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Fusion gene ID: 11396 |
FusionGeneSummary for ELF2_ICA1L |
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Fusion gene information | Fusion gene name: ELF2_ICA1L | Fusion gene ID: 11396 | Hgene | Tgene | Gene symbol | ELF2 | ICA1L | Gene ID | 1998 | 130026 |
Gene name | E74 like ETS transcription factor 2 | islet cell autoantigen 1 like | |
Synonyms | EU32|NERF|NERF-1A|NERF-1B|NERF-1a,b|NERF-2 | ALS2CR14|ALS2CR15 | |
Cytomap | 4q31.1 | 2q33.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ETS-related transcription factor Elf-2E74-like factor 2 (ets domain transcription factor)ets family transcription factor ELF2Cnew Ets-related factor | islet cell autoantigen 1-like proteinIca69-related proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 14amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15amyotrophic lateral sclerosis 2 chromosomal r | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q15723 | Q8NDH6 | |
Ensembl transtripts involved in fusion gene | ENST00000394235, ENST00000379549, ENST00000379550, ENST00000265495, ENST00000358635, ENST00000510408, ENST00000515489, | ENST00000392237, ENST00000358299, ENST00000425178, ENST00000418208, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 4 X 3 X 4=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ELF2 [Title/Abstract] AND ICA1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ELF2 | GO:0006357 | regulation of transcription by RNA polymerase II | 8756667 |
Hgene | ELF2 | GO:0045893 | positive regulation of transcription, DNA-templated | 8756667 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-56-7579-01A | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000394235 | ENST00000392237 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000394235 | ENST00000358299 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000394235 | ENST00000425178 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000394235 | ENST00000418208 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000379549 | ENST00000392237 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000379549 | ENST00000358299 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000379549 | ENST00000425178 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000379549 | ENST00000418208 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000379550 | ENST00000392237 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000379550 | ENST00000358299 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000379550 | ENST00000425178 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000379550 | ENST00000418208 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000265495 | ENST00000392237 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000265495 | ENST00000358299 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000265495 | ENST00000425178 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000265495 | ENST00000418208 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000358635 | ENST00000392237 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000358635 | ENST00000358299 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000358635 | ENST00000425178 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000358635 | ENST00000418208 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000510408 | ENST00000392237 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000510408 | ENST00000358299 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000510408 | ENST00000425178 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5CDS-5UTR | ENST00000510408 | ENST00000418208 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5UTR-5UTR | ENST00000515489 | ENST00000392237 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5UTR-5UTR | ENST00000515489 | ENST00000358299 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5UTR-5UTR | ENST00000515489 | ENST00000425178 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
5UTR-5UTR | ENST00000515489 | ENST00000418208 | ELF2 | chr4 | 139981478 | - | ICA1L | chr2 | 203693739 | - |
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FusionProtFeatures for ELF2_ICA1L |
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Hgene | Tgene |
ELF2 | ICA1L |
Isoform 1 transcriptionally activates the LYN and BLKpromoters and acts synergistically with RUNX1 to transactivate theBLK promoter. Isoform 2 may function in repression of RUNX1-mediatedtransactivation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ELF2_ICA1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ELF2_ICA1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ELF2 | RUNX1, ZBTB32, BAP1, ELAVL1, APP, HSPBP1, PSME3, SPINT2, PRPS1, PSMC3, HIST1H2BG, HIST1H3A, DYNLT1, IKZF5, NFATC2IP, TRIM25 | ICA1L | KIFC3, PICK1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ELF2_ICA1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ELF2_ICA1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ELF2 | C3495559 | Juvenile arthritis | 1 | CTD_human |