00000360467, ENST00000462309, | |
Fusion gene scores | * DoF score | 14 X 15 X 7=1470 | 6 X 6 X 3=108 |
# samples | 21 | 5 | |
** MAII score | log2(21/1470*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/108*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ENO1 [Title/Abstract] AND COL4A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ENO1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 2005901 |
Hgene | ENO1 | GO:0030308 | negative regulation of cell growth | 10082554 |
Hgene | ENO1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10082554 |
Hgene | ENO1 | GO:1903298 | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 15459207 |
Hgene | ENO1 | GO:2001171 | positive regulation of ATP biosynthetic process | 15459207 |
Tgene | COL4A2 | GO:0016525 | negative regulation of angiogenesis | 10625665 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW362574 | ENO1 | chr1 | 8926485 | + | COL4A2 | chr13 | 111125307 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000234590 | ENST00000360467 | ENO1 | chr1 | 8926485 | + | COL4A2 | chr13 | 111125307 | - |
intron-intron | ENST00000234590 | ENST00000462309 | ENO1 | chr1 | 8926485 | + | COL4A2 | chr13 | 111125307 | - |
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FusionProtFeatures for ENO1_COL4A2 |
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Hgene | Tgene |
ENO1 | COL4A2 |
Type IV collagen is the major structural component ofglomerular basement membranes (GBM), forming a 'chicken-wire'meshwork together with laminins, proteoglycans andentactin/nidogen. Canstatin, a cleavage product corresponding to thecollagen alpha 2(IV) NC1 domain, possesses both anti-angiogenicand anti-tumor cell activity. It inhibits proliferation andmigration of endothelial cells, reduces mitochondrial membranepotential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity.Ligand for alphavbeta3 and alphavbeta5 integrins. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ENO1_COL4A2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ENO1_COL4A2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ENO1_COL4A2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ENO1 | P06733 | DB01593 | Zinc | Alpha-enolase | small molecule | approved|investigational |
Hgene | ENO1 | P06733 | DB11638 | Artenimol | Alpha-enolase | small molecule | approved|investigational |
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RelatedDiseases for ENO1_COL4A2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ENO1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | ENO1 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Hgene | ENO1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | ENO1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | ENO1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | ENO1 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | ENO1 | C0021364 | Male infertility | 1 | CTD_human |
Hgene | ENO1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ENO1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ENO1 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Hgene | ENO1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ENO1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | ENO1 | C0029456 | Osteoporosis | 1 | CTD_human |
Hgene | ENO1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ENO1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | ENO1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | ENO1 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |
Hgene | ENO1 | C0948089 | Acute Coronary Syndrome | 1 | CTD_human |
Hgene | ENO1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | ENO1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | ENO1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | COL4A2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | COL4A2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Tgene | COL4A2 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Tgene | COL4A2 | C3280970 | PORENCEPHALY 2 | 1 | UNIPROT |