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Fusion gene ID: 11526 |
FusionGeneSummary for EMC7_CD27 |
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Fusion gene information | Fusion gene name: EMC7_CD27 | Fusion gene ID: 11526 | Hgene | Tgene | Gene symbol | EMC7 | CD27 | Gene ID | 56851 | 939 |
Gene name | ER membrane protein complex subunit 7 | CD27 molecule | |
Synonyms | C11orf3|C15orf24|HT022|ORF1-FL1 | S152|S152. LPFS2|T14|TNFRSF7|Tp55 | |
Cytomap | 15q14 | 12p13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | ER membrane protein complex subunit 7UPF0480 protein C15orf24chromosome 15 hypothetical ATG/GTP binding protein | CD27 antigenCD27L receptorT cell activation antigen S152T-cell activation antigen CD27tumor necrosis factor receptor superfamily, member 7 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9NPA0 | P26842 | |
Ensembl transtripts involved in fusion gene | ENST00000256545, ENST00000532113, | ENST00000266557, ENST00000541233, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 1 X 3=9 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EMC7 [Title/Abstract] AND CD27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CD27 | GO:0043066 | negative regulation of apoptotic process | 12324477 |
Tgene | CD27 | GO:0097191 | extrinsic apoptotic signaling pathway | 9177220 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-X6-A8C6-01A | EMC7 | chr15 | 34388096 | - | CD27 | chr12 | 6554590 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000256545 | ENST00000266557 | EMC7 | chr15 | 34388096 | - | CD27 | chr12 | 6554590 | + |
5CDS-3UTR | ENST00000256545 | ENST00000541233 | EMC7 | chr15 | 34388096 | - | CD27 | chr12 | 6554590 | + |
intron-3CDS | ENST00000532113 | ENST00000266557 | EMC7 | chr15 | 34388096 | - | CD27 | chr12 | 6554590 | + |
intron-3UTR | ENST00000532113 | ENST00000541233 | EMC7 | chr15 | 34388096 | - | CD27 | chr12 | 6554590 | + |
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FusionProtFeatures for EMC7_CD27 |
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Hgene | Tgene |
EMC7 | CD27 |
Receptor for CD70/CD27L. May play a role in survival ofactivated T-cells. May play a role in apoptosis throughassociation with SIVA1. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EMC7_CD27 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EMC7_CD27 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EMC7 | ATP13A2, FBXO6, EMC9, UBQLN2, EMC8, EMC2, EMC3, EMC10, CLPTM1L, EMC6, MMGT1, EMC1, EMC4, TMED10, SDF2L1, ATP1B3, SLC8A3, OR2S2, SLC18A1, P2RX4, ENPP6, CD164L2, TCTN2, TCTN3, TMEM17, TMEM216, TRDN, SLC4A8, PDIA4, KLHL22, IFNA21, KLK6, GPR6, MTNR1A | CD27 | SIVA1, TRAF1, TRAF3, TRAF2, TRAF5, UHRF2, ELAVL1, CD70, C1GALT1, ATP2B3, ADCK4, BIRC2, CD59, CTNNA2, FAM115C, TTYH3, ADCY9, SCAMP1, SEMG2, SEMG1, GOLGA5, C4orf32, TMEM67, SLC25A51, SAAL1, SLC19A2, GNB2, HRAS, TMEM214, CRELD1, PROCR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EMC7_CD27 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EMC7_CD27 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CD27 | C0006625 | Cachexia | 1 | CTD_human |
Tgene | CD27 | C3554540 | LYMPHOPROLIFERATIVE SYNDROME 2 | 1 | UNIPROT |