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Fusion gene ID: 11579 |
FusionGeneSummary for EMP2_TERF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EMP2_TERF2 | Fusion gene ID: 11579 | Hgene | Tgene | Gene symbol | EMP2 | TERF2 | Gene ID | 2013 | 7014 |
| Gene name | epithelial membrane protein 2 | telomeric repeat binding factor 2 | |
| Synonyms | XMP | TRBF2|TRF2 | |
| Cytomap | 16p13.13 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | epithelial membrane protein 2 | telomeric repeat-binding factor 2TTAGGG repeat-binding factor 2telomeric DNA-binding proteintelomeric repeat binding protein 2 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P54851 | Q15554 | |
| Ensembl transtripts involved in fusion gene | ENST00000359543, ENST00000566033, ENST00000536829, | ENST00000254942, ENST00000603068, ENST00000569611, ENST00000567296, | |
| Fusion gene scores | * DoF score | 8 X 7 X 7=392 | 3 X 3 X 3=27 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/392*10)=-2.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EMP2 [Title/Abstract] AND TERF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EMP2 | GO:0001954 | positive regulation of cell-matrix adhesion | 16216233 |
| Hgene | EMP2 | GO:0003093 | regulation of glomerular filtration | 24814193 |
| Hgene | EMP2 | GO:0007015 | actin filament organization | 19494199 |
| Hgene | EMP2 | GO:0007155 | cell adhesion | 19494199 |
| Hgene | EMP2 | GO:0007160 | cell-matrix adhesion | 19494199 |
| Hgene | EMP2 | GO:0008219 | cell death | 12107182 |
| Hgene | EMP2 | GO:0008283 | cell proliferation | 21637765 |
| Hgene | EMP2 | GO:0010594 | regulation of endothelial cell migration | 23334331 |
| Hgene | EMP2 | GO:0016477 | cell migration | 21637765 |
| Hgene | EMP2 | GO:0032060 | bleb assembly | 12107182 |
| Hgene | EMP2 | GO:0032147 | activation of protein kinase activity | 21637765 |
| Hgene | EMP2 | GO:0043534 | blood vessel endothelial cell migration | 23439602 |
| Hgene | EMP2 | GO:0043549 | regulation of kinase activity | 18469192 |
| Hgene | EMP2 | GO:0045765 | regulation of angiogenesis | 23334331 |
| Hgene | EMP2 | GO:0070252 | actin-mediated cell contraction | 18469192|22728127 |
| Hgene | EMP2 | GO:2001046 | positive regulation of integrin-mediated signaling pathway | 16216233 |
| Hgene | EMP2 | GO:2001212 | regulation of vasculogenesis | 23334331 |
| Tgene | TERF2 | GO:0031627 | telomeric loop formation | 10338214 |
| Tgene | TERF2 | GO:0032205 | negative regulation of telomere maintenance | 17055345 |
| Tgene | TERF2 | GO:0032210 | regulation of telomere maintenance via telomerase | 23685356 |
| Tgene | TERF2 | GO:0032211 | negative regulation of telomere maintenance via telomerase | 17055345 |
| Tgene | TERF2 | GO:1903770 | negative regulation of beta-galactosidase activity | 11927518 |
| Tgene | TERF2 | GO:1905778 | negative regulation of exonuclease activity | 15200954 |
| Tgene | TERF2 | GO:1905839 | negative regulation of telomeric D-loop disassembly | 15200954 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-77-7463-01A | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000359543 | ENST00000254942 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| In-frame | ENST00000359543 | ENST00000603068 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| 5CDS-5UTR | ENST00000359543 | ENST00000569611 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| 5CDS-5UTR | ENST00000359543 | ENST00000567296 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| intron-3CDS | ENST00000566033 | ENST00000254942 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| intron-3CDS | ENST00000566033 | ENST00000603068 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| intron-5UTR | ENST00000566033 | ENST00000569611 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| intron-5UTR | ENST00000566033 | ENST00000567296 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| In-frame | ENST00000536829 | ENST00000254942 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| In-frame | ENST00000536829 | ENST00000603068 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| 5CDS-5UTR | ENST00000536829 | ENST00000569611 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
| 5CDS-5UTR | ENST00000536829 | ENST00000567296 | EMP2 | chr16 | 10637427 | - | TERF2 | chr16 | 69419389 | - |
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FusionProtFeatures for EMP2_TERF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EMP2 | TERF2 |
| Functions as a key regulator of cell membranecomposition by regulating proteins surface expression. Also, playsa role in regulation of processes including cell migration, cellproliferation, cell contraction and cell adhesion. Negativelyregulates caveolae formation by reducing CAV1 expression and CAV1amount by increasing lysosomal degradation (PubMed:24814193).Facilitates surface trafficking and formation of lipid raftsbearing GPI-anchor proteins (By similarity). Regulates surfaceexpression of MHC1 and ICAM1 proteins increasing susceptibility toT-cell mediated cytotoxicity (By similarity). Regulates the plasmamembrane expression of the integrin heterodimers ITGA6-ITGB1,ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrixadhesion (PubMed:16216233). Also regulates many processes throughPTK2. Regulates blood vessel endothelial cell migration andangiogenesis by regulating VEGF protein expression through PTK2activation (PubMed:23439602). Regulates cell migration and cellcontraction through PTK2 and SRC activation (PubMed:21637765,PubMed:22728127). Regulates focal adhesion density, F-actinconformation and cell adhesion capacity through interaction withPTK2 (PubMed:19494199). Positively regulates cell proliferation(PubMed:24814193). Plays a role during cell death and cellblebbing (PubMed:12107182). Promotes angiogenesis andvasculogenesis through induction of VEGFA via a HIF1A-dependentpathway (PubMed:23334331). Also plays a role in embryoimplantation by regulating surface trafficking of integrinheterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role inglomerular filtration (By similarity).{ECO:0000250|UniProtKB:F1QIK8, ECO:0000250|UniProtKB:O88662,ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:16216233,ECO:0000269|PubMed:16487956, ECO:0000269|PubMed:19494199,ECO:0000269|PubMed:21637765, ECO:0000269|PubMed:22728127,ECO:0000269|PubMed:23334331, ECO:0000269|PubMed:23439602,ECO:0000269|PubMed:24814193}. | Binds the telomeric double-stranded 5'-TTAGGG-3' repeatand plays a central role in telomere maintenance and protectionagainst end-to-end fusion of chromosomes. In addition to itstelomeric DNA-binding role, required to recruit a number offactors and enzymes required for telomere protection, includingthe shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Componentof the shelterin complex (telosome) that is involved in theregulation of telomere length and protection. Shelterin associateswith arrays of double-stranded 5'-TTAGGG-3' repeats added bytelomerase and protects chromosome ends; without its protectiveactivity, telomeres are no longer hidden from the DNA damagesurveillance and chromosome ends are inappropriately processed byDNA repair pathways. Together with DCLRE1B/Apollo, plays a keyrole in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have beenproposed to protect chromosome ends from degradation and repair.Required both to recruit DCLRE1B/Apollo to telomeres and activatethe exonuclease activity of DCLRE1B/Apollo. Preferentially bindsto positive supercoiled DNA. Together with DCLRE1B/Apollo,required to control the amount of DNA topoisomerase (TOP1, TOP2Aand TOP2B) needed for telomere replication during fork passage andprevent aberrant telomere topology. Recruits TERF2IP/RAP1 totelomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.{ECO:0000269|PubMed:16166375, ECO:0000269|PubMed:20655466,ECO:0000269|PubMed:9476899}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EMP2 | chr16:10637427 | chr16:69419389 | ENST00000359543 | - | 3 | 5 | 1_21 | 56 | 168 | Transmembrane | Helical |
| Hgene | EMP2 | chr16:10637427 | chr16:69419389 | ENST00000536829 | - | 3 | 5 | 1_21 | 56 | 168 | Transmembrane | Helical |
| Tgene | >TERF2 | chr16:10637427 | chr16:69419389 | ENST00000254942 | - | 0 | 10 | 512_537 | 126 | 543 | DNA binding | H-T-H motif |
| Tgene | >TERF2 | chr16:10637427 | chr16:69419389 | ENST00000603068 | - | 0 | 10 | 512_537 | 84 | 501 | DNA binding | H-T-H motif |
| Tgene | >TERF2 | chr16:10637427 | chr16:69419389 | ENST00000254942 | - | 0 | 10 | 484_541 | 126 | 543 | Domain | HTH myb-type |
| Tgene | >TERF2 | chr16:10637427 | chr16:69419389 | ENST00000603068 | - | 0 | 10 | 484_541 | 84 | 501 | Domain | HTH myb-type |
| Tgene | >TERF2 | chr16:10637427 | chr16:69419389 | ENST00000254942 | - | 0 | 10 | 371_375 | 126 | 543 | Motif | Nuclear localization signal |
| Tgene | >TERF2 | chr16:10637427 | chr16:69419389 | ENST00000603068 | - | 0 | 10 | 371_375 | 84 | 501 | Motif | Nuclear localization signal |
| Tgene | >TERF2 | chr16:10637427 | chr16:69419389 | ENST00000603068 | - | 0 | 10 | 84_287 | 84 | 501 | Region | Note=TRFH dimerization |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EMP2 | chr16:10637427 | chr16:69419389 | ENST00000359543 | - | 3 | 5 | 143_163 | 56 | 168 | Transmembrane | Helical |
| Hgene | >EMP2 | chr16:10637427 | chr16:69419389 | ENST00000359543 | - | 3 | 5 | 67_87 | 56 | 168 | Transmembrane | Helical |
| Hgene | >EMP2 | chr16:10637427 | chr16:69419389 | ENST00000359543 | - | 3 | 5 | 95_115 | 56 | 168 | Transmembrane | Helical |
| Hgene | >EMP2 | chr16:10637427 | chr16:69419389 | ENST00000536829 | - | 3 | 5 | 143_163 | 56 | 168 | Transmembrane | Helical |
| Hgene | >EMP2 | chr16:10637427 | chr16:69419389 | ENST00000536829 | - | 3 | 5 | 67_87 | 56 | 168 | Transmembrane | Helical |
| Hgene | >EMP2 | chr16:10637427 | chr16:69419389 | ENST00000536829 | - | 3 | 5 | 95_115 | 56 | 168 | Transmembrane | Helical |
| Tgene | TERF2 | chr16:10637427 | chr16:69419389 | ENST00000254942 | - | 0 | 10 | 55_72 | 126 | 543 | Compositional bias | Note=Arg-rich (basic) |
| Tgene | TERF2 | chr16:10637427 | chr16:69419389 | ENST00000603068 | - | 0 | 10 | 55_72 | 84 | 501 | Compositional bias | Note=Arg-rich (basic) |
| Tgene | TERF2 | chr16:10637427 | chr16:69419389 | ENST00000254942 | - | 0 | 10 | 84_287 | 126 | 543 | Region | Note=TRFH dimerization |
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FusionGeneSequence for EMP2_TERF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EMP2_ENST00000359543_chr16_10637427_-_TERF2_ENST00000254942_chr16_69419389_-_473aa MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPV IQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGA QDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPP SKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYP >In-frame_EMP2_ENST00000359543_chr16_10637427_-_TERF2_ENST00000603068_chr16_69419389_-_473aa MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPV IQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGA QDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPP SKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYP >In-frame_EMP2_ENST00000536829_chr16_10637427_-_TERF2_ENST00000254942_chr16_69419389_-_473aa MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPV IQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGA QDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPP SKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYP >In-frame_EMP2_ENST00000536829_chr16_10637427_-_TERF2_ENST00000603068_chr16_69419389_-_473aa MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDC SFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPV IQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGA QDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPP SKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EMP2_ENST00000359543_chr16_10637427_-_TERF2_ENST00000254942_chr16_69419389_-_1419nt ATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAGCCTTGCTGTTCATTGCCACCGTCGACAATGCCTGGTGGGTA GGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGAATTGCACAGTCATCAATGACAGCTTTCAAGCTTTGCTTGTC AGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGT TCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCA GTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGCTGTCATTATTTGTATCAAAAACAAAGAATTTGAAAAGGCTTCAAAAATTTTG AAAAAACATATGTCCAAGGACCCCACAACTCAGAAGCTGAGAAATGATCTCCTGAATATTATTCGAGAAAAGAACTTGGCCCATCCTGTT ATCCAGAACTTTTCATATGAGACCTTCCAGCAGAAGATGCTGCGCTTCCTGGAGAGCCACCTGGATGACGCCGAGCCCTACCTCCTCACG ATGGCCAAAAAGGCTTTGAAATCTGAGTCCGCTGCCTCAAGTACAGGGAAGGAAGATAAACAGCCAGCACCAGGGCCTGTGGAAAAGCCA CCCAGAGAACCCGCAAGGCAGCTACGGAATCCTCCAACCACCATTGGAATGATGACTCTGAAAGCAGCTTTCAAGACTCTGTCTGGTGCA CAGGATTCTGAGGCAGCCTTTGCAAAACTGGACCAGAAGGATCTGGTTCTTCCTACTCAAGCTCTCCCAGCATCACCAGCCCTCAAAAAC AAGAGACCCAGAAAAGATGAAAACGAAAGTTCAGCCCCGGCTGACGGTGAGGGTGGCTCGGAACTGCAGCCCAAGAACAAGCGCATGACA ATAAGCAGATTGGTCTTGGAGGAGGACAGCCAGAGTACTGAGCCCAGCGCAGGCCTCAACTCCTCCCAGGAGGCCGCTTCAGCGCCACCA TCCAAGCCCACCGTTCTCAACCAACCCCTCCCTGGAGAGAAGAATCCCAAAGTACCCAAAGGCAAGTGGAACAGCTCTAATGGGGTTGAA GAAAAGGAGACTTGGGTGGAAGAGGATGAACTGTTTCAAGTTCAGGCAGCACCAGATGAAGACAGTACAACCAATATAACAAAAAAGCAG AAGTGGACTGTAGAAGAAAGCGAGTGGGTCAAGGCTGGAGTGCAGAAATATGGGGAAGGAAACTGGGCTGCCATTTCTAAAAATTACCCA >In-frame_EMP2_ENST00000359543_chr16_10637427_-_TERF2_ENST00000603068_chr16_69419389_-_1419nt ATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAGCCTTGCTGTTCATTGCCACCGTCGACAATGCCTGGTGGGTA GGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGAATTGCACAGTCATCAATGACAGCTTTCAAGCTTTGCTTGTC AGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGT TCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCA GTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGCTGTCATTATTTGTATCAAAAACAAAGAATTTGAAAAGGCTTCAAAAATTTTG AAAAAACATATGTCCAAGGACCCCACAACTCAGAAGCTGAGAAATGATCTCCTGAATATTATTCGAGAAAAGAACTTGGCCCATCCTGTT ATCCAGAACTTTTCATATGAGACCTTCCAGCAGAAGATGCTGCGCTTCCTGGAGAGCCACCTGGATGACGCCGAGCCCTACCTCCTCACG ATGGCCAAAAAGGCTTTGAAATCTGAGTCCGCTGCCTCAAGTACAGGGAAGGAAGATAAACAGCCAGCACCAGGGCCTGTGGAAAAGCCA CCCAGAGAACCCGCAAGGCAGCTACGGAATCCTCCAACCACCATTGGAATGATGACTCTGAAAGCAGCTTTCAAGACTCTGTCTGGTGCA CAGGATTCTGAGGCAGCCTTTGCAAAACTGGACCAGAAGGATCTGGTTCTTCCTACTCAAGCTCTCCCAGCATCACCAGCCCTCAAAAAC AAGAGACCCAGAAAAGATGAAAACGAAAGTTCAGCCCCGGCTGACGGTGAGGGTGGCTCGGAACTGCAGCCCAAGAACAAGCGCATGACA ATAAGCAGATTGGTCTTGGAGGAGGACAGCCAGAGTACTGAGCCCAGCGCAGGCCTCAACTCCTCCCAGGAGGCCGCTTCAGCGCCACCA TCCAAGCCCACCGTTCTCAACCAACCCCTCCCTGGAGAGAAGAATCCCAAAGTACCCAAAGGCAAGTGGAACAGCTCTAATGGGGTTGAA GAAAAGGAGACTTGGGTGGAAGAGGATGAACTGTTTCAAGTTCAGGCAGCACCAGATGAAGACAGTACAACCAATATAACAAAAAAGCAG AAGTGGACTGTAGAAGAAAGCGAGTGGGTCAAGGCTGGAGTGCAGAAATATGGGGAAGGAAACTGGGCTGCCATTTCTAAAAATTACCCA >In-frame_EMP2_ENST00000536829_chr16_10637427_-_TERF2_ENST00000254942_chr16_69419389_-_1419nt ATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAGCCTTGCTGTTCATTGCCACCGTCGACAATGCCTGGTGGGTA GGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGAATTGCACAGTCATCAATGACAGCTTTCAAGCTTTGCTTGTC AGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGT TCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCA GTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGCTGTCATTATTTGTATCAAAAACAAAGAATTTGAAAAGGCTTCAAAAATTTTG AAAAAACATATGTCCAAGGACCCCACAACTCAGAAGCTGAGAAATGATCTCCTGAATATTATTCGAGAAAAGAACTTGGCCCATCCTGTT ATCCAGAACTTTTCATATGAGACCTTCCAGCAGAAGATGCTGCGCTTCCTGGAGAGCCACCTGGATGACGCCGAGCCCTACCTCCTCACG ATGGCCAAAAAGGCTTTGAAATCTGAGTCCGCTGCCTCAAGTACAGGGAAGGAAGATAAACAGCCAGCACCAGGGCCTGTGGAAAAGCCA CCCAGAGAACCCGCAAGGCAGCTACGGAATCCTCCAACCACCATTGGAATGATGACTCTGAAAGCAGCTTTCAAGACTCTGTCTGGTGCA CAGGATTCTGAGGCAGCCTTTGCAAAACTGGACCAGAAGGATCTGGTTCTTCCTACTCAAGCTCTCCCAGCATCACCAGCCCTCAAAAAC AAGAGACCCAGAAAAGATGAAAACGAAAGTTCAGCCCCGGCTGACGGTGAGGGTGGCTCGGAACTGCAGCCCAAGAACAAGCGCATGACA ATAAGCAGATTGGTCTTGGAGGAGGACAGCCAGAGTACTGAGCCCAGCGCAGGCCTCAACTCCTCCCAGGAGGCCGCTTCAGCGCCACCA TCCAAGCCCACCGTTCTCAACCAACCCCTCCCTGGAGAGAAGAATCCCAAAGTACCCAAAGGCAAGTGGAACAGCTCTAATGGGGTTGAA GAAAAGGAGACTTGGGTGGAAGAGGATGAACTGTTTCAAGTTCAGGCAGCACCAGATGAAGACAGTACAACCAATATAACAAAAAAGCAG AAGTGGACTGTAGAAGAAAGCGAGTGGGTCAAGGCTGGAGTGCAGAAATATGGGGAAGGAAACTGGGCTGCCATTTCTAAAAATTACCCA >In-frame_EMP2_ENST00000536829_chr16_10637427_-_TERF2_ENST00000603068_chr16_69419389_-_1419nt ATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAGCCTTGCTGTTCATTGCCACCGTCGACAATGCCTGGTGGGTA GGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGAATTGCACAGTCATCAATGACAGCTTTCAAGCTTTGCTTGTC AGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGT TCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCA GTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGCTGTCATTATTTGTATCAAAAACAAAGAATTTGAAAAGGCTTCAAAAATTTTG AAAAAACATATGTCCAAGGACCCCACAACTCAGAAGCTGAGAAATGATCTCCTGAATATTATTCGAGAAAAGAACTTGGCCCATCCTGTT ATCCAGAACTTTTCATATGAGACCTTCCAGCAGAAGATGCTGCGCTTCCTGGAGAGCCACCTGGATGACGCCGAGCCCTACCTCCTCACG ATGGCCAAAAAGGCTTTGAAATCTGAGTCCGCTGCCTCAAGTACAGGGAAGGAAGATAAACAGCCAGCACCAGGGCCTGTGGAAAAGCCA CCCAGAGAACCCGCAAGGCAGCTACGGAATCCTCCAACCACCATTGGAATGATGACTCTGAAAGCAGCTTTCAAGACTCTGTCTGGTGCA CAGGATTCTGAGGCAGCCTTTGCAAAACTGGACCAGAAGGATCTGGTTCTTCCTACTCAAGCTCTCCCAGCATCACCAGCCCTCAAAAAC AAGAGACCCAGAAAAGATGAAAACGAAAGTTCAGCCCCGGCTGACGGTGAGGGTGGCTCGGAACTGCAGCCCAAGAACAAGCGCATGACA ATAAGCAGATTGGTCTTGGAGGAGGACAGCCAGAGTACTGAGCCCAGCGCAGGCCTCAACTCCTCCCAGGAGGCCGCTTCAGCGCCACCA TCCAAGCCCACCGTTCTCAACCAACCCCTCCCTGGAGAGAAGAATCCCAAAGTACCCAAAGGCAAGTGGAACAGCTCTAATGGGGTTGAA GAAAAGGAGACTTGGGTGGAAGAGGATGAACTGTTTCAAGTTCAGGCAGCACCAGATGAAGACAGTACAACCAATATAACAAAAAAGCAG AAGTGGACTGTAGAAGAAAGCGAGTGGGTCAAGGCTGGAGTGCAGAAATATGGGGAAGGAAACTGGGCTGCCATTTCTAAAAATTACCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EMP2_ENST00000359543_chr16_10637427_-_TERF2_ENST00000254942_chr16_69419389_-_2966nt GGCGGGATCGGGGAAGGAGGGGCCCCGCCGCCTAGAGGGTGGAGGGAGGGCGCGCAGTCCCAGCCCAGAGCTTCAAAACAGCCCGGCGGC CTCGCCTCGCACCCCCAGCCAGTCCGTCGATCCAGCTGCCAGCGCAGCCGCCAGCGCCGGCACATCCCGCTCTGGGCTTTAAACGTGACC CCTCGCCTCGACTCGCCCTGCCCTGTGAAAATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAGCCTTGCTGTTC ATTGCCACCGTCGACAATGCCTGGTGGGTAGGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGAATTGCACAGTC ATCAATGACAGCTTTCAAGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCG CGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATG ATTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGCTGTCATTATTTGTATCAAAAAC AAAGAATTTGAAAAGGCTTCAAAAATTTTGAAAAAACATATGTCCAAGGACCCCACAACTCAGAAGCTGAGAAATGATCTCCTGAATATT ATTCGAGAAAAGAACTTGGCCCATCCTGTTATCCAGAACTTTTCATATGAGACCTTCCAGCAGAAGATGCTGCGCTTCCTGGAGAGCCAC CTGGATGACGCCGAGCCCTACCTCCTCACGATGGCCAAAAAGGCTTTGAAATCTGAGTCCGCTGCCTCAAGTACAGGGAAGGAAGATAAA CAGCCAGCACCAGGGCCTGTGGAAAAGCCACCCAGAGAACCCGCAAGGCAGCTACGGAATCCTCCAACCACCATTGGAATGATGACTCTG AAAGCAGCTTTCAAGACTCTGTCTGGTGCACAGGATTCTGAGGCAGCCTTTGCAAAACTGGACCAGAAGGATCTGGTTCTTCCTACTCAA GCTCTCCCAGCATCACCAGCCCTCAAAAACAAGAGACCCAGAAAAGATGAAAACGAAAGTTCAGCCCCGGCTGACGGTGAGGGTGGCTCG GAACTGCAGCCCAAGAACAAGCGCATGACAATAAGCAGATTGGTCTTGGAGGAGGACAGCCAGAGTACTGAGCCCAGCGCAGGCCTCAAC TCCTCCCAGGAGGCCGCTTCAGCGCCACCATCCAAGCCCACCGTTCTCAACCAACCCCTCCCTGGAGAGAAGAATCCCAAAGTACCCAAA GGCAAGTGGAACAGCTCTAATGGGGTTGAAGAAAAGGAGACTTGGGTGGAAGAGGATGAACTGTTTCAAGTTCAGGCAGCACCAGATGAA GACAGTACAACCAATATAACAAAAAAGCAGAAGTGGACTGTAGAAGAAAGCGAGTGGGTCAAGGCTGGAGTGCAGAAATATGGGGAAGGA AACTGGGCTGCCATTTCTAAAAATTACCCATTTGTTAACCGAACAGCTGTGATGATTAAGGATCGCTGGCGGACCATGAAAAGACTTGGC ATGAACTGAAACAGGCTTTCATTTCCACAGAATTCACAGGAGCATGGTTCCTAATAATAGCCCCTGATAGTCTGCTCTTTCTTTCTTTTT CTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCGACCTCCGTCTC CCGGGCTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCATCACGCCCGGCTAATGTTTTGTATTTTT AGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCAACTCGGCCTCCCAAAGTGCTGGGA TTACAGGCATGAGCCACCGCGCCTGGCATCTGCTGTTTCTTTCAGAAGCTGGGCTGGGATGAGAATTTTGGGCAACCTCCTTCGACGTGG GGGAGGTCCCATTTCCACTTCATCACTGTTGGAGATCATGGAGCTAAGAAGCAGAGCCAAGTCCACCCATGTCCTTGGCAGAGATGACAG GCACACAGCTTGTGCAGTGCCAGAATATCATTAGCGTTTCCCTTCTTTAGTGGTTTGCTTAAATTTAAATCCCTGGTAATCTGTAGAACC TTCTCCTAGGAAATGGTGAAGTCTATTAGGAGCCACTTGTGACTCCATGACCTGTTAAAACCAGCAATGTGAGTATTATTTGGAGTAAAT TTGTTCCACGTCAAGTTCTGGCCTTCTGATGCAAATGCAAAGGAACTTAGTCTGTTATGAACCCAGGTTGATGACAGACCAGTCCTTGTG GAATAAGATTCCCTTTAAAAACTCTTTAGCCAGTCGTGACATCAACCCTAGACCTGTCTGCCTTGGCATTTGCTGTCAACATCTGCTGGG CTATGTAGGCAGGTTAATCCTCCACTTCTCATGTGGTTGAACCAGTGTGTTTTTTGGTAAAATGGTGATTGTAGATAAGATTAGTTCCCT GATCCCCTGCCCCCTGTCCCCTGCCTCTTTTCCCAATTCCCTTCCTTATGCTGGACTTTTAAAGCTTAAAAAAAATCCGATTGAATATAA ATGCCTAATTTCATTCTTTGTGAAATGGTTGCTTCCTCCTGATTCCCTAATTGTGCTGTGTTCGTGTCTTGCACTGGAATTCAACATTCC CTTCTCCTTTTGTACTGTGTTGTGCTTGCTGTCTCTCCCGGACACCCTTAAAGACTGTCTTTTTAGCAAAAAATTTCAGTAAAGTGTTTT >In-frame_EMP2_ENST00000359543_chr16_10637427_-_TERF2_ENST00000603068_chr16_69419389_-_2895nt GGCGGGATCGGGGAAGGAGGGGCCCCGCCGCCTAGAGGGTGGAGGGAGGGCGCGCAGTCCCAGCCCAGAGCTTCAAAACAGCCCGGCGGC CTCGCCTCGCACCCCCAGCCAGTCCGTCGATCCAGCTGCCAGCGCAGCCGCCAGCGCCGGCACATCCCGCTCTGGGCTTTAAACGTGACC CCTCGCCTCGACTCGCCCTGCCCTGTGAAAATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAGCCTTGCTGTTC ATTGCCACCGTCGACAATGCCTGGTGGGTAGGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGAATTGCACAGTC ATCAATGACAGCTTTCAAGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGCAGTGTCTGTCG CGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATGTGCTGGAGATG ATTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGCTGTCATTATTTGTATCAAAAAC AAAGAATTTGAAAAGGCTTCAAAAATTTTGAAAAAACATATGTCCAAGGACCCCACAACTCAGAAGCTGAGAAATGATCTCCTGAATATT ATTCGAGAAAAGAACTTGGCCCATCCTGTTATCCAGAACTTTTCATATGAGACCTTCCAGCAGAAGATGCTGCGCTTCCTGGAGAGCCAC CTGGATGACGCCGAGCCCTACCTCCTCACGATGGCCAAAAAGGCTTTGAAATCTGAGTCCGCTGCCTCAAGTACAGGGAAGGAAGATAAA CAGCCAGCACCAGGGCCTGTGGAAAAGCCACCCAGAGAACCCGCAAGGCAGCTACGGAATCCTCCAACCACCATTGGAATGATGACTCTG AAAGCAGCTTTCAAGACTCTGTCTGGTGCACAGGATTCTGAGGCAGCCTTTGCAAAACTGGACCAGAAGGATCTGGTTCTTCCTACTCAA GCTCTCCCAGCATCACCAGCCCTCAAAAACAAGAGACCCAGAAAAGATGAAAACGAAAGTTCAGCCCCGGCTGACGGTGAGGGTGGCTCG GAACTGCAGCCCAAGAACAAGCGCATGACAATAAGCAGATTGGTCTTGGAGGAGGACAGCCAGAGTACTGAGCCCAGCGCAGGCCTCAAC TCCTCCCAGGAGGCCGCTTCAGCGCCACCATCCAAGCCCACCGTTCTCAACCAACCCCTCCCTGGAGAGAAGAATCCCAAAGTACCCAAA GGCAAGTGGAACAGCTCTAATGGGGTTGAAGAAAAGGAGACTTGGGTGGAAGAGGATGAACTGTTTCAAGTTCAGGCAGCACCAGATGAA GACAGTACAACCAATATAACAAAAAAGCAGAAGTGGACTGTAGAAGAAAGCGAGTGGGTCAAGGCTGGAGTGCAGAAATATGGGGAAGGA AACTGGGCTGCCATTTCTAAAAATTACCCATTTGTTAACCGAACAGCTGTGATGATTAAGGATCGCTGGCGGACCATGAAAAGACTTGGC ATGAACTGAAACAGGCTTTCATTTCCACAGAATTCACAGGAGCATGGTTCCTAATAATAGCCCCTGATAGTCTGCTCTTTCTTTCTTTTT CTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCGACCTCCGTCTC CCGGGCTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCATCACGCCCGGCTAATGTTTTGTATTTTT AGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCAACTCGGCCTCCCAAAGTGCTGGGA TTACAGGCATGAGCCACCGCGCCTGGCATCTGCTGTTTCTTTCAGAAGCTGGGCTGGGATGAGAATTTTGGGCAACCTCCTTCGACGTGG GGGAGGTCCCATTTCCACTTCATCACTGTTGGAGATCATGGAGCTAAGAAGCAGAGCCAAGTCCACCCATGTCCTTGGCAGAGATGACAG GCACACAGCTTGTGCAGTGCCAGAATATCATTAGCGTTTCCCTTCTTTAGTGGTTTGCTTAAATTTAAATCCCTGGTAATCTGTAGAACC TTCTCCTAGGAAATGGTGAAGTCTATTAGGAGCCACTTGTGACTCCATGACCTGTTAAAACCAGCAATGTGAGTATTATTTGGAGTAAAT TTGTTCCACGTCAAGTTCTGGCCTTCTGATGCAAATGCAAAGGAACTTAGTCTGTTATGAACCCAGGTTGATGACAGACCAGTCCTTGTG GAATAAGATTCCCTTTAAAAACTCTTTAGCCAGTCGTGACATCAACCCTAGACCTGTCTGCCTTGGCATTTGCTGTCAACATCTGCTGGG CTATGTAGGCAGGTTAATCCTCCACTTCTCATGTGGTTGAACCAGTGTGTTTTTTGGTAAAATGGTGATTGTAGATAAGATTAGTTCCCT GATCCCCTGCCCCCTGTCCCCTGCCTCTTTTCCCAATTCCCTTCCTTATGCTGGACTTTTAAAGCTTAAAAAAAATCCGATTGAATATAA ATGCCTAATTTCATTCTTTGTGAAATGGTTGCTTCCTCCTGATTCCCTAATTGTGCTGTGTTCGTGTCTTGCACTGGAATTCAACATTCC CTTCTCCTTTTGTACTGTGTTGTGCTTGCTGTCTCTCCCGGACACCCTTAAAGACTGTCTTTTTAGCAAAAAATTTCAGTAAAGTGTTTT >In-frame_EMP2_ENST00000536829_chr16_10637427_-_TERF2_ENST00000254942_chr16_69419389_-_2977nt GGCCTGGGAGTCCTTGCAGGGTGGCCTGGGTGACTGCTCACCAGCCCGGCCCTCCCCAGGGTTCTGGGCCAGAGCCTCCCTGGCCGTTGG AGCGGGAGCTGTGGGTGGAACACTTCTGAATTGGGAGATTGCCTCGGACCTCCAGACGCCGAACATCTCAGCACATCCCGCTCTGGGCTT TAAACGTGACCCCTCGCCTCGACTCGCCCTGCCCTGTGAAAATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAG CCTTGCTGTTCATTGCCACCGTCGACAATGCCTGGTGGGTAGGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGA ATTGCACAGTCATCAATGACAGCTTTCAAGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGC AGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATG TGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGCTGTCATTATTT GTATCAAAAACAAAGAATTTGAAAAGGCTTCAAAAATTTTGAAAAAACATATGTCCAAGGACCCCACAACTCAGAAGCTGAGAAATGATC TCCTGAATATTATTCGAGAAAAGAACTTGGCCCATCCTGTTATCCAGAACTTTTCATATGAGACCTTCCAGCAGAAGATGCTGCGCTTCC TGGAGAGCCACCTGGATGACGCCGAGCCCTACCTCCTCACGATGGCCAAAAAGGCTTTGAAATCTGAGTCCGCTGCCTCAAGTACAGGGA AGGAAGATAAACAGCCAGCACCAGGGCCTGTGGAAAAGCCACCCAGAGAACCCGCAAGGCAGCTACGGAATCCTCCAACCACCATTGGAA TGATGACTCTGAAAGCAGCTTTCAAGACTCTGTCTGGTGCACAGGATTCTGAGGCAGCCTTTGCAAAACTGGACCAGAAGGATCTGGTTC TTCCTACTCAAGCTCTCCCAGCATCACCAGCCCTCAAAAACAAGAGACCCAGAAAAGATGAAAACGAAAGTTCAGCCCCGGCTGACGGTG AGGGTGGCTCGGAACTGCAGCCCAAGAACAAGCGCATGACAATAAGCAGATTGGTCTTGGAGGAGGACAGCCAGAGTACTGAGCCCAGCG CAGGCCTCAACTCCTCCCAGGAGGCCGCTTCAGCGCCACCATCCAAGCCCACCGTTCTCAACCAACCCCTCCCTGGAGAGAAGAATCCCA AAGTACCCAAAGGCAAGTGGAACAGCTCTAATGGGGTTGAAGAAAAGGAGACTTGGGTGGAAGAGGATGAACTGTTTCAAGTTCAGGCAG CACCAGATGAAGACAGTACAACCAATATAACAAAAAAGCAGAAGTGGACTGTAGAAGAAAGCGAGTGGGTCAAGGCTGGAGTGCAGAAAT ATGGGGAAGGAAACTGGGCTGCCATTTCTAAAAATTACCCATTTGTTAACCGAACAGCTGTGATGATTAAGGATCGCTGGCGGACCATGA AAAGACTTGGCATGAACTGAAACAGGCTTTCATTTCCACAGAATTCACAGGAGCATGGTTCCTAATAATAGCCCCTGATAGTCTGCTCTT TCTTTCTTTTTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCG ACCTCCGTCTCCCGGGCTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCATCACGCCCGGCTAATGT TTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCAACTCGGCCTCCCA AAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCATCTGCTGTTTCTTTCAGAAGCTGGGCTGGGATGAGAATTTTGGGCAACCTC CTTCGACGTGGGGGAGGTCCCATTTCCACTTCATCACTGTTGGAGATCATGGAGCTAAGAAGCAGAGCCAAGTCCACCCATGTCCTTGGC AGAGATGACAGGCACACAGCTTGTGCAGTGCCAGAATATCATTAGCGTTTCCCTTCTTTAGTGGTTTGCTTAAATTTAAATCCCTGGTAA TCTGTAGAACCTTCTCCTAGGAAATGGTGAAGTCTATTAGGAGCCACTTGTGACTCCATGACCTGTTAAAACCAGCAATGTGAGTATTAT TTGGAGTAAATTTGTTCCACGTCAAGTTCTGGCCTTCTGATGCAAATGCAAAGGAACTTAGTCTGTTATGAACCCAGGTTGATGACAGAC CAGTCCTTGTGGAATAAGATTCCCTTTAAAAACTCTTTAGCCAGTCGTGACATCAACCCTAGACCTGTCTGCCTTGGCATTTGCTGTCAA CATCTGCTGGGCTATGTAGGCAGGTTAATCCTCCACTTCTCATGTGGTTGAACCAGTGTGTTTTTTGGTAAAATGGTGATTGTAGATAAG ATTAGTTCCCTGATCCCCTGCCCCCTGTCCCCTGCCTCTTTTCCCAATTCCCTTCCTTATGCTGGACTTTTAAAGCTTAAAAAAAATCCG ATTGAATATAAATGCCTAATTTCATTCTTTGTGAAATGGTTGCTTCCTCCTGATTCCCTAATTGTGCTGTGTTCGTGTCTTGCACTGGAA TTCAACATTCCCTTCTCCTTTTGTACTGTGTTGTGCTTGCTGTCTCTCCCGGACACCCTTAAAGACTGTCTTTTTAGCAAAAAATTTCAG TAAAGTGTTTTCTGTAATCTTTTTTTAAAAGGTGAGAACTAATTATTGTCCATACTTGTAGCATTCTTCATTAAAGTCTTGCTTCTCTCA >In-frame_EMP2_ENST00000536829_chr16_10637427_-_TERF2_ENST00000603068_chr16_69419389_-_2906nt GGCCTGGGAGTCCTTGCAGGGTGGCCTGGGTGACTGCTCACCAGCCCGGCCCTCCCCAGGGTTCTGGGCCAGAGCCTCCCTGGCCGTTGG AGCGGGAGCTGTGGGTGGAACACTTCTGAATTGGGAGATTGCCTCGGACCTCCAGACGCCGAACATCTCAGCACATCCCGCTCTGGGCTT TAAACGTGACCCCTCGCCTCGACTCGCCCTGCCCTGTGAAAATGTTGGTGCTTCTTGCTTTCATCATCGCCTTCCACATCACCTCTGCAG CCTTGCTGTTCATTGCCACCGTCGACAATGCCTGGTGGGTAGGAGATGAGTTTTTTGCAGATGTCTGGAGAATATGTACCAACAACACGA ATTGCACAGTCATCAATGACAGCTTTCAAGCTTTGCTTGTCAGGCCCTTGGGGAAGGAGCACACCGTGTCCCGATTGCTGCGGGTTATGC AGTGTCTGTCGCGGATTGAAGAAGGGGAAAATTTAGACTGTTCCTTTGATATGGAGGCTGAGCTCACACCACTGGAATCAGCTATCAATG TGCTGGAGATGATTAAAACGGAATTTACACTGACAGAAGCAGTGGTCGAATCCAGTAGAAAACTGGTCAAGGAAGCTGCTGTCATTATTT GTATCAAAAACAAAGAATTTGAAAAGGCTTCAAAAATTTTGAAAAAACATATGTCCAAGGACCCCACAACTCAGAAGCTGAGAAATGATC TCCTGAATATTATTCGAGAAAAGAACTTGGCCCATCCTGTTATCCAGAACTTTTCATATGAGACCTTCCAGCAGAAGATGCTGCGCTTCC TGGAGAGCCACCTGGATGACGCCGAGCCCTACCTCCTCACGATGGCCAAAAAGGCTTTGAAATCTGAGTCCGCTGCCTCAAGTACAGGGA AGGAAGATAAACAGCCAGCACCAGGGCCTGTGGAAAAGCCACCCAGAGAACCCGCAAGGCAGCTACGGAATCCTCCAACCACCATTGGAA TGATGACTCTGAAAGCAGCTTTCAAGACTCTGTCTGGTGCACAGGATTCTGAGGCAGCCTTTGCAAAACTGGACCAGAAGGATCTGGTTC TTCCTACTCAAGCTCTCCCAGCATCACCAGCCCTCAAAAACAAGAGACCCAGAAAAGATGAAAACGAAAGTTCAGCCCCGGCTGACGGTG AGGGTGGCTCGGAACTGCAGCCCAAGAACAAGCGCATGACAATAAGCAGATTGGTCTTGGAGGAGGACAGCCAGAGTACTGAGCCCAGCG CAGGCCTCAACTCCTCCCAGGAGGCCGCTTCAGCGCCACCATCCAAGCCCACCGTTCTCAACCAACCCCTCCCTGGAGAGAAGAATCCCA AAGTACCCAAAGGCAAGTGGAACAGCTCTAATGGGGTTGAAGAAAAGGAGACTTGGGTGGAAGAGGATGAACTGTTTCAAGTTCAGGCAG CACCAGATGAAGACAGTACAACCAATATAACAAAAAAGCAGAAGTGGACTGTAGAAGAAAGCGAGTGGGTCAAGGCTGGAGTGCAGAAAT ATGGGGAAGGAAACTGGGCTGCCATTTCTAAAAATTACCCATTTGTTAACCGAACAGCTGTGATGATTAAGGATCGCTGGCGGACCATGA AAAGACTTGGCATGAACTGAAACAGGCTTTCATTTCCACAGAATTCACAGGAGCATGGTTCCTAATAATAGCCCCTGATAGTCTGCTCTT TCTTTCTTTTTCTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCG ACCTCCGTCTCCCGGGCTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCATCACGCCCGGCTAATGT TTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCAACTCGGCCTCCCA AAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCATCTGCTGTTTCTTTCAGAAGCTGGGCTGGGATGAGAATTTTGGGCAACCTC CTTCGACGTGGGGGAGGTCCCATTTCCACTTCATCACTGTTGGAGATCATGGAGCTAAGAAGCAGAGCCAAGTCCACCCATGTCCTTGGC AGAGATGACAGGCACACAGCTTGTGCAGTGCCAGAATATCATTAGCGTTTCCCTTCTTTAGTGGTTTGCTTAAATTTAAATCCCTGGTAA TCTGTAGAACCTTCTCCTAGGAAATGGTGAAGTCTATTAGGAGCCACTTGTGACTCCATGACCTGTTAAAACCAGCAATGTGAGTATTAT TTGGAGTAAATTTGTTCCACGTCAAGTTCTGGCCTTCTGATGCAAATGCAAAGGAACTTAGTCTGTTATGAACCCAGGTTGATGACAGAC CAGTCCTTGTGGAATAAGATTCCCTTTAAAAACTCTTTAGCCAGTCGTGACATCAACCCTAGACCTGTCTGCCTTGGCATTTGCTGTCAA CATCTGCTGGGCTATGTAGGCAGGTTAATCCTCCACTTCTCATGTGGTTGAACCAGTGTGTTTTTTGGTAAAATGGTGATTGTAGATAAG ATTAGTTCCCTGATCCCCTGCCCCCTGTCCCCTGCCTCTTTTCCCAATTCCCTTCCTTATGCTGGACTTTTAAAGCTTAAAAAAAATCCG ATTGAATATAAATGCCTAATTTCATTCTTTGTGAAATGGTTGCTTCCTCCTGATTCCCTAATTGTGCTGTGTTCGTGTCTTGCACTGGAA TTCAACATTCCCTTCTCCTTTTGTACTGTGTTGTGCTTGCTGTCTCTCCCGGACACCCTTAAAGACTGTCTTTTTAGCAAAAAATTTCAG |
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FusionGenePPI for EMP2_TERF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EMP2 | EPM2AIP1, GLP1R | TERF2 | BLM, WRN, TINF2, RAD50, XRCC5, TERF2IP, XRCC6, MRE11A, NBN, MUS81, DCLRE1B, ORC1, ORC2, ORC3, ORC6, SLX4, BRCA1, PRMT1, ZC3HAV1L, RBM15B, POT1, PLAT, KPNA2, TERF1, STUB1, YY1, RBM33, PABPC4, MCCC2, CSNK2B, BMP2K, CYFIP1, DDX3X, SF3B4, S100A8, HSPA4, ACTN1, MCM7, DDB1, PRDX4, RASGEF1C, CDK9, FBXO21, BAIAP2L1, CHD8, TOX4, CLK3, SEC16A, DNAJB11, TLN1, MYO10, ABCD1, S100A7, HSP90AB2P, KPNB1, USP9X, CSNK2A2, PLOD2, RING1, ZNF281, FOXJ3, LARP7, IRS4, SAP30BP, DST, UGDH, ERH, PITRM1, MYH10, ATP2B1, ATP2B3, CARM1, SLTM, NT5DC2, THRAP3, CALD1, HSP90B1, ACLY, PRPS1L1, IDH3A, HSPH1, MACROD2, BAG3, TNKS, CCNT1, MYH9, TBPL1, RPS8, KCTD15, PLOD1, TBX1, RSBN1L, TRPC5, GTF2A2, POLD1, SYNE1, POLDIP3, RPS6, AP2A2, ZNF703, G3BP2, SEC24B, CCNT2, OSBPL11, SKIV2L2, ZGPAT, CHD7, KIAA1429, MACF1, SMC3, C20orf27, PCMT1, GANAB, PRMT5, KIAA2022, TDRD6, SYNE2, CENPF, TAF2, RYR2, ATN1, CDC37, CDK13, RNF40, UTRN, DMD, RALGAPA1, DNAJA2, GTF2A1, DHX33, KIF13B, ARHGAP20, MCM3AP, RAVER1, EDC3, U2AF2, PRDX3, IVD, LDOC1L, ARMC6, SRSF11, SNRNP70, MARK3, PFKL, CLASRP, DKC1, FXR2, DARS2, SDF2L1, TBC1D15, CLPB, USP15, PAXBP1, HSPA4L, REPIN1, DHX40, LLGL1, MYOM2, BRD2, KIAA0430, ZC3H13, NFRKB, DHX37, REV3L, SRRM2, MECP2, TCOF1, PYCR2, NME4, DUSP11, BCKDK, TRIM47, SNX22, WDR5, EEFSEC, AASS, GPATCH8, OSBPL9, ZKSCAN4, TFIP11, CYLC2, PCBP1, ACD, TERF2, SIAH1, ELAVL1, HMGN1, RNF113A, NCL, RPRD1B, HMGN2, RPL13, H2AFX, CCDC137, ASS1, WDR4, LYAR, DDX21, HDGFRP2, ZC3H18, HEXIM1, HEXIM2, SRSF6, NASP, HMGB1, NAIF1, CTBP1, LANCL2, MAGOHB, BANP, TOR1AIP1, SET, PTMA, TALDO1, APEX1, DDX24, OCM2, PPM1G, HMGN4, SP100, NUMA1, HMGN3, DDX39A, ANXA5, TMSB10, NXNL1, AFAP1L2, GNMT, REST, TFAP4, TEP1, HSP90AA1, TOP2A, SF3B2, TOP3A, HMGA1, VCP, ATM, RPA3, RPA2, RPA1, EP300, BMI1, PRPF40A, CCDC106, TEX264, FBL, TADA2B, CHAMP1, NUMB, PIK3R3, HIST1H2BG, PIAS1, UBE2I, RNF4, AKTIP, PPP1CA, ARL4D, XAGE1B, FGFRL1, ARL4C, HEXA, PTRF, UCHL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EMP2_TERF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EMP2_TERF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EMP2 | C4014507 | NEPHROTIC SYNDROME, TYPE 10 | 1 | UNIPROT |
| Tgene | TERF2 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
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