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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11399

FusionGeneSummary for ELF2_PSMD8

check button Fusion gene summary
Fusion gene informationFusion gene name: ELF2_PSMD8
Fusion gene ID: 11399
HgeneTgene
Gene symbol

ELF2

PSMD8

Gene ID

1998

5714

Gene nameE74 like ETS transcription factor 2proteasome 26S subunit, non-ATPase 8
SynonymsEU32|NERF|NERF-1A|NERF-1B|NERF-1a,b|NERF-2HEL-S-91n|HIP6|HYPF|Nin1p|Rpn12|S14|p31
Cytomap

4q31.1

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionETS-related transcription factor Elf-2E74-like factor 2 (ets domain transcription factor)ets family transcription factor ELF2Cnew Ets-related factor26S proteasome non-ATPase regulatory subunit 826S proteasome regulatory subunit RPN1226S proteasome regulatory subunit S1426S proteasome regulatory subunit p31epididymis secretory sperm binding protein Li 91nproteasome (prosome, macropain) 26S subuni
Modification date2018052320180523
UniProtAcc

Q15723

P48556

Ensembl transtripts involved in fusion geneENST00000394235, ENST00000379549, 
ENST00000379550, ENST00000265495, 
ENST00000358635, ENST00000510408, 
ENST00000515489, 
ENST00000215071, 
ENST00000602911, ENST00000592035, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 1=4
# samples 43
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/4*10)=2.90689059560852
Context

PubMed: ELF2 [Title/Abstract] AND PSMD8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneELF2

GO:0006357

regulation of transcription by RNA polymerase II

8756667

HgeneELF2

GO:0045893

positive regulation of transcription, DNA-templated

8756667


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC071826ELF2chr4

140036280

+PSMD8chr19

38865435

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000394235ENST00000215071ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000394235ENST00000602911ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-intronENST00000394235ENST00000592035ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000379549ENST00000215071ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000379549ENST00000602911ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-intronENST00000379549ENST00000592035ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000379550ENST00000215071ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000379550ENST00000602911ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-intronENST00000379550ENST00000592035ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000265495ENST00000215071ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000265495ENST00000602911ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-intronENST00000265495ENST00000592035ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000358635ENST00000215071ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000358635ENST00000602911ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-intronENST00000358635ENST00000592035ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000510408ENST00000215071ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000510408ENST00000602911ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-intronENST00000510408ENST00000592035ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000515489ENST00000215071ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-3CDSENST00000515489ENST00000602911ELF2chr4

140036280

+PSMD8chr19

38865435

+
intron-intronENST00000515489ENST00000592035ELF2chr4

140036280

+PSMD8chr19

38865435

+

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FusionProtFeatures for ELF2_PSMD8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELF2

Q15723

PSMD8

P48556

Isoform 1 transcriptionally activates the LYN and BLKpromoters and acts synergistically with RUNX1 to transactivate theBLK promoter. Isoform 2 may function in repression of RUNX1-mediatedtransactivation. Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair.{ECO:0000269|PubMed:1317798}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELF2_PSMD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELF2_PSMD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELF2_PSMD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ELF2_PSMD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELF2C3495559Juvenile arthritis1CTD_human
TgenePSMD8C0019693HIV Infections1CTD_human