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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11524

FusionGeneSummary for EMC3_RHOA

check button Fusion gene summary
Fusion gene informationFusion gene name: EMC3_RHOA
Fusion gene ID: 11524
HgeneTgene
Gene symbol

EMC3

RHOA

Gene ID

55831

387

Gene nameER membrane protein complex subunit 3ras homolog family member A
SynonymsPOB|TMEM111ARH12|ARHA|RHO12|RHOH12
Cytomap

3p25.3

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionER membrane protein complex subunit 330 kDa proteinpartial optokinetic response btransmembrane protein 111transforming protein RhoAAplysia ras-related homolog 12oncogene RHO H12small GTP binding protein RhoA
Modification date2018052320180527
UniProtAcc

Q9P0I2

P61586

Ensembl transtripts involved in fusion geneENST00000245046, ENST00000497557, 
ENST00000429759, 
ENST00000418115, 
ENST00000454011, ENST00000422781, 
ENST00000265538, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 9 X 4=360
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EMC3 [Title/Abstract] AND RHOA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRHOA

GO:0007266

Rho protein signal transduction

26529257

TgeneRHOA

GO:0016477

cell migration

26529257

TgeneRHOA

GO:0032956

regulation of actin cytoskeleton organization

25911094

TgeneRHOA

GO:0035385

Roundabout signaling pathway

26529257

TgeneRHOA

GO:0036089

cleavage furrow formation

16103226

TgeneRHOA

GO:0051496

positive regulation of stress fiber assembly

15467718

TgeneRHOA

GO:0060193

positive regulation of lipase activity

19887681

TgeneRHOA

GO:0071222

cellular response to lipopolysaccharide

19734146

TgeneRHOA

GO:0071902

positive regulation of protein serine/threonine kinase activity

8617235


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDREADTCGA-EI-6510-01AEMC3chr3

10012266

-RHOAchr3

49400059

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000245046ENST00000418115EMC3chr3

10012266

-RHOAchr3

49400059

-
In-frameENST00000245046ENST00000454011EMC3chr3

10012266

-RHOAchr3

49400059

-
In-frameENST00000245046ENST00000422781EMC3chr3

10012266

-RHOAchr3

49400059

-
5CDS-intronENST00000245046ENST00000265538EMC3chr3

10012266

-RHOAchr3

49400059

-
5UTR-3CDSENST00000497557ENST00000418115EMC3chr3

10012266

-RHOAchr3

49400059

-
5UTR-3CDSENST00000497557ENST00000454011EMC3chr3

10012266

-RHOAchr3

49400059

-
5UTR-3CDSENST00000497557ENST00000422781EMC3chr3

10012266

-RHOAchr3

49400059

-
5UTR-intronENST00000497557ENST00000265538EMC3chr3

10012266

-RHOAchr3

49400059

-
intron-3CDSENST00000429759ENST00000418115EMC3chr3

10012266

-RHOAchr3

49400059

-
intron-3CDSENST00000429759ENST00000454011EMC3chr3

10012266

-RHOAchr3

49400059

-
intron-3CDSENST00000429759ENST00000422781EMC3chr3

10012266

-RHOAchr3

49400059

-
intron-intronENST00000429759ENST00000265538EMC3chr3

10012266

-RHOAchr3

49400059

-

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FusionProtFeatures for EMC3_RHOA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EMC3

Q9P0I2

RHOA

P61586

Regulates a signal transduction pathway linking plasmamembrane receptors to the assembly of focal adhesions and actinstress fibers. Involved in a microtubule-dependent signal that isrequired for the myosin contractile ring formation during cellcycle cytokinesis. Plays an essential role in cleavage furrowformation. Required for the apical junction formation ofkeratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity.May be an activator of PLCE1. Activated by ARHGEF2, which promotesthe exchange of GDP for GTP. Essential for the SPATA13-mediatedregulation of cell migration and adhesion assembly anddisassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays animportant role in ERBB2-dependent stabilization of microtubules atthe cell cortex. It controls the localization of APC and CLASP2 tothe cell membrane, via the regulation of GSK3B activity. In turn,membrane-bound APC allows the localization of the MACF1 to thecell membrane, which is required for microtubule capture andstabilization. Regulates a signal transduction pathway linkingplasma membrane receptors to the assembly of focal adhesions andactin stress fibers. Involved in a microtubule-dependent signalthat is required for the myosin contractile ring formation duringcell cycle cytokinesis. Plays an essential role in cleavage furrowformation. Required for the apical junction formation ofkeratinocyte cell-cell adhesion. May be an activator of PLCE1.Activated by ARHGEF2, which promotes the exchange of GDP for GTP.Essential for the SPATA13-mediated regulation of cell migrationand adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1signaling pathway plays an important role in ERBB2-dependentstabilization of microtubules at the cell cortex. It controls thelocalization of APC and CLASP2 to the cell membrane, via theregulation of GSK3B activity. In turn, membrane-bound APC allowsthe localization of the MACF1 to the cell membrane, which isrequired for microtubule capture and stabilization (Bysimilarity). Regulates KCNA2 potassium channel activity byreducing its location at the cell surface in response to CHRM1activation; promotes KCNA2 endocytosis (PubMed:9635436,PubMed:19403695). {ECO:0000250, ECO:0000269|PubMed:12900402,ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794,ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854,ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:8910519,ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}. (Microbial infection) Serves as a target for the yopTcysteine peptidase from Yersinia pestis, vector of the plague.{ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}. (Microbial infection) Serves as a target for the yopTcysteine peptidase from Yersinia pseudotuberculosis, which causesgastrointestinal disorders. {ECO:0000269|PubMed:12062101,ECO:0000269|PubMed:12538863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEMC3chr3:10012266chr3:49400059ENST00000245046-68118_138191262TransmembraneHelical
HgeneEMC3chr3:10012266chr3:49400059ENST00000245046-6814_34191262TransmembraneHelical
TgeneRHOAchr3:10012266chr3:49400059ENST00000418115-25182_18792194Compositional biasNote=Arg/Lys-rich (basic)
TgeneRHOAchr3:10012266chr3:49400059ENST00000418115-25117_12092194Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRHOAchr3:10012266chr3:49400059ENST00000418115-2534_4292194MotifEffector region
TgeneRHOAchr3:10012266chr3:49400059ENST00000418115-2512_1992194Nucleotide bindingGTP
TgeneRHOAchr3:10012266chr3:49400059ENST00000418115-2559_6392194Nucleotide bindingGTP


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FusionGeneSequence for EMC3_RHOA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000418115_chr3_49400059_-_293aa
MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKTTFNNPEDGFFKK
TKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLR
SIYSLILGQDNENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVF

>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000454011_chr3_49400059_-_230aa
MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKTTFNNPEDGFFKK
TKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLR

>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000422781_chr3_49400059_-_287aa
MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKTTFNNPEDGFFKK
TKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLR
SIYSLILGQDNENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPHCVARLECCGTILAQLQPPPPRFKRFPCLSLLS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000418115_chr3_49400059_-_879nt
ATGGCAGGGCCAGAACTGTTGCTCGACTCCAACATCCGCCTCTGGGTGGTCCTACCCATCGTTATCATCACTTTCTTCGTAGGCATGATC
CGCCACTACGTGTCCATCCTGCTGCAGAGCGACAAGAAGCTCACCCAGGAACAAGTATCTGACAGTCAAGTCCTAATTCGAAGCAGAGTC
CTCAGGGAAAATGGAAAATACATTCCCAAACAGTCTTTCTTGACACGAAAATATTATTTCAACAACCCAGAGGATGGATTTTTCAAAAAA
ACTAAACGGAAGGTAGTGCCACCTTCTCCTATGACTGATCCTACTATGTTGACAGACATGATGAAAGGGAATGTAACAAATGTCCTCCCT
ATGATTCTTATTGGTGGATGGATCAACATGACATTCTCAGGCTTTGTCACAACCAAGGTCCCATTTCCACTGACCCTCCGTTTTAAGCCT
ATGTTACAGCAAGGAATCGAGCTACTCACATTAGATGCATCCTGGGTGAGTTCTGCATCCTGGTACTTCCTCAATGTATTTGGGCTTCGG
AGCATTTACTCTCTGATTCTGGGCCAAGATAATGAAAACATCCCAGAAAAGTGGACCCCAGAAGTCAAGCATTTCTGTCCCAACGTGCCC
ATCATCCTGGTTGGGAATAAGAAGGATCTTCGGAATGATGAGCACACAAGGCGGGAGCTAGCCAAGATGAAGCAGGAGCCGGTGAAACCT
GAAGAAGGCAGAGATATGGCAAACAGGATTGGCGCTTTTGGGTACATGGAGTGTTCAGCAAAGACCAAAGATGGAGTGAGAGAGGTTTTT

