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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11557

FusionGeneSummary for EML3_HNRNPH3

check button Fusion gene summary
Fusion gene informationFusion gene name: EML3_HNRNPH3
Fusion gene ID: 11557
HgeneTgene
Gene symbol

EML3

HNRNPH3

Gene ID

256364

3189

Gene nameechinoderm microtubule associated protein like 3heterogeneous nuclear ribonucleoprotein H3
SynonymsELP952H9|HNRPH3
Cytomap

11q12.3

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionechinoderm microtubule-associated protein-like 3EMAP-3heterogeneous nuclear ribonucleoprotein H3heterogeneous nuclear ribonucleoprotein 2H9hnRNP 2H9hnRNP H3
Modification date2018052320180519
UniProtAcc

Q32P44

P31942

Ensembl transtripts involved in fusion geneENST00000394773, ENST00000278845, 
ENST00000531557, ENST00000494176, 
ENST00000529309, ENST00000438258, 
ENST00000469172, ENST00000265866, 
ENST00000441000, ENST00000354695, 
Fusion gene scores* DoF score5 X 5 X 4=1006 X 6 X 2=72
# samples 710
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/72*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EML3 [Title/Abstract] AND HNRNPH3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF902815EML3chr11

62376523

+HNRNPH3chr10

70101604

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000394773ENST00000469172EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000394773ENST00000265866EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000394773ENST00000441000EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000394773ENST00000354695EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000278845ENST00000469172EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000278845ENST00000265866EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000278845ENST00000441000EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000278845ENST00000354695EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000531557ENST00000469172EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000531557ENST00000265866EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000531557ENST00000441000EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000531557ENST00000354695EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000494176ENST00000469172EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000494176ENST00000265866EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000494176ENST00000441000EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000494176ENST00000354695EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000529309ENST00000469172EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000529309ENST00000265866EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000529309ENST00000441000EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000529309ENST00000354695EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000438258ENST00000469172EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000438258ENST00000265866EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000438258ENST00000441000EML3chr11

62376523

+HNRNPH3chr10

70101604

-
intron-intronENST00000438258ENST00000354695EML3chr11

62376523

+HNRNPH3chr10

70101604

-

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FusionProtFeatures for EML3_HNRNPH3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EML3

Q32P44

HNRNPH3

P31942

May modify the assembly dynamics of microtubules, suchthat microtubules are slightly longer, but more dynamic.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EML3_HNRNPH3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EML3_HNRNPH3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EML3_HNRNPH3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EML3_HNRNPH3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource