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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1147

FusionGeneSummary for AGPAT4_CASC17

check button Fusion gene summary
Fusion gene informationFusion gene name: AGPAT4_CASC17
Fusion gene ID: 1147
HgeneTgene
Gene symbol

AGPAT4

CASC17

Gene ID

56895

101928165

Gene name1-acylglycerol-3-phosphate O-acyltransferase 4cancer susceptibility 17
Synonyms1-AGPAT4|LPAAT-delta|dJ473J16.2LINC00600
Cytomap

6q26

17q24.3

Type of geneprotein-codingncRNA
Description1-acyl-sn-glycerol-3-phosphate acyltransferase delta1-AGP acyltransferase 41-AGPAT 41-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)lysophosphatidic acid acyltransferase deltalysophosphatidic acid acyltrancancer susceptibility 17 (non-protein coding)cancer susceptibility candidate 17 (non-protein coding)long intergenic non-protein coding RNA 600
Modification date2018052320180517
UniProtAcc

Q9NRZ5

Ensembl transtripts involved in fusion geneENST00000366911, ENST00000320285, 
ENST00000457520, ENST00000366908, 
ENST00000366906, ENST00000366905, 
ENST00000569074, 
Fusion gene scores* DoF score3 X 4 X 2=242 X 1 X 2=4
# samples 52
** MAII scorelog2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: AGPAT4 [Title/Abstract] AND CASC17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1724-01AAGPAT4chr6

161653068

-CASC17chr17

69181796

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000366911ENST00000569074AGPAT4chr6

161653068

-CASC17chr17

69181796

-
5CDS-5UTRENST00000320285ENST00000569074AGPAT4chr6

161653068

-CASC17chr17

69181796

-
5CDS-5UTRENST00000457520ENST00000569074AGPAT4chr6

161653068

-CASC17chr17

69181796

-
5CDS-5UTRENST00000366908ENST00000569074AGPAT4chr6

161653068

-CASC17chr17

69181796

-
intron-5UTRENST00000366906ENST00000569074AGPAT4chr6

161653068

-CASC17chr17

69181796

-
5CDS-5UTRENST00000366905ENST00000569074AGPAT4chr6

161653068

-CASC17chr17

69181796

-

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FusionProtFeatures for AGPAT4_CASC17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGPAT4

Q9NRZ5

CASC17

Converts lysophosphatidic acid (LPA) into phosphatidicacid by incorporating an acyl moiety at the sn-2 position of theglycerol backbone. {ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AGPAT4_CASC17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AGPAT4_CASC17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AGPAT4REL, TSPAN5, TSPAN17, SLC39A4, VIPR2, SLC7A1, C3AR1, CYB5A, VIPR1CASC17


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGPAT4_CASC17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AGPAT4_CASC17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource