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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11354

FusionGeneSummary for EIF4G3_LAPTM4A

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4G3_LAPTM4A
Fusion gene ID: 11354
HgeneTgene
Gene symbol

EIF4G3

LAPTM4A

Gene ID

8672

9741

Gene nameeukaryotic translation initiation factor 4 gamma 3lysosomal protein transmembrane 4 alpha
SynonymseIF-4G 3|eIF4G 3|eIF4GIIHUMORF13|LAPTM4|MBNT|Mtrp
Cytomap

1p36.12

2p24.1

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma IIlysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporter
Modification date2018052320180523
UniProtAcc

O43432

Q15012

Ensembl transtripts involved in fusion geneENST00000264211, ENST00000400422, 
ENST00000602326, ENST00000374935, 
ENST00000374937, ENST00000536266, 
ENST00000374933, ENST00000544689, 
ENST00000356916, ENST00000374927, 
ENST00000537738, 
ENST00000175091, 
Fusion gene scores* DoF score13 X 10 X 10=13003 X 3 X 1=9
# samples 183
** MAII scorelog2(18/1300*10)=-2.85244281158614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EIF4G3 [Title/Abstract] AND LAPTM4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP326154EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000264211ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000400422ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000602326ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000374935ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000374937ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000536266ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000374933ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000544689ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000356916ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000374927ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-
intron-5UTRENST00000537738ENST00000175091EIF4G3chr1

21268407

-LAPTM4Achr2

20251361

-

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FusionProtFeatures for EIF4G3_LAPTM4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4G3

O43432

LAPTM4A

Q15012

Probable component of the protein complex eIF4F, whichis involved in the recognition of the mRNA cap, ATP-dependentunwinding of 5'-terminal secondary structure and recruitment ofmRNA to the ribosome. Thought to be a functional homolog ofEIF4G1. {ECO:0000269|PubMed:9418880}. May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF4G3_LAPTM4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF4G3_LAPTM4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF4G3_LAPTM4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF4G3_LAPTM4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource