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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 11563

FusionGeneSummary for EML4_EPHA3

check button Fusion gene summary
Fusion gene informationFusion gene name: EML4_EPHA3
Fusion gene ID: 11563
HgeneTgene
Gene symbol

EML4

EPHA3

Gene ID

27436

2042

Gene nameechinoderm microtubule associated protein like 4EPH receptor A3
SynonymsC2orf2|ELP120|EMAP-4|EMAPL4|ROPP120EK4|ETK|ETK1|HEK|HEK4|TYRO4
Cytomap

2p21

3p11.1

Type of geneprotein-codingprotein-coding
Descriptionechinoderm microtubule-associated protein-like 4restrictedly overexpressed proliferation-associated proteinropp 120ephrin type-A receptor 3EPH-like kinase 4TYRO4 protein tyrosine kinaseeph-like tyrosine kinase 1human embryo kinase 1testicular tissue protein Li 64tyrosine-protein kinase receptor ETK1
Modification date2018052320180523
UniProtAcc

Q9HC35

P29320

Ensembl transtripts involved in fusion geneENST00000318522, ENST00000402711, 
ENST00000482660, ENST00000401738, 
ENST00000453191, 		ENST00000336596, 
ENST00000452448, ENST00000494014, 
Fusion gene scores* DoF score9 X 17 X 13=19894 X 4 X 4=64
# samples 274
** MAII scorelog2(27/1989*10)=-2.88101196378291
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EML4 [Title/Abstract] AND EPHA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEPHA3

GO:0018108

peptidyl-tyrosine phosphorylation

11877430

TgeneEPHA3

GO:0032956

regulation of actin cytoskeleton organization

11870224

TgeneEPHA3

GO:0043087

regulation of GTPase activity

11870224

TgeneEPHA3

GO:0045806

negative regulation of endocytosis

11877430

TgeneEPHA3

GO:0048013

ephrin receptor signaling pathway

11870224

TgeneEPHA3

GO:0051893

regulation of focal adhesion assembly

11870224

TgeneEPHA3

GO:0070507

regulation of microtubule cytoskeleton organization

11870224

TgeneEPHA3

GO:1903078

positive regulation of protein localization to plasma membrane

11877430


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-IG-A8O2-01AEML4chr2

42528532

+EPHA3chr3

89498375

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000318522ENST00000336596EML4chr2

42528532

+EPHA3chr3

89498375

+
5CDS-intronENST00000318522ENST00000452448EML4chr2

42528532

+EPHA3chr3

89498375

+
5CDS-intronENST00000318522ENST00000494014EML4chr2

42528532

+EPHA3chr3

89498375

+
In-frameENST00000402711ENST00000336596EML4chr2

42528532

+EPHA3chr3

89498375

+
5CDS-intronENST00000402711ENST00000452448EML4chr2

42528532

+EPHA3chr3

89498375

+
5CDS-intronENST00000402711ENST00000494014EML4chr2

42528532

+EPHA3chr3

89498375

+
intron-3CDSENST00000482660ENST00000336596EML4chr2

42528532

+EPHA3chr3

89498375

+
intron-intronENST00000482660ENST00000452448EML4chr2

42528532

+EPHA3chr3

89498375

+
intron-intronENST00000482660ENST00000494014EML4chr2

42528532

+EPHA3chr3

89498375

+
In-frameENST00000401738ENST00000336596EML4chr2

42528532

+EPHA3chr3

89498375

+
5CDS-intronENST00000401738ENST00000452448EML4chr2

42528532

+EPHA3chr3

89498375

+
5CDS-intronENST00000401738ENST00000494014EML4chr2

42528532

+EPHA3chr3

89498375

+
5UTR-3CDSENST00000453191ENST00000336596EML4chr2

42528532

+EPHA3chr3

89498375

+
5UTR-intronENST00000453191ENST00000452448EML4chr2

42528532

+EPHA3chr3

89498375

+
5UTR-intronENST00000453191ENST00000494014EML4chr2

42528532

+EPHA3chr3

89498375

+

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FusionProtFeatures for EML4_EPHA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EML4

Q9HC35

EPHA3

P29320

Receptor tyrosine kinase which binds promiscuouslymembrane-bound ephrin family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling intoneighboring cells. The signaling pathway downstream of thereceptor is referred to as forward signaling while the signalingpathway downstream of the ephrin ligand is referred to as reversesignaling. Highly promiscuous for ephrin-A ligands it bindspreferentially EFNA5. Upon activation by EFNA5 regulates cell-celladhesion, cytoskeletal organization and cell migration. Plays arole in cardiac cells migration and differentiation and regulatesthe formation of the atrioventricular canal and septum duringdevelopment probably through activation by EFNA1. Involved in theretinotectal mapping of neurons. May also control the segregationbut not the guidance of motor and sensory axons duringneuromuscular circuit development. {ECO:0000269|PubMed:11870224}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423259_297547982RepeatNote=WD 1
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423301_348547982RepeatNote=WD 2
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423356_396547982RepeatNote=WD 3
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423403_438547982RepeatNote=WD 4
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423445_484547982RepeatNote=WD 5
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423500_538547982RepeatNote=WD 6
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322259_297489924RepeatNote=WD 1
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322301_348489924RepeatNote=WD 2
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322356_396489924RepeatNote=WD 3
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322403_438489924RepeatNote=WD 4
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322445_484489924RepeatNote=WD 5
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07189_322-29540Compositional biasNote=Cys-rich
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217911_975782984DomainSAM
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+0729_207-29540DomainEph LBD
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07325_435-29540DomainFibronectin type-III 1
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07436_531-29540DomainFibronectin type-III 2
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07621_882-29540DomainProtein kinase
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07911_975-29540DomainSAM
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217981_983782984MotifPDZ-binding
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07981_983-29540MotifPDZ-binding
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07628_633-29540Nucleotide bindingNote=ATP
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07700_706-29540Nucleotide bindingNote=ATP
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07750_751-29540Nucleotide bindingNote=ATP
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+0721_541-29540Topological domainExtracellular
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07566_983-29540Topological domainCytoplasmic
TgeneEPHA3chr2:42528532chr3:89498375ENST00000452448+07542_565-29540TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423543_579547982RepeatNote=WD 7
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423582_621547982RepeatNote=WD 8
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423625_662547982RepeatNote=WD 9
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423668_704547982RepeatNote=WD 10
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423711_750547982RepeatNote=WD 11
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423760_818547982RepeatNote=WD 12
HgeneEML4chr2:42528532chr3:89498375ENST00000318522+1423825_864547982RepeatNote=WD 13
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322500_538489924RepeatNote=WD 6
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322543_579489924RepeatNote=WD 7
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322582_621489924RepeatNote=WD 8
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322625_662489924RepeatNote=WD 9
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322668_704489924RepeatNote=WD 10
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322711_750489924RepeatNote=WD 11
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322760_818489924RepeatNote=WD 12
HgeneEML4chr2:42528532chr3:89498375ENST00000402711+1322825_864489924RepeatNote=WD 13
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217189_322782984Compositional biasNote=Cys-rich
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+121729_207782984DomainEph LBD
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217325_435782984DomainFibronectin type-III 1
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217436_531782984DomainFibronectin type-III 2
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217621_882782984DomainProtein kinase
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217628_633782984Nucleotide bindingNote=ATP
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217700_706782984Nucleotide bindingNote=ATP
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217750_751782984Nucleotide bindingNote=ATP
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+121721_541782984Topological domainExtracellular
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217566_983782984Topological domainCytoplasmic
TgeneEPHA3chr2:42528532chr3:89498375ENST00000336596+1217542_565782984TransmembraneHelical


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FusionGeneSequence for EML4_EPHA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_EML4_ENST00000318522_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_749aa
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN
RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGK
DCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLG
TFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTRKQGIF
GKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDL
NPEREIEGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDR
NNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVG

>In-frame_EML4_ENST00000402711_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_691aa
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN
RKPSHTSAVSIAGKETLSSAAKSIKRPSPAEKSHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQEGEYIKMFMRGRPITM
FIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQ
IAGVDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFH
PTDANTIITCGKSHIFFWTWSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAH
DGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDV
IKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGV

>In-frame_EML4_ENST00000401738_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_760aa
MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVASVKKSVSSKGQPSPRAVIPMSCITNGSGAN
RKPSHTSAVSIAGKETLSSAAKSGTEKKKEKPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKL
KLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSV
TLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWS
GNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGGGK
DRKIILWDHDLNPEREIEGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALY
QLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_EML4_ENST00000318522_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_2247nt
ATGGACGGTTTCGCCGGCAGTCTCGATGATAGTATTTCTGCTGCAAGTACTTCTGATGTTCAAGATCGCCTGTCAGCTCTTGAGTCACGA
GTTCAGCAACAAGAAGATGAAATCACTGTGCTAAAGGCGGCTTTGGCTGATGTTTTGAGGCGTCTTGCAATCTCTGAAGATCATGTGGCC
TCAGTGAAAAAATCAGTCTCAAGTAAAGGCCAACCAAGCCCTCGAGCAGTTATTCCCATGTCCTGTATAACCAATGGAAGTGGTGCAAAC
AGAAAACCAAGTCATACCAGTGCTGTCTCAATTGCAGGAAAAGAAACTCTTTCATCTGCTGCTAAAAGTGGTACAGAAAAAAAGAAAGAA
AAACCACAAGGACAGAGAGAAAAAAAAGAGGAATCTCATTCTAATGATCAAAGTCCACAAATTCGAGCATCACCTTCTCCCCAGCCCTCT
TCACAACCTCTCCAAATACACAGACAAACTCCAGAAAGCAAGAATGCTACTCCCACCAAAAGCATAAAACGACCATCACCAGCTGAAAAG
TCACATAATTCTTGGGAAAATTCAGATGATAGCCGTAATAAATTGTCGAAAATACCTTCAACACCCAAATTAATACCAAAAGTTACCAAA
ACTGCAGACAAGCATAAAGATGTCATCATCAACCAAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTTCATT
CCTTCCGATGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGAGGAAAG
GACTGTAGAGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAGGAGAGA
ACTCAGCGACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAGATAGCT
GGCGTGGATAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACTTGGC
ACTTTTGAGCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAGCATATG
CTTACTGTATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCCAACA
GATGCAAATACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGAATTTTT
GGGAAATATGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTT
ATATGGAGCAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCATGATGGC
AGTGTGTTCACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCATGATCTG
AATCCTGAAAGAGAAATAGAGGGAGGGAAGATCCCAATCAGGTGGACATCACCAGAAGCTATAGCCTACCGCAAGTTCACGTCAGCCAGC
GATGTATGGAGTTATGGGATTGTTCTCTGGGAGGTGATGTCTTATGGAGAGAGACCATACTGGGAGATGTCCAATCAGGATGTAATTAAA
GCTGTAGATGAGGGCTATCGACTGCCACCCCCCATGGACTGCCCAGCTGCCTTGTATCAGCTGATGCTGGACTGCTGGCAGAAAGACAGG
AACAACAGACCCAAGTTTGAGCAGATTGTTAGTATTCTGGACAAGCTTATCCGGAATCCCGGCAGCCTGAAGATCATCACCAGTGCAGCC
GCAAGGCCATCAAACCTTCTTCTGGACCAAAGCAATGTGGATATCACTACCTTCCGCACAACAGGTGACTGGCTTAATGGTGTCTGGACA
GCACACTGCAAGGAAATCTTCACGGGTGTGGAGTACAGTTCTTGTGACACAATAGCCAAGATTTCCACAGATGACATGAAAAAGGTTGGT

>In-frame_EML4_ENST00000402711_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_2073nt
ATGGACGGTTTCGCCGGCAGTCTCGATGATAGTATTTCTGCTGCAAGTACTTCTGATGTTCAAGATCGCCTGTCAGCTCTTGAGTCACGA
GTTCAGCAACAAGAAGATGAAATCACTGTGCTAAAGGCGGCTTTGGCTGATGTTTTGAGGCGTCTTGCAATCTCTGAAGATCATGTGGCC
TCAGTGAAAAAATCAGTCTCAAGTAAAGGCCAACCAAGCCCTCGAGCAGTTATTCCCATGTCCTGTATAACCAATGGAAGTGGTGCAAAC
AGAAAACCAAGTCATACCAGTGCTGTCTCAATTGCAGGAAAAGAAACTCTTTCATCTGCTGCTAAAAGCATAAAACGACCATCACCAGCT
GAAAAGTCACATAATTCTTGGGAAAATTCAGATGATAGCCGTAATAAATTGTCGAAAATACCTTCAACACCCAAATTAATACCAAAAGTT
ACCAAAACTGCAGACAAGCATAAAGATGTCATCATCAACCAAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATG
TTCATTCCTTCCGATGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGA
GGAAAGGACTGTAGAGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAG
GAGAGAACTCAGCGACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAG
ATAGCTGGCGTGGATAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGA
CTTGGCACTTTTGAGCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAG
CATATGCTTACTGTATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCAC
CCAACAGATGCAAATACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGA
ATTTTTGGGAAATATGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTC
ATGCTTATATGGAGCAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCAT
GATGGCAGTGTGTTCACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCAT
GATCTGAATCCTGAAAGAGAAATAGAGGGAGGGAAGATCCCAATCAGGTGGACATCACCAGAAGCTATAGCCTACCGCAAGTTCACGTCA
GCCAGCGATGTATGGAGTTATGGGATTGTTCTCTGGGAGGTGATGTCTTATGGAGAGAGACCATACTGGGAGATGTCCAATCAGGATGTA
ATTAAAGCTGTAGATGAGGGCTATCGACTGCCACCCCCCATGGACTGCCCAGCTGCCTTGTATCAGCTGATGCTGGACTGCTGGCAGAAA
GACAGGAACAACAGACCCAAGTTTGAGCAGATTGTTAGTATTCTGGACAAGCTTATCCGGAATCCCGGCAGCCTGAAGATCATCACCAGT
GCAGCCGCAAGGCCATCAAACCTTCTTCTGGACCAAAGCAATGTGGATATCACTACCTTCCGCACAACAGGTGACTGGCTTAATGGTGTC
TGGACAGCACACTGCAAGGAAATCTTCACGGGTGTGGAGTACAGTTCTTGTGACACAATAGCCAAGATTTCCACAGATGACATGAAAAAG
GTTGGTGTCACCGTGGTTGGGCCACAGAAGAAGATCATCAGTAGCATTAAAGCTCTAGAAACGCAATCAAAGAATGGCCCAGTTCCCGTG

>In-frame_EML4_ENST00000401738_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_2280nt
ATGGACGGTTTCGCCGGCAGTCTCGATGATAGTATTTCTGCTGCAAGTACTTCTGATGTTCAAGATCGCCTGTCAGCTCTTGAGTCACGA
GTTCAGCAACAAGAAGATGAAATCACTGTGCTAAAGGCGGCTTTGGCTGATGTTTTGAGGCGTCTTGCAATCTCTGAAGATCATGTGGCC
TCAGTGAAAAAATCAGTCTCAAGTAAAGGCCAACCAAGCCCTCGAGCAGTTATTCCCATGTCCTGTATAACCAATGGAAGTGGTGCAAAC
AGAAAACCAAGTCATACCAGTGCTGTCTCAATTGCAGGAAAAGAAACTCTTTCATCTGCTGCTAAAAGTGGTACAGAAAAAAAGAAAGAA
AAACCACAAGGACAGAGAGAAAAAAAAGAGGAATCTCATTCTAATGATCAAAGTCCACAAATTCGAGCATCACCTTCTCCCCAGCCCTCT
TCACAACCTCTCCAAATACACAGACAAACTCCAGAAAGCAAGAATGCTACTCCCACCAAAAGCATAAAACGACCATCACCAGCTGAAAAG
TCACATAATTCTTGGGAAAATTCAGATGATAGCCGTAATAAATTGTCGAAAATACCTTCAACACCCAAATTAATACCAAAAGTTACCAAA
ACTGCAGACAAGCATAAAGATGTCATCATCAACCAAGCAAAAATGTCAACTCGCGAAAAAAACAGCCAAGAAGGAGAATATATTAAAATG
TTTATGCGCGGTCGGCCAATTACCATGTTCATTCCTTCCGATGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTC
AAACTGGAGTGGGCATATGGTTATCGAGGAAAGGACTGTAGAGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCA
TCAGTAGTAGTACTATTTAATTATGAGGAGAGAACTCAGCGACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCT
GACAAAATTAGGATTGCAACTGGACAGATAGCTGGCGTGGATAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTT
ACTCTATCCACACTGCAGATTATTGGACTTGGCACTTTTGAGCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCAT
TTATGTATTATTGATGACTCCAATGAGCATATGCTTACTGTATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAAT
GAAGTTGTTTTGGCTGTGGAGTTTCACCCAACAGATGCAAATACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGC
GGCAATTCACTAACAAGAAAACAGGGAATTTTTGGGAAATATGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGAT
GTTCTTACTGGAGACTCAGGTGGAGTCATGCTTATATGGAGCAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATAT
CAAATCAGCAAACAAATCAAAGCTCATGATGGCAGTGTGTTCACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAA
GACAGAAAAATAATTCTGTGGGATCATGATCTGAATCCTGAAAGAGAAATAGAGGGAGGGAAGATCCCAATCAGGTGGACATCACCAGAA
GCTATAGCCTACCGCAAGTTCACGTCAGCCAGCGATGTATGGAGTTATGGGATTGTTCTCTGGGAGGTGATGTCTTATGGAGAGAGACCA
TACTGGGAGATGTCCAATCAGGATGTAATTAAAGCTGTAGATGAGGGCTATCGACTGCCACCCCCCATGGACTGCCCAGCTGCCTTGTAT
CAGCTGATGCTGGACTGCTGGCAGAAAGACAGGAACAACAGACCCAAGTTTGAGCAGATTGTTAGTATTCTGGACAAGCTTATCCGGAAT
CCCGGCAGCCTGAAGATCATCACCAGTGCAGCCGCAAGGCCATCAAACCTTCTTCTGGACCAAAGCAATGTGGATATCACTACCTTCCGC
ACAACAGGTGACTGGCTTAATGGTGTCTGGACAGCACACTGCAAGGAAATCTTCACGGGTGTGGAGTACAGTTCTTGTGACACAATAGCC
AAGATTTCCACAGATGACATGAAAAAGGTTGGTGTCACCGTGGTTGGGCCACAGAAGAAGATCATCAGTAGCATTAAAGCTCTAGAAACG


