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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11409

FusionGeneSummary for ELK3_CDK17

check button Fusion gene summary
Fusion gene informationFusion gene name: ELK3_CDK17
Fusion gene ID: 11409
HgeneTgene
Gene symbol

ELK3

CDK17

Gene ID

2004

5128

Gene nameELK3, ETS transcription factorcyclin dependent kinase 17
SynonymsERP|NET|SAP-2|SAP2PCTAIRE2|PCTK2
Cytomap

12q23.1

12q23.1

Type of geneprotein-codingprotein-coding
DescriptionETS domain-containing protein Elk-3ELK3, ETS-domain protein (SRF accessory protein 2)ETS-related protein ERPETS-related protein NETSRF accessory protein 2serum response factor accessory protein 2cyclin-dependent kinase 17PCTAIRE-motif protein kinase 2cell division protein kinase 17protein kinase cdc2-related PCTAIRE-2serine/threonine-protein kinase PCTAIRE-2
Modification date2018052320180523
UniProtAcc

P41970

Q00537

Ensembl transtripts involved in fusion geneENST00000228741, ENST00000552142, 
ENST00000549529, 
ENST00000261211, 
ENST00000543119, ENST00000542666, 
ENST00000553042, 
Fusion gene scores* DoF score10 X 3 X 4=1207 X 5 X 3=105
# samples 97
** MAII scorelog2(9/120*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ELK3 [Title/Abstract] AND CDK17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneELK3

GO:0045892

negative regulation of transcription, DNA-templated

12933792

HgeneELK3

GO:0045944

positive regulation of transcription by RNA polymerase II

12788937


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A2J0-01AELK3chr12

96617551

+CDK17chr12

96694138

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000228741ENST00000261211ELK3chr12

96617551

+CDK17chr12

96694138

-
In-frameENST00000228741ENST00000543119ELK3chr12

96617551

+CDK17chr12

96694138

-
In-frameENST00000228741ENST00000542666ELK3chr12

96617551

+CDK17chr12

96694138

-
5CDS-5UTRENST00000228741ENST00000553042ELK3chr12

96617551

+CDK17chr12

96694138

-
In-frameENST00000552142ENST00000261211ELK3chr12

96617551

+CDK17chr12

96694138

-
In-frameENST00000552142ENST00000543119ELK3chr12

96617551

+CDK17chr12

96694138

-
In-frameENST00000552142ENST00000542666ELK3chr12

96617551

+CDK17chr12

96694138

-
5CDS-5UTRENST00000552142ENST00000553042ELK3chr12

96617551

+CDK17chr12

96694138

-
intron-3CDSENST00000549529ENST00000261211ELK3chr12

96617551

+CDK17chr12

96694138

-
intron-3CDSENST00000549529ENST00000543119ELK3chr12

96617551

+CDK17chr12

96694138

-
intron-3CDSENST00000549529ENST00000542666ELK3chr12

96617551

+CDK17chr12

96694138

-
intron-5UTRENST00000549529ENST00000553042ELK3chr12

96617551

+CDK17chr12

96694138

-

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FusionProtFeatures for ELK3_CDK17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELK3

P41970

CDK17

Q00537

May be a negative regulator of transcription, but canactivate transcription when coexpressed with Ras, Src or Mos.Forms a ternary complex with the serum response factor and the ETSand SRF motifs of the Fos serum response element. May play a role in terminally differentiated neurons.Has a Ser/Thr-phosphorylating activity for histone H1 (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDK17chr12:96617551chr12:96694138ENST00000261211-417192_473181524DomainProtein kinase
TgeneCDK17chr12:96617551chr12:96694138ENST00000543119-416192_473181524DomainProtein kinase
TgeneCDK17chr12:96617551chr12:96694138ENST00000261211-417198_206181524Nucleotide bindingATP
TgeneCDK17chr12:96617551chr12:96694138ENST00000543119-416198_206181524Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneELK3chr12:96617551chr12:96694138ENST00000228741+25207_21269408Compositional biasNote=Poly-Ala
HgeneELK3chr12:96617551chr12:96694138ENST00000228741+255_8569408DNA bindingETS
HgeneELK3chr12:96617551chr12:96694138ENST00000228741+25273_27769408MotifNote=CTBP-binding motif


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FusionGeneSequence for ELK3_CDK17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELK3_CDK17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELK3TCF3, TOP1, APPCDK17TDRD7, YWHAG, APP, MMS19, BAG3, EPHA2, PRKACG, PTMA, PPP2R2A, PPP2CB, GAPDH, NOP10, YWHAQ, YWHAB, TUBGCP3, CDK14, CDK1, CDK16, PPP2R3A, SUGP1, DHPS, PPP2R5E, C12orf43, FEM1A, XPO1, PFDN2, UNC45A, MANSC1, HDGFRP3, UBC, DCAF7, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELK3_CDK17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ELK3_CDK17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELK3C1458155Mammary Neoplasms1CTD_human