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Fusion gene ID: 11368 |
FusionGeneSummary for EIF5A_DNAJC24 |
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Fusion gene information | Fusion gene name: EIF5A_DNAJC24 | Fusion gene ID: 11368 | Hgene | Tgene | Gene symbol | EIF5A | DNAJC24 | Gene ID | 1984 | 120526 |
Gene name | eukaryotic translation initiation factor 5A | DnaJ heat shock protein family (Hsp40) member C24 | |
Synonyms | EIF-5A|EIF5A1|eIF5AI | DPH4|JJJ3|ZCSL3 | |
Cytomap | 17p13.1 | 11p13 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation initiation factor 5A-1eIF-4DeIF-5A-1eIF-5A1eukaryotic initiation factor 5Arev-binding factor | dnaJ homolog subfamily C member 241700030A21RikCSL-type zinc finger-containing protein 3DPH4 homolog (JJJ3, S. cerevisiae)DPH4, JJJ3 homologDnaJ (Hsp40) homolog, subfamily C, member 24diphthamide biosynthesis protein 4zinc finger, CSL domain contai | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P63241 | Q6P3W2 | |
Ensembl transtripts involved in fusion gene | ENST00000336452, ENST00000336458, ENST00000576930, ENST00000572815, ENST00000573542, ENST00000419711, ENST00000571955, ENST00000416016, | ENST00000527601, ENST00000465995, ENST00000536040, | |
Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: EIF5A [Title/Abstract] AND DNAJC24 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EIF5A | GO:0006913 | nucleocytoplasmic transport | 12210765 |
Hgene | EIF5A | GO:0006915 | apoptotic process | 15371445|17187778 |
Tgene | DNAJC24 | GO:0032781 | positive regulation of ATPase activity | 22367199 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN340509 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000336452 | ENST00000527601 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000336452 | ENST00000465995 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000336452 | ENST00000536040 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-3UTR | ENST00000336458 | ENST00000527601 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000336458 | ENST00000465995 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000336458 | ENST00000536040 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-3UTR | ENST00000576930 | ENST00000527601 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000576930 | ENST00000465995 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000576930 | ENST00000536040 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-3UTR | ENST00000572815 | ENST00000527601 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000572815 | ENST00000465995 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000572815 | ENST00000536040 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-3UTR | ENST00000573542 | ENST00000527601 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000573542 | ENST00000465995 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000573542 | ENST00000536040 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-3UTR | ENST00000419711 | ENST00000527601 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000419711 | ENST00000465995 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000419711 | ENST00000536040 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-3UTR | ENST00000571955 | ENST00000527601 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000571955 | ENST00000465995 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000571955 | ENST00000536040 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-3UTR | ENST00000416016 | ENST00000527601 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000416016 | ENST00000465995 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
5CDS-5UTR | ENST00000416016 | ENST00000536040 | EIF5A | chr17 | 7213009 | + | DNAJC24 | chr11 | 31391414 | + |
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FusionProtFeatures for EIF5A_DNAJC24 |
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Hgene | Tgene |
EIF5A | DNAJC24 |
mRNA-binding protein involved in translation elongation.Has an important function at the level of mRNA turnover, probablyacting downstream of decapping. Involved in actin dynamics andcell cycle progression, mRNA decay and probably in a pathwayinvolved in stress response and maintenance of cell wallintegrity. With syntenin SDCBP, functions as a regulator ofp53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines onneuronal process extension and survival. May play an importantrole in brain development and function, and in skeletal musclestem cell differentiation. Also described as a cellular cofactorof human T-cell leukemia virus type I (HTLV-1) Rex protein and ofhuman immunodeficiency virus type 1 (HIV-1) Rev protein, essentialfor mRNA export of retroviral transcripts.{ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064,ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778,ECO:0000269|PubMed:17360499}. | Stimulates the ATPase activity of several Hsp70-typechaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier.Plays a role in the diphthamide biosynthesis, a post-translationalmodification of histidine which occurs in translation elongationfactor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxinand by Pseudomonas exotoxin A (Eta). {ECO:0000269|PubMed:22367199,ECO:0000269|PubMed:22509046}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF5A_DNAJC24 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF5A_DNAJC24 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF5A_DNAJC24 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF5A_DNAJC24 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EIF5A | C0022548 | Keloid | 1 | CTD_human |
Hgene | EIF5A | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | EIF5A | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |