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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11396

FusionGeneSummary for ELF2_ICA1L

check button Fusion gene summary
Fusion gene informationFusion gene name: ELF2_ICA1L
Fusion gene ID: 11396
HgeneTgene
Gene symbol

ELF2

ICA1L

Gene ID

1998

130026

Gene nameE74 like ETS transcription factor 2islet cell autoantigen 1 like
SynonymsEU32|NERF|NERF-1A|NERF-1B|NERF-1a,b|NERF-2ALS2CR14|ALS2CR15
Cytomap

4q31.1

2q33.2

Type of geneprotein-codingprotein-coding
DescriptionETS-related transcription factor Elf-2E74-like factor 2 (ets domain transcription factor)ets family transcription factor ELF2Cnew Ets-related factorislet cell autoantigen 1-like proteinIca69-related proteinamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 14amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15amyotrophic lateral sclerosis 2 chromosomal r
Modification date2018052320180519
UniProtAcc

Q15723

Q8NDH6

Ensembl transtripts involved in fusion geneENST00000394235, ENST00000379549, 
ENST00000379550, ENST00000265495, 
ENST00000358635, ENST00000510408, 
ENST00000515489, 
ENST00000392237, 
ENST00000358299, ENST00000425178, 
ENST00000418208, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 3 X 4=48
# samples 44
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ELF2 [Title/Abstract] AND ICA1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneELF2

GO:0006357

regulation of transcription by RNA polymerase II

8756667

HgeneELF2

GO:0045893

positive regulation of transcription, DNA-templated

8756667


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-56-7579-01AELF2chr4

139981478

-ICA1Lchr2

203693739

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000394235ENST00000392237ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000394235ENST00000358299ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000394235ENST00000425178ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000394235ENST00000418208ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000379549ENST00000392237ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000379549ENST00000358299ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000379549ENST00000425178ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000379549ENST00000418208ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000379550ENST00000392237ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000379550ENST00000358299ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000379550ENST00000425178ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000379550ENST00000418208ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000265495ENST00000392237ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000265495ENST00000358299ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000265495ENST00000425178ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000265495ENST00000418208ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000358635ENST00000392237ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000358635ENST00000358299ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000358635ENST00000425178ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000358635ENST00000418208ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000510408ENST00000392237ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000510408ENST00000358299ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000510408ENST00000425178ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5CDS-5UTRENST00000510408ENST00000418208ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5UTR-5UTRENST00000515489ENST00000392237ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5UTR-5UTRENST00000515489ENST00000358299ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5UTR-5UTRENST00000515489ENST00000425178ELF2chr4

139981478

-ICA1Lchr2

203693739

-
5UTR-5UTRENST00000515489ENST00000418208ELF2chr4

139981478

-ICA1Lchr2

203693739

-

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FusionProtFeatures for ELF2_ICA1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELF2

Q15723

ICA1L

Q8NDH6

Isoform 1 transcriptionally activates the LYN and BLKpromoters and acts synergistically with RUNX1 to transactivate theBLK promoter. Isoform 2 may function in repression of RUNX1-mediatedtransactivation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELF2_ICA1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELF2_ICA1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ELF2RUNX1, ZBTB32, BAP1, ELAVL1, APP, HSPBP1, PSME3, SPINT2, PRPS1, PSMC3, HIST1H2BG, HIST1H3A, DYNLT1, IKZF5, NFATC2IP, TRIM25ICA1LKIFC3, PICK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELF2_ICA1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ELF2_ICA1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneELF2C3495559Juvenile arthritis1CTD_human