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Fusion gene ID: 11486 |
FusionGeneSummary for ELOVL2-AS1_LRP1B |
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Fusion gene information | Fusion gene name: ELOVL2-AS1_LRP1B | Fusion gene ID: 11486 | Hgene | Tgene | Gene symbol | ELOVL2-AS1 | LRP1B | Gene ID | 100506409 | 53353 |
Gene name | ELOVL2 antisense RNA 1 | LDL receptor related protein 1B | |
Synonyms | - | LRP-1B|LRP-DIT|LRPDIT | |
Cytomap | 6p24.2 | 2q22.1-q22.2 | |
Type of gene | ncRNA | protein-coding | |
Description | ELOVL2 antisense RNA 1 (non-protein coding) | low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors) | |
Modification date | 20180329 | 20180519 | |
UniProtAcc | Q9NZR2 | ||
Ensembl transtripts involved in fusion gene | ENST00000606532, ENST00000456190, ENST00000607275, ENST00000456616, | ENST00000389484, ENST00000486364, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 4=100 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ELOVL2-AS1 [Title/Abstract] AND LRP1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE065041 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000606532 | ENST00000389484 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
intron-intron | ENST00000606532 | ENST00000486364 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
intron-intron | ENST00000456190 | ENST00000389484 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
intron-intron | ENST00000456190 | ENST00000486364 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
intron-intron | ENST00000607275 | ENST00000389484 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
intron-intron | ENST00000607275 | ENST00000486364 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
intron-intron | ENST00000456616 | ENST00000389484 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
intron-intron | ENST00000456616 | ENST00000486364 | ELOVL2-AS1 | chr6 | 11066324 | - | LRP1B | chr2 | 142171176 | - |
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FusionProtFeatures for ELOVL2-AS1_LRP1B |
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Hgene | Tgene |
ELOVL2-AS1 | LRP1B |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Potential cell surface proteins that bind andinternalize ligands in the process of receptor-mediatedendocytosis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ELOVL2-AS1_LRP1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ELOVL2-AS1_LRP1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ELOVL2-AS1_LRP1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ELOVL2-AS1_LRP1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LRP1B | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | LRP1B | C0025202 | melanoma | 1 | CTD_human |