* Fusion transcript sequences (Full-length transcript).
>In-frame_EML4_ENST00000318522_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_5141nt
GGCGCGGCGCTCGCGGCTGCTGCCTGGGAGGGAGGCCGGGCAGGCGGCTGAGCGGCGCGGCTCTCAACGTGACGGGGAAGTGGTTCGGGC
GGCCGCGGCTTACTACCCCAGGGCGAACGGACGGACGACGGAGGCGGGAGCCGGTAGCCGAGCCGGGCGACCTAGAGAACGAGCGGGTCA
GGCTCAGCGTCGGCCACTCTGTCGGTCCGCTGAATGAAGTGCCCGCCCCTCTAAGCCCGGAGCCCGGCGCTTTCCCCGCAAGATGGACGG
TTTCGCCGGCAGTCTCGATGATAGTATTTCTGCTGCAAGTACTTCTGATGTTCAAGATCGCCTGTCAGCTCTTGAGTCACGAGTTCAGCA
ACAAGAAGATGAAATCACTGTGCTAAAGGCGGCTTTGGCTGATGTTTTGAGGCGTCTTGCAATCTCTGAAGATCATGTGGCCTCAGTGAA
AAAATCAGTCTCAAGTAAAGGCCAACCAAGCCCTCGAGCAGTTATTCCCATGTCCTGTATAACCAATGGAAGTGGTGCAAACAGAAAACC
AAGTCATACCAGTGCTGTCTCAATTGCAGGAAAAGAAACTCTTTCATCTGCTGCTAAAAGTGGTACAGAAAAAAAGAAAGAAAAACCACA
AGGACAGAGAGAAAAAAAAGAGGAATCTCATTCTAATGATCAAAGTCCACAAATTCGAGCATCACCTTCTCCCCAGCCCTCTTCACAACC
TCTCCAAATACACAGACAAACTCCAGAAAGCAAGAATGCTACTCCCACCAAAAGCATAAAACGACCATCACCAGCTGAAAAGTCACATAA
TTCTTGGGAAAATTCAGATGATAGCCGTAATAAATTGTCGAAAATACCTTCAACACCCAAATTAATACCAAAAGTTACCAAAACTGCAGA
CAAGCATAAAGATGTCATCATCAACCAAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTTCATTCCTTCCGA
TGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGAGGAAAGGACTGTAG
AGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAGGAGAGAACTCAGCG
ACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAGATAGCTGGCGTGGA
TAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACTTGGCACTTTTGA
GCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAGCATATGCTTACTGT
ATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCCAACAGATGCAAA
TACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGAATTTTTGGGAAATA
TGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTTATATGGAG
CAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCATGATGGCAGTGTGTT
CACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCATGATCTGAATCCTGA
AAGAGAAATAGAGGGAGGGAAGATCCCAATCAGGTGGACATCACCAGAAGCTATAGCCTACCGCAAGTTCACGTCAGCCAGCGATGTATG
GAGTTATGGGATTGTTCTCTGGGAGGTGATGTCTTATGGAGAGAGACCATACTGGGAGATGTCCAATCAGGATGTAATTAAAGCTGTAGA
TGAGGGCTATCGACTGCCACCCCCCATGGACTGCCCAGCTGCCTTGTATCAGCTGATGCTGGACTGCTGGCAGAAAGACAGGAACAACAG
ACCCAAGTTTGAGCAGATTGTTAGTATTCTGGACAAGCTTATCCGGAATCCCGGCAGCCTGAAGATCATCACCAGTGCAGCCGCAAGGCC
ATCAAACCTTCTTCTGGACCAAAGCAATGTGGATATCACTACCTTCCGCACAACAGGTGACTGGCTTAATGGTGTCTGGACAGCACACTG
CAAGGAAATCTTCACGGGTGTGGAGTACAGTTCTTGTGACACAATAGCCAAGATTTCCACAGATGACATGAAAAAGGTTGGTGTCACCGT
GGTTGGGCCACAGAAGAAGATCATCAGTAGCATTAAAGCTCTAGAAACGCAATCAAAGAATGGCCCAGTTCCCGTGTAAAGCACGGGACG
GAAGTGCTTCTGGACGGAAGTGGTGGCTGTGGAAGGCGTAGCATCATCCTGCAGACAGACAATAATTCTGGAGATACTGGTGGAAGTTCC
AAGTCCAATAAGACACTCAAATATGAGTACAAATGCCTTAAAATGGAATTGAAAAACTCTTTATTTTCCCCTATCATTTATTGGATGGGT
GGGTGGGGTATTTTTTTGTAATTGCTTTTTTAAATATTAGTTAATGGATTAAATTTAATTCTTCAGCGTAAAATGGTGAAGAACTAGCAT
ATAGCCATTGATCATAAACTGACTATCATAAAATCAAAACAAGTGAAATAACAAAATGGACATGGTGGCTTTGTTTAGGTAGAGCCACAA
AAGAAAAGACTTGTAATATTTTTATATACAGAGGAAATCTGTAACAGGTATTTTGTTTCTTTTAAAGCAAGCAACACAGAGGAATTTATA
CCTCAAACTATCTGGCCATATTTACTACCTTATCACTGCATTATTCTCTTTTATCTGTTTAAAGCATATAGAGATGAAGTTTGTAGTTGT
TTTAAGTACTACACATTTTTAAATTGTTAGCTTCCTTAAGTATATCATGTAAAGAAATGTCTTAATTTTTGAAAAAAGTACATATTTATT
TTCTTTTGAATTGTTTTTATTGTTTTCTATTTATGCCTTGATGATTTAATATGGATTTGTTACAGCCAAGTGCCAAATGCTCTCTCAAAT
TGTCAGCAATTTAACTAGACACAGATAATAATGGGTTTCTTTCAGATTTTTTGAACCATCCACTTACATATATTTTTAAAAAATGAAATC
CTTTTCCTGTTCATACACTAACCAAATCTCTCAAATCTGTTATCCCAATCATTGTTGCCTCTCCGTTTATTATAAACTGTATGCTCACAA
CTTAGTGTAATATACCAGCTTGTATGCAATGGATTTTCAACCAGATAACATACCTTTCCTGCTCTGGTGCTTAGAGACTATCAACTCCCT
CCTTTAGTGAAGGAGCCGTGTTAGAGCTTCCGAGAATAGCTCCACTGGAGAGAAGTGGAATCCTATATAGAATGCTGCACTAATTGACAA
CACAGCCTATAGGCCAATGCATGAGTAAAAAAAAAAACAATTACTGGCTCACTGGCTTTGAAAAGTCACTTACTATTGTTGCTGAAACTT
GCTGAGCTGTTTATAGAGAATGATGATAACAGAACTTTTCCTCTGTATCACTGGTGTTTAGGTGAATTAATTAAACATTGTGATCATTAG
TACCAGGTATTATTATCTTTAAGAGTCTTCCACTTCAATGCACATGGTGCAGTTTTGGTGTGTAACTTAGAAGGATTGAACTTCTTTGAA
TTTACTGGACATAACATTTTCAGAATAGTTGGTCATCTAGCAACCGCCTCAAAATGTGTAAGCAGGAGAGAAATTTCTCATCACAGGGAT
TTAGACTTACTATTACATAAAGGCTAACTATGAGCTTGCTCATTAATTTTGAAAAGATGTACCTGGTGGATATCTAGCTAGTAATATATT
CTGAAGCAACATTTTAGCTCTATTGATACTCTTTCTAATGCTGATATGATCTTGAGTATAAGAAATGCATATGTCACTAGAATGGATAAA
ATAATGCTGCAAACTTAATGTTCTTATGCAAAATGGAACGCTAATGAAACACAGCTTACAATCGCAAATCAAAACTCACAAGTGCTCATC
TGTTGTAGATTTAGTGTAATAAGACTTAGATTGTGCTCCTTCGGATATGATTGTTTCTCAAATCTTGGCAATATTCCTTAGTCAAATCAG
GCTACTAGAATTCTGTATTGGATATATAAGAGCATGAAATTTTTAAAAATACACTTGTGATTATAAAATTAATCACAAATTTCACTTATA
CCTGCTATCAGCAGCTAGAAAACATTTTTTTTTTAAATCAAGTATTTTGTGTTTGGAATGTTAGAATGAGATCTGAATGTGGTTTCAATC
TAATTTTTTCCCAGACTACTATTTTCTTTTTTAGGTACTATTCTGAGCATACTCAACAAAACCCATGCATTTCATAAACTAATAGAAGTT
GAGGATTGTTGAATCTATTTCACTTATTTTGGCTGTGGTTTCCATCTGAAAGTAGAGGTTGTATACACCATATACTGTTCTTCATTTTAT
TAATATTTTTCTCCTTGACCTCTCATAAATTTACTTTACACAATTCTTACCCTGTACATATGTAAACATAAGTGTACGATTCTTAACCAT
GGAGTAGAGGTACTAGAATGCTTACGGCCATCTCTTTGTACAGGAACTGCATTGACTTTCAGTAAACATAAAGCCACAACTCCTACATGA
TGTTATGTACCATATGATCTGTTTTGTATCTTAAATTTGATTTACATATATTATTTATTTCTGGTAACTCACTCAGTTTATGCTGTGCTA
AATATCAATCAAGCCATGTATAAATGTGATATGATTGGCAATATGTGTTTACTTTAAACTTGTCTTTTCAAAATATTACTCAGTTTATGT
TGTACAATGTAGATGGCCTCTTACTAATGTAAAATGATTTGTAGTGGAAACATTTATATTTTTATAATAAACATAATGAAAATATTTTTT

>In-frame_EML4_ENST00000402711_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_4964nt
GCGGCGCTCGCGGCTGCTGCCTGGGAGGGAGGCCGGGCAGGCGGCTGAGCGGCGCGGCTCTCAACGTGACGGGGAAGTGGTTCGGGCGGC
CGCGGCTTACTACCCCAGGGCGAACGGACGGACGACGGAGGCGGGAGCCGGTAGCCGAGCCGGGCGACCTAGAGAACGAGCGGGTCAGGC
TCAGCGTCGGCCACTCTGTCGGTCCGCTGAATGAAGTGCCCGCCCCTCTAAGCCCGGAGCCCGGCGCTTTCCCCGCAAGATGGACGGTTT
CGCCGGCAGTCTCGATGATAGTATTTCTGCTGCAAGTACTTCTGATGTTCAAGATCGCCTGTCAGCTCTTGAGTCACGAGTTCAGCAACA
AGAAGATGAAATCACTGTGCTAAAGGCGGCTTTGGCTGATGTTTTGAGGCGTCTTGCAATCTCTGAAGATCATGTGGCCTCAGTGAAAAA
ATCAGTCTCAAGTAAAGGCCAACCAAGCCCTCGAGCAGTTATTCCCATGTCCTGTATAACCAATGGAAGTGGTGCAAACAGAAAACCAAG
TCATACCAGTGCTGTCTCAATTGCAGGAAAAGAAACTCTTTCATCTGCTGCTAAAAGCATAAAACGACCATCACCAGCTGAAAAGTCACA
TAATTCTTGGGAAAATTCAGATGATAGCCGTAATAAATTGTCGAAAATACCTTCAACACCCAAATTAATACCAAAAGTTACCAAAACTGC
AGACAAGCATAAAGATGTCATCATCAACCAAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTTCATTCCTTC
CGATGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGAGGAAAGGACTG
TAGAGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAGGAGAGAACTCA
GCGACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAGATAGCTGGCGT
GGATAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACTTGGCACTTT
TGAGCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAGCATATGCTTAC
TGTATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCCAACAGATGC
AAATACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGAATTTTTGGGAA
ATATGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTTATATG
GAGCAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCATGATGGCAGTGT
GTTCACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCATGATCTGAATCC
TGAAAGAGAAATAGAGGGAGGGAAGATCCCAATCAGGTGGACATCACCAGAAGCTATAGCCTACCGCAAGTTCACGTCAGCCAGCGATGT
ATGGAGTTATGGGATTGTTCTCTGGGAGGTGATGTCTTATGGAGAGAGACCATACTGGGAGATGTCCAATCAGGATGTAATTAAAGCTGT
AGATGAGGGCTATCGACTGCCACCCCCCATGGACTGCCCAGCTGCCTTGTATCAGCTGATGCTGGACTGCTGGCAGAAAGACAGGAACAA
CAGACCCAAGTTTGAGCAGATTGTTAGTATTCTGGACAAGCTTATCCGGAATCCCGGCAGCCTGAAGATCATCACCAGTGCAGCCGCAAG
GCCATCAAACCTTCTTCTGGACCAAAGCAATGTGGATATCACTACCTTCCGCACAACAGGTGACTGGCTTAATGGTGTCTGGACAGCACA
CTGCAAGGAAATCTTCACGGGTGTGGAGTACAGTTCTTGTGACACAATAGCCAAGATTTCCACAGATGACATGAAAAAGGTTGGTGTCAC
CGTGGTTGGGCCACAGAAGAAGATCATCAGTAGCATTAAAGCTCTAGAAACGCAATCAAAGAATGGCCCAGTTCCCGTGTAAAGCACGGG
ACGGAAGTGCTTCTGGACGGAAGTGGTGGCTGTGGAAGGCGTAGCATCATCCTGCAGACAGACAATAATTCTGGAGATACTGGTGGAAGT
TCCAAGTCCAATAAGACACTCAAATATGAGTACAAATGCCTTAAAATGGAATTGAAAAACTCTTTATTTTCCCCTATCATTTATTGGATG
GGTGGGTGGGGTATTTTTTTGTAATTGCTTTTTTAAATATTAGTTAATGGATTAAATTTAATTCTTCAGCGTAAAATGGTGAAGAACTAG
CATATAGCCATTGATCATAAACTGACTATCATAAAATCAAAACAAGTGAAATAACAAAATGGACATGGTGGCTTTGTTTAGGTAGAGCCA
CAAAAGAAAAGACTTGTAATATTTTTATATACAGAGGAAATCTGTAACAGGTATTTTGTTTCTTTTAAAGCAAGCAACACAGAGGAATTT
ATACCTCAAACTATCTGGCCATATTTACTACCTTATCACTGCATTATTCTCTTTTATCTGTTTAAAGCATATAGAGATGAAGTTTGTAGT
TGTTTTAAGTACTACACATTTTTAAATTGTTAGCTTCCTTAAGTATATCATGTAAAGAAATGTCTTAATTTTTGAAAAAAGTACATATTT
ATTTTCTTTTGAATTGTTTTTATTGTTTTCTATTTATGCCTTGATGATTTAATATGGATTTGTTACAGCCAAGTGCCAAATGCTCTCTCA
AATTGTCAGCAATTTAACTAGACACAGATAATAATGGGTTTCTTTCAGATTTTTTGAACCATCCACTTACATATATTTTTAAAAAATGAA
ATCCTTTTCCTGTTCATACACTAACCAAATCTCTCAAATCTGTTATCCCAATCATTGTTGCCTCTCCGTTTATTATAAACTGTATGCTCA
CAACTTAGTGTAATATACCAGCTTGTATGCAATGGATTTTCAACCAGATAACATACCTTTCCTGCTCTGGTGCTTAGAGACTATCAACTC
CCTCCTTTAGTGAAGGAGCCGTGTTAGAGCTTCCGAGAATAGCTCCACTGGAGAGAAGTGGAATCCTATATAGAATGCTGCACTAATTGA
CAACACAGCCTATAGGCCAATGCATGAGTAAAAAAAAAAACAATTACTGGCTCACTGGCTTTGAAAAGTCACTTACTATTGTTGCTGAAA
CTTGCTGAGCTGTTTATAGAGAATGATGATAACAGAACTTTTCCTCTGTATCACTGGTGTTTAGGTGAATTAATTAAACATTGTGATCAT
TAGTACCAGGTATTATTATCTTTAAGAGTCTTCCACTTCAATGCACATGGTGCAGTTTTGGTGTGTAACTTAGAAGGATTGAACTTCTTT
GAATTTACTGGACATAACATTTTCAGAATAGTTGGTCATCTAGCAACCGCCTCAAAATGTGTAAGCAGGAGAGAAATTTCTCATCACAGG
GATTTAGACTTACTATTACATAAAGGCTAACTATGAGCTTGCTCATTAATTTTGAAAAGATGTACCTGGTGGATATCTAGCTAGTAATAT
ATTCTGAAGCAACATTTTAGCTCTATTGATACTCTTTCTAATGCTGATATGATCTTGAGTATAAGAAATGCATATGTCACTAGAATGGAT
AAAATAATGCTGCAAACTTAATGTTCTTATGCAAAATGGAACGCTAATGAAACACAGCTTACAATCGCAAATCAAAACTCACAAGTGCTC
ATCTGTTGTAGATTTAGTGTAATAAGACTTAGATTGTGCTCCTTCGGATATGATTGTTTCTCAAATCTTGGCAATATTCCTTAGTCAAAT
CAGGCTACTAGAATTCTGTATTGGATATATAAGAGCATGAAATTTTTAAAAATACACTTGTGATTATAAAATTAATCACAAATTTCACTT
ATACCTGCTATCAGCAGCTAGAAAACATTTTTTTTTTAAATCAAGTATTTTGTGTTTGGAATGTTAGAATGAGATCTGAATGTGGTTTCA
ATCTAATTTTTTCCCAGACTACTATTTTCTTTTTTAGGTACTATTCTGAGCATACTCAACAAAACCCATGCATTTCATAAACTAATAGAA
GTTGAGGATTGTTGAATCTATTTCACTTATTTTGGCTGTGGTTTCCATCTGAAAGTAGAGGTTGTATACACCATATACTGTTCTTCATTT
TATTAATATTTTTCTCCTTGACCTCTCATAAATTTACTTTACACAATTCTTACCCTGTACATATGTAAACATAAGTGTACGATTCTTAAC
CATGGAGTAGAGGTACTAGAATGCTTACGGCCATCTCTTTGTACAGGAACTGCATTGACTTTCAGTAAACATAAAGCCACAACTCCTACA
TGATGTTATGTACCATATGATCTGTTTTGTATCTTAAATTTGATTTACATATATTATTTATTTCTGGTAACTCACTCAGTTTATGCTGTG
CTAAATATCAATCAAGCCATGTATAAATGTGATATGATTGGCAATATGTGTTTACTTTAAACTTGTCTTTTCAAAATATTACTCAGTTTA
TGTTGTACAATGTAGATGGCCTCTTACTAATGTAAAATGATTTGTAGTGGAAACATTTATATTTTTATAATAAACATAATGAAAATATTT

