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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11289

FusionGeneSummary for EIF3L_MTUS1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3L_MTUS1
Fusion gene ID: 11289
HgeneTgene
Gene symbol

EIF3L

MTUS1

Gene ID

51386

57509

Gene nameeukaryotic translation initiation factor 3 subunit Lmicrotubule associated scaffold protein 1
SynonymsEIF3EIP|EIF3S11|EIF3S6IP|HSPC021|HSPC025|MSTP005ATBP|ATIP|ATIP3|ICIS|MP44|MTSG1
Cytomap

22q13.1

8p22

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit LeIEF associated protein HSPC021eukaryotic translation initiation factor 3 subunit 6-interacting proteineukaryotic translation initiation factor 3 subunit E-interacting proteinmicrotubule-associated tumor suppressor 1AT2 receptor-binding proteinAT2 receptor-interacting proteinAT2R binding proteinangiotensin-II type 2 receptor-interacting proteinerythroid differentiation-relatedmicrotubule associated tumor suppressor 1mit
Modification date2018052320180523
UniProtAcc

Q9Y262

Q9ULD2

Ensembl transtripts involved in fusion geneENST00000412331, ENST00000381683, 
ENST00000406934, ENST00000476955, 
ENST00000544260, ENST00000381869, 
ENST00000381861, ENST00000262102, 
ENST00000519263, ENST00000400046, 
ENST00000297488, ENST00000518713, 
ENST00000381862, 
Fusion gene scores* DoF score9 X 5 X 8=3603 X 3 X 2=18
# samples 113
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EIF3L [Title/Abstract] AND MTUS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3L

GO:0006413

translational initiation

17581632

HgeneEIF3L

GO:0075525

viral translational termination-reinitiation

21347434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA039338EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000412331ENST00000544260EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000381869EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000381861EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000262102EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000519263EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000412331ENST00000400046EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000412331ENST00000297488EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000412331ENST00000518713EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000412331ENST00000381862EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000544260EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000381869EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000381861EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000262102EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000519263EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000381683ENST00000400046EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000381683ENST00000297488EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000381683ENST00000518713EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000381683ENST00000381862EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000544260EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000381869EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000381861EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000262102EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000519263EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000406934ENST00000400046EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000406934ENST00000297488EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000406934ENST00000518713EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000406934ENST00000381862EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000544260EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000381869EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000381861EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000262102EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000519263EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-intronENST00000476955ENST00000400046EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-intronENST00000476955ENST00000297488EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-intronENST00000476955ENST00000518713EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-intronENST00000476955ENST00000381862EIF3Lchr22

38247497

+MTUS1chr8

17573414

-

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FusionProtFeatures for EIF3L_MTUS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3L

Q9Y262

MTUS1

Q9ULD2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF3L_MTUS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF3L_MTUS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EIF3LEIF3K, EIF3A, EIF1B, EIF4A2, EIF3D, EIF3E, EIF3H, EIF3F, H2AFX, TADA2A, AGO3, HDAC5, EIF3B, RGS2, SIRT7, CUL1, EIF3C, EIF3G, EIF3M, EIF3I, NCL, FN1, VCAM1, SMAD2, ITGA4, RRN3, CD81, IGSF8, ICAM1, XRN2, DDX3X, KCMF1, LARP1, RPS13, RPS16, RPS18, RPS20, RPS25, RPS28, RPS4X, RPS5, RPS8, RPS9, RIOK2, RNF2, EIF3CL, EIF2B5, NUMA1, NTRK1, HERC2, XPO1, AHSA1, NPM1, RPL10, CEP170P1, GAN, MCM2, C1orf131, ZNF746, PRRC2B, PSMD12, GNB2, PTP4A1, TTC21B, CYLD, G3BP1, BRCA1, YAP1MTUS1AGTR2, MMS19, ORC4, FHL3, CEP104, SPICE1, NINL, DCTN1, DYNLT1, LCA5, POC1A, CLTC, KIF11, MAGEA10, SMC1A, CDC14A, MTUS2, CLUH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF3L_MTUS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF3L_MTUS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMTUS1C2239176Liver carcinoma1UNIPROT