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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11391

FusionGeneSummary for ELF1_PKM

check button Fusion gene summary
Fusion gene informationFusion gene name: ELF1_PKM
Fusion gene ID: 11391
HgeneTgene
Gene symbol

ELF1

PKM

Gene ID

84337

5315

Gene nameelongation factor 1 homologpyruvate kinase M1/2
SynonymsELF1CTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1
Cytomap

19p13.2

15q23

Type of geneprotein-codingprotein-coding
Descriptiontranscription elongation factor 1 homologELF1 homolog, elongation factor 1elongation factor 1 homolog (ELF1, S. cerevisiae)pyruvate kinase PKMOIP-3OPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30p58pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymepyruvate kinase, muscle
Modification date2018052920180527
UniProtAcc

P32519

P14618

Ensembl transtripts involved in fusion geneENST00000442101, ENST00000498824, 
ENST00000239882, 		ENST00000319622, 
ENST00000565184, ENST00000389093, 
ENST00000335181, ENST00000568883, 
ENST00000449901, ENST00000565154, 
ENST00000568459, 
Fusion gene scores* DoF score8 X 6 X 4=19220 X 23 X 3=1380
# samples 724
** MAII scorelog2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/1380*10)=-2.52356195605701
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ELF1 [Title/Abstract] AND PKM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePKM

GO:0012501

programmed cell death

17308100


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF753099ELF1chr13

41507779

+PKMchr15

72502082

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000442101ENST00000319622ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000442101ENST00000565184ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000442101ENST00000389093ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000442101ENST00000335181ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000442101ENST00000568883ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000442101ENST00000449901ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000442101ENST00000565154ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000442101ENST00000568459ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000498824ENST00000319622ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000498824ENST00000565184ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000498824ENST00000389093ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000498824ENST00000335181ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000498824ENST00000568883ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000498824ENST00000449901ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000498824ENST00000565154ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000498824ENST00000568459ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000239882ENST00000319622ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000239882ENST00000565184ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000239882ENST00000389093ELF1chr13

41507779

+PKMchr15

72502082

-
intron-3CDSENST00000239882ENST00000335181ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000239882ENST00000568883ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000239882ENST00000449901ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000239882ENST00000565154ELF1chr13

41507779

+PKMchr15

72502082

-
intron-intronENST00000239882ENST00000568459ELF1chr13

41507779

+PKMchr15

72502082

-

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FusionProtFeatures for ELF1_PKM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ELF1

P32519

PKM

P14618

Transcription factor that activates the LYN and BLKpromoters. Appears to be required for the T-cell-receptor-mediatedtrans activation of HIV-2 gene expression. Binds specifically totwo purine-rich motifs in the HIV-2 enhancer.{ECO:0000269|PubMed:8756667}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ELF1_PKM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ELF1_PKM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ELF1_PKM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePKMP14618DB11638ArtenimolPyruvate kinase PKMsmall moleculeapproved|investigational

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RelatedDiseases for ELF1_PKM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePKMC0027626Neoplasm Invasiveness2CTD_human
TgenePKMC0024667Animal Mammary Neoplasms1CTD_human
TgenePKMC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePKMC0029456Osteoporosis1CTD_human
TgenePKMC2239176Liver carcinoma1CTD_human