	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 1132

FusionGeneSummary for AGPAT3_AGO3

Fusion gene summary

Fusion gene information	Fusion gene name: AGPAT3_AGO3
	Fusion gene ID: 1132
		Hgene	Tgene
	Gene symbol	AGPAT3	AGO3
	Gene ID	56894	192669
	Gene name	1-acylglycerol-3-phosphate O-acyltransferase 3	argonaute 3, RISC catalytic component
	Synonyms	LPAAT-GAMMA1\|LPAAT3	EIF2C3
	Cytomap	21q22.3	1p34.3
	Type of gene	protein-coding	protein-coding
	Description	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma1-AGP acyltransferase 31-AGPAT 3lysophosphatidic acid acyltransferase gammalysophosphatidic acid acyltransferase-gamma1	protein argonaute-3argonaute RISC catalytic component 3eukaryotic translation initiation factor 2C, 3hAgo3
	Modification date	20180523	20180522
	UniProtAcc	Q9NRZ7	Q9H9G7
	Ensembl transtripts involved in fusion gene	ENST00000291572, ENST00000398061, ENST00000327505, ENST00000398063, ENST00000398058, ENST00000546158, ENST00000479117,	ENST00000324350, ENST00000373191, ENST00000397828, ENST00000246314, ENST00000471099,
Fusion gene scores	* DoF score	13 X 4 X 9=468	8 X 5 X 8=320
	# samples	15	8
	** MAII score	log2(15/468*10)=-1.64154602908752 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AGPAT3 [Title/Abstract] AND AGO3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AGO3	GO:0006402	mRNA catabolic process	18771919
Tgene	AGO3	GO:0010501	RNA secondary structure unwinding	19966796
Tgene	AGO3	GO:0031054	pre-miRNA processing	19966796
Tgene	AGO3	GO:0035278	miRNA mediated inhibition of translation	18771919
Tgene	AGO3	GO:0035279	mRNA cleavage involved in gene silencing by miRNA	15260970
Tgene	AGO3	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	19966796
Tgene	AGO3	GO:0090625	mRNA cleavage involved in gene silencing by siRNA	15260970

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-20-0987-01A	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-intron	ENST00000291572	ENST00000324350	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
5UTR-intron	ENST00000291572	ENST00000373191	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
5UTR-intron	ENST00000291572	ENST00000397828	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
5UTR-intron	ENST00000291572	ENST00000246314	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
5UTR-intron	ENST00000291572	ENST00000471099	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398061	ENST00000324350	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398061	ENST00000373191	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398061	ENST00000397828	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398061	ENST00000246314	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398061	ENST00000471099	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000327505	ENST00000324350	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000327505	ENST00000373191	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000327505	ENST00000397828	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000327505	ENST00000246314	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000327505	ENST00000471099	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398063	ENST00000324350	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398063	ENST00000373191	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398063	ENST00000397828	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398063	ENST00000246314	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398063	ENST00000471099	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398058	ENST00000324350	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398058	ENST00000373191	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398058	ENST00000397828	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398058	ENST00000246314	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000398058	ENST00000471099	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000546158	ENST00000324350	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000546158	ENST00000373191	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000546158	ENST00000397828	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000546158	ENST00000246314	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000546158	ENST00000471099	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000479117	ENST00000324350	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000479117	ENST00000373191	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000479117	ENST00000397828	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000479117	ENST00000246314	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+
intron-intron	ENST00000479117	ENST00000471099	AGPAT3	chr21	45285226	+	AGO3	chr1	36492715	+

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FusionProtFeatures for AGPAT3_AGO3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AGPAT3 Q9NRZ7	AGO3 Q9H9G7
Converts lysophosphatidic acid (LPA) into phosphatidicacid by incorporating an acyl moiety at the sn-2 position of theglycerol backbone. Acts on LPA containing saturated or unsaturatedfatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 orC18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine,lysophosphatidylinositol and lysophosphatidylserine using C18:1 orC20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoAas a donor. Has also a modest lysophosphatidylinositolacyltransferase (LPIAT) activity, convertslysophosphatidylinositol (LPI) into phosphatidylinositol (Bysimilarity). {ECO:0000250\|UniProtKB:Q9D517,ECO:0000269\|PubMed:21173190}.	Required for RNA-mediated gene silencing (RNAi). Bindsto short RNAs such as microRNAs (miRNAs) and represses thetranslation of mRNAs which are complementary to them. Proposed tobe involved in stabilization of small RNA derivates (riRNA)derived from processed RNA polymerase III-transcribed Alu repeatscontaining a DR2 retinoic acid response element (RARE) in stemcells and in the subsequent riRNA-dependent degradation of asubset of RNA polymerase II-transcribed coding mRNAs by recruitinga mRNA decapping complex involving EDC4. Possesses RNA sliceractivity but only on select RNAs bearing 5'- and 3'-flankingsequences to the region of guide-target complementarity(PubMed:29040713). {ECO:0000255\|HAMAP-Rule:MF_03032,ECO:0000269\|PubMed:18771919, ECO:0000269\|PubMed:23064648,ECO:0000269\|PubMed:29040713}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for AGPAT3_AGO3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AGPAT3_AGO3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
AGPAT3	APP, TSPAN3, TSPAN5, GPM6A, TSPAN17, PTH1R, GPR52, FAM189A2, FNDC4, CREB3, TOM1L1, SLC7A1, SLC6A15, SCYL1, YIPF3, HSPA8, KDELR3, GPR89A, NOMO1, ARL15, METTL9, SERINC1, NCLN, TMEM120B, TMEM120A	AGO3	DICER1, UBC, FLNA, PRMT5, SF3B6, SPTBN1, SPTAN1, OTUD4, MYH9, TNRC6B, EIF4B, IPO8, AGO2, HSP90AB1, HSPA9, SUN2, PSPC1, CCT3, EIF3L, ATAD3B, TAB1, PRPF31, TUBA1A, STK38, TUBB4A, TUBB4B, TUBB2A, TUBB, TRIM21, EEF1A1, DBT, RUVBL2, WDR77, DNAJA1, DDOST, QPCTL, CLNS1A, PHB2, SPIN1, AGO4, CUL3, CUL5, CAND1, TNRC6A, TNRC6C, ATP4B, SLC22A2, BDNF, ATP6V0D2, AGO1, PRKAR1A, TARBP2, ZNF346, HSP90AA1, HSP90AB4P, HSP90AB3P, HSP90AA5P, AP3M1, AP3D1, FKBP5, AP3B1, AP3S1, ANKMY2, LONRF3, RANGRF, XPO1, BAG5, CIR1, ATOH1, BRCA1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for AGPAT3_AGO3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AGPAT3_AGO3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	AGPAT3	C0524851	Neurodegenerative Disorders	1	CTD_human

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Fusion gene ID: 1132

FusionGeneSummary for AGPAT3_AGO3

FusionProtFeatures for AGPAT3_AGO3

FusionGeneSequence for AGPAT3_AGO3

FusionGenePPI for AGPAT3_AGO3

RelatedDrugs for AGPAT3_AGO3

RelatedDiseases for AGPAT3_AGO3