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Fusion gene ID: 11456 |
FusionGeneSummary for ELMO2_MYBL2 |
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Fusion gene information | Fusion gene name: ELMO2_MYBL2 | Fusion gene ID: 11456 | Hgene | Tgene | Gene symbol | ELMO2 | MYBL2 | Gene ID | 63916 | 4605 |
Gene name | engulfment and cell motility 2 | MYB proto-oncogene like 2 | |
Synonyms | CED-12|CED12|Ced-12A|ELMO-2|VMPI | B-MYB|BMYB | |
Cytomap | 20q13.12 | 20q13.12 | |
Type of gene | protein-coding | protein-coding | |
Description | engulfment and cell motility protein 2PH domain protein CED12Aced-12 homolog 2protein ced-12 homolog A | myb-related protein Bmyb-like protein 2v-myb avian myeloblastosis viral oncogene homolog-like 2v-myb myeloblastosis viral oncogene homolog-like 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96JJ3 | P10244 | |
Ensembl transtripts involved in fusion gene | ENST00000290246, ENST00000372176, ENST00000396391, ENST00000439931, ENST00000445496, ENST00000454865, ENST00000352077, ENST00000488853, | ENST00000396863, ENST00000217026, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 5 X 3=60 |
# samples | 3 | 8 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/60*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ELMO2 [Title/Abstract] AND MYBL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MYBL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10770937 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | MESO | TCGA-TS-A7P7-01A | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000290246 | ENST00000396863 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5CDS-intron | ENST00000290246 | ENST00000217026 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5UTR-intron | ENST00000372176 | ENST00000396863 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5UTR-intron | ENST00000372176 | ENST00000217026 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5CDS-intron | ENST00000396391 | ENST00000396863 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5CDS-intron | ENST00000396391 | ENST00000217026 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5CDS-intron | ENST00000439931 | ENST00000396863 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5CDS-intron | ENST00000439931 | ENST00000217026 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5UTR-intron | ENST00000445496 | ENST00000396863 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5UTR-intron | ENST00000445496 | ENST00000217026 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
intron-intron | ENST00000454865 | ENST00000396863 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
intron-intron | ENST00000454865 | ENST00000217026 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5CDS-intron | ENST00000352077 | ENST00000396863 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5CDS-intron | ENST00000352077 | ENST00000217026 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5UTR-intron | ENST00000488853 | ENST00000396863 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
5UTR-intron | ENST00000488853 | ENST00000217026 | ELMO2 | chr20 | 45023044 | - | MYBL2 | chr20 | 42310424 | + |
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FusionProtFeatures for ELMO2_MYBL2 |
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Hgene | Tgene |
ELMO2 | MYBL2 |
Transcription factor involved in the regulation of cellsurvival, proliferation, and differentiation. Transactivates theexpression of the CLU gene. {ECO:0000269|PubMed:10770937}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ELMO2_MYBL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ELMO2_MYBL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ELMO2 | GRB2, NPM1, FBXW11, BTRC, ELMO1, CRKL, MLH1, CEP135, ARL4A, CDC27, DOCK5, ELMO3, RAC2, ERMAP, EPHA1, ARRB1 | MYBL2 | ZNF622, CDKN1C, RBL1, E2F1, E2F3, EP300, CREBBP, PARP1, CDK2, CCNA1, MYBL2, CDK9, CCNT1, SKP2, LZTR1, TRIM15, ZBTB9, NLK, HIPK2, LIN54, LIN9, LIN37, LIN52, MAPK6, MAP1LC3B, RBBP4, FLNA, SPTA1, CLTC, SPTBN1, CLTA, CCNE1, CXCR4, UBE2D4, TTF2, EWSR1, CTDSPL2, NUF2, PPP2R3C, ZSCAN26, TEAD2, CCNF, FOXM1, PLA2G4A, EPAS1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ELMO2_MYBL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ELMO2_MYBL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |