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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11479

FusionGeneSummary for ELN_METTL2B

check button Fusion gene summary
Fusion gene informationFusion gene name: ELN_METTL2B
Fusion gene ID: 11479
HgeneTgene
Gene symbol

ELN

METTL2B

Gene ID

100130933

55798

Gene namesmall integral membrane protein 6methyltransferase like 2B
SynonymsC17orf110|ELNMETL|METTL2|METTL2A|PSENIP1
Cytomap

17q25.1

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionsmall integral membrane protein 6endoregulinmethyltransferase-like protein 2B
Modification date2018040220180523
UniProtAcc

P15502

Q6P1Q9

Ensembl transtripts involved in fusion geneENST00000445912, ENST00000252034, 
ENST00000358929, ENST00000320492, 
ENST00000414324, ENST00000380562, 
ENST00000380575, ENST00000380584, 
ENST00000458204, ENST00000357036, 
ENST00000429192, ENST00000380553, 
ENST00000380576, ENST00000320399, 
ENST00000466878, 		ENST00000262432, 
ENST00000480046, ENST00000473488, 
Fusion gene scores* DoF score8 X 6 X 3=1443 X 3 X 3=27
# samples 73
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ELN [Title/Abstract] AND METTL2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AO-A0J3-01AELNchr7

73442599

+METTL2Bchr7

128133858

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000445912ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000445912ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000445912ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000252034ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000252034ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000252034ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000358929ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000358929ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000358929ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000320492ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000320492ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000320492ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000414324ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000414324ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000414324ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380562ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380562ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000380562ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380575ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380575ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000380575ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380584ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380584ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000380584ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000458204ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000458204ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000458204ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000357036ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000357036ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000357036ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000429192ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000429192ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000429192ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380553ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380553ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000380553ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380576ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000380576ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000380576ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000320399ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
Frame-shiftENST00000320399ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
5CDS-intronENST00000320399ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+
intron-3CDSENST00000466878ENST00000262432ELNchr7

73442599

+METTL2Bchr7

128133858

+
intron-3CDSENST00000466878ENST00000480046ELNchr7

73442599

+METTL2Bchr7

128133858

+
intron-intronENST00000466878ENST00000473488ELNchr7

73442599

+METTL2Bchr7

128133858

+

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FusionProtFeatures for ELN_METTL2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELN

P15502

METTL2B

Q6P1Q9

Probable S-adenosyl-L-methionine-dependentmethyltransferase that mediates 3-methylcytidine modification ofsome tRNAs. {ECO:0000269|PubMed:21518805}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELN_METTL2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELN_METTL2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELNBGN, DCN, FBN1, FBN2, FBLN1, FBLN2, NID2, PRTN3, LGALS3, FCN1, CLU, LOX, CKMT2, MAGEH1METTL2BAPP, MAPK3, CENPU, METTL2A, NAT16, TPM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELN_METTL2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneELNP15502DB00533RofecoxibElastinsmall moleculeapproved|investigational|withdrawn

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RelatedDiseases for ELN_METTL2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELNC0003499Supravalvular aortic stenosis2CTD_human;HPO;ORPHANET
HgeneELNC0034069Pulmonary Fibrosis2CTD_human
HgeneELNC0010495Cutis Laxa1CTD_human;HPO
HgeneELNC0019284Diaphragmatic Hernia1CTD_human
HgeneELNC0020538Hypertensive disease1CTD_human
HgeneELNC0024117Chronic Obstructive Airway Disease1CTD_human
HgeneELNC0034067Pulmonary Emphysema1CTD_human;HPO
HgeneELNC0151744Myocardial Ischemia1CTD_human
HgeneELNC0238288Muscular Dystrophy, Facioscapulohumeral1CTD_human