FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 11486

FusionGeneSummary for ELOVL2-AS1_LRP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ELOVL2-AS1_LRP1B
Fusion gene ID: 11486
HgeneTgene
Gene symbol

ELOVL2-AS1

LRP1B

Gene ID

100506409

53353

Gene nameELOVL2 antisense RNA 1LDL receptor related protein 1B
Synonyms-LRP-1B|LRP-DIT|LRPDIT
Cytomap

6p24.2

2q22.1-q22.2

Type of genencRNAprotein-coding
DescriptionELOVL2 antisense RNA 1 (non-protein coding)low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors)
Modification date2018032920180519
UniProtAcc

Q9NZR2

Ensembl transtripts involved in fusion geneENST00000606532, ENST00000456190, 
ENST00000607275, ENST00000456616, 
ENST00000389484, ENST00000486364, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 4=100
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ELOVL2-AS1 [Title/Abstract] AND LRP1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE065041ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000606532ENST00000389484ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-
intron-intronENST00000606532ENST00000486364ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-
intron-intronENST00000456190ENST00000389484ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-
intron-intronENST00000456190ENST00000486364ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-
intron-intronENST00000607275ENST00000389484ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-
intron-intronENST00000607275ENST00000486364ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-
intron-intronENST00000456616ENST00000389484ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-
intron-intronENST00000456616ENST00000486364ELOVL2-AS1chr6

11066324

-LRP1Bchr2

142171176

-

Top

FusionProtFeatures for ELOVL2-AS1_LRP1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELOVL2-AS1

LRP1B

Q9NZR2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Potential cell surface proteins that bind andinternalize ligands in the process of receptor-mediatedendocytosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ELOVL2-AS1_LRP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ELOVL2-AS1_LRP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ELOVL2-AS1_LRP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ELOVL2-AS1_LRP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLRP1BC0007134Renal Cell Carcinoma1CTD_human
TgeneLRP1BC0025202melanoma1CTD_human