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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11410

FusionGeneSummary for ELK3_DDIT4L

check button Fusion gene summary
Fusion gene informationFusion gene name: ELK3_DDIT4L
Fusion gene ID: 11410
HgeneTgene
Gene symbol

ELK3

DDIT4L

Gene ID

2004

115265

Gene nameELK3, ETS transcription factorDNA damage inducible transcript 4 like
SynonymsERP|NET|SAP-2|SAP2REDD2|Rtp801L
Cytomap

12q23.1

4q24

Type of geneprotein-codingprotein-coding
DescriptionETS domain-containing protein Elk-3ELK3, ETS-domain protein (SRF accessory protein 2)ETS-related protein ERPETS-related protein NETSRF accessory protein 2serum response factor accessory protein 2DNA damage-inducible transcript 4-like proteinHIF-1 responsive protein RTP801-likeREDD-2homolog of mouse SMHS1protein regulated in development and DNA damage response 2regulated in development and DNA damage response 2
Modification date2018052320180522
UniProtAcc

P41970

Q96D03

Ensembl transtripts involved in fusion geneENST00000228741, ENST00000552142, 
ENST00000549529, 
ENST00000273990, 
Fusion gene scores* DoF score10 X 3 X 4=1201 X 1 X 1=1
# samples 91
** MAII scorelog2(9/120*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ELK3 [Title/Abstract] AND DDIT4L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneELK3

GO:0045892

negative regulation of transcription, DNA-templated

12933792

HgeneELK3

GO:0045944

positive regulation of transcription by RNA polymerase II

12788937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-ED-A82E-01AELK3chr12

96617551

+DDIT4Lchr4

101111189

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000228741ENST00000273990ELK3chr12

96617551

+DDIT4Lchr4

101111189

-
5CDS-5UTRENST00000552142ENST00000273990ELK3chr12

96617551

+DDIT4Lchr4

101111189

-
intron-5UTRENST00000549529ENST00000273990ELK3chr12

96617551

+DDIT4Lchr4

101111189

-

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FusionProtFeatures for ELK3_DDIT4L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELK3

P41970

DDIT4L

Q96D03

May be a negative regulator of transcription, but canactivate transcription when coexpressed with Ras, Src or Mos.Forms a ternary complex with the serum response factor and the ETSand SRF motifs of the Fos serum response element. Inhibits cell growth by regulating the TOR signalingpathway upstream of the TSC1-TSC2 complex and downstream of AKT1.{ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELK3_DDIT4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELK3_DDIT4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELK3TCF3, TOP1, APPDDIT4LSNRPG, PRKAB2, MORF4L2, CALCOCO2, LSM7, TENC1, LRRC15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELK3_DDIT4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ELK3_DDIT4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELK3C1458155Mammary Neoplasms1CTD_human
TgeneDDIT4LC0025202melanoma1CTD_human