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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11451

FusionGeneSummary for ELMO1_HDAC9

check button Fusion gene summary
Fusion gene informationFusion gene name: ELMO1_HDAC9
Fusion gene ID: 11451
HgeneTgene
Gene symbol

ELMO1

HDAC9

Gene ID

9844

9734

Gene nameengulfment and cell motility 1histone deacetylase 9
SynonymsCED-12|CED12|ELMO-1HD7|HD7b|HD9|HDAC|HDAC7|HDAC7B|HDAC9B|HDAC9FL|HDRP|MITR
Cytomap

7p14.2-p14.1

7p21.1

Type of geneprotein-codingprotein-coding
Descriptionengulfment and cell motility protein 1ced-12 homolog 1histone deacetylase 9MEF-2 interacting transcription repressor (MITR) proteinhistone deacetylase 4/5-related proteinhistone deacetylase 7B
Modification date2018051920180519
UniProtAcc

Q92556

Q9UKV0

Ensembl transtripts involved in fusion geneENST00000341056, ENST00000396045, 
ENST00000310758, ENST00000396040, 
ENST00000442504, ENST00000448602, 
ENST00000479447, 		ENST00000406451, 
ENST00000401921, ENST00000432645, 
ENST00000441542, ENST00000417496, 
ENST00000476135, ENST00000405010, 
ENST00000428307, ENST00000406072, 
ENST00000456174, ENST00000524023, 
Fusion gene scores* DoF score7 X 7 X 3=1476 X 4 X 4=96
# samples 75
** MAII scorelog2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ELMO1 [Title/Abstract] AND HDAC9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHDAC9

GO:0000122

negative regulation of transcription by RNA polymerase II

10655483|11535832

TgeneHDAC9

GO:0016575

histone deacetylation

11535832

TgeneHDAC9

GO:0032869

cellular response to insulin stimulus

19303849

TgeneHDAC9

GO:0034983

peptidyl-lysine deacetylation

11535832

TgeneHDAC9

GO:0045892

negative regulation of transcription, DNA-templated

11535832

TgeneHDAC9

GO:0070932

histone H3 deacetylation

12590135

TgeneHDAC9

GO:0070933

histone H4 deacetylation

12590135


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-EO-A3AS-01AELMO1chr7

37488278

-HDAC9chr7

18535885

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000341056ENST00000406451ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000341056ENST00000401921ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000341056ENST00000432645ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000341056ENST00000441542ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000341056ENST00000417496ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-3UTRENST00000341056ENST00000476135ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000341056ENST00000405010ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000341056ENST00000428307ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000341056ENST00000406072ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000341056ENST00000456174ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000341056ENST00000524023ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396045ENST00000406451ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396045ENST00000401921ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396045ENST00000432645ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396045ENST00000441542ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396045ENST00000417496ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-3UTRENST00000396045ENST00000476135ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396045ENST00000405010ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396045ENST00000428307ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396045ENST00000406072ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396045ENST00000456174ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396045ENST00000524023ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-5UTRENST00000310758ENST00000406451ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-5UTRENST00000310758ENST00000401921ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-intronENST00000310758ENST00000432645ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-intronENST00000310758ENST00000441542ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-intronENST00000310758ENST00000417496ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-3UTRENST00000310758ENST00000476135ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-5UTRENST00000310758ENST00000405010ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-5UTRENST00000310758ENST00000428307ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-5UTRENST00000310758ENST00000406072ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-intronENST00000310758ENST00000456174ELMO1chr7

37488278

-HDAC9chr7

18535885

+
5UTR-intronENST00000310758ENST00000524023ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396040ENST00000406451ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396040ENST00000401921ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396040ENST00000432645ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396040ENST00000441542ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396040ENST00000417496ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-3UTRENST00000396040ENST00000476135ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396040ENST00000405010ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396040ENST00000428307ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000396040ENST00000406072ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396040ENST00000456174ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000396040ENST00000524023ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000442504ENST00000406451ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000442504ENST00000401921ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000442504ENST00000432645ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000442504ENST00000441542ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000442504ENST00000417496ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-3UTRENST00000442504ENST00000476135ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000442504ENST00000405010ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000442504ENST00000428307ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000442504ENST00000406072ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000442504ENST00000456174ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000442504ENST00000524023ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000448602ENST00000406451ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000448602ENST00000401921ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000448602ENST00000432645ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000448602ENST00000441542ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000448602ENST00000417496ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-3UTRENST00000448602ENST00000476135ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000448602ENST00000405010ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000448602ENST00000428307ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000448602ENST00000406072ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000448602ENST00000456174ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000448602ENST00000524023ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000479447ENST00000406451ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000479447ENST00000401921ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000479447ENST00000432645ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000479447ENST00000441542ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000479447ENST00000417496ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-3UTRENST00000479447ENST00000476135ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000479447ENST00000405010ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000479447ENST00000428307ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-5UTRENST00000479447ENST00000406072ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000479447ENST00000456174ELMO1chr7

37488278

-HDAC9chr7

18535885

+
intron-intronENST00000479447ENST00000524023ELMO1chr7

37488278

-HDAC9chr7

18535885

+

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FusionProtFeatures for ELMO1_HDAC9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELMO1

Q92556

HDAC9

Q9UKV0

Involved in cytoskeletal rearrangements required forphagocytosis of apoptotic cells and cell motility. Acts inassociation with DOCK1 and CRK. Was initially proposed to berequired in complex with DOCK1 to activate Rac Rho small GTPases.May enhance the guanine nucleotide exchange factor (GEF) activityof DOCK1. {ECO:0000269|PubMed:11595183,ECO:0000269|PubMed:12134158}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELMO1_HDAC9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELMO1_HDAC9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELMO1HCK, DOCK1, BAG3, PTGS2, TRIM54, ZNF398, DOCK4, DOCK3, USP4, MED31, DOCK5, TTC19, ELMO2, CALML3, NTRK1, RHOG, DOCK2, BAI1, BAI3, ARL4A, CDC27, ARHGEF16, ELMO3HDAC9CTBP1, SIN3A, MORF4L2, HIST4H4, HIST2H3A, HDAC3, SIN3B, NCOR1, ETV6, HDAC4, MEF2A, HDAC1, HEY2, FOXP3, YWHAE, YWHAZ, MEF2C, ESR1, MAPK8, MAPK9, MAPK10, JUN, NUP214, SYK, RFXANK, ANKRA2, PKD1, MEF2B, HDAC9, SFN, CAMK1, H3F3A, CEBPB, PARP1, SMARCA4, MAML1, TRIM29, TP53, BCL6, HINT1, MKI67, TOP1, ADAR, EIF6, H1FX, TMPO, NUP93, TPR, FIP1L1, CCAR2, NOP2, RCC1, RBM14, SMC3, TPX2, ZC3H11A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ELMO1_HDAC9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHDAC9Q9UKV0DB00313Valproic AcidHistone deacetylase 9small moleculeapproved|investigational

Top

RelatedDiseases for ELMO1_HDAC9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELMO1C0011881Diabetic Nephropathy1CTD_human
HgeneELMO1C0038325Stevens-Johnson Syndrome1CTD_human
HgeneELMO1C0279628Adenocarcinoma Of Esophagus1CTD_human
TgeneHDAC9C0011570Mental Depression2PSYGENET
TgeneHDAC9C0036341Schizophrenia2PSYGENET
TgeneHDAC9C0011581Depressive disorder1PSYGENET
TgeneHDAC9C0038454Cerebrovascular accident1CTD_human
TgeneHDAC9C0041696Unipolar Depression1PSYGENET