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Fusion gene ID: 11594 |
FusionGeneSummary for ENDOD1_BBS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ENDOD1_BBS1 | Fusion gene ID: 11594 | Hgene | Tgene | Gene symbol | ENDOD1 | BBS1 | Gene ID | 23052 | 582 |
| Gene name | endonuclease domain containing 1 | Bardet-Biedl syndrome 1 | |
| Synonyms | - | BBS2L2 | |
| Cytomap | 11q21 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endonuclease domain-containing 1 protein | Bardet-Biedl syndrome 1 proteinBBS2-like protein 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O94919 | Q8NFJ9 | |
| Ensembl transtripts involved in fusion gene | ENST00000278505, | ENST00000318312, ENST00000537537, ENST00000455748, ENST00000529766, ENST00000393994, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ENDOD1 [Title/Abstract] AND BBS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AJ-A3IA-01A | ENDOD1 | chr11 | 94823391 | + | BBS1 | chr11 | 66288741 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000278505 | ENST00000318312 | ENDOD1 | chr11 | 94823391 | + | BBS1 | chr11 | 66288741 | + |
| In-frame | ENST00000278505 | ENST00000537537 | ENDOD1 | chr11 | 94823391 | + | BBS1 | chr11 | 66288741 | + |
| In-frame | ENST00000278505 | ENST00000455748 | ENDOD1 | chr11 | 94823391 | + | BBS1 | chr11 | 66288741 | + |
| 5CDS-3UTR | ENST00000278505 | ENST00000529766 | ENDOD1 | chr11 | 94823391 | + | BBS1 | chr11 | 66288741 | + |
| 5CDS-intron | ENST00000278505 | ENST00000393994 | ENDOD1 | chr11 | 94823391 | + | BBS1 | chr11 | 66288741 | + |
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FusionProtFeatures for ENDOD1_BBS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ENDOD1 | BBS1 |
| May act as a DNase and a RNase. {ECO:0000305}. | The BBSome complex is thought to function as a coatcomplex required for sorting of specific membrane proteins to theprimary cilia. The BBSome complex is required for ciliogenesis butis dispensable for centriolar satellite function. This ciliogenicfunction is mediated in part by the Rab8 GDP/GTP exchange factor,which localizes to the basal body and contacts the BBSome.Rab8(GTP) enters the primary cilium and promotes extension of theciliary membrane. Firstly the BBSome associates with the ciliarymembrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium andpromotes docking and fusion of carrier vesicles to the base of theciliary membrane. The BBSome complex, together with the LTZL1,controls SMO ciliary trafficking and contributes to the sonichedgehog (SHH) pathway regulation. Required for proper BBSomecomplex assembly and its ciliary localization (PubMed:17574030,PubMed:22072986). Plays a role in olfactory ciliumbiogenesis/maintenance and trafficking (By similarity).{ECO:0000250|UniProtKB:Q3V3N7, ECO:0000269|PubMed:17574030,ECO:0000269|PubMed:22072986}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ENDOD1_BBS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000318312_chr11_66288741_+_453aa MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGG AEQRWLVEPQMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKL WTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEG GSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKL TLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLA >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000537537_chr11_66288741_+_137aa MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGG >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000455748_chr11_66288741_+_453aa MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGG AEQRWLVEPQMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKL WTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEG GSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKL TLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000318312_chr11_66288741_+_1359nt ATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGGCCGGCTCGTGGGCGAGGAGGAAGCCGGC TTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTCCCACGTGAAGATCTGTCAGCGCGCGGAG GGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTTCCGCGCCCCGCGCCCTGCGCCCGGCGGC GCCGAGCAGCGATGGCTGGTGGAGCCGCAGATGAGCCTTCCCAGCGTCCCCGTCTTCCTAGAGGTTTCTGGCCAGTTTGATGTTGAGTTC CGGCTTGCCGCGGCCTGCCGCAATGGAAACATCTATATTCTGAGAAGAGACTCCAAGCACCCCAAGTACTGCATCGAGCTGAGCGCCCAG CCTGTGGGACTTATCCGGGTACACAAGGTCCTAGTGGTGGGCAGCACCCAAGACAGCCTGCATGGCTTCACCCACAAGGGGAAGAAGCTG TGGACAGTGCAGATGCCCGCAGCCATCCTGACCATGAACCTCCTGGAGCAGCATTCCCGGGGCCTGCAGGCCGTCATGGCTGGGCTGGCC AATGGAGAGGTCCGCATTTATCGTGACAAGGCCCTGCTCAATGTCATCCACACCCCGGATGCAGTGACCAGCCTTTGCTTTGGCCGGTAC GGGCGGGAGGACAACACCCTCATCATGACCACTCGAGGTGGTGGCCTGATCATCAAGATCCTGAAGCGTACAGCAGTGTTTGTAGAGGGA GGAAGTGAGGTGGGTCCCCCACCAGCCCAGGCCATGAAACTCAATGTGCCCCGAAAGACCCGGCTTTACGTGGATCAGACACTGCGAGAG CGGGAGGCTGGCACCGCCATGCACCGGGCCTTCCAGACAGACCTATACCTGCTGCGCCTACGTGCTGCCCGCGCCTACCTGCAGGCCCTC GAGTCCAGCCTGAGCCCCCTGTCCACGACAGCCCGAGAGCCACTCAAGCTGCACGCCGTGGTTCAGGGCCTTGGCCCCACCTTTAAGCTC ACACTTCACCTGCAGAACACCTCAACAACCCGTCCTGTCCTGGGGCTGCTGGTCTGCTTCCTGTACAACGAGGCGCTCTATTCCCTGCCC CGGGCCTTCTTCAAGGTACCCTTGCTGGTGCCAGGGCTCAACTACCCCCTGGAGACCTTTGTGGAGAGTCTCAGTAACAAGGGCATCTCA GACATCATCAAGGTGCTGGTGCTTCGAGAAGGCCAAAGTGCACCCCTGCTGAGTGCCCACGTCAACATGCCTGGGAGCGAGGGGCTGGCG >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000537537_chr11_66288741_+_411nt ATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGGCCGGCTCGTGGGCGAGGAGGAAGCCGGC TTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTCCCACGTGAAGATCTGTCAGCGCGCGGAG GGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTTCCGCGCCCCGCGCCCTGCGCCCGGCGGC GCCGAGCAGCGATGGCTGGTGGAGCCGCAGATGAGCCTTCCCAGCGTCCCCGTCTTCCTAGAGGTTTCTGGCCAGTTTGATGTTGAGTTC >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000455748_chr11_66288741_+_1359nt ATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGGCCGGCTCGTGGGCGAGGAGGAAGCCGGC TTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTCCCACGTGAAGATCTGTCAGCGCGCGGAG GGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTTCCGCGCCCCGCGCCCTGCGCCCGGCGGC GCCGAGCAGCGATGGCTGGTGGAGCCGCAGATGAGCCTTCCCAGCGTCCCCGTCTTCCTAGAGGTTTCTGGCCAGTTTGATGTTGAGTTC CGGCTTGCCGCGGCCTGCCGCAATGGAAACATCTATATTCTGAGAAGAGACTCCAAGCACCCCAAGTACTGCATCGAGCTGAGCGCCCAG CCTGTGGGACTTATCCGGGTACACAAGGTCCTAGTGGTGGGCAGCACCCAAGACAGCCTGCATGGCTTCACCCACAAGGGGAAGAAGCTG TGGACAGTGCAGATGCCCGCAGCCATCCTGACCATGAACCTCCTGGAGCAGCATTCCCGGGGCCTGCAGGCCGTCATGGCTGGGCTGGCC AATGGAGAGGTCCGCATTTATCGTGACAAGGCCCTGCTCAATGTCATCCACACCCCGGATGCAGTGACCAGCCTTTGCTTTGGCCGGTAC GGGCGGGAGGACAACACCCTCATCATGACCACTCGAGGTGGTGGCCTGATCATCAAGATCCTGAAGCGTACAGCAGTGTTTGTAGAGGGA GGAAGTGAGGTGGGTCCCCCACCAGCCCAGGCCATGAAACTCAATGTGCCCCGAAAGACCCGGCTTTACGTGGATCAGACACTGCGAGAG CGGGAGGCTGGCACCGCCATGCACCGGGCCTTCCAGACAGACCTATACCTGCTGCGCCTACGTGCTGCCCGCGCCTACCTGCAGGCCCTC GAGTCCAGCCTGAGCCCCCTGTCCACGACAGCCCGAGAGCCACTCAAGCTGCACGCCGTGGTTCAGGGCCTTGGCCCCACCTTTAAGCTC ACACTTCACCTGCAGAACACCTCAACAACCCGTCCTGTCCTGGGGCTGCTGGTCTGCTTCCTGTACAACGAGGCGCTCTATTCCCTGCCC CGGGCCTTCTTCAAGGTACCCTTGCTGGTGCCAGGGCTCAACTACCCCCTGGAGACCTTTGTGGAGAGTCTCAGTAACAAGGGCATCTCA GACATCATCAAGGTGCTGGTGCTTCGAGAAGGCCAAAGTGCACCCCTGCTGAGTGCCCACGTCAACATGCCTGGGAGCGAGGGGCTGGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000318312_chr11_66288741_+_3067nt AGGTTGCGACTTCCCTTCCCTACCCTGCTCGGCTGCGTAGTGCGCTCCCCGCCCAGCCTGCAGAGCTCGCGCCGCGGCAGCCCAGCCGCT CGGCCCCGCCGCGCTCGCAGAGGCCGCCATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGG CCGGCTCGTGGGCGAGGAGGAAGCCGGCTTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTC CCACGTGAAGATCTGTCAGCGCGCGGAGGGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTT CCGCGCCCCGCGCCCTGCGCCCGGCGGCGCCGAGCAGCGATGGCTGGTGGAGCCGCAGATGAGCCTTCCCAGCGTCCCCGTCTTCCTAGA GGTTTCTGGCCAGTTTGATGTTGAGTTCCGGCTTGCCGCGGCCTGCCGCAATGGAAACATCTATATTCTGAGAAGAGACTCCAAGCACCC CAAGTACTGCATCGAGCTGAGCGCCCAGCCTGTGGGACTTATCCGGGTACACAAGGTCCTAGTGGTGGGCAGCACCCAAGACAGCCTGCA TGGCTTCACCCACAAGGGGAAGAAGCTGTGGACAGTGCAGATGCCCGCAGCCATCCTGACCATGAACCTCCTGGAGCAGCATTCCCGGGG CCTGCAGGCCGTCATGGCTGGGCTGGCCAATGGAGAGGTCCGCATTTATCGTGACAAGGCCCTGCTCAATGTCATCCACACCCCGGATGC AGTGACCAGCCTTTGCTTTGGCCGGTACGGGCGGGAGGACAACACCCTCATCATGACCACTCGAGGTGGTGGCCTGATCATCAAGATCCT