|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 1153 |
FusionGeneSummary for AGPAT9_COPS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGPAT9_COPS4 | Fusion gene ID: 1153 | Hgene | Tgene | Gene symbol | AGPAT9 | COPS4 | Gene ID | 84803 | 51138 |
| Gene name | glycerol-3-phosphate acyltransferase 3 | COP9 signalosome subunit 4 | |
| Synonyms | AGPAT 10|AGPAT10|AGPAT8|AGPAT9|HMFN0839|LPAAT-theta|MAG1 | CSN4|SGN4 | |
| Cytomap | 4q21.23 | 4q21.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glycerol-3-phosphate acyltransferase 31-AGP acyltransferase 91-AGPAT 91-acyl-sn-glycerol-3-phosphate O-acyltransferase 101-acyl-sn-glycerol-3-phosphate O-acyltransferase 91-acylglycerol-3-phosphate O-acyltransferase 81-acylglycerol-3-phosphate O-acy | COP9 signalosome complex subunit 4COP9 constitutive photomorphogenic homolog subunit 4COP9 constitutive photomorphogenic-like protein subunit 4JAB1-containing signalosome subunit 4signalosome subunit 4testis tissue sperm-binding protein Li 42a | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BT78 | ||
| Ensembl transtripts involved in fusion gene | ENST00000395226, ENST00000264409, ENST00000509044, | ENST00000509093, ENST00000264389, ENST00000503682, ENST00000511653, ENST00000511708, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 3=27 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AGPAT9 [Title/Abstract] AND COPS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AGPAT9 | GO:0019432 | triglyceride biosynthetic process | 17170135 |
| Hgene | AGPAT9 | GO:0032006 | regulation of TOR signaling | 17002884 |
| Tgene | COPS4 | GO:0000338 | protein deneddylation | 19141280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-K1-A6RV-01A | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000395226 | ENST00000509093 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| In-frame | ENST00000395226 | ENST00000264389 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| In-frame | ENST00000395226 | ENST00000503682 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| In-frame | ENST00000395226 | ENST00000511653 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| 5CDS-intron | ENST00000395226 | ENST00000511708 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| In-frame | ENST00000264409 | ENST00000509093 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| In-frame | ENST00000264409 | ENST00000264389 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| In-frame | ENST00000264409 | ENST00000503682 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| In-frame | ENST00000264409 | ENST00000511653 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| 5CDS-intron | ENST00000264409 | ENST00000511708 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| intron-3CDS | ENST00000509044 | ENST00000509093 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| intron-3CDS | ENST00000509044 | ENST00000264389 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| intron-3CDS | ENST00000509044 | ENST00000503682 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| intron-3CDS | ENST00000509044 | ENST00000511653 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
| intron-intron | ENST00000509044 | ENST00000511708 | AGPAT9 | chr4 | 84465755 | + | COPS4 | chr4 | 83987591 | + |
Top |
FusionProtFeatures for AGPAT9_COPS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGPAT9 | COPS4 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Component of the COP9 signalosome complex (CSN), acomplex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl)conjugation pathway by mediating the deneddylation of the cullinsubunits of SCF-type E3 ligase complexes, leading to decrease theUbl ligase activity of SCF-type complexes such as SCF, CSA orDDB2. Also involved in the deneddylation of non-cullin subunitssuch as STON2. The complex is also involved in phosphorylation ofp53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP andSNAPIN, possibly via its association with CK2 and PKD kinases.CSN-dependent phosphorylation of TP53 and JUN promotes andprotects degradation by the Ubl system, respectively.{ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588,ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143,ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AGPAT9 | chr4:84465755 | chr4:83987591 | ENST00000264409 | + | 2 | 12 | 14_34 | 69 | 435 | Transmembrane | Helical |
| Hgene | AGPAT9 | chr4:84465755 | chr4:83987591 | ENST00000395226 | + | 3 | 13 | 14_34 | 69 | 435 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >AGPAT9 | chr4:84465755 | chr4:83987591 | ENST00000264409 | + | 2 | 12 | 229_234 | 69 | 435 | Motif | Note=HXXXXD motif |
| Hgene | >AGPAT9 | chr4:84465755 | chr4:83987591 | ENST00000395226 | + | 3 | 13 | 229_234 | 69 | 435 | Motif | Note=HXXXXD motif |
| Hgene | >AGPAT9 | chr4:84465755 | chr4:83987591 | ENST00000264409 | + | 2 | 12 | 137_157 | 69 | 435 | Transmembrane | Helical |
| Hgene | >AGPAT9 | chr4:84465755 | chr4:83987591 | ENST00000264409 | + | 2 | 12 | 161_181 | 69 | 435 | Transmembrane | Helical |
| Hgene | >AGPAT9 | chr4:84465755 | chr4:83987591 | ENST00000395226 | + | 3 | 13 | 137_157 | 69 | 435 | Transmembrane | Helical |
| Hgene | >AGPAT9 | chr4:84465755 | chr4:83987591 | ENST00000395226 | + | 3 | 13 | 161_181 | 69 | 435 | Transmembrane | Helical |
| Tgene | COPS4 | chr4:84465755 | chr4:83987591 | ENST00000264389 | + | 6 | 10 | 197_366 | 295 | 407 | Domain | PCI |
| Tgene | COPS4 | chr4:84465755 | chr4:83987591 | ENST00000509093 | + | 6 | 9 | 197_366 | 295 | 353 | Domain | PCI |
Top |
FusionGeneSequence for AGPAT9_COPS4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000509093_chr4_83987591_+_127aa MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGSSILDRAVIEHNLLSASKLY >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000264389_chr4_83987591_+_181aa MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGSSILDRAVIEHNLLSASKLY NNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000503682_chr4_83987591_+_181aa MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGSSILDRAVIEHNLLSASKLY NNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000511653_chr4_83987591_+_195aa MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGSSILDRAVIEHNLLSASKLY NNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETSGNHQSIFCLWIYLVWIVHINGIIQYVTCDLLADSTQHSIFRV >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000509093_chr4_83987591_+_127aa MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGSSILDRAVIEHNLLSASKLY >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000264389_chr4_83987591_+_181aa MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGSSILDRAVIEHNLLSASKLY NNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000503682_chr4_83987591_+_181aa MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGSSILDRAVIEHNLLSASKLY NNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000511653_chr4_83987591_+_195aa MEGAELAGKILSTWLTLVLGFILLPSVFGVSLGISEIYMKILVKTLEWATIRIEKGTPKESILKNSASVGSSILDRAVIEHNLLSASKLY NNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETSGNHQSIFCLWIYLVWIVHINGIIQYVTCDLLADSTQHSIFRV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000509093_chr4_83987591_+_381nt ATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTG TCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAG TCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATAT AATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGCACGAGAAGCCCTGCCAACGTGGGATAAGCAGATCC >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000264389_chr4_83987591_+_543nt ATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTG TCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAG TCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATAT AATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGA CGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACACGAGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCA CTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGAATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAG >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000503682_chr4_83987591_+_543nt ATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTG TCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAG TCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATAT AATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGA CGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACACGAGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCA CTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGAATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAG >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000511653_chr4_83987591_+_585nt ATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTG TCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAG TCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATAT AATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGA CGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACTTCTGGCAACCACCAATCCATCTTCTGTCTCTGGATTTAC CTAGTCTGGATAGTTCATATAAATGGAATCATACAATATGTGACATGTGACCTTTTGGCTGATTCCACTCAGCATAGTATCTTTAGGGTT >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000509093_chr4_83987591_+_381nt ATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTG TCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAG TCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATAT AATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGCACGAGAAGCCCTGCCAACGTGGGATAAGCAGATCC >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000264389_chr4_83987591_+_543nt ATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTG TCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAG TCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATAT AATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGA CGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACACGAGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCA CTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGAATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAG >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000503682_chr4_83987591_+_543nt ATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTG TCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAG TCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATAT AATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGA CGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACACGAGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCA CTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGAATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAG >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000511653_chr4_83987591_+_585nt ATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTG TCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAG TCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTGAACACAATTTGTTGTCTGCAAGCAAATTATAT AATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGA CGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACTTCTGGCAACCACCAATCCATCTTCTGTCTCTGGATTTAC CTAGTCTGGATAGTTCATATAAATGGAATCATACAATATGTGACATGTGACCTTTTGGCTGATTCCACTCAGCATAGTATCTTTAGGGTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000509093_chr4_83987591_+_1035nt AGCTTCCAGCACAGCCCGCGGCCCGGTGCCAGCTCCGCCGGCGACCGGTGTGCCAAAGTGCGGTGCTCCCGCAGGGAACCTGGCTCGGGG AGGGCCTCCAGGTGAGTGCCGGGCTCGGCGCTCTGCTCCTGGAGCTCCCGCGGGACTGCCTGGGGACAGGGACTGCTGTGGCGCTCGGCC CTCCACTGCGGACCTCTCCTGAGTGGGTGCGCCGAGTCATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGG TTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTGTCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGT GGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAGTCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTG TTATTGAACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTA AGCACGAGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCACTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGC ACCAGAATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAGTGAATCCTTGCAGAACTTCTGTGCACATGACATCTTTTTCCATGTTG TGCAGATCAGTTTCACTATCTCCAAAGCATTTGCATCATGACCTTATACATTTCAATCCCTTTTATGCTGGATTCCGTTTAAAGAAGACA TTATTAGAGCAGGAAGTACAAGCATTTAAAATATGTAGTTCCCATATATTTCAGGGTCTCTGTGTATTAAGCTAACTCAGATGTTTTGAA AGCTTTTTCTTTAAACAGAGGTGAAATATCTGTGGCTAAAAAGTTTGAGATTTGTGATAACTTTGTAGTCATGTAAAACTTAAGTGCTTC >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000264389_chr4_83987591_+_1149nt AGCTTCCAGCACAGCCCGCGGCCCGGTGCCAGCTCCGCCGGCGACCGGTGTGCCAAAGTGCGGTGCTCCCGCAGGGAACCTGGCTCGGGG AGGGCCTCCAGGTGAGTGCCGGGCTCGGCGCTCTGCTCCTGGAGCTCCCGCGGGACTGCCTGGGGACAGGGACTGCTGTGGCGCTCGGCC CTCCACTGCGGACCTCTCCTGAGTGGGTGCGCCGAGTCATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGG TTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTGTCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGT GGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAGTCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTG TTATTGAACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTA AGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGACGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACAC GAGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCACTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAG AATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAGTGAATCCTTGCAGAACTTCTGTGCACATGACATCTTTTTCCATGTTGTGCAG ATCAGTTTCACTATCTCCAAAGCATTTGCATCATGACCTTATACATTTCAATCCCTTTTATGCTGGATTCCGTTTAAAGAAGACATTATT AGAGCAGGAAGTACAAGCATTTAAAATATGTAGTTCCCATATATTTCAGGGTCTCTGTGTATTAAGCTAACTCAGATGTTTTGAAAGCTT TTTCTTTAAACAGAGGTGAAATATCTGTGGCTAAAAAGTTTGAGATTTGTGATAACTTTGTAGTCATGTAAAACTTAAGTGCTTCATGCC >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000503682_chr4_83987591_+_1128nt AGCTTCCAGCACAGCCCGCGGCCCGGTGCCAGCTCCGCCGGCGACCGGTGTGCCAAAGTGCGGTGCTCCCGCAGGGAACCTGGCTCGGGG AGGGCCTCCAGGTGAGTGCCGGGCTCGGCGCTCTGCTCCTGGAGCTCCCGCGGGACTGCCTGGGGACAGGGACTGCTGTGGCGCTCGGCC CTCCACTGCGGACCTCTCCTGAGTGGGTGCGCCGAGTCATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGG TTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTGTCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGT GGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAGTCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTG TTATTGAACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTA AGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGACGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACAC GAGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCACTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAG AATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAGTGAATCCTTGCAGAACTTCTGTGCACATGACATCTTTTTCCATGTTGTGCAG ATCAGTTTCACTATCTCCAAAGCATTTGCATCATGACCTTATACATTTCAATCCCTTTTATGCTGGATTCCGTTTAAAGAAGACATTATT AGAGCAGGAAGTACAAGCATTTAAAATATGTAGTTCCCATATATTTCAGGGTCTCTGTGTATTAAGCTAACTCAGATGTTTTGAAAGCTT TTTCTTTAAACAGAGGTGAAATATCTGTGGCTAAAAAGTTTGAGATTTGTGATAACTTTGTAGTCATGTAAAACTTAAGTGCTTCATGCC >In-frame_AGPAT9_ENST00000395226_chr4_84465755_+_COPS4_ENST00000511653_chr4_83987591_+_1235nt AGCTTCCAGCACAGCCCGCGGCCCGGTGCCAGCTCCGCCGGCGACCGGTGTGCCAAAGTGCGGTGCTCCCGCAGGGAACCTGGCTCGGGG AGGGCCTCCAGGTGAGTGCCGGGCTCGGCGCTCTGCTCCTGGAGCTCCCGCGGGACTGCCTGGGGACAGGGACTGCTGTGGCGCTCGGCC CTCCACTGCGGACCTCTCCTGAGTGGGTGCGCCGAGTCATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGG TTCTCGGCTTCATCCTTTTACCTTCGGTCTTCGGAGTGTCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGT GGGCCACAATACGAATTGAAAAAGGAACCCCAAAGGAGTCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTG TTATTGAACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTA AGGCGGAAAAGATAGCATCTCAAATGATAACCGAAGGACGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACTT CTGGCAACCACCAATCCATCTTCTGTCTCTGGATTTACCTAGTCTGGATAGTTCATATAAATGGAATCATACAATATGTGACATGTGACC TTTTGGCTGATTCCACTCAGCATAGTATCTTTAGGGTTCATCCATGTCATGGCAGCACGAGAAGCCCTGCCAACGTGGGATAAGCAGATC CAATCACTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGAATGGACAGCACAAGCCATGGAAGCCCAGATG GCTCAGTGAATCCTTGCAGAACTTCTGTGCACATGACATCTTTTTCCATGTTGTGCAGATCAGTTTCACTATCTCCAAAGCATTTGCATC ATGACCTTATACATTTCAATCCCTTTTATGCTGGATTCCGTTTAAAGAAGACATTATTAGAGCAGGAAGTACAAGCATTTAAAATATGTA GTTCCCATATATTTCAGGGTCTCTGTGTATTAAGCTAACTCAGATGTTTTGAAAGCTTTTTCTTTAAACAGAGGTGAAATATCTGTGGCT >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000509093_chr4_83987591_+_1029nt GTTAACTGGCAGGGGCGAGGAGGAGCCCAGGGAGGAAGGAAGGATATTGCCGTAATTCTGAAAGTTTTTTTCCTTCCTCTCTTCCCTTCG CAGAGGTGAGTGCCGGGCTCGGCGCTCTGCTCCTGGAGCTCCCGCGGGACTGCCTGGGGACAGGGACTGCTGTGGCGCTCGGCCCTCCAC TGCGGACCTCTCCTGAGTGGGTGCGCCGAGTCATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCG GCTTCATCCTTTTACCTTCGGTCTTCGGAGTGTCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCA CAATACGAATTGAAAAAGGAACCCCAAAGGAGTCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTG AACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGCACG AGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCACTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGA ATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAGTGAATCCTTGCAGAACTTCTGTGCACATGACATCTTTTTCCATGTTGTGCAGA TCAGTTTCACTATCTCCAAAGCATTTGCATCATGACCTTATACATTTCAATCCCTTTTATGCTGGATTCCGTTTAAAGAAGACATTATTA GAGCAGGAAGTACAAGCATTTAAAATATGTAGTTCCCATATATTTCAGGGTCTCTGTGTATTAAGCTAACTCAGATGTTTTGAAAGCTTT TTCTTTAAACAGAGGTGAAATATCTGTGGCTAAAAAGTTTGAGATTTGTGATAACTTTGTAGTCATGTAAAACTTAAGTGCTTCATGCCT >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000264389_chr4_83987591_+_1143nt GTTAACTGGCAGGGGCGAGGAGGAGCCCAGGGAGGAAGGAAGGATATTGCCGTAATTCTGAAAGTTTTTTTCCTTCCTCTCTTCCCTTCG CAGAGGTGAGTGCCGGGCTCGGCGCTCTGCTCCTGGAGCTCCCGCGGGACTGCCTGGGGACAGGGACTGCTGTGGCGCTCGGCCCTCCAC TGCGGACCTCTCCTGAGTGGGTGCGCCGAGTCATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCG GCTTCATCCTTTTACCTTCGGTCTTCGGAGTGTCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCA CAATACGAATTGAAAAAGGAACCCCAAAGGAGTCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTG AACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGG AAAAGATAGCATCTCAAATGATAACCGAAGGACGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACACGAGAAG CCCTGCCAACGTGGGATAAGCAGATCCAATCACTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGAATGGA CAGCACAAGCCATGGAAGCCCAGATGGCTCAGTGAATCCTTGCAGAACTTCTGTGCACATGACATCTTTTTCCATGTTGTGCAGATCAGT TTCACTATCTCCAAAGCATTTGCATCATGACCTTATACATTTCAATCCCTTTTATGCTGGATTCCGTTTAAAGAAGACATTATTAGAGCA