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Fusion gene ID: 11323 |
FusionGeneSummary for EIF4E_UBXN7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF4E_UBXN7 | Fusion gene ID: 11323 | Hgene | Tgene | Gene symbol | EIF4E | UBXN7 | Gene ID | 1977 | 26043 |
| Gene name | eukaryotic translation initiation factor 4E | UBX domain protein 7 | |
| Synonyms | AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E | UBXD7 | |
| Cytomap | 4q23 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein | UBX domain-containing protein 7UBX domain containing 7 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P06730 | O94888 | |
| Ensembl transtripts involved in fusion gene | ENST00000450253, ENST00000280892, ENST00000504432, ENST00000505992, ENST00000504472, | ENST00000296328, ENST00000428095, ENST00000535858, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 1=9 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EIF4E [Title/Abstract] AND UBXN7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF4E | GO:0006417 | regulation of translation | 22578813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA724990 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shit | ENST00000450253 | ENST00000296328 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5CDS-intron | ENST00000450253 | ENST00000428095 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5CDS-intron | ENST00000450253 | ENST00000535858 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| Frame-shit | ENST00000280892 | ENST00000296328 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5CDS-intron | ENST00000280892 | ENST00000428095 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5CDS-intron | ENST00000280892 | ENST00000535858 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| In-frame | ENST00000504432 | ENST00000296328 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5CDS-intron | ENST00000504432 | ENST00000428095 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5CDS-intron | ENST00000504432 | ENST00000535858 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| Frame-shit | ENST00000505992 | ENST00000296328 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5CDS-intron | ENST00000505992 | ENST00000428095 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5CDS-intron | ENST00000505992 | ENST00000535858 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5UTR-3CDS | ENST00000504472 | ENST00000296328 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5UTR-intron | ENST00000504472 | ENST00000428095 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
| 5UTR-intron | ENST00000504472 | ENST00000535858 | EIF4E | chr4 | 99823025 | - | UBXN7 | chr3 | 196134267 | - |
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FusionProtFeatures for EIF4E_UBXN7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF4E | UBXN7 |
| Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis and facilitates ribosome binding by inducing theunwinding of the mRNAs secondary structures. Component of theCYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediatestranslational repression. In the CYFIP1-EIF4E-FMR1 complex thissubunit mediates the binding to the mRNA cap.{ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813}. | Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, toregulate turnover of their ubiquitination substrates.{ECO:0000269|PubMed:22537386}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF4E_UBXN7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EIF4E_ENST00000504432_chr4_99823025_-_UBXN7_ENST00000296328_chr3_196134267_-_10840nt AGATCGATCTAAGATGGCGACTGTCGAACCGGGTGCTGTGAGGAAATGCATGGTTTGTTGAAAAGAACTGAGGACTGACAGCCGCCTCCT CCATGATTACCCTGGCTCTCTGTCCCACCCTTCTCATGGCGCTTGGGGGACCATGGCTGATCCTGTCCTGAGACAAATTAAGACTCCTGT GGTGAAGCAGTTGGTCGAGAAAAAGTGATGCATGAAAAAGAAGCAAAACAAGAAGGAAAGAAAAAAAATGAGAGCTGAAGATGGTGAAAA TGATGCCATTAAAAAGCAGGCAGAAAGTCTGCGAGAATCCCAGGAAACCACCCCTACTCCTAATCCCCCGACTACAGAAGAGGAGAAAAC GGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAGAACAGGTGCAAGTGAAAGTGTAGGAAAACATATGC TTGAAGCGTGCAACAATAATCTGGAAATGGCAGTCACTATGTTTTTGGATGGTGGAGGAATCGCTGAAGAGCCCAGTACCAGTTCAGCAA GTGTCTCTACTGTCAGACCACACACAGAAGAAGAAGTTCGTGCCCCAATTCCTCAAAAGCAGGAAATACTGGTGGAACCAGAACCATTAT TTGGTGCTCCTAAAAGACGACGGCCTGCACGTTCAATTTTTGATGGTTTCCGGGATTTTCAGACTGAAACTATTCGGCAAGAACAAGAAT TAAGAAATGGAGGAGCTATCGATAAGAAATTAACTACCCTTGCAGATCTATTCCGGCCACCCATTGATTTGATGCATAAAGGCAGCTTTG AAACAGCCAAAGAGTGTGGCCAGATGCAAAATAAGTGGCTGATGATAAACATTCAAAATGTTCAAGACTTTGCATGTCAGTGCCTCAACC GCGATGTGTGGAGCAACGAAGCTGTGAAGAATATTATCCGGGAACATTTCATTTTCTGGCAGGTTTATCATGACAGTGAGGAAGGTCAGA GATACATACAGTTTTATAAGTTAGGGGATTTCCCCTATGTTTCCATATTGGACCCACGGACAGGTCAGAAGCTAGTAGAATGGCACCAGT