GAAGCGTACAGCAGTGTTTGTAGAGGGAGGAAGTGAGGTGGGTCCCCCACCAGCCCAGGCCATGAAACTCAATGTGCCCCGAAAGACCCG GCTTTACGTGGATCAGACACTGCGAGAGCGGGAGGCTGGCACCGCCATGCACCGGGCCTTCCAGACAGACCTATACCTGCTGCGCCTACG TGCTGCCCGCGCCTACCTGCAGGCCCTCGAGTCCAGCCTGAGCCCCCTGTCCACGACAGCCCGAGAGCCACTCAAGCTGCACGCCGTGGT TCAGGGCCTTGGCCCCACCTTTAAGCTCACACTTCACCTGCAGAACACCTCAACAACCCGTCCTGTCCTGGGGCTGCTGGTCTGCTTCCT GTACAACGAGGCGCTCTATTCCCTGCCCCGGGCCTTCTTCAAGGTACCCTTGCTGGTGCCAGGGCTCAACTACCCCCTGGAGACCTTTGT GGAGAGTCTCAGTAACAAGGGCATCTCAGACATCATCAAGGTGCTGGTGCTTCGAGAAGGCCAAAGTGCACCCCTGCTGAGTGCCCACGT CAACATGCCTGGGAGCGAGGGGCTGGCGGCCGCCTGAGACCTGAGCTGCTGTGAAAGCCCCTGCACAATCAGCCAGGGAGAACTGGGCGG GTTTAGTGGCCCCAGGCCCACTCCTCATGCAGCAGTGTGCTGGGGCGACAGCTCGTCTCCCCTCTCTTAAGCACCCGCTTCCTCACCACC CCCACTGTTGGGCCTATAGTAGCAGGTTAGTGAGTACCTAGGGCGGCTCAACTCCTCCCACAGCACCAACCCAGCATGGTCCCACTGAAG TCCTACTACGCCCTCCCCTCCCCAGCCTTTTCCAGAAACCATACTGGGCTCAGATCAGAGCTCCGAAGCGGTCAAAGTGAGCTGAGCAGG ACAGGCCCAGCCTTTCTCCACTGCCACGTCCCTCATGCACATCACTCATCTCCTGCTGCAGGCCAAGGCCAAAATTGGGCTAGTCCTGGC CAGGGAAATCAGAAGCTCTTCTTGGGTGAGATTGAGCCTCCTGTTGCTCCCTGGAGTTCCGGAGGCTGGGCTGCAGCCCACTCAGCTTGC GGGCAAAATACGTGCTCTCCTCTCTCCTTGTCAGCTGAGCAAACCCAGGGAATAGCCCTCCTCTCCCCAGGAAACTTCTCTGAAATCTTA GACTTAGCCAGTCTTAGGCCTACGATGCCACACAAAGGTTGTTCAGGGAGAAGGGGGTGCAGGAGGCAGAGGGTGCCCCGCAGGGAGCTG GTGGCTCCAGCCCCACTAGAGCTCCTAAAGATCACACAGCAGCTGCTCCTGACAGGGATGCTCATGCCCAGAAAGCAAGCCCAGGAGAGG AAGGCAGAGTGTGACAGAGCAGAGCCAGGGCCAGGCGCACCAGGAGAGGCGTTTCTGGGGCTCCAGAGAAGTGCCACGGGAGGCAGAAGT CCAGAACTGCCCATATAGATGCCCTTCTACATCCTGGAGCCCAAATCAGTCATGTGGGTGGGAAGTTCCCAGGGCAGTGGTCACATCGTG AGAATTAGCAGGAAAGGCGGGGCCTTTCTTGTCATAGCTATTTCTGAGGATGAAATGGGAGACATATGCCCAGCACCTGATGTAAGTTTA TATAATGTAATATTATGTACCTACCACTAAGAAATACATGAACCGTGCCATGAGGACAGTAAGTGTTCATAAAGCAACATGAAGCAAGAA ACAGTGCAGGGTGCCCAGTGCACACACTAGAGAGAAATTGTGAACATTAAGGACAAGGAGAATTGGTGTCTTTCTAAAACATACTTATTT AAAAACACATACCCACTTACTAATGTGGAATTACACAGTTTGTAACAAGAAAACAGTCTCTCCCATTCTCTAGTACTGCTCCCCTACCCA GCAGTCACTTCCAGTTCATTCAGCTATTTTTAAAATGTGCTTATATGACTCTTGCTTGATATATCAATCTTAGACATTACCTGTTGACTC CCTGTTGTCATACATGAGGCTTTAGCTCTCTTTTGTCAGCAACCCTCCCCCATCCCTAGTTATTAGGTTAAAAAATACTCAGATTACTAT TTCTATTACTATGTGAAAGTTAACTGCGGAGCCAAGAGTTGGACTATAATTAAATTACCTTCCTTGTACTTTCTTTTTAATGGAGTTAAT >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000537537_chr11_66288741_+_754nt AGGTTGCGACTTCCCTTCCCTACCCTGCTCGGCTGCGTAGTGCGCTCCCCGCCCAGCCTGCAGAGCTCGCGCCGCGGCAGCCCAGCCGCT CGGCCCCGCCGCGCTCGCAGAGGCCGCCATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGG CCGGCTCGTGGGCGAGGAGGAAGCCGGCTTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTC CCACGTGAAGATCTGTCAGCGCGCGGAGGGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTT CCGCGCCCCGCGCCCTGCGCCCGGCGGCGCCGAGCAGCGATGGCTGGTGGAGCCGCAGATGAGCCTTCCCAGCGTCCCCGTCTTCCTAGA GGTTTCTGGCCAGTTTGATGTTGAGTTCCGGCTTGCCGCGGCCTGCCGCAATGGAAACATCTATATTCTGAGAAGATGATCATACAAGCC ACCATAGTGAAGGTGGGCGGAAGACAAGACACCATAGTGAAGGTGGGAGGAAGACAAGACACCATAGTGAAGGTGGGAGGAAGACACACT TGATGTTTTCCAAGGCCACACATTTACTAAGGTGGCAGAAGTGGAAATAATCCCAGGGTCATCTGCTTTGGGGCCAGTGTTCCTCCCAGA >In-frame_ENDOD1_ENST00000278505_chr11_94823391_+_BBS1_ENST00000455748_chr11_66288741_+_1520nt AGGTTGCGACTTCCCTTCCCTACCCTGCTCGGCTGCGTAGTGCGCTCCCCGCCCAGCCTGCAGAGCTCGCGCCGCGGCAGCCCAGCCGCT CGGCCCCGCCGCGCTCGCAGAGGCCGCCATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGG CCGGCTCGTGGGCGAGGAGGAAGCCGGCTTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTC CCACGTGAAGATCTGTCAGCGCGCGGAGGGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTT CCGCGCCCCGCGCCCTGCGCCCGGCGGCGCCGAGCAGCGATGGCTGGTGGAGCCGCAGATGAGCCTTCCCAGCGTCCCCGTCTTCCTAGA GGTTTCTGGCCAGTTTGATGTTGAGTTCCGGCTTGCCGCGGCCTGCCGCAATGGAAACATCTATATTCTGAGAAGAGACTCCAAGCACCC CAAGTACTGCATCGAGCTGAGCGCCCAGCCTGTGGGACTTATCCGGGTACACAAGGTCCTAGTGGTGGGCAGCACCCAAGACAGCCTGCA TGGCTTCACCCACAAGGGGAAGAAGCTGTGGACAGTGCAGATGCCCGCAGCCATCCTGACCATGAACCTCCTGGAGCAGCATTCCCGGGG CCTGCAGGCCGTCATGGCTGGGCTGGCCAATGGAGAGGTCCGCATTTATCGTGACAAGGCCCTGCTCAATGTCATCCACACCCCGGATGC AGTGACCAGCCTTTGCTTTGGCCGGTACGGGCGGGAGGACAACACCCTCATCATGACCACTCGAGGTGGTGGCCTGATCATCAAGATCCT GAAGCGTACAGCAGTGTTTGTAGAGGGAGGAAGTGAGGTGGGTCCCCCACCAGCCCAGGCCATGAAACTCAATGTGCCCCGAAAGACCCG GCTTTACGTGGATCAGACACTGCGAGAGCGGGAGGCTGGCACCGCCATGCACCGGGCCTTCCAGACAGACCTATACCTGCTGCGCCTACG TGCTGCCCGCGCCTACCTGCAGGCCCTCGAGTCCAGCCTGAGCCCCCTGTCCACGACAGCCCGAGAGCCACTCAAGCTGCACGCCGTGGT TCAGGGCCTTGGCCCCACCTTTAAGCTCACACTTCACCTGCAGAACACCTCAACAACCCGTCCTGTCCTGGGGCTGCTGGTCTGCTTCCT GTACAACGAGGCGCTCTATTCCCTGCCCCGGGCCTTCTTCAAGGTACCCTTGCTGGTGCCAGGGCTCAACTACCCCCTGGAGACCTTTGT GGAGAGTCTCAGTAACAAGGGCATCTCAGACATCATCAAGGTGCTGGTGCTTCGAGAAGGCCAAAGTGCACCCCTGCTGAGTGCCCACGT |
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FusionGenePPI for ENDOD1_BBS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ENDOD1 | ENO1, SHMT2, MOV10, NXF1, CTDSP2, LYPD3, GOLT1B, KIF21A, CAV3, IL13RA2, YIPF3, SMPD3, SLC34A2, BZW2, DPEP1, CYB5A, SPPL2B, FNDC5, STOM | BBS1 | KEAP1, OSBPL10, PARK7, ALDOB, BHMT, CALCA, DCTN1, EEF1A1, EIF3A, EPAS1, EXOC7, FHOD1, HSCB, KRT18, PAX2, TSPAN7, GLIS2, LZTFL1, WDR53, TSSC1, PRKCSH, BBS5, BBS9, BBS4, BBS7, TTC8, DPP3, BBS2, IFT43, KIAA1279, OMD, HSPA8, TRIM44, IARS2, AVIL, DARS2, RNF126, CLUAP1, RAB8A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ENDOD1_BBS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ENDOD1_BBS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | BBS1 | C2936862 | Bardet-Biedl syndrome 1 (disorder) | 3 | UNIPROT |
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