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Fusion gene ID: 1147 |
FusionGeneSummary for AGPAT4_CASC17 |
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Fusion gene information | Fusion gene name: AGPAT4_CASC17 | Fusion gene ID: 1147 | Hgene | Tgene | Gene symbol | AGPAT4 | CASC17 | Gene ID | 56895 | 101928165 |
Gene name | 1-acylglycerol-3-phosphate O-acyltransferase 4 | cancer susceptibility 17 | |
Synonyms | 1-AGPAT4|LPAAT-delta|dJ473J16.2 | LINC00600 | |
Cytomap | 6q26 | 17q24.3 | |
Type of gene | protein-coding | ncRNA | |
Description | 1-acyl-sn-glycerol-3-phosphate acyltransferase delta1-AGP acyltransferase 41-AGPAT 41-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)lysophosphatidic acid acyltransferase deltalysophosphatidic acid acyltran | cancer susceptibility 17 (non-protein coding)cancer susceptibility candidate 17 (non-protein coding)long intergenic non-protein coding RNA 600 | |
Modification date | 20180523 | 20180517 | |
UniProtAcc | Q9NRZ5 | ||
Ensembl transtripts involved in fusion gene | ENST00000366911, ENST00000320285, ENST00000457520, ENST00000366908, ENST00000366906, ENST00000366905, | ENST00000569074, | |
Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 2 X 1 X 2=4 |
# samples | 5 | 2 | |
** MAII score | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: AGPAT4 [Title/Abstract] AND CASC17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-61-1724-01A | AGPAT4 | chr6 | 161653068 | - | CASC17 | chr17 | 69181796 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000366911 | ENST00000569074 | AGPAT4 | chr6 | 161653068 | - | CASC17 | chr17 | 69181796 | - |
5CDS-5UTR | ENST00000320285 | ENST00000569074 | AGPAT4 | chr6 | 161653068 | - | CASC17 | chr17 | 69181796 | - |
5CDS-5UTR | ENST00000457520 | ENST00000569074 | AGPAT4 | chr6 | 161653068 | - | CASC17 | chr17 | 69181796 | - |
5CDS-5UTR | ENST00000366908 | ENST00000569074 | AGPAT4 | chr6 | 161653068 | - | CASC17 | chr17 | 69181796 | - |
intron-5UTR | ENST00000366906 | ENST00000569074 | AGPAT4 | chr6 | 161653068 | - | CASC17 | chr17 | 69181796 | - |
5CDS-5UTR | ENST00000366905 | ENST00000569074 | AGPAT4 | chr6 | 161653068 | - | CASC17 | chr17 | 69181796 | - |
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FusionProtFeatures for AGPAT4_CASC17 |
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Hgene | Tgene |
AGPAT4 | CASC17 |
Converts lysophosphatidic acid (LPA) into phosphatidicacid by incorporating an acyl moiety at the sn-2 position of theglycerol backbone. {ECO:0000250}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AGPAT4_CASC17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AGPAT4_CASC17 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AGPAT4 | REL, TSPAN5, TSPAN17, SLC39A4, VIPR2, SLC7A1, C3AR1, CYB5A, VIPR1 | CASC17 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AGPAT4_CASC17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AGPAT4_CASC17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |