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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11356

FusionGeneSummary for EIF4G3_NSUN4

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4G3_NSUN4
Fusion gene ID: 11356
HgeneTgene
Gene symbol

EIF4G3

NSUN4

Gene ID

8672

387338

Gene nameeukaryotic translation initiation factor 4 gamma 3NOP2/Sun RNA methyltransferase family member 4
SynonymseIF-4G 3|eIF4G 3|eIF4GIISHTAP
Cytomap

1p36.12

1p33

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II5-methylcytosine rRNA methyltransferase NSUN4NOL1/NOP2/Sun domain family member 4NOP2/Sun domain family, member 4putative methyltransferase NSUN4sperm head and tail associated protein
Modification date2018052320180523
UniProtAcc

O43432

Q96CB9

Ensembl transtripts involved in fusion geneENST00000264211, ENST00000400422, 
ENST00000602326, ENST00000374935, 
ENST00000374937, ENST00000536266, 
ENST00000374933, ENST00000544689, 
ENST00000356916, ENST00000374927, 
ENST00000537738, 
ENST00000474844, 
ENST00000536062, ENST00000537428, 
ENST00000498008, 
Fusion gene scores* DoF score13 X 10 X 10=13001 X 1 X 1=1
# samples 181
** MAII scorelog2(18/1300*10)=-2.85244281158614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: EIF4G3 [Title/Abstract] AND NSUN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNSUN4

GO:0031167

rRNA methylation

23022348


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7153-01AEIF4G3chr1

21415631

-NSUN4chr1

46818540

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000264211ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000264211ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000264211ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3UTRENST00000264211ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000400422ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000400422ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000400422ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3UTRENST00000400422ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000602326ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000602326ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000602326ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3UTRENST00000602326ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374935ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374935ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374935ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3UTRENST00000374935ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374937ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374937ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374937ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3UTRENST00000374937ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000536266ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000536266ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000536266ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3UTRENST00000536266ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374933ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374933ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000374933ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3UTRENST00000374933ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000544689ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000544689ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000544689ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3UTRENST00000544689ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000356916ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000356916ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000356916ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3UTRENST00000356916ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000374927ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000374927ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3CDSENST00000374927ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
5UTR-3UTRENST00000374927ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000537738ENST00000474844EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000537738ENST00000536062EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3CDSENST00000537738ENST00000537428EIF4G3chr1

21415631

-NSUN4chr1

46818540

+
intron-3UTRENST00000537738ENST00000498008EIF4G3chr1

21415631

-NSUN4chr1

46818540

+

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FusionProtFeatures for EIF4G3_NSUN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4G3

O43432

NSUN4

Q96CB9

Probable component of the protein complex eIF4F, whichis involved in the recognition of the mRNA cap, ATP-dependentunwinding of 5'-terminal secondary structure and recruitment ofmRNA to the ribosome. Thought to be a functional homolog ofEIF4G1. {ECO:0000269|PubMed:9418880}. Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved inmitochondrial ribosome small subunit (SSU) maturation bymethylation of mitochondrial 12S rRNA; the function is independentof MTERFD2/MTERF4 and assembled mitochondrial ribosome largesubunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably isinvolved in a final step in ribosome biogenesis to ensure that SSUand LSU are assembled. In vitro can methylate 16S rRNA of the LSU;the methylation is enhanced by MTERFD/MTERF4.{ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:23022348}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF4G3_NSUN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF4G3_NSUN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EIF4G3EIF4A2, EIF4A1, PABPC1, USP10, EIF3H, EIF3F, MKNK1, VAV2, SIRT7, EIF4G1, EIF4G2, ESR1, LIG4, TARDBP, LGR4, EIF4E, COMTD1, QPRT, BCAT1, PNKD, RBFOX2, KPTN, PSMC3, ALDH3A2, HSPB1, EIF2B5, PUS7, PABPC4, SF3A2, NTRK1, EIF3B, CTR9, FAM46A, WDYHV1, NFATC2IP, EPHA1, SIGLECL1, HAO2NSUN4EWSR1, MAGEA11, KBTBD7, SQSTM1, ICT1, ELAVL1, RPL13, SLC25A41, CA10, INSL3, PHKG2, YWHAH, MYEF2, FOXL2, ZNF131, MND1, SSMEM1, HSPD1, AURKAIP1, DENR, RPL18, ZNF324B, C11orf57, BPNT1, RPL30, FGF8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF4G3_NSUN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF4G3_NSUN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource