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Fusion gene ID: 11356 |
FusionGeneSummary for EIF4G3_NSUN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF4G3_NSUN4 | Fusion gene ID: 11356 | Hgene | Tgene | Gene symbol | EIF4G3 | NSUN4 | Gene ID | 8672 | 387338 |
| Gene name | eukaryotic translation initiation factor 4 gamma 3 | NOP2/Sun RNA methyltransferase family member 4 | |
| Synonyms | eIF-4G 3|eIF4G 3|eIF4GII | SHTAP | |
| Cytomap | 1p36.12 | 1p33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II | 5-methylcytosine rRNA methyltransferase NSUN4NOL1/NOP2/Sun domain family member 4NOP2/Sun domain family, member 4putative methyltransferase NSUN4sperm head and tail associated protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43432 | Q96CB9 | |
| Ensembl transtripts involved in fusion gene | ENST00000264211, ENST00000400422, ENST00000602326, ENST00000374935, ENST00000374937, ENST00000536266, ENST00000374933, ENST00000544689, ENST00000356916, ENST00000374927, ENST00000537738, | ENST00000474844, ENST00000536062, ENST00000537428, ENST00000498008, | |
| Fusion gene scores | * DoF score | 13 X 10 X 10=1300 | 1 X 1 X 1=1 |
| # samples | 18 | 1 | |
| ** MAII score | log2(18/1300*10)=-2.85244281158614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: EIF4G3 [Title/Abstract] AND NSUN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NSUN4 | GO:0031167 | rRNA methylation | 23022348 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-78-7153-01A | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000264211 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000264211 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000264211 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3UTR | ENST00000264211 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000400422 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000400422 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000400422 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3UTR | ENST00000400422 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000602326 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000602326 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000602326 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3UTR | ENST00000602326 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374935 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374935 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374935 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3UTR | ENST00000374935 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374937 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374937 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374937 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3UTR | ENST00000374937 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000536266 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000536266 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000536266 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3UTR | ENST00000536266 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374933 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374933 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000374933 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3UTR | ENST00000374933 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000544689 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000544689 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000544689 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3UTR | ENST00000544689 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000356916 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000356916 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000356916 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3UTR | ENST00000356916 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000374927 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000374927 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3CDS | ENST00000374927 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| 5UTR-3UTR | ENST00000374927 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000537738 | ENST00000474844 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000537738 | ENST00000536062 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3CDS | ENST00000537738 | ENST00000537428 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
| intron-3UTR | ENST00000537738 | ENST00000498008 | EIF4G3 | chr1 | 21415631 | - | NSUN4 | chr1 | 46818540 | + |
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FusionProtFeatures for EIF4G3_NSUN4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF4G3 | NSUN4 |
| Probable component of the protein complex eIF4F, whichis involved in the recognition of the mRNA cap, ATP-dependentunwinding of 5'-terminal secondary structure and recruitment ofmRNA to the ribosome. Thought to be a functional homolog ofEIF4G1. {ECO:0000269|PubMed:9418880}. | Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved inmitochondrial ribosome small subunit (SSU) maturation bymethylation of mitochondrial 12S rRNA; the function is independentof MTERFD2/MTERF4 and assembled mitochondrial ribosome largesubunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably isinvolved in a final step in ribosome biogenesis to ensure that SSUand LSU are assembled. In vitro can methylate 16S rRNA of the LSU;the methylation is enhanced by MTERFD/MTERF4.{ECO:0000269|PubMed:21531335, ECO:0000269|PubMed:23022348}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF4G3_NSUN4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF4G3_NSUN4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EIF4G3 | EIF4A2, EIF4A1, PABPC1, USP10, EIF3H, EIF3F, MKNK1, VAV2, SIRT7, EIF4G1, EIF4G2, ESR1, LIG4, TARDBP, LGR4, EIF4E, COMTD1, QPRT, BCAT1, PNKD, RBFOX2, KPTN, PSMC3, ALDH3A2, HSPB1, EIF2B5, PUS7, PABPC4, SF3A2, NTRK1, EIF3B, CTR9, FAM46A, WDYHV1, NFATC2IP, EPHA1, SIGLECL1, HAO2 | NSUN4 | EWSR1, MAGEA11, KBTBD7, SQSTM1, ICT1, ELAVL1, RPL13, SLC25A41, CA10, INSL3, PHKG2, YWHAH, MYEF2, FOXL2, ZNF131, MND1, SSMEM1, HSPD1, AURKAIP1, DENR, RPL18, ZNF324B, C11orf57, BPNT1, RPL30, FGF8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF4G3_NSUN4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF4G3_NSUN4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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