>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000454011_chr3_49400059_-_691nt
ATGGCAGGGCCAGAACTGTTGCTCGACTCCAACATCCGCCTCTGGGTGGTCCTACCCATCGTTATCATCACTTTCTTCGTAGGCATGATC
CGCCACTACGTGTCCATCCTGCTGCAGAGCGACAAGAAGCTCACCCAGGAACAAGTATCTGACAGTCAAGTCCTAATTCGAAGCAGAGTC
CTCAGGGAAAATGGAAAATACATTCCCAAACAGTCTTTCTTGACACGAAAATATTATTTCAACAACCCAGAGGATGGATTTTTCAAAAAA
ACTAAACGGAAGGTAGTGCCACCTTCTCCTATGACTGATCCTACTATGTTGACAGACATGATGAAAGGGAATGTAACAAATGTCCTCCCT
ATGATTCTTATTGGTGGATGGATCAACATGACATTCTCAGGCTTTGTCACAACCAAGGTCCCATTTCCACTGACCCTCCGTTTTAAGCCT
ATGTTACAGCAAGGAATCGAGCTACTCACATTAGATGCATCCTGGGTGAGTTCTGCATCCTGGTACTTCCTCAATGTATTTGGGCTTCGG
AGCATTTACTCTCTGATTCTGGGCCAAGATAATGAAAACATCCCAGAAAAGTGGACCCCAGAAGTCAAGCATTTCTGTCCCAACGTGCCC

>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000422781_chr3_49400059_-_861nt
ATGGCAGGGCCAGAACTGTTGCTCGACTCCAACATCCGCCTCTGGGTGGTCCTACCCATCGTTATCATCACTTTCTTCGTAGGCATGATC
CGCCACTACGTGTCCATCCTGCTGCAGAGCGACAAGAAGCTCACCCAGGAACAAGTATCTGACAGTCAAGTCCTAATTCGAAGCAGAGTC
CTCAGGGAAAATGGAAAATACATTCCCAAACAGTCTTTCTTGACACGAAAATATTATTTCAACAACCCAGAGGATGGATTTTTCAAAAAA
ACTAAACGGAAGGTAGTGCCACCTTCTCCTATGACTGATCCTACTATGTTGACAGACATGATGAAAGGGAATGTAACAAATGTCCTCCCT
ATGATTCTTATTGGTGGATGGATCAACATGACATTCTCAGGCTTTGTCACAACCAAGGTCCCATTTCCACTGACCCTCCGTTTTAAGCCT
ATGTTACAGCAAGGAATCGAGCTACTCACATTAGATGCATCCTGGGTGAGTTCTGCATCCTGGTACTTCCTCAATGTATTTGGGCTTCGG
AGCATTTACTCTCTGATTCTGGGCCAAGATAATGAAAACATCCCAGAAAAGTGGACCCCAGAAGTCAAGCATTTCTGTCCCAACGTGCCC
ATCATCCTGGTTGGGAATAAGAAGGATCTTCGGAATGATGAGCACACAAGGCGGGAGCTAGCCAAGATGAAGCAGGAGCCTCACTGTGTC
GCCAGGCTGGAGTGCTGTGGCACGATCTTGGCTCAACTGCAACCTCCGCCTCCCAGATTTAAGCGATTCCCCTGCCTCAGCCTCCTGAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000418115_chr3_49400059_-_2402nt
TGCCTCAGCCTCCCGAGTAGCTGCGACTACAGGCGCCTCCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACC
TGTTAGCCAGGATGGTCTCGATCCCCTGACCTCGTGATCCCCCCACCTTGGCCTCCCAAAGTGCTGGGATTCCAGGAGTGAGCCACCGAG
CCTGGGCCACCGCCGATAGTTTTCCACTTTCCCGCCAGGCCCGACGCCGCTCTGACGCCACTGAGGTGCGCCACGACGTGACGTCAACGT
TCGCGCCGGAAGTGGAAGACCAGGCAGCCCAGCTGAAGGCAGTAAGCTCGGCTCACAGTCGCAGGAGAGTTCTGGGGTACACGGGCAAAG
GGGCTTGAGAAGGCCCGGAGGCGAAGCCGAAGAGAAGCAACTGTGCCCCGGAGAAGAGAAGCTCGCCCATTCCAGACTGGGAACCAGCTT
TCAGTGAAGATGGCAGGGCCAGAACTGTTGCTCGACTCCAACATCCGCCTCTGGGTGGTCCTACCCATCGTTATCATCACTTTCTTCGTA
GGCATGATCCGCCACTACGTGTCCATCCTGCTGCAGAGCGACAAGAAGCTCACCCAGGAACAAGTATCTGACAGTCAAGTCCTAATTCGA
AGCAGAGTCCTCAGGGAAAATGGAAAATACATTCCCAAACAGTCTTTCTTGACACGAAAATATTATTTCAACAACCCAGAGGATGGATTT
TTCAAAAAAACTAAACGGAAGGTAGTGCCACCTTCTCCTATGACTGATCCTACTATGTTGACAGACATGATGAAAGGGAATGTAACAAAT
GTCCTCCCTATGATTCTTATTGGTGGATGGATCAACATGACATTCTCAGGCTTTGTCACAACCAAGGTCCCATTTCCACTGACCCTCCGT
TTTAAGCCTATGTTACAGCAAGGAATCGAGCTACTCACATTAGATGCATCCTGGGTGAGTTCTGCATCCTGGTACTTCCTCAATGTATTT
GGGCTTCGGAGCATTTACTCTCTGATTCTGGGCCAAGATAATGAAAACATCCCAGAAAAGTGGACCCCAGAAGTCAAGCATTTCTGTCCC
AACGTGCCCATCATCCTGGTTGGGAATAAGAAGGATCTTCGGAATGATGAGCACACAAGGCGGGAGCTAGCCAAGATGAAGCAGGAGCCG
GTGAAACCTGAAGAAGGCAGAGATATGGCAAACAGGATTGGCGCTTTTGGGTACATGGAGTGTTCAGCAAAGACCAAAGATGGAGTGAGA
GAGGTTTTTGAAATGGCTACGAGAGCTGCTCTGCAAGCTAGACGTGGGAAGAAAAAATCTGGGTGCCTTGTCTTGTGAAACCTTGCTGCA
AGCACAGCCCTTATGCGGTTAATTTTGAAGTGCTGTTTATTAATCTTAGTGTATGATTACTGGCCTTTTTCATTTATCTATAATTTACCT
AAGATTACAAATCAGAAGTCATCTTGCTACCAGTATTTAGAAGCCAACTATGATTATTAACGATGTCCAACCCGTCTGGCCCACCAGGGT
CCTTTTGACACTGCTCTAACAGCCCTCCTCTGCACTCCCACCTGACACACCAGGCGCTAATTCAAGGAATTTCTTAACTTCTTGCTTCTT
TCTAGAAAGAGAAACAGTTGGTAACTTTTGTGAATTAGGCTGTAACTACTTTATAACTAACATGTCCTGCCTATTATCTGTCAGCTGCAA
GGTACTCTGGTGAGTCACCACTTCAGGGCTTTACTCCGTAACAGATTTTGTTGGCATAGCTCTGGGGTGGGCAGTTTTTTGAAAATGGGC
TCAACCAGAAAAGCCCAAGTTCATGCAGCTGTGGCAGAGTTACAGTTCTGTGGTTTCATGTTAGTTACCTTATAGTTACTGTGTAATTAG
TGCCACTTAATGTATGTTACCAAAAATAAATATATCTACCCCAGACTAGATGTAGTATTTTTTGTATAATTGGATTTCCTAATACTGTCA
TCCTCAAAGAAAGTGTATTGGTTTTTTAAAAAAGAAAGTGTATTTGGAAATAAAGTCAGATGGAAAATTCATTTTTTAAATTCCCGTTTT
GTCACTTTTTCTGATAAAAGATGGCCATATTACCCCTTTTCGGCCCCATGTATCTCAGTACCCCATGGAGCTGGGCTAAGTAAATAGGAA
TTGGTTTCACGCCTGAGGCAATTAGACACTTTGGAAGATGGCATAACCTGTCTCACCTGGACTTAAGCATCTGGCTCTAATTCACAGTGC
TCTTTTCTCCTCACTGTATCCAGGTTCCCTCCCAGAGGAGCCACCAGTTCTCATGGGTGGCACTCAGTCTCTCTTCTCTCCAGCTGACTA

>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000454011_chr3_49400059_-_1655nt
TGCCTCAGCCTCCCGAGTAGCTGCGACTACAGGCGCCTCCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACC
TGTTAGCCAGGATGGTCTCGATCCCCTGACCTCGTGATCCCCCCACCTTGGCCTCCCAAAGTGCTGGGATTCCAGGAGTGAGCCACCGAG
CCTGGGCCACCGCCGATAGTTTTCCACTTTCCCGCCAGGCCCGACGCCGCTCTGACGCCACTGAGGTGCGCCACGACGTGACGTCAACGT
TCGCGCCGGAAGTGGAAGACCAGGCAGCCCAGCTGAAGGCAGTAAGCTCGGCTCACAGTCGCAGGAGAGTTCTGGGGTACACGGGCAAAG
GGGCTTGAGAAGGCCCGGAGGCGAAGCCGAAGAGAAGCAACTGTGCCCCGGAGAAGAGAAGCTCGCCCATTCCAGACTGGGAACCAGCTT
TCAGTGAAGATGGCAGGGCCAGAACTGTTGCTCGACTCCAACATCCGCCTCTGGGTGGTCCTACCCATCGTTATCATCACTTTCTTCGTA
GGCATGATCCGCCACTACGTGTCCATCCTGCTGCAGAGCGACAAGAAGCTCACCCAGGAACAAGTATCTGACAGTCAAGTCCTAATTCGA
AGCAGAGTCCTCAGGGAAAATGGAAAATACATTCCCAAACAGTCTTTCTTGACACGAAAATATTATTTCAACAACCCAGAGGATGGATTT
TTCAAAAAAACTAAACGGAAGGTAGTGCCACCTTCTCCTATGACTGATCCTACTATGTTGACAGACATGATGAAAGGGAATGTAACAAAT
GTCCTCCCTATGATTCTTATTGGTGGATGGATCAACATGACATTCTCAGGCTTTGTCACAACCAAGGTCCCATTTCCACTGACCCTCCGT
TTTAAGCCTATGTTACAGCAAGGAATCGAGCTACTCACATTAGATGCATCCTGGGTGAGTTCTGCATCCTGGTACTTCCTCAATGTATTT
GGGCTTCGGAGCATTTACTCTCTGATTCTGGGCCAAGATAATGAAAACATCCCAGAAAAGTGGACCCCAGAAGTCAAGCATTTCTGTCCC
AACGTGCCCATCATCCTGGTTGGGAATAAGAAGGATCTTCGGAATGATGAGCACACAAGGCGGGAGCTAGCCAAGATGAAGCAGGAGCCG
GTGAAACCTGAAGAAGGCAGAGATATGGCAAACAGGATTGGCGCTTTTGGGTACATGGAGTGTTCAGCAAAGACCAAAGATGGAGTGAGA
GAGGTTTTTGAAATGGCTACGAGAGCTGCTCTGCAAGCTAGACGTGGGAAGAAAAAATCTGGGTGCCTTGTCTTGTGAAACCTTGCTGCA
AGCACAGCCCTTATGCGGTTAATTTTGAAGTGCTGTTTATTAATCTTAGTGTATGATTACTGGCCTTTTTCATTTATCTATAATTTACCT
AAGATTACAAATCAGAAGTCATCTTGCTACCAGTATTTAGAAGCCAACTATGATTATTAACGATGTCCAACCCGTCTGGCCCACCAGGGT
CCTTTTGACACTGCTCTAACAGCCCTCCTCTGCACTCCCACCTGACACACCAGGCGCTAATTCAAGGAATTTCTTAACTTCTTGCTTCTT

>In-frame_EMC3_ENST00000245046_chr3_10012266_-_RHOA_ENST00000422781_chr3_49400059_-_1564nt
TGCCTCAGCCTCCCGAGTAGCTGCGACTACAGGCGCCTCCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACC
TGTTAGCCAGGATGGTCTCGATCCCCTGACCTCGTGATCCCCCCACCTTGGCCTCCCAAAGTGCTGGGATTCCAGGAGTGAGCCACCGAG
CCTGGGCCACCGCCGATAGTTTTCCACTTTCCCGCCAGGCCCGACGCCGCTCTGACGCCACTGAGGTGCGCCACGACGTGACGTCAACGT
TCGCGCCGGAAGTGGAAGACCAGGCAGCCCAGCTGAAGGCAGTAAGCTCGGCTCACAGTCGCAGGAGAGTTCTGGGGTACACGGGCAAAG
GGGCTTGAGAAGGCCCGGAGGCGAAGCCGAAGAGAAGCAACTGTGCCCCGGAGAAGAGAAGCTCGCCCATTCCAGACTGGGAACCAGCTT
TCAGTGAAGATGGCAGGGCCAGAACTGTTGCTCGACTCCAACATCCGCCTCTGGGTGGTCCTACCCATCGTTATCATCACTTTCTTCGTA
GGCATGATCCGCCACTACGTGTCCATCCTGCTGCAGAGCGACAAGAAGCTCACCCAGGAACAAGTATCTGACAGTCAAGTCCTAATTCGA
AGCAGAGTCCTCAGGGAAAATGGAAAATACATTCCCAAACAGTCTTTCTTGACACGAAAATATTATTTCAACAACCCAGAGGATGGATTT
TTCAAAAAAACTAAACGGAAGGTAGTGCCACCTTCTCCTATGACTGATCCTACTATGTTGACAGACATGATGAAAGGGAATGTAACAAAT
GTCCTCCCTATGATTCTTATTGGTGGATGGATCAACATGACATTCTCAGGCTTTGTCACAACCAAGGTCCCATTTCCACTGACCCTCCGT
TTTAAGCCTATGTTACAGCAAGGAATCGAGCTACTCACATTAGATGCATCCTGGGTGAGTTCTGCATCCTGGTACTTCCTCAATGTATTT
GGGCTTCGGAGCATTTACTCTCTGATTCTGGGCCAAGATAATGAAAACATCCCAGAAAAGTGGACCCCAGAAGTCAAGCATTTCTGTCCC
AACGTGCCCATCATCCTGGTTGGGAATAAGAAGGATCTTCGGAATGATGAGCACACAAGGCGGGAGCTAGCCAAGATGAAGCAGGAGCCT
CACTGTGTCGCCAGGCTGGAGTGCTGTGGCACGATCTTGGCTCAACTGCAACCTCCGCCTCCCAGATTTAAGCGATTCCCCTGCCTCAGC
CTCCTGAGTAGCTGGGGTTACAGGCGCCCACTACCACACCCAGGAGCCGGTGAAACCTGAAGAAGGCAGAGATATGGCAAACAGGATTGG
CGCTTTTGGGTACATGGAGTGTTCAGCAAAGACCAAAGATGGAGTGAGAGAGGTTTTTGAAATGGCTACGAGAGCTGCTCTGCAAGCTAG
ACGTGGGAAGAAAAAATCTGGGTGCCTTGTCTTGTGAAACCTTGCTGCAAGCACAGCCCTTATGCGGTTAATTTTGAAGTGCTGTTTATT


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FusionGenePPI for EMC3_RHOA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EMC3UBC, FBXO6, CCDC8, EGFR, EMC7, EMC8, DERL2, EMC1, EMC9, UBQLN2, EMC2, MMGT1, UBAC2, EMC4, EMC10, SDF2L1, ATP1B4, ENPP6, OFD1, TCTN2, TCTN3, RPGRIP1L, DCTN1, TMEM237, TCTN1, TMEM17, TMEM216, TMEM67, CTDNEP1, TPTE, TRDN, IFNA21, SCGB1D1, PDIA4, SLC18A1, SLC4A8, CSGALNACT2, GNRH1, SLC17A2, EDEM3RHOAPDE6D, RAP1GDS1, ARHGAP1, ARHGDIA, BID, TNFRSF10B, EZR, FADD, FASLG, MAPK8, MSN, CASP10, CASP8, FAS, TNFRSF1A, ARHGEF25, DEF6, ARHGAP32, ARHGAP5, ROCK1, PKN1, DIAPH1, CIT, RHPN2, KTN1, ITPR1, TRPC1, ARHGEF1, PLD1, RTKN, NET1, CRMP1, DPYSL2, ARHGEF12, HSPA1A, PLCG1, ARHGEF3, AKAP13, PKN2, ICMT, VAV3, ARHGEF18, ARHGAP26, ARHGAP10, KCNA2, ARHGEF4, ARHGEF2, ARHGAP35, ARHGEF11, RIPK4, MPRIP, OPHN1, DGKQ, ROCK2, TRIO, MCF2, PLEKHG2, ARHGDIG, MCF2L, BCR, PLXNB1, SMURF1, SMURF2, OTUB1, CUL3, SRGAP1, CAV1, HTR1A, MAP3K1, MDM2, PSMD10, MARK2, LRRK2, PPP1R12A, RPS27A, CLNS1A, MPV17, PON2, PRDX6, NUBP2, SLC25A5, PLIN3, CPT1A, RPL18, DDX1, BAIAP2, DIAPH3, CDKN1B, GNB2L1, RPN2, FAM65B, SMAD2, TBXA2R, BIRC2, IKBKG, KCTD13, TNFAIP1, TRIP6, IKZF3, UBC, DCUN1D1, KLHL20, MBD5, SERPINB5, TM4SF20, DIRAS3, LDB3, NFKBIA, TSC22D4, RASL10A, APOA1BP, ARHGDIB, GORASP2, PAFAH1B2, PRRC1, NUTF2, RPE, SHMT2, SLC25A12, CNKSR1, RHPN1, MED20, RPGR, LIMA1, ATP6AP2, NVL, UBE2V2, FUBP3, BAZ1A, STK39, SYNPO2, DAAM1, RASSF1, S100A4, ANLN, U2AF2, SH3GLB2, GOSR1, AGAP2, AGAP1, RHOC, PKN3, DNAL1, RABL3, AK9, IRGC, RAP2C, HDAC7, GLB1, VASH1, CTSA, FGB, LUM, PTEN, COX15, DLST, HSD17B10, PDHA1, SOD1, KRAS, NOTCH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EMC3_RHOA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EMC3_RHOA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRHOAC0038356Stomach Neoplasms3CTD_human
TgeneRHOAC0020981Angioimmunoblastic Lymphadenopathy2CTD_human
TgeneRHOAC0079774Peripheral T-Cell Lymphoma2CTD_human
TgeneRHOAC0005695Bladder Neoplasm1CTD_human
TgeneRHOAC0027626Neoplasm Invasiveness1CTD_human
TgeneRHOAC0033687Proteinuria1CTD_human
TgeneRHOAC0079772T-Cell Lymphoma1CTD_human
TgeneRHOAC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneRHOAC0235833Congenital diaphragmatic hernia1CTD_human