GGAAGTACAAGCATTTAAAATATGTAGTTCCCATATATTTCAGGGTCTCTGTGTATTAAGCTAACTCAGATGTTTTGAAAGCTTTTTCTT TAAACAGAGGTGAAATATCTGTGGCTAAAAAGTTTGAGATTTGTGATAACTTTGTAGTCATGTAAAACTTAAGTGCTTCATGCCTCTCCA >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000503682_chr4_83987591_+_1122nt GTTAACTGGCAGGGGCGAGGAGGAGCCCAGGGAGGAAGGAAGGATATTGCCGTAATTCTGAAAGTTTTTTTCCTTCCTCTCTTCCCTTCG CAGAGGTGAGTGCCGGGCTCGGCGCTCTGCTCCTGGAGCTCCCGCGGGACTGCCTGGGGACAGGGACTGCTGTGGCGCTCGGCCCTCCAC TGCGGACCTCTCCTGAGTGGGTGCGCCGAGTCATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCG GCTTCATCCTTTTACCTTCGGTCTTCGGAGTGTCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCA CAATACGAATTGAAAAAGGAACCCCAAAGGAGTCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTG AACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGG AAAAGATAGCATCTCAAATGATAACCGAAGGACGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACACGAGAAG CCCTGCCAACGTGGGATAAGCAGATCCAATCACTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGAATGGA CAGCACAAGCCATGGAAGCCCAGATGGCTCAGTGAATCCTTGCAGAACTTCTGTGCACATGACATCTTTTTCCATGTTGTGCAGATCAGT TTCACTATCTCCAAAGCATTTGCATCATGACCTTATACATTTCAATCCCTTTTATGCTGGATTCCGTTTAAAGAAGACATTATTAGAGCA GGAAGTACAAGCATTTAAAATATGTAGTTCCCATATATTTCAGGGTCTCTGTGTATTAAGCTAACTCAGATGTTTTGAAAGCTTTTTCTT TAAACAGAGGTGAAATATCTGTGGCTAAAAAGTTTGAGATTTGTGATAACTTTGTAGTCATGTAAAACTTAAGTGCTTCATGCCTCTCCA >In-frame_AGPAT9_ENST00000264409_chr4_84465755_+_COPS4_ENST00000511653_chr4_83987591_+_1229nt GTTAACTGGCAGGGGCGAGGAGGAGCCCAGGGAGGAAGGAAGGATATTGCCGTAATTCTGAAAGTTTTTTTCCTTCCTCTCTTCCCTTCG CAGAGGTGAGTGCCGGGCTCGGCGCTCTGCTCCTGGAGCTCCCGCGGGACTGCCTGGGGACAGGGACTGCTGTGGCGCTCGGCCCTCCAC TGCGGACCTCTCCTGAGTGGGTGCGCCGAGTCATGGAGGGCGCAGAGCTGGCCGGGAAGATCCTTTCCACCTGGCTGACGCTGGTTCTCG GCTTCATCCTTTTACCTTCGGTCTTCGGAGTGTCTCTGGGCATCTCCGAGATCTACATGAAGATCCTAGTGAAAACTTTAGAGTGGGCCA CAATACGAATTGAAAAAGGAACCCCAAAGGAGTCGATTCTTAAAAACTCTGCTTCTGTTGGTTCCAGCATCTTGGACAGAGCTGTTATTG AACACAATTTGTTGTCTGCAAGCAAATTATATAATAATATTACCTTCGAAGAACTTGGAGCTCTTTTAGAGATCCCTGCAGCTAAGGCGG AAAAGATAGCATCTCAAATGATAACCGAAGGACGTATGAATGGATTTATTGACCAGATTGATGGAATAGTTCATTTTGAAACTTCTGGCA ACCACCAATCCATCTTCTGTCTCTGGATTTACCTAGTCTGGATAGTTCATATAAATGGAATCATACAATATGTGACATGTGACCTTTTGG CTGATTCCACTCAGCATAGTATCTTTAGGGTTCATCCATGTCATGGCAGCACGAGAAGCCCTGCCAACGTGGGATAAGCAGATCCAATCA CTTTGTTTCCAAGTGAATAACCTTTTGGAGAAAATTAGTCAAACAGCACCAGAATGGACAGCACAAGCCATGGAAGCCCAGATGGCTCAG TGAATCCTTGCAGAACTTCTGTGCACATGACATCTTTTTCCATGTTGTGCAGATCAGTTTCACTATCTCCAAAGCATTTGCATCATGACC TTATACATTTCAATCCCTTTTATGCTGGATTCCGTTTAAAGAAGACATTATTAGAGCAGGAAGTACAAGCATTTAAAATATGTAGTTCCC ATATATTTCAGGGTCTCTGTGTATTAAGCTAACTCAGATGTTTTGAAAGCTTTTTCTTTAAACAGAGGTGAAATATCTGTGGCTAAAAAG |
Top |
FusionGenePPI for AGPAT9_COPS4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AGPAT9 | ELAVL1, HLA-DPA1, TSPAN17, SLC39A4, TCTN2, TCTN3, TMEM17, TMEM216, SLC6A15, TRIM25 | COPS4 | RCBTB2, CCDC85B, USHBP1, C19orf57, MBIP, WRAP73, COPS8, COPS5, COPS6, BTRC, KLHL13, DDB1, CUL4A, COPS3, CUL1, UBC, IKBKB, IRF8, GPS1, COPS2, NEDD8, COPS7A, DDB2, ERCC8, VPRBP, CUL3, CUL4B, CUL5, CUL2, DCUN1D1, PTPN14, TOR1A, SNAPIN, STON2, ERCC6, GRK5, LRR1, DDA1, RFWD2, COPS7B, RBX1, SKP1, FBXO17, TCEB2, TCEB1, FEM1B, LRRC14, BTBD1, BTBD2, KLHL42, KLHL18, DCAF11, DTL, CRBN, TOR1AIP2, IRF5, FBXW4, BAG3, FOS, YWHAQ, FBXO6, CAST, DCAF8, ENAH, EPB41L1, EPB41L2, HSP90AB1, KPNA2, PRMT5, WDR77, STIP1, MOV10, NXF1, STK11, GUCY1A3, TP53, CSNK2A1, EIF3M, NTRK1, KRAS, IBTK, FGFR1OP, HEMGN, APBB3, DET1, UBE2M, FBXO7, KLHL10, DCAF4, DENR, DLD, DCAF4L2, SIRT7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for AGPAT9_COPS4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for AGPAT9_COPS4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|