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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11294

FusionGeneSummary for EIF3M_EIF3M

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3M_EIF3M
Fusion gene ID: 11294
HgeneTgene
Gene symbol

EIF3M

EIF3M

Gene ID

10480

10480

Gene nameeukaryotic translation initiation factor 3 subunit Meukaryotic translation initiation factor 3 subunit M
SynonymsB5|GA17|PCID1|TANGO7|hfl-B5B5|GA17|PCID1|TANGO7|hfl-B5
Cytomap

11p13

11p13

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homologeukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog
Modification date2018052320180523
UniProtAcc

Q7L2H7

Q7L2H7

Ensembl transtripts involved in fusion geneENST00000531120, ENST00000524896, 
ENST00000532054, 		ENST00000531120, 
ENST00000524896, ENST00000532054, 
Fusion gene scores* DoF score6 X 7 X 3=1267 X 5 X 4=140
# samples 78
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3M [Title/Abstract] AND EIF3M [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ428530EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
ChiTaRS3.1CA312302EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000531120ENST00000531120EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
In-frameENST00000531120ENST00000524896EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
5CDS-intronENST00000531120ENST00000532054EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
In-frameENST00000524896ENST00000531120EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
In-frameENST00000524896ENST00000524896EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
5CDS-intronENST00000524896ENST00000532054EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
intron-3CDSENST00000532054ENST00000531120EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
intron-3CDSENST00000532054ENST00000524896EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
intron-intronENST00000532054ENST00000532054EIF3Mchr11

32611166

-EIF3Mchr11

32616460

+
Frame-shiftENST00000531120ENST00000531120EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
Frame-shiftENST00000531120ENST00000524896EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
5CDS-intronENST00000531120ENST00000532054EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
Frame-shiftENST00000524896ENST00000531120EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
Frame-shiftENST00000524896ENST00000524896EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
5CDS-intronENST00000524896ENST00000532054EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
intron-3CDSENST00000532054ENST00000531120EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
intron-3CDSENST00000532054ENST00000524896EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+
intron-intronENST00000532054ENST00000532054EIF3Mchr11

32623319

-EIF3Mchr11

32617512

+

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FusionProtFeatures for EIF3M_EIF3M


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3M

Q7L2H7

EIF3M

Q7L2H7

Component of the eukaryotic translation initiationfactor 3 (eIF-3) complex, which is required for several steps inthe initiation of protein synthesis (PubMed:17403899,PubMed:25849773, PubMed:27462815). The eIF-3 complex associateswith the 40S ribosome and facilitates the recruitment of eIF-1,eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNArecruitment to the 43S PIC and scanning of the mRNA for AUGrecognition. The eIF-3 complex is also required for disassemblyand recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60Sribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of asubset of mRNAs involved in cell proliferation, including cellcycling, differentiation and apoptosis, and uses different modesof RNA stem-loop binding to exert either translational activationor repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012,ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}. (Microbial infection) May favor virus entry in case ofinfection with herpes simplex virus 1 (HSV1) or herpes simplexvirus 2 (HSV2). {ECO:0000269|PubMed:15919898}. Component of the eukaryotic translation initiationfactor 3 (eIF-3) complex, which is required for several steps inthe initiation of protein synthesis (PubMed:17403899,PubMed:25849773, PubMed:27462815). The eIF-3 complex associateswith the 40S ribosome and facilitates the recruitment of eIF-1,eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNArecruitment to the 43S PIC and scanning of the mRNA for AUGrecognition. The eIF-3 complex is also required for disassemblyand recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60Sribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of asubset of mRNAs involved in cell proliferation, including cellcycling, differentiation and apoptosis, and uses different modesof RNA stem-loop binding to exert either translational activationor repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012,ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}. (Microbial infection) May favor virus entry in case ofinfection with herpes simplex virus 1 (HSV1) or herpes simplexvirus 2 (HSV2). {ECO:0000269|PubMed:15919898}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Mchr11:32611166chr11:32616460ENST00000531120+111180_339-21375DomainPCI
TgeneEIF3Mchr11:32611166chr11:32616460ENST00000531120+511180_339205375DomainPCI


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FusionGeneSequence for EIF3M_EIF3M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF3M_EIF3M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EIF3MEIF1B, EIF4A2, EIF3A, EIF3F, EIF3H, TADA2A, EIF3B, APP, EIF3C, EIF3E, EIF3D, EIF3I, EIF3K, EIF3L, EIF3G, MMS19, NPM1, EXOSC10, SRPK1, FAM96B, HUWE1, EGFR, EIF3CL, USP34, HSPB1, AHCYL1, COPS4, RPN1, EIF3J, NTRK1, MED4, HERC2, NF2, PTP4A1, PSMD12, EIF4A1, GPBP1L1, UBE2N, CYLD, DLD, TRIM25, G3BP1, BRCA1EIF3MEIF1B, EIF4A2, EIF3A, EIF3F, EIF3H, TADA2A, EIF3B, APP, EIF3C, EIF3E, EIF3D, EIF3I, EIF3K, EIF3L, EIF3G, MMS19, NPM1, EXOSC10, SRPK1, FAM96B, HUWE1, EGFR, EIF3CL, USP34, HSPB1, AHCYL1, COPS4, RPN1, EIF3J, NTRK1, MED4, HERC2, NF2, PTP4A1, PSMD12, EIF4A1, GPBP1L1, UBE2N, CYLD, DLD, TRIM25, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneEIF3Mchr11:32611166chr11:32616460ENST00000531120+511344_374205375HSV-1 and HSV-2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEIF3Mchr11:32611166chr11:32616460ENST00000531120+111344_374-21375HSV-1 and HSV-2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF3M_EIF3M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF3M_EIF3M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource