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Fusion gene ID: 11315 |
FusionGeneSummary for EIF4EBP1_ADAM18 |
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Fusion gene information | Fusion gene name: EIF4EBP1_ADAM18 | Fusion gene ID: 11315 | Hgene | Tgene | Gene symbol | EIF4EBP1 | ADAM18 | Gene ID | 1978 | 8749 |
Gene name | eukaryotic translation initiation factor 4E binding protein 1 | ADAM metallopeptidase domain 18 | |
Synonyms | 4E-BP1|4EBP1|BP-1|PHAS-I | ADAM27|tMDCIII | |
Cytomap | 8p11.23 | 8p11.22 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation initiation factor 4E-binding protein 1eIF4E-binding protein 1phosphorylated heat- and acid-stable protein regulated by insulin 1 | disintegrin and metalloproteinase domain-containing protein 18a disintegrin and metalloproteinase domain 18transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q13541 | Q9Y3Q7 | |
Ensembl transtripts involved in fusion gene | ENST00000338825, ENST00000520657, | ENST00000265707, ENST00000379866, ENST00000520772, ENST00000541111, ENST00000523755, | |
Fusion gene scores | * DoF score | 4 X 1 X 3=12 | 6 X 5 X 5=150 |
# samples | 4 | 6 | |
** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EIF4EBP1 [Title/Abstract] AND ADAM18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EIF4EBP1 | GO:0031929 | TOR signaling | 12150926|22578813 |
Hgene | EIF4EBP1 | GO:0045947 | negative regulation of translational initiation | 22578813 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-LI-A67I-01A | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000338825 | ENST00000265707 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
Frame-shift | ENST00000338825 | ENST00000379866 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
5CDS-intron | ENST00000338825 | ENST00000520772 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
5CDS-intron | ENST00000338825 | ENST00000541111 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
5CDS-3UTR | ENST00000338825 | ENST00000523755 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
intron-3CDS | ENST00000520657 | ENST00000265707 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
intron-3CDS | ENST00000520657 | ENST00000379866 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
intron-intron | ENST00000520657 | ENST00000520772 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
intron-intron | ENST00000520657 | ENST00000541111 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
intron-3UTR | ENST00000520657 | ENST00000523755 | EIF4EBP1 | chr8 | 37888236 | + | ADAM18 | chr8 | 39564309 | + |
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FusionProtFeatures for EIF4EBP1_ADAM18 |
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Hgene | Tgene |
EIF4EBP1 | ADAM18 |
Repressor of translation initiation that regulates EIF4Eactivity by preventing its assembly into the eIF4F complex:hypophosphorylated form competes with EIF4G1/EIF4G3 and stronglybinds to EIF4E, leading to repress translation. In contrast,hyperphosphorylated form dissociates from EIF4E, allowinginteraction between EIF4G1/EIF4G3 and EIF4E, leading to initiationof translation. Mediates the regulation of protein translation byhormones, growth factors and other stimuli that signal through theMAP kinase and mTORC1 pathways. {ECO:0000269|PubMed:22578813,ECO:0000269|PubMed:7935836}. | Sperm surface membrane protein that may be involved inspermatogenesis and fertilization. This is a non catalyticmetalloprotease-like protein (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF4EBP1_ADAM18 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF4EBP1_ADAM18 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EIF4EBP1 | CHTF8, EIF4E, UBAC1, ATM, MTOR, LRPAP1, PPP2R2A, RPTOR, GSK3B, IRAK4, PRKCA, KLHL25, MAPK1, AGO2, LRRK2, MAPK14, STK3, PPP2R4, PRKDC, LATS1, SLMAP, MLST8, REL, TCF4, AKT2, AKT3, CCDC94, CHMP2A, DDX1, FLNB, GGA1, HNRNPA1, SHMT2, HNRNPAB, AKT1, BUB1, MAPKAPK5, TRIM25 | ADAM18 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF4EBP1_ADAM18 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF4EBP1_ADAM18 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EIF4EBP1 | C0019693 | HIV Infections | 1 | CTD_human |
Hgene | EIF4EBP1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Hgene | EIF4EBP1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | EIF4EBP1 | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | CTD_human |