TAGATGTATCTTCTTTCTTGGACCAAGTGACGGGATTTCTGGGTGAACATGGACAACTGGATGGACTTTCTAGCAGTCCCCCCAAAAAAT GTGCCCGTTCAGAGAGCCTTATAGATGCAAGTGAAGACAGCCAGCTAGAAGCTGCCATCAGAGCCTCCTTACAAGAAACACATTTTGATT CAACACAGACAAAACAGGATAGCCGCTCAGATGAAGAATCTGAATCTGAACTTTTTTCTGGCAGTGAGGAGTTCATATCCGTTTGTGGCT CTGATGAAGAAGAAGAGGTAGAGAATCTTGCCAAGTCCAGAAAGTCTCCCCACAAAGATTTGGGGCATAGAAAAGAGGAGAATAGAAGGC CGCTGACTGAGCCACCAGTCAGAACTGATCCTGGAACAGCCACAAACCACCAAGGATTGCCAGCTGTGGATTCAGAGATACTGGAGATGC CACCTGAAAAAGCAGATGGAGTAGTGGAGGGGATAGATGTAAATGGACCAAAAGCACAGCTGATGTTGCGGTATCCAGATGGAAAAAGGG AACAGATCACTCTTCCAGAGCAAGCTAAACTGCTAGCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTC TCACCAACTTTCCTCGAAGGAAATTATCTCATCTGGACTATGATATTACATTGCAAGAGGCAGGCCTTTGTCCTCAAGAGACTGTCTTTG TACAGGAAAGAAATTAACACCATGGCTTGACCTCTCTCAGCTTACCCCTTTTTTCCCTTTTCCTGTGAGATACATGTCACTAAGTATGCA TTTTGGCTCATAGGACCACAGAGCCAAAGTTGGGCAAGCAAGTCACCTTCCTTCTCTTATTTCTTGATCTCTCCTATAATCAGTCTCTTT CTCCCCCTTTGTTTCTTTCTCCTCTTCTGTTTTCTCGCTCCCCACTCCGTACCCTTCTGCCTCCCCCTCCCCCCACACTTTTCTTTCTTA CCTAATCTGGTGACCAAACTGAAGTGTAAGGATAAGACCTCTCCTAGTACTAGCAGCAGGAATTGTGTGTTCCAGTAAGTGGTCTCTTGC ACGGCACTTTTTTGGGATCAAATGTTAACGTTACTCCCCAGACTCTTCGGGCAAAGGAATGGCTAGATTCAGAGTAAGAACAACCCTCCC TTTTTTGTAAGTCCCCGTGTTTAGCAGGGAGAAGAAATTCTCTAACATGGGTTTGGTTTTGTTGTGTTCTTCATGTGGAAATGTCGCTTA ACAAAATATCCAGGCTTTTGTTTACGTGGAAAAAGCATCCCTTGTAATGATTGCTCATCATACTTAAAAACCTTTTTCAAAGGATTTTCA TGTTCCCAGCTATAAGGACTATTTCCATGACATGTGTTATTGGCAGAATGAGTGTTAAATATGGAGCATATAGCATGGGGTGACTTTCAT TGTCCTAACCTGAGACAGTTTTCCTTATTACTCTGTATTGATCCTGCTAGTCCAAGAATGGACATGAAGTGAACCTATCGTGGTGACTGG GATAGGAAGGTGCTTGCTATTTTTGCCAGCACAGCATATTAGTTCCTTTGGAGCCCTCCATTGTCTGAGTCTGCAGTGATCTGTAGGAAG GCAGCTGGTCAATAATCATGTAGTACAATGGCTTGGAATTGTAACCACTATGGTTATTGATTGTCCTGTGTTGTTTCAGGCATACTTAGG TATGTCCCTGGGGAAAAAGAAAACCATTCAGCTGAGAGTTGCTAACCATGTTCTTTTGGTTAGAAATAATGGTTCATTTTTTGCCCCTGG TTGGAATAGTCTCTAAAAGGCTCTGGTGACTGAATTGAACATGAGTCCGCATGCTGTTTTCTTTCAAAAGGTATCAAAACGGAAAGCCTC TCTAAGGGGAAGACCTTTCAACTCCATTCAGAAGACAACATTTAGTAAGGAGGATGGCGGAGGTTACTAGTAATTTTCAGATGTCTTGGG CTTTTTCTGCCAACAAAACCCAAAATCAAATTAGAGTTGGTGAAAGCTTTCTTCAGTGTTTTTAGAAGAGGCCATCTTGAATCTGTAGAA TACCATTTACACATCAACTTCACCCTATGCTCATTTCGTATTTTGAGCTTAAATGGAGTCCTCTGAAGGGGGGGTAGTCGTGATTCTGGT GGCAAAACTAGAACTTTTAACTTGTAAAATGAAAAATATTAAATGGACCTTTTTGTCAGTTGAGGATTTAGATTGATTCTTTTATCTGAG GAGCGTATGTTCCTCAGATGTTGCGTAGAGACCTTTAGGTTTTCATCTACTTTAAGATTGCTCTCTTGGCAATTAGGGGATTTGGGAAAA GAAGAAAAAAAGATGCCATGTGTTGCTAGTACACAGTTATAGGATATGGTTTCTAATGGTTGAATTTTGAGGAACTCTCCCTAAAGAATG AGTTTTATATCTCCTCAAGGAAATCATGGAAAAATCTGTTTATTCTTCAGTGAGTCCTTTTGAATTAATGTTCTTAAATTTTTTTCTAAG TCTGTGTAAGTGCTTATGTATAAGTATATAATTGTATAAATATTTATAAATATATTTATATAATTACGGTTTCATTTCTACCTTGAGTCA AAGTTCTGTCTTTAGATTGGTGACTGAGTAATACTTACACTTTGGTGTTTTTTCTTAGGTTCTTGAGGCTTACTTAACTAGCAGCTTCTG ATTTATTGAGTGAAAGATGGTTTTCATGTTAATTCCTCAGTTGCATCTCTGAACTTGGATAACATACTTGCCGTTTGAAAAATAGAGCTG TATACTGTCAAAGGTGCACTGGAGGGTAAAACATTTGTTGGTAGTAGACAAGCTCAGAAATCCAAAAATTCAGGGAGGGCACAGGGTAAG AAGAGAGGTTTGCTCAGCTTTGTGCTCTGATGGCACCCATCTGTACTCCAGCAAAGTCATAGCTGAAGCCCAAATCGCTCAAACGTGTGA AGTCAATCATTTTTCCTATAGGGCTCTGTTTCCTTTTCTTTACCTTCTAGCTTCTCTTGATAAAACAGTTGGGAGAACTGCCAACGTGTT CATCAGTGAGAGGGTGTGGTTCTTTCCGATATGTTCAGCACGTGCATATTCATTTATGAGAAACCAAAGTAACTTCTTCAACTCGGGTTA CTGTGGGATGATTAAGTAGATATAAAGTGATTTAAAAGACAGCATGGTACTTTCACTCAGCTTAACATGCAGCTGGGATGTCTACAATAC AAGATGTGGTGGGTTTTATTTTATTTTATTTTGAGGCAGGAGTGTAATTATCTTAGGGTTGATATAAAGGCCCATGGGAAGAGTTACGGA TTGTACATGGGAAGAATCCATAAGGAGTATTGCCTTGCTCAAGAATTTAATCCGCTGACAGTATGCTTCTTCCAGTTTGCCTTACTTCCT CTGCAAGTTTCTTTGCTCCTTAGGGCAGAGGTTTTATTGAATAGATTAAATGAGGTCAGTAAGATTAGTTAAAAATAGTCATTCCTTGTG GGTGTTGGACACAGCTTGAAAGGAGTGTTTAAAAAAAAAAAGCTAGGGAGGAAAAGAACAAGAAAGATAGACTTCGAGAGTGATAAGAGA AAAATACAGGGAGATGGAATGGAAACTACCAGGAAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCGGAGGTGG GCAGATCACCTAAGGTCAGGAGATCGAGGCCAGCCTGAGCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTACCTGGGTGT GGTGGCGTGCACCTGTAATCCCAGCTACTCAGAGGCTGAGGCAGGGGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGAT CGCACCATTACACTCCAGCCTGGGCGACAAAGCGACACTCCATCTCAAATTTAAAAAAAAAAAAGAAGAAGAAGAAGAAAACTAGTGGGA AAAAAGTGAGAGGAATACTTTTTTGAAATTGGTATCGGAAGGAACTGGAGAAGAGAAAACAACAGTGCCAAATGAGAAAAGAACAGGAAA CTTAATACTAATTGGCATGCACCAGATACTTTTGTGTACATTTGCCTCTTCAATCTCCCGAAGAATCGTACAAAATGTATACTTTCTTCC CATGTTAAGAAAACAGGTATAGAGAACTTATTCAGGACTCATAGCTAGTGAGTGGCAAATCAGAATTGGAATCCAGAGTCCATGCTGTGG TCTCCTTCAGCAAGAGAATCAAGCTACCCAGATGATTCTCTTCTCATTGTTTGGCTTTGTAAAGTGTCACTTAGTTTTGTTCCCATAAAT ATAGAGGAAGTAGTTGGGTTAAAGTTGTGGGATTTGCACTATGCCTATACATTTTTATTTATGCCATTATTTTGAGAGGCTGATTATTGC TTTTTTAAAATGATGCACTGGTGAAGATGTGAAAGTAAAATTGCCACGTGGCATTATTTGCCAAGAATAAATGAAAAGGGTAAAAAAACA ATTTTTTCTTTTTTTAAACATTTTTCAGAAAAGATACAATTACCTTTTTTAATAGGTGAGCGCCACCACGCCCGGCTAATTTTTGCATTT TTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGATCTCGTGTTCCGCCCACCTCGGCCTCCTAAAGTGCTGG GATTACAGGCATGAGCCACTGCGCCCGATCTACAATTCTGTTTTCTGTGTCCCATCCATACCAGATTATTGAACCCTCTGTGTGTATGTT TTTAAATCTTGTATATAATTCTACTTCCTTGACTTACAAGTCAACAATTAGCTATTGAGTTCTTTATAGAAGTTGGAAGTATTTTGAAAT CTGAGATCTAATTCCTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAATATTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTTGG GAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTGAAAAATACAAAAATTAGCCAGGCATGGTGGCTGTCTGTAATCC CAGCTAATGGGGAGGCTGAGGCACAAGAATCTCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCATCC TGGGCAATGGAGCGAGACTCTGTCTCAAAAAATAATAAATAAGATATGATTCCTGCCTGTTTTATCCAGTTAGAGAGACACACTACACAT GAAATAATTGGAGAGCATGTAAATGTTTACCTATTAGTTCAAACTTAGAAAAAGGGAAGAATATGTTTTAGTTAGCAAAGTCTTAAACAA GACTGAAGTGGCAAGCACTGTAGCTCACGTTTTCTTTTGACTCACCTTTTTCTTTAGCTCCACCTTTTGTAACTTCTAGATTTGGGGCAT GAAGTTCTGCCACTAAGGCATAACCAGTACCCAAGTAGGAAAGGATTATTGATCCCTGGAGTAAAGATTCCTAGCTTGCGGGGATCTCAC TATTGATCCCCCGGAGTAAAGATTCCTAGCTCGCAGGAATCTTACTTGCACACTTAGGGAAAATACCAGAGGGAGCCACTAGCAACCGAA AAATGAAGGAAAGATTTAATTTCTCTACCCAGGTACAAATCCAATGCATAGTATAGTATATGTTATATGCAGAAAGGGCACTGGAGGTGT GAGAGCCCTTTGGGTAACAGCTCTGCTAGTTGTTACCTTCACACTTCTCTTTCTTCTTAATCTCTGGTTTCTCGTCTGAAAAATGAGATA ATTGGACTAGATTAATAGTTCTCAGCCTTTTCTAGAACAACAAATTAGATTATCTCTGAAGTCCTTTTCCAAAATTTCATGCTTCCAGTC TCTCCCCGTGATTGCGTATTATCCCTAGGCTAATTAAAAGTGTGCTGGTTAATCAGTTTCTTTACTTTTTTTTTCTCTCTTTTTTTTATT CTGTGTTCAGGTATCATTTGACCAACAACTTGCTCTTAATCTTACTGCGATGACTGAAATCTCCAAAGAGGAGAGTATAGTAGTTATAGG TCTAGTAATAATAATCTTGTAAACAATTCATTATTTTTTAAAACTTAATGCTGTGTGCCTAATCAGTGTTGAGTATGACTAAAATGTAAA TGAGAACCAAATATGACACTAACGCTGGCACTAAATTTTATTTTTACTTGTGTACTTAAAGTACTTTACTGGCCTGTTGGGAAATTGATT TGTATAAGATTCACACCTGGTTTTGGCAGAAACAGCTTTTTAAAGATACAATTAGGCTGACTTAAAAATGTTTTTTATTCCACAGAATGT ATCTTTATTATGTCATTCTTACCGTCTCTCTGCCTTTTTTGACCATCATGTAACTACGCAGTAGTAAATCATGGGGTGCAGGCTGATGAA TTAGTAGTCTTTGTAAAACTAAAATGTAATGAGCATAGGAAGAGACAGCTCTTCTGGTGAACATGGCAGTTTTCCGGTAATACCAGCCTT GATGAATAGGCTAAAGACAGCTGTGTACTATGGACATTCAACTTCACTGGATTGCCTGGCTTAGCTTTTCAGTTATTGTCTTGCCGTGAA ACATGGTGTTGCACTGTACACATTTTAGAATAGTGGCAAGAATGTTCTTTAGAACTGCAGATAACCCAACAGAGAATACCATACCAATAT ATCGGTTTCTCCTGTTACATAGAGATTTGGTATTTCAGTGATGGTTATGGTTTTTGACTCACCTGTGTGTCAGTCCTGCTAGAGAGACAG TATAGAATCAAGAATTTCTTGATGTCTTTTTAAAAATAGAGATTATAATGGCCTTGCTAGTTGTCCTGTGAAGTGACAGACCCTTAATTA GAAATCTTTTAATCCTGCTTTCCATTTTACTTCTCCACCATTTATTTTTAACATTCATTCTCTGAAAATAGTTATGATTTTTAGTGTAAT TGGCTATGTTTAAGAAATTCCATTTCAAAGTCTTAATATGTAACAATCTTCATTTTTTATAAAATTGAAGGACATTTTTGAGGCAAACTT ACTTTTATAGCTCATTTTCTCCCTAGTTAAGGAGAATTCTCTGGTTTCATATAGAGAATGGCTAGCTCTGTGATACCCCACCCTCTTTGT GGCCTACCAGTTGCTGTTGTGTTGCTTAAAATTGCAGATATTCTCATAAACATGATGATTTTTGGCACAGGCCTTTCTTTGCTATTGATT TCAAAATAAAGTTGGGCAATCCAATTTGAACTACTTTAATAAACATAATTTAGCATTCCTGTAATGAGAAAGTATTTTCAAAAGATAACC AGATTTATTTCTAGGATTAGAGATGGCAAATACCAATGATAGTATTTTTCCCAAGAGCAATCACAGATTAATCTATAAATATGAGAAGTC GCATTATTGTACTTAATTCTTTGGCAACAAACAGCAAGTTTTTATTGTTTAATTGTATTTCCTCTCTAGAGATCACAATACTCTGGGTAT TTTATATCCCTTCTAAAGGTCATTTGGGTTTTCAAATGGGAAGAATAGTCAAGCTAAGCTGGACTAAACCTAAGTAATATTTTTTCTCAT CAAAAGAAGTTATTAATCTAACTGGGTTAGCATGAGTCATTCATTTTTTAGACATGATAAATGGGAAACATATCAAATCATTAGATAAAT TCTGACCTGGAATTGAATTCCCCCTTTCTTAAAATCTTTTTAATTTGCTTTTTTCATAGACTCAGTATGGAACTCTTAACTGATAAGGGA GAGATTCTTGATCTGGAACCGTTCCCTGCCATTCTCCTTTTTTCTCTCTATCTAGGTAGCTGGTTCCATAGTGCCCGTCACGAGGGTCCA TTTCAGTTTGATGACATTAGACTGCTTACACTCAGCTGGATGCCTTGCTGTTTGCAGCAACATGATTTTACAGTATGCTTTTCTCAAAGC TTTGCATTCTTAATGGAGATATCAAATGGTGTAATTCCAAATATAAATATGTTTATGACACTAATCATATGCTTTTAACAATAACTTTTT GATAACTTATTGCCCTGTAAGTTAAACCTTACACGGAGTGACTGTTGCCATCAGAAAATCCCCTTTCACCTGCTAGAGAGAGTGAAAGTA GTGCGTGGCCTCCACTTTTCAGTTAACGAGTAGCAAGCTTCTAGTAGGGGCTGCTTATCTGACCCATGTGGGGTCTTGGGCCTTGTTACT TTCCTGGGTTCGTCCCTTCAGCTGGAAAGGCTGTTGAAAACACTTGCCAGGAAACAGTAAAGCTGTGAGAGAATCTTCTAGTCTTAGATA TAGAGAAATGAGTACCAGTTGATGCTAACACGATACTTAGACTTTGAGGGGCTTCCATCCAAGCTTTGGCATGAATCTGTTAGACACGGT TTTCTTCACTCCTCTGATAATCTTTTTTTCCAGAATGGTTTTTTGTTGTTGTTGTTGTTAACAAATTCTAAACATCCAGTGTTACTTTTT GTTTTGTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTGCCCTTCAGGAAAGTCCTTTTTCGAGTAGGTATTGATTGTTCCCTGGAAACT CTCAGCAGTGTCTGTGCAGGCTCTGTGCATGCTTTGTATGAGTTCGGCTTGAACAATGCATTTGAAGTCACCTGGGATGTCCAGTTCTGG CATGTCTTCATTGATTGTGTTTTTAAACATGTTTCATGTTTCATGTCATTTTCCAAACCTCACTTTACATCTTACTCAGAGAAGTTAATC AAGGAATGAAATTTCTAGGGGGATAGGGATGATGAGGGTGGGTTGGGGGCTTGAGTGAAGTCAACTTGGGGTATTTGCTTTAAAGTGTTT TCTAAAGCAGTTCCTAACAGTATTTAGAGATTCCCTGGGATGTTTGTGGCTCAACTTATTCTGGACAAAGTGTGTGTGGGGGTGGTCTTA CTGAGATTTGCATTCTTAATGCAGGACAGGCTCTAAATTTCATCTGTACTCTAAATTTGTGATTGAATCCAAGAAGATAACAGAGACAGT GCTCCTGTTGTAATGTTTCTGGCAAGTGCTCCCTAAAATGCACATCGAATTCTGTTTTCTGGGCCTTTTCTCCAATGGTGCTAGGAGATA CCGTTGATTTCTGCAGCTCTTCTCAGTGGTGGGAAGAAGTCTTTGGGATTGTTGAGCAAGGGGCAGCTGGACCATCCACTAAATTTTTTT GTTCAAGACACATTAGAGACCCTCCTGTATATCTAGTAAGTCATAATAAAGGTGCTTGGGAAAGCCTTAAATTTGAAGACACATGGAGGC GGTAGAAAATTAAACTTGTAAGAGGAGAAAAACATGCCATTAGGTAACGCAGAGTTGTAACTACTGGCTAAGACTCAATGGAACTTCCAC TTGCTCTAAAACCAGGGAAATCTTAGATAACTGGGTGTGATCTACCTATAGATCTACCTAGTCTATAGGTAATAATTTCCAGAAGGAGGA TCTTGCTGTCAGTTGGGGATCCTCTGGTTTGGTCTGTACCAAATTGTGAATACTCTTGCTGTGTTGTACCCAGTTGCTTTATATTAATAC TGCAACTTGAAACGGGGAGGGTGGGGGGACAATGGGGTGGGGGAGGGAAGGGAGTGGGACGATAAGTCTTTTGAAGACATCAGCTCACTG TGCTGAGAGAGGGACCAAACTCAAGGAAACCTCTGATCTATACATTCAACTGCTGCATTTTTTTATAAATACATGTAAATGTCCTGTTGT |
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FusionGenePPI for EIF4E_UBXN7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EIF4E | EIF4EBP1, EIF4A2, EIF4A1, EIF4ENIF1, PML, EIF4G1, EIF4EBP2, EIF3B, MKNK1, EIF4EBP3, EIF3F, STUB1, DCC, HSPB2, RPTOR, APP, EIF4H, GEMIN5, ITGA4, CD83, PRDM4, AHSA1, ASS1, CAPN1, HSPA9, NANS, EIF6, HSPD1, PEPD, PROSC, TYMP, KANK2, TDO2, TRIM27, UBXN11, RPS6KB1, MTOR, TRIM22, EIF4G3, ANGEL1, DDX19A, CSK, UBFD1, KIAA0368, PABPC1, PABPC3, PABPC4, PDXK, NTRK1, CYLD | UBXN7 | VCP, NPLOC4, UFD1L, CUL1, CUL2, CUL3, UBR1, PSMD2, HIF1A, ALPP, SKP1, RBX1, TCEB2, TCEB1, VHL, KLHL12, KLHL13, KLHL22, KBTBD7, KBTBD2, KLHDC3, CUL4A, CUL4B, DDB1, VPRBP, WDR26, WDR11, BRWD1, BRWD3, AMFR, UBR2, UBR4, PJA2, BIRC2, TOPORS, UBR5, NEDD8, APP, OXCT1, UBE2V2, ATP6V1F, USP34, UBE2B, SSSCA1, TTLL12, ATP6V1B2, ZFYVE19, TYMS, UBE2D1, UBE2L3, UBE2V1, UBE2D2, ZYX, NUBP2, UBE2C, UCHL3, VPS26A, ZPR1, ZRANB2, SDHAF2, SEC23A, UBE4B, SULT1A1, RAD23B, SRXN1, UFC1, UFM1, YAP1, USP9X, UBC, DPP8, LZTFL1, NSUN2, MAP3K1, KCNK16, NTRK1, ERCC8, ACAD11, ERCC3, CSNK1G3, ASPSCR1, KCTD10, BTBD9, KCTD13, FAF2, ABCF1, JUN, RANBP6, SETD7, RNF138, KIFC1, MORF4L2, PHF6, PHIP, CSNK1E, POU3F2, CSTF1, NSFL1C, VCPIP1, FAF1, FAM91A1, KLHDC2, KLHDC10, KPNA3, TNFAIP1, UBXN1, SMURF1, TCEANC2, RNF111, FAM189B, NUAK2, ATG9A, XKRX, TGIF2LY |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF4E_UBXN7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF4E_UBXN7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EIF4E | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |
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