	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 11352

FusionGeneSummary for EIF4G3_GGA1

Fusion gene summary

Fusion gene information	Fusion gene name: EIF4G3_GGA1
	Fusion gene ID: 11352
		Hgene	Tgene
	Gene symbol	EIF4G3	GGA1
	Gene ID	8672	26088
	Gene name	eukaryotic translation initiation factor 4 gamma 3	golgi associated, gamma adaptin ear containing, ARF binding protein 1
	Synonyms	eIF-4G 3\|eIF4G 3\|eIF4GII	-
	Cytomap	1p36.12	22q13.1
	Type of gene	protein-coding	protein-coding
	Description	eukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II	ADP-ribosylation factor-binding protein GGA1ADP-ribosylation factor binding protein 1gamma-adaptin related protein 1golgi-localized, gamma ear-containing, ARF-binding protein 1
	Modification date	20180523	20180522
	UniProtAcc	O43432	Q9UJY5
	Ensembl transtripts involved in fusion gene	ENST00000264211, ENST00000400422, ENST00000602326, ENST00000374935, ENST00000374937, ENST00000536266, ENST00000374933, ENST00000544689, ENST00000356916, ENST00000374927, ENST00000537738,	ENST00000414350, ENST00000343632, ENST00000381756, ENST00000405147, ENST00000325180, ENST00000337437, ENST00000406772, ENST00000488672,
Fusion gene scores	* DoF score	13 X 10 X 10=1300	5 X 5 X 3=75
	# samples	18	8
	** MAII score	log2(18/1300*10)=-2.85244281158614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/75*10)=0.0931094043914815 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: EIF4G3 [Title/Abstract] AND GGA1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BQ319981	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
ChiTaRS3.1			BQ320238	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000264211	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000264211	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000264211	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000264211	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000264211	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000264211	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000264211	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000264211	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000400422	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000400422	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000400422	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000400422	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000400422	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000400422	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000400422	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000400422	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000602326	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000602326	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000602326	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000602326	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000602326	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000602326	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000602326	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000602326	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374935	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374935	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374935	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374935	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374935	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374935	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374935	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374935	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374937	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374937	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374937	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374937	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374937	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374937	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374937	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374937	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000536266	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000536266	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000536266	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000536266	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000536266	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000536266	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000536266	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000536266	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374933	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374933	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374933	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374933	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374933	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374933	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374933	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374933	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000544689	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000544689	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000544689	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000544689	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000544689	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000544689	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000544689	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000544689	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000356916	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000356916	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000356916	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000356916	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000356916	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000356916	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000356916	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000356916	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374927	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374927	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374927	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374927	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374927	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374927	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374927	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000374927	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000537738	ENST00000414350	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000537738	ENST00000343632	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000537738	ENST00000381756	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000537738	ENST00000405147	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000537738	ENST00000325180	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000537738	ENST00000337437	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000537738	ENST00000406772	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+
intron-intron	ENST00000537738	ENST00000488672	EIF4G3	chr1	21268229	+	GGA1	chr22	38021101	+

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FusionProtFeatures for EIF4G3_GGA1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EIF4G3 O43432	GGA1 Q9UJY5
Probable component of the protein complex eIF4F, whichis involved in the recognition of the mRNA cap, ATP-dependentunwinding of 5'-terminal secondary structure and recruitment ofmRNA to the ribosome. Thought to be a functional homolog ofEIF4G1. {ECO:0000269\|PubMed:9418880}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for EIF4G3_GGA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF4G3_GGA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for EIF4G3_GGA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for EIF4G3_GGA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 11352

FusionGeneSummary for EIF4G3_GGA1

FusionProtFeatures for EIF4G3_GGA1

FusionGeneSequence for EIF4G3_GGA1

FusionGenePPI for EIF4G3_GGA1

RelatedDrugs for EIF4G3_GGA1

RelatedDiseases for EIF4G3_GGA1