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Fusion gene ID: 11295 |
FusionGeneSummary for EIF3M_KRT7 |
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Fusion gene information | Fusion gene name: EIF3M_KRT7 | Fusion gene ID: 11295 | Hgene | Tgene | Gene symbol | EIF3M | KRT7 | Gene ID | 10480 | 3855 |
Gene name | eukaryotic translation initiation factor 3 subunit M | keratin 7 | |
Synonyms | B5|GA17|PCID1|TANGO7|hfl-B5 | CK7|K2C7|K7|SCL | |
Cytomap | 11p13 | 12q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog | keratin, type II cytoskeletal 7CK-7cytokeratin 7keratin 7, type IIkeratin, 55K type II cytoskeletalkeratin, simple epithelial type I, K7sarcolectintype II mesothelial keratin K7type-II keratin Kb7 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q7L2H7 | P08729 | |
Ensembl transtripts involved in fusion gene | ENST00000531120, ENST00000524896, ENST00000532054, | ENST00000331817, ENST00000552322, | |
Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 7 X 7 X 2=98 |
# samples | 7 | 7 | |
** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EIF3M [Title/Abstract] AND KRT7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG002942 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000531120 | ENST00000331817 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
intron-intron | ENST00000531120 | ENST00000552322 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
intron-intron | ENST00000524896 | ENST00000331817 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
intron-intron | ENST00000524896 | ENST00000552322 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
intron-intron | ENST00000532054 | ENST00000331817 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
intron-intron | ENST00000532054 | ENST00000552322 | EIF3M | chr11 | 32616166 | - | KRT7 | chr12 | 52637084 | - |
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FusionProtFeatures for EIF3M_KRT7 |
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Hgene | Tgene |
EIF3M | KRT7 |
Component of the eukaryotic translation initiationfactor 3 (eIF-3) complex, which is required for several steps inthe initiation of protein synthesis (PubMed:17403899,PubMed:25849773, PubMed:27462815). The eIF-3 complex associateswith the 40S ribosome and facilitates the recruitment of eIF-1,eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNArecruitment to the 43S PIC and scanning of the mRNA for AUGrecognition. The eIF-3 complex is also required for disassemblyand recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60Sribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of asubset of mRNAs involved in cell proliferation, including cellcycling, differentiation and apoptosis, and uses different modesof RNA stem-loop binding to exert either translational activationor repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012,ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}. (Microbial infection) May favor virus entry in case ofinfection with herpes simplex virus 1 (HSV1) or herpes simplexvirus 2 (HSV2). {ECO:0000269|PubMed:15919898}. | Blocks interferon-dependent interphase and stimulatesDNA synthesis in cells. Involved in the translational regulationof the human papillomavirus type 16 E7 mRNA (HPV16 E7).{ECO:0000269|PubMed:10492017, ECO:0000269|PubMed:12072504}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF3M_KRT7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF3M_KRT7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF3M_KRT7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | KRT7 | P08729 | DB01087 | Primaquine | Keratin, type II cytoskeletal 7 | small molecule | approved |
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RelatedDiseases for EIF3M_KRT7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | KRT7 | C0007134 | Renal Cell Carcinoma | 2 | CTD_human |
Tgene | KRT7 | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
Tgene | KRT7 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
Tgene | KRT7 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | KRT7 | C1510502 | Oxyphilic Adenoma | 1 | CTD_human |
Tgene | KRT7 | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |