![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 11322 |
FusionGeneSummary for EIF4E_EIF4E |
![]() |
Fusion gene information | Fusion gene name: EIF4E_EIF4E | Fusion gene ID: 11322 | Hgene | Tgene | Gene symbol | EIF4E | EIF4E | Gene ID | 1977 | 1977 |
Gene name | eukaryotic translation initiation factor 4E | eukaryotic translation initiation factor 4E | |
Synonyms | AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E | AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E | |
Cytomap | 4q23 | 4q23 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation initiation factor 4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein | eukaryotic translation initiation factor 4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P06730 | P06730 | |
Ensembl transtripts involved in fusion gene | ENST00000450253, ENST00000280892, ENST00000504432, ENST00000505992, ENST00000504472, | ENST00000450253, ENST00000280892, ENST00000504432, ENST00000505992, ENST00000504472, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EIF4E [Title/Abstract] AND EIF4E [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EIF4E | GO:0006417 | regulation of translation | 22578813 |
Tgene | EIF4E | GO:0006417 | regulation of translation | 22578813 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB240919 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000450253 | ENST00000450253 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000450253 | ENST00000280892 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000450253 | ENST00000504432 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000450253 | ENST00000505992 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000450253 | ENST00000504472 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-3UTR | ENST00000280892 | ENST00000450253 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000280892 | ENST00000280892 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000280892 | ENST00000504432 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000280892 | ENST00000505992 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000280892 | ENST00000504472 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-3UTR | ENST00000504432 | ENST00000450253 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000504432 | ENST00000280892 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000504432 | ENST00000504432 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000504432 | ENST00000505992 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000504432 | ENST00000504472 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-3UTR | ENST00000505992 | ENST00000450253 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000505992 | ENST00000280892 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000505992 | ENST00000504432 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000505992 | ENST00000505992 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000505992 | ENST00000504472 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-3UTR | ENST00000504472 | ENST00000450253 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000504472 | ENST00000280892 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000504472 | ENST00000504432 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000504472 | ENST00000505992 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
intron-intron | ENST00000504472 | ENST00000504472 | EIF4E | chr4 | 99793191 | + | EIF4E | chr4 | 99793280 | - |
Top |
FusionProtFeatures for EIF4E_EIF4E |
![]() |
Hgene | Tgene |
EIF4E | EIF4E |
Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis and facilitates ribosome binding by inducing theunwinding of the mRNAs secondary structures. Component of theCYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediatestranslational repression. In the CYFIP1-EIF4E-FMR1 complex thissubunit mediates the binding to the mRNA cap.{ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813}. | Recognizes and binds the 7-methylguanosine-containingmRNA cap during an early step in the initiation of proteinsynthesis and facilitates ribosome binding by inducing theunwinding of the mRNAs secondary structures. Component of theCYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediatestranslational repression. In the CYFIP1-EIF4E-FMR1 complex thissubunit mediates the binding to the mRNA cap.{ECO:0000269|PubMed:16271312, ECO:0000269|PubMed:22578813}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for EIF4E_EIF4E |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for EIF4E_EIF4E |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for EIF4E_EIF4E |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for EIF4E_EIF4E |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EIF4E | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |
Tgene | EIF4E | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |