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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11368

FusionGeneSummary for EIF5A_DNAJC24

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF5A_DNAJC24
Fusion gene ID: 11368
HgeneTgene
Gene symbol

EIF5A

DNAJC24

Gene ID

1984

120526

Gene nameeukaryotic translation initiation factor 5ADnaJ heat shock protein family (Hsp40) member C24
SynonymsEIF-5A|EIF5A1|eIF5AIDPH4|JJJ3|ZCSL3
Cytomap

17p13.1

11p13

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 5A-1eIF-4DeIF-5A-1eIF-5A1eukaryotic initiation factor 5Arev-binding factordnaJ homolog subfamily C member 241700030A21RikCSL-type zinc finger-containing protein 3DPH4 homolog (JJJ3, S. cerevisiae)DPH4, JJJ3 homologDnaJ (Hsp40) homolog, subfamily C, member 24diphthamide biosynthesis protein 4zinc finger, CSL domain contai
Modification date2018052220180523
UniProtAcc

P63241

Q6P3W2

Ensembl transtripts involved in fusion geneENST00000336452, ENST00000336458, 
ENST00000576930, ENST00000572815, 
ENST00000573542, ENST00000419711, 
ENST00000571955, ENST00000416016, 
ENST00000527601, ENST00000465995, 
ENST00000536040, 
Fusion gene scores* DoF score6 X 6 X 2=721 X 1 X 1=1
# samples 61
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: EIF5A [Title/Abstract] AND DNAJC24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF5A

GO:0006913

nucleocytoplasmic transport

12210765

HgeneEIF5A

GO:0006915

apoptotic process

15371445|17187778

TgeneDNAJC24

GO:0032781

positive regulation of ATPase activity

22367199


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN340509EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000336452ENST00000527601EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000336452ENST00000465995EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000336452ENST00000536040EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-3UTRENST00000336458ENST00000527601EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000336458ENST00000465995EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000336458ENST00000536040EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-3UTRENST00000576930ENST00000527601EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000576930ENST00000465995EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000576930ENST00000536040EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-3UTRENST00000572815ENST00000527601EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000572815ENST00000465995EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000572815ENST00000536040EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-3UTRENST00000573542ENST00000527601EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000573542ENST00000465995EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000573542ENST00000536040EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-3UTRENST00000419711ENST00000527601EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000419711ENST00000465995EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000419711ENST00000536040EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-3UTRENST00000571955ENST00000527601EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000571955ENST00000465995EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000571955ENST00000536040EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-3UTRENST00000416016ENST00000527601EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000416016ENST00000465995EIF5Achr17

7213009

+DNAJC24chr11

31391414

+
5CDS-5UTRENST00000416016ENST00000536040EIF5Achr17

7213009

+DNAJC24chr11

31391414

+

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FusionProtFeatures for EIF5A_DNAJC24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF5A

P63241

DNAJC24

Q6P3W2

mRNA-binding protein involved in translation elongation.Has an important function at the level of mRNA turnover, probablyacting downstream of decapping. Involved in actin dynamics andcell cycle progression, mRNA decay and probably in a pathwayinvolved in stress response and maintenance of cell wallintegrity. With syntenin SDCBP, functions as a regulator ofp53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines onneuronal process extension and survival. May play an importantrole in brain development and function, and in skeletal musclestem cell differentiation. Also described as a cellular cofactorof human T-cell leukemia virus type I (HTLV-1) Rex protein and ofhuman immunodeficiency virus type 1 (HIV-1) Rev protein, essentialfor mRNA export of retroviral transcripts.{ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064,ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778,ECO:0000269|PubMed:17360499}. Stimulates the ATPase activity of several Hsp70-typechaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier.Plays a role in the diphthamide biosynthesis, a post-translationalmodification of histidine which occurs in translation elongationfactor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxinand by Pseudomonas exotoxin A (Eta). {ECO:0000269|PubMed:22367199,ECO:0000269|PubMed:22509046}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF5A_DNAJC24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF5A_DNAJC24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF5A_DNAJC24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF5A_DNAJC24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF5AC0022548Keloid1CTD_human
HgeneEIF5AC0024667Animal Mammary Neoplasms1CTD_human
HgeneEIF5AC0024668Mammary Neoplasms, Experimental1CTD_human