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Fusion gene ID: 11409 |
FusionGeneSummary for ELK3_CDK17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ELK3_CDK17 | Fusion gene ID: 11409 | Hgene | Tgene | Gene symbol | ELK3 | CDK17 | Gene ID | 2004 | 5128 |
| Gene name | ELK3, ETS transcription factor | cyclin dependent kinase 17 | |
| Synonyms | ERP|NET|SAP-2|SAP2 | PCTAIRE2|PCTK2 | |
| Cytomap | 12q23.1 | 12q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ETS domain-containing protein Elk-3ELK3, ETS-domain protein (SRF accessory protein 2)ETS-related protein ERPETS-related protein NETSRF accessory protein 2serum response factor accessory protein 2 | cyclin-dependent kinase 17PCTAIRE-motif protein kinase 2cell division protein kinase 17protein kinase cdc2-related PCTAIRE-2serine/threonine-protein kinase PCTAIRE-2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P41970 | Q00537 | |
| Ensembl transtripts involved in fusion gene | ENST00000228741, ENST00000552142, ENST00000549529, | ENST00000261211, ENST00000543119, ENST00000542666, ENST00000553042, | |
| Fusion gene scores | * DoF score | 10 X 3 X 4=120 | 7 X 5 X 3=105 |
| # samples | 9 | 7 | |
| ** MAII score | log2(9/120*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ELK3 [Title/Abstract] AND CDK17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ELK3 | GO:0045892 | negative regulation of transcription, DNA-templated | 12933792 |
| Hgene | ELK3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12788937 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A2J0-01A | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000228741 | ENST00000261211 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| In-frame | ENST00000228741 | ENST00000543119 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| In-frame | ENST00000228741 | ENST00000542666 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| 5CDS-5UTR | ENST00000228741 | ENST00000553042 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| In-frame | ENST00000552142 | ENST00000261211 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| In-frame | ENST00000552142 | ENST00000543119 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| In-frame | ENST00000552142 | ENST00000542666 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| 5CDS-5UTR | ENST00000552142 | ENST00000553042 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| intron-3CDS | ENST00000549529 | ENST00000261211 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| intron-3CDS | ENST00000549529 | ENST00000543119 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| intron-3CDS | ENST00000549529 | ENST00000542666 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
| intron-5UTR | ENST00000549529 | ENST00000553042 | ELK3 | chr12 | 96617551 | + | CDK17 | chr12 | 96694138 | - |
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FusionProtFeatures for ELK3_CDK17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ELK3 | CDK17 |
| May be a negative regulator of transcription, but canactivate transcription when coexpressed with Ras, Src or Mos.Forms a ternary complex with the serum response factor and the ETSand SRF motifs of the Fos serum response element. | May play a role in terminally differentiated neurons.Has a Ser/Thr-phosphorylating activity for histone H1 (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CDK17 | chr12:96617551 | chr12:96694138 | ENST00000261211 | - | 4 | 17 | 192_473 | 181 | 524 | Domain | Protein kinase |
| Tgene | >CDK17 | chr12:96617551 | chr12:96694138 | ENST00000543119 | - | 4 | 16 | 192_473 | 181 | 524 | Domain | Protein kinase |
| Tgene | >CDK17 | chr12:96617551 | chr12:96694138 | ENST00000261211 | - | 4 | 17 | 198_206 | 181 | 524 | Nucleotide binding | ATP |
| Tgene | >CDK17 | chr12:96617551 | chr12:96694138 | ENST00000543119 | - | 4 | 16 | 198_206 | 181 | 524 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ELK3 | chr12:96617551 | chr12:96694138 | ENST00000228741 | + | 2 | 5 | 207_212 | 69 | 408 | Compositional bias | Note=Poly-Ala |
| Hgene | >ELK3 | chr12:96617551 | chr12:96694138 | ENST00000228741 | + | 2 | 5 | 5_85 | 69 | 408 | DNA binding | ETS |
| Hgene | >ELK3 | chr12:96617551 | chr12:96694138 | ENST00000228741 | + | 2 | 5 | 273_277 | 69 | 408 | Motif | Note=CTBP-binding motif |
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FusionGeneSequence for ELK3_CDK17 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ELK3_CDK17 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ELK3 | TCF3, TOP1, APP | CDK17 | TDRD7, YWHAG, APP, MMS19, BAG3, EPHA2, PRKACG, PTMA, PPP2R2A, PPP2CB, GAPDH, NOP10, YWHAQ, YWHAB, TUBGCP3, CDK14, CDK1, CDK16, PPP2R3A, SUGP1, DHPS, PPP2R5E, C12orf43, FEM1A, XPO1, PFDN2, UNC45A, MANSC1, HDGFRP3, UBC, DCAF7, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ELK3_CDK17 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ELK3_CDK17 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ELK3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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