>In-frame_EML4_ENST00000401738_chr2_42528532_+_EPHA3_ENST00000336596_chr3_89498375_+_5063nt
GGCGAACGGACGGACGACGGAGGCGGGAGCCGGTAGCCGAGCCGGGCGACCTAGAGAACGAGCGGGTCAGGCTCAGCGTCGGCCACTCTG
TCGGTCCGCTGAATGAAGTGCCCGCCCCTCTAAGCCCGGAGCCCGGCGCTTTCCCCGCAAGATGGACGGTTTCGCCGGCAGTCTCGATGA
TAGTATTTCTGCTGCAAGTACTTCTGATGTTCAAGATCGCCTGTCAGCTCTTGAGTCACGAGTTCAGCAACAAGAAGATGAAATCACTGT
GCTAAAGGCGGCTTTGGCTGATGTTTTGAGGCGTCTTGCAATCTCTGAAGATCATGTGGCCTCAGTGAAAAAATCAGTCTCAAGTAAAGG
CCAACCAAGCCCTCGAGCAGTTATTCCCATGTCCTGTATAACCAATGGAAGTGGTGCAAACAGAAAACCAAGTCATACCAGTGCTGTCTC
AATTGCAGGAAAAGAAACTCTTTCATCTGCTGCTAAAAGTGGTACAGAAAAAAAGAAAGAAAAACCACAAGGACAGAGAGAAAAAAAAGA
GGAATCTCATTCTAATGATCAAAGTCCACAAATTCGAGCATCACCTTCTCCCCAGCCCTCTTCACAACCTCTCCAAATACACAGACAAAC
TCCAGAAAGCAAGAATGCTACTCCCACCAAAAGCATAAAACGACCATCACCAGCTGAAAAGTCACATAATTCTTGGGAAAATTCAGATGA
TAGCCGTAATAAATTGTCGAAAATACCTTCAACACCCAAATTAATACCAAAAGTTACCAAAACTGCAGACAAGCATAAAGATGTCATCAT
CAACCAAGCAAAAATGTCAACTCGCGAAAAAAACAGCCAAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTT
CATTCCTTCCGATGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGAGG
AAAGGACTGTAGAGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAGGA
GAGAACTCAGCGACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAGAT
AGCTGGCGTGGATAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACT
TGGCACTTTTGAGCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAGCA
TATGCTTACTGTATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCC
AACAGATGCAAATACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGAAT
TTTTGGGAAATATGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCAT
GCTTATATGGAGCAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCATGA
TGGCAGTGTGTTCACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCATGA
TCTGAATCCTGAAAGAGAAATAGAGGGAGGGAAGATCCCAATCAGGTGGACATCACCAGAAGCTATAGCCTACCGCAAGTTCACGTCAGC
CAGCGATGTATGGAGTTATGGGATTGTTCTCTGGGAGGTGATGTCTTATGGAGAGAGACCATACTGGGAGATGTCCAATCAGGATGTAAT
TAAAGCTGTAGATGAGGGCTATCGACTGCCACCCCCCATGGACTGCCCAGCTGCCTTGTATCAGCTGATGCTGGACTGCTGGCAGAAAGA
CAGGAACAACAGACCCAAGTTTGAGCAGATTGTTAGTATTCTGGACAAGCTTATCCGGAATCCCGGCAGCCTGAAGATCATCACCAGTGC
AGCCGCAAGGCCATCAAACCTTCTTCTGGACCAAAGCAATGTGGATATCACTACCTTCCGCACAACAGGTGACTGGCTTAATGGTGTCTG
GACAGCACACTGCAAGGAAATCTTCACGGGTGTGGAGTACAGTTCTTGTGACACAATAGCCAAGATTTCCACAGATGACATGAAAAAGGT
TGGTGTCACCGTGGTTGGGCCACAGAAGAAGATCATCAGTAGCATTAAAGCTCTAGAAACGCAATCAAAGAATGGCCCAGTTCCCGTGTA
AAGCACGGGACGGAAGTGCTTCTGGACGGAAGTGGTGGCTGTGGAAGGCGTAGCATCATCCTGCAGACAGACAATAATTCTGGAGATACT
GGTGGAAGTTCCAAGTCCAATAAGACACTCAAATATGAGTACAAATGCCTTAAAATGGAATTGAAAAACTCTTTATTTTCCCCTATCATT
TATTGGATGGGTGGGTGGGGTATTTTTTTGTAATTGCTTTTTTAAATATTAGTTAATGGATTAAATTTAATTCTTCAGCGTAAAATGGTG
AAGAACTAGCATATAGCCATTGATCATAAACTGACTATCATAAAATCAAAACAAGTGAAATAACAAAATGGACATGGTGGCTTTGTTTAG
GTAGAGCCACAAAAGAAAAGACTTGTAATATTTTTATATACAGAGGAAATCTGTAACAGGTATTTTGTTTCTTTTAAAGCAAGCAACACA
GAGGAATTTATACCTCAAACTATCTGGCCATATTTACTACCTTATCACTGCATTATTCTCTTTTATCTGTTTAAAGCATATAGAGATGAA
GTTTGTAGTTGTTTTAAGTACTACACATTTTTAAATTGTTAGCTTCCTTAAGTATATCATGTAAAGAAATGTCTTAATTTTTGAAAAAAG
TACATATTTATTTTCTTTTGAATTGTTTTTATTGTTTTCTATTTATGCCTTGATGATTTAATATGGATTTGTTACAGCCAAGTGCCAAAT
GCTCTCTCAAATTGTCAGCAATTTAACTAGACACAGATAATAATGGGTTTCTTTCAGATTTTTTGAACCATCCACTTACATATATTTTTA
AAAAATGAAATCCTTTTCCTGTTCATACACTAACCAAATCTCTCAAATCTGTTATCCCAATCATTGTTGCCTCTCCGTTTATTATAAACT
GTATGCTCACAACTTAGTGTAATATACCAGCTTGTATGCAATGGATTTTCAACCAGATAACATACCTTTCCTGCTCTGGTGCTTAGAGAC
TATCAACTCCCTCCTTTAGTGAAGGAGCCGTGTTAGAGCTTCCGAGAATAGCTCCACTGGAGAGAAGTGGAATCCTATATAGAATGCTGC
ACTAATTGACAACACAGCCTATAGGCCAATGCATGAGTAAAAAAAAAAACAATTACTGGCTCACTGGCTTTGAAAAGTCACTTACTATTG
TTGCTGAAACTTGCTGAGCTGTTTATAGAGAATGATGATAACAGAACTTTTCCTCTGTATCACTGGTGTTTAGGTGAATTAATTAAACAT
TGTGATCATTAGTACCAGGTATTATTATCTTTAAGAGTCTTCCACTTCAATGCACATGGTGCAGTTTTGGTGTGTAACTTAGAAGGATTG
AACTTCTTTGAATTTACTGGACATAACATTTTCAGAATAGTTGGTCATCTAGCAACCGCCTCAAAATGTGTAAGCAGGAGAGAAATTTCT
CATCACAGGGATTTAGACTTACTATTACATAAAGGCTAACTATGAGCTTGCTCATTAATTTTGAAAAGATGTACCTGGTGGATATCTAGC
TAGTAATATATTCTGAAGCAACATTTTAGCTCTATTGATACTCTTTCTAATGCTGATATGATCTTGAGTATAAGAAATGCATATGTCACT
AGAATGGATAAAATAATGCTGCAAACTTAATGTTCTTATGCAAAATGGAACGCTAATGAAACACAGCTTACAATCGCAAATCAAAACTCA
CAAGTGCTCATCTGTTGTAGATTTAGTGTAATAAGACTTAGATTGTGCTCCTTCGGATATGATTGTTTCTCAAATCTTGGCAATATTCCT
TAGTCAAATCAGGCTACTAGAATTCTGTATTGGATATATAAGAGCATGAAATTTTTAAAAATACACTTGTGATTATAAAATTAATCACAA
ATTTCACTTATACCTGCTATCAGCAGCTAGAAAACATTTTTTTTTTAAATCAAGTATTTTGTGTTTGGAATGTTAGAATGAGATCTGAAT
GTGGTTTCAATCTAATTTTTTCCCAGACTACTATTTTCTTTTTTAGGTACTATTCTGAGCATACTCAACAAAACCCATGCATTTCATAAA
CTAATAGAAGTTGAGGATTGTTGAATCTATTTCACTTATTTTGGCTGTGGTTTCCATCTGAAAGTAGAGGTTGTATACACCATATACTGT
TCTTCATTTTATTAATATTTTTCTCCTTGACCTCTCATAAATTTACTTTACACAATTCTTACCCTGTACATATGTAAACATAAGTGTACG
ATTCTTAACCATGGAGTAGAGGTACTAGAATGCTTACGGCCATCTCTTTGTACAGGAACTGCATTGACTTTCAGTAAACATAAAGCCACA
ACTCCTACATGATGTTATGTACCATATGATCTGTTTTGTATCTTAAATTTGATTTACATATATTATTTATTTCTGGTAACTCACTCAGTT
TATGCTGTGCTAAATATCAATCAAGCCATGTATAAATGTGATATGATTGGCAATATGTGTTTACTTTAAACTTGTCTTTTCAAAATATTA
CTCAGTTTATGTTGTACAATGTAGATGGCCTCTTACTAATGTAAAATGATTTGTAGTGGAAACATTTATATTTTTATAATAAACATAATG


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FusionGenePPI for EML4_EPHA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EML4NEK6, ARL4D, ARIH2, ELAVL1, EML4, ILK, PRPS1, TUBB2A, TUBB2B, FBXW11, NTRK1, SPICE1, DCTN1, TFEB, NUDC, EML1, FBXO28, TUBB3, CTAGE5, TUBB, TKT, PHKG2, NEK7EPHA3TP53, CRK, EFNB2, EFNA5, EFNA1, EFNB1, EFNA3, EFNA4, SRC, FYN, ABL1, RBM18, SRPK1, CDKN2A, HLA-DRA, CEACAM21, TMEM231, EPHA7, LRRIQ1, FAM118B, SLAMF1, ILKAP, CTDSP2, DUSP18, DUSP21, STYX, TPTE, MTMR11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EML4_EPHA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EML4_EPHA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEML4C0007131Non-Small Cell Lung Carcinoma6CTD_human
HgeneEML4C0027627Neoplasm Metastasis2CTD_human
HgeneEML4C0152013Adenocarcinoma of lung (disorder)2CTD_human
HgeneEML4C0006118Brain Neoplasms1CTD_human