	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 1145

FusionGeneSummary for AGPAT4_AGPAT4

Fusion gene summary

Fusion gene information	Fusion gene name: AGPAT4_AGPAT4
	Fusion gene ID: 1145
		Hgene	Tgene
	Gene symbol	AGPAT4	AGPAT4
	Gene ID	56895	56895
	Gene name	1-acylglycerol-3-phosphate O-acyltransferase 4	1-acylglycerol-3-phosphate O-acyltransferase 4
	Synonyms	1-AGPAT4\|LPAAT-delta\|dJ473J16.2	1-AGPAT4\|LPAAT-delta\|dJ473J16.2
	Cytomap	6q26	6q26
	Type of gene	protein-coding	protein-coding
	Description	1-acyl-sn-glycerol-3-phosphate acyltransferase delta1-AGP acyltransferase 41-AGPAT 41-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)lysophosphatidic acid acyltransferase deltalysophosphatidic acid acyltran	1-acyl-sn-glycerol-3-phosphate acyltransferase delta1-AGP acyltransferase 41-AGPAT 41-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)lysophosphatidic acid acyltransferase deltalysophosphatidic acid acyltran
	Modification date	20180523	20180523
	UniProtAcc	Q9NRZ5	Q9NRZ5
	Ensembl transtripts involved in fusion gene	ENST00000366911, ENST00000320285, ENST00000457520, ENST00000366908, ENST00000366906, ENST00000366905,	ENST00000366911, ENST00000320285, ENST00000457520, ENST00000366908, ENST00000366906, ENST00000366905,
Fusion gene scores	* DoF score	3 X 4 X 2=24	2 X 3 X 1=6
	# samples	5	4
	** MAII score	log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/6*10)=2.73696559416621
Context	PubMed: AGPAT4 [Title/Abstract] AND AGPAT4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BU073418	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
ChiTaRS3.1			BU071898	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
ChiTaRS3.1			BU947826	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000366911	ENST00000366911	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000366911	ENST00000320285	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366911	ENST00000457520	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366911	ENST00000366908	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366911	ENST00000366906	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366911	ENST00000366905	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000320285	ENST00000366911	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000320285	ENST00000320285	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000320285	ENST00000457520	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000320285	ENST00000366908	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000320285	ENST00000366906	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000320285	ENST00000366905	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000457520	ENST00000366911	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000457520	ENST00000320285	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000457520	ENST00000457520	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000457520	ENST00000366908	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000457520	ENST00000366906	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000457520	ENST00000366905	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000366908	ENST00000366911	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000366908	ENST00000320285	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366908	ENST00000457520	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366908	ENST00000366908	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366908	ENST00000366906	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366908	ENST00000366905	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000366906	ENST00000366911	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000366906	ENST00000320285	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366906	ENST00000457520	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366906	ENST00000366908	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366906	ENST00000366906	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366906	ENST00000366905	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000366905	ENST00000366911	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000366905	ENST00000320285	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366905	ENST00000457520	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366905	ENST00000366908	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366905	ENST00000366906	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-intron	ENST00000366905	ENST00000366905	AGPAT4	chr6	161551572	-	AGPAT4	chr6	161551334	+
intron-3UTR	ENST00000366911	ENST00000366911	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000366911	ENST00000320285	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366911	ENST00000457520	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366911	ENST00000366908	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366911	ENST00000366906	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366911	ENST00000366905	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000320285	ENST00000366911	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000320285	ENST00000320285	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000320285	ENST00000457520	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000320285	ENST00000366908	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000320285	ENST00000366906	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000320285	ENST00000366905	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000457520	ENST00000366911	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000457520	ENST00000320285	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000457520	ENST00000457520	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000457520	ENST00000366908	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000457520	ENST00000366906	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000457520	ENST00000366905	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000366908	ENST00000366911	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000366908	ENST00000320285	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366908	ENST00000457520	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366908	ENST00000366908	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366908	ENST00000366906	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366908	ENST00000366905	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000366906	ENST00000366911	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000366906	ENST00000320285	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366906	ENST00000457520	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366906	ENST00000366908	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366906	ENST00000366906	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366906	ENST00000366905	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000366905	ENST00000366911	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-3UTR	ENST00000366905	ENST00000320285	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366905	ENST00000457520	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366905	ENST00000366908	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366905	ENST00000366906	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+
intron-intron	ENST00000366905	ENST00000366905	AGPAT4	chr6	161551334	-	AGPAT4	chr6	161551572	+

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FusionProtFeatures for AGPAT4_AGPAT4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AGPAT4 Q9NRZ5	AGPAT4 Q9NRZ5
Converts lysophosphatidic acid (LPA) into phosphatidicacid by incorporating an acyl moiety at the sn-2 position of theglycerol backbone. {ECO:0000250}.	Converts lysophosphatidic acid (LPA) into phosphatidicacid by incorporating an acyl moiety at the sn-2 position of theglycerol backbone. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for AGPAT4_AGPAT4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AGPAT4_AGPAT4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for AGPAT4_AGPAT4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AGPAT4_AGPAT4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 1145

FusionGeneSummary for AGPAT4_AGPAT4

FusionProtFeatures for AGPAT4_AGPAT4

FusionGeneSequence for AGPAT4_AGPAT4

FusionGenePPI for AGPAT4_AGPAT4

RelatedDrugs for AGPAT4_AGPAT4

RelatedDiseases for AGPAT4_